Article
Peripheral Vascular Disease
Liyue Xu, Brendan T. Keenan, David Maislin, Thorarinn Gislason, Bryndis Benediktsdottir, Sigrun Gudmundsdottir, Marianna Gardarsdottir, Bethany Staley, Frances M. Pack, Xiaofeng Guo, Yuan Feng, Jugal Chahwala, Pritika Manaktala, Anila Hussein, Maheshwara Reddy-Koppula, Zeba Hashmath, Jonathan Lee, Raymond R. Townsend, Richard J. Schwab, Allan Pack, Samuel T. Kuna, Julio A. Chirinos
Summary: This study investigated the impact of obesity on the effectiveness of PAP therapy and the levels of NT-proBNP in adults with and without OSA. The results indicated that obesity modified the effects of PAP treatment on NT-proBNP and left atrial volume index, suggesting potential differences in cardiac remodeling in obese individuals with OSA.
Article
Cardiac & Cardiovascular Systems
Andreas Schuster, Alexander Schulz, Torben Lange, Ruben Evertz, Finn Hartmann, Johannes T. Kowallick, Kristian Hellenkamp, Martin Uecker, Tim Seidler, Gerd Hasenfuss, Soeren J. Backhaus
Summary: The study aimed to determine whether exercise stress cardiovascular magnetic resonance (CMR) imaging can help in the selection of patients with heart failure with preserved ejection fraction (HFpEF) for interatrial shunt device (IASD) placement. The study recruited 75 patients with exertional dyspnea and diastolic dysfunction, and conducted various tests including CMR imaging. The study found that latent pulmonary vascular disease (PVD) is associated with impaired right ventricular (RV) functional reserve, global diastolic filling, and left ventricular (LV) cardiac index (CI), which can be quantified by CMR imaging.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Maciej Marciniak, Arend W. van Deutekom, Liza Toemen, Adam J. Lewandowski, Romy Gaillard, Alistair A. Young, Vincent W. V. Jaddoe, Pablo Lamata
Summary: This study utilizes statistical shape models (SSMs) to analyze the correlation between the morphology of pediatric hearts and obesity, providing new parameters for risk stratification.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Song Luo, Shu Tian Xu, Jun Zhang, U. Joseph Schoepf, Akos Varga-Szemes, Charles R. T. Carpenter, Ling Yan Zhang, Yan Ma, Zhe Li, Yang Wang, Wei Wei Huang, Bei Bei Zhi, Wei Qiang Dou, Li Qi, Long Jiang Zhang
Summary: This study aimed to explore the clinical potential of multiparametric cardiac magnetic resonance (CMR) in evaluating myocardial inflammation in patients with exertional heat illness (EHI). The results showed that EHI patients had increased global ECV, T2, and persistent myocardial inflammation at 3-month follow-up after the episode. Therefore, multiparametric CMR might be an effective method in evaluating myocardial inflammation in patients with EHI.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chris Anthony, Muhammad Imran, Jim Pouliopoulos, Sam Emmanuel, James Iliff, Zhixin Liu, Kirsten Moffat, Min Ru Qiu, Catriona A. McLean, Christian Stehning, Valentina Puntmann, Vass Vassiliou, Tevfik F. Ismail, Ankur Gulati, Sanjay Prasad, Robert M. Graham, Jane McCrohon, Cameron Holloway, Eugene Kotlyar, Kavitha Muthiah, Anne M. Keogh, Christopher S. Hayward, Peter S. Macdonald, Andrew Jabbour
Summary: This study aimed to assess the feasibility of cardiovascular magnetic resonance (CMR)-based myocardial tissue characterization for monitoring acute cardiac allograft rejection (ACAR)-induced myocarditis after heart transplantation. The results showed that CMR-based multiparametric assessment was highly reproducible and reliable, with higher specificity and negative predictive value for detecting ACAR compared to single CMR mapping. Compared to biopsy-based surveillance, CMR-based surveillance strategy could reduce hospitalization and infection rates.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoxuan Zhang, Caixia Cui, Shifeng Zhao, Lizhi Xie, Yun Tian
Summary: This study investigated the discriminability of quantitative radiomics features extracted from cardiac magnetic resonance (CMR) images for hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and healthy (NOR) patients. A predictive model was proposed based on CMR radiomics features for classifying HCM, DCM, and NOR patients, which had good discriminability and improved sensitivity and accuracy compared to state-of-the-art methods.
EUROPEAN RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Robert J. Holtackers, Joachim E. Wildberger, Bernd J. Wintersperger, Amedeo Chiribiri
Summary: Cardiac magnetic resonance imaging (MRI) is commonly used for noninvasive assessment of cardiac structure and function, with 1.5 T traditionally being the preferred field strength. While 3 T systems have seen significant growth in the past decade, there are still challenges hindering their widespread clinical use for cardiac applications. Different clinical benefits exist for each field strength and there is no universal recommendation for the ideal field strength for cardiac MRI. The review discusses the physical differences between 1.5 and 3 T, their impact on various cardiac MRI applications, and provides solutions to overcome potential limitations.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Brendan L. Eck, Nicole Seiberlich, Scott D. Flamm, Jesse Hamilton, Abhilash Suresh, Yash Kumar, Mazen Hanna, Angel Houston, Derrek Tew, W. H. Wilson Tang, Deborah H. Kwon
Summary: Elevated native myocardial T-1 and T-2 were observed in patients with cardiac amyloidosis (CA) compared to controls. Cardiac Magnetic Resonance Fingerprinting (cMRF) shows potential for detecting and characterizing CA, with signal timecourse-based analysis proving to be more effective than relaxometric-based analysis.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Pei-Lun Han, Xue-Ming Li, Li Jiang, Wei-Feng Yan, Ying-Kun Guo, Yuan Li, Kang Li, Zhi-Gang Yang
Summary: This study investigated the impact of obesity on myocardial microcirculation and left ventricular deformation in hypertensive patients using cardiac magnetic resonance. The findings suggest that obesity has adverse effects on microvascular changes and subclinical left ventricular dysfunction in hypertension, and body mass index is independently associated with both myocardial perfusion and left ventricular deformation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Theo Pezel, Thierry Unterseeh, Philippe Garot, Thomas Hovasse, Marine Kinnel, Stephane Champagne, Solenn Toupin, Francesca Sanguineti, Jerome Garot
Summary: This study evaluated the prognostic value of vasodilator stress cardiovascular magnetic resonance (CMR) parameters and CMR-based coronary revascularization in predicting major adverse cardiovascular events (MACE) after inconclusive stress testing. Inducible ischemia and late gadolinium enhancement (LGE) were significantly associated with the occurrence of MACE, with the extent of inducible ischemia showing the best improvement in model discrimination. The study suggested no benefit of CMR-related coronary revascularization in reducing MACE.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew J. M. Lewis, Ines Abdesselam, Jennifer J. Rayner, James Byrne, Barry A. Borlaug, Stefan Neubauer, Oliver J. Rider
Summary: Increasing body weight has significant effects on right ventricular volumes, energetics, systolic function, and stress responses. Weight loss can improve these adverse effects.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hang Zhou, Yuehan Wei, Dong-Aolei An, Zhaohui Ni, Jianrong Xu, Wei Fang, Renhua Lu, Liang Ying, Binghua Chen, Haijiao Jin, Jiaying Huang, Qiuying Yao, Luke Wesemann, Lian-Ming Wu, Shan Mou
Summary: This study explored myocardial iron content using Cardiac T2* Mapping in dialysis patients undergoing different iron therapies compared to healthy controls, finding that peritoneal dialysis patients have higher cardiac T2* values and may be at a higher risk of myocardial iron deficiency compared to hemodialysis patients. The T2* value was found to be negatively correlated with cardiac function indicators, suggesting it may be an independent predictor of left ventricular function and altered mechanics.
ACADEMIC RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Panagiotis Antiochos, Yin Ge, Bobak Heydari, Kevin Steel, Scott Bingham, Shuaib M. Abdullah, J. Ronald Mikolich, Andrew E. Arai, Patricia Bandettini, Amit R. Patel, Afshin Farzaneh-Far, John F. Heitner, Chetan Shenoy, Steve W. Leung, Jorge A. Gonzalez, Dipan J. Shah, Subha Raman, Victor A. Ferrari, Jeanette Schulz-Menger, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
Summary: Stress CMR-assessed ischemia was strongly associated with MI/CV death and reclassified patient risk beyond CV risk factors, especially in those considered to be at intermediate risk. Absence of ischemia was associated with a <2% annual rate of MI/CV death.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Qi, Xuefeng Ni, U. Joseph Schoepf, Akos Varga-Szemes, Liam McGill, Wei Wang, Lingyan Zhang, Song Luo, Jiqiu Wen, Long Jiang Zhang
Summary: After renal transplantation, cardiac structural and functional changes were observed. While some parameters returned to normal levels, left ventricular mass index remained impaired in median 14 months after transplantation.
EUROPEAN RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Bishwas Chamling, Michael Bietenbeck, Stefanos Drakos, Dennis Korthals, Volker Vehof, Philipp Stalling, Claudia Meier, Ali Yilmaz
Summary: Cardiovascular magnetic resonance (CMR) is crucial for diagnosing and monitoring cardiac amyloidosis (CA). A study found a paradox in wild-type transthyretin amyloidosis (ATTRwt) where native T1 values were lower compared to light-chain amyloidosis (AL), despite ATTRwt having higher LV mass and ECV values. This paradox can be explained by differences in myocardial density, resulting in a lower TICM/TECM ratio in ATTRwt compared to AL.
SCIENTIFIC REPORTS
(2022)
Correction
Cardiac & Cardiovascular Systems
Sharmila Dorbala, Yukio Ando, Sabahat Bokhari, Angela Dispenzieri, Rodney H. Falk, Victor A. Ferrari, Marianna Fontana, Olivier Gheysens, Julian D. Gillmore, Andor W. J. M. Glaudemans, Mazen A. Hanna, Bouke P. C. Hazenberg, Arnt V. Kristen, Raymond Y. Kwong, Mathew S. Maurer, Giampaolo Merlini, Edward J. Miller, James C. Moon, Venkatesh L. Murthy, C. Cristina Quarta, Claudio Rapezzi, Frederick L. Ruberg, Sanjiv J. Shah, Riemer H. J. A. Slart, Hein J. Verberne, Jamieson M. Bourque
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Panagiotis Antiochos, Yin Ge, Bobak Heydari, Kevin Steel, Scott Bingham, Shuaib M. Abdullah, J. Ronald Mikolich, Andrew E. Arai, Patricia Bandettini, Amit R. Patel, Afshin Farzaneh-Far, John F. Heitner, Chetan Shenoy, Steve W. Leung, Jorge A. Gonzalez, Dipan J. Shah, Subha Raman, Victor A. Ferrari, Jeanette Schulz-Menger, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
Summary: Stress CMR-assessed ischemia was strongly associated with MI/CV death and reclassified patient risk beyond CV risk factors, especially in those considered to be at intermediate risk. Absence of ischemia was associated with a <2% annual rate of MI/CV death.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Ayako Seno, Panagiotis Antiochos, Helena Lichtenfeld, Eva Rickers, Iqra Qamar, Yin Ge, Ron Blankstein, Michael Steigner, Ayaz Aghayev, Michael Jerosch-Herold, Raymond Y. Kwong
Summary: Recent research has found that the assessment of extracellular volume fraction (ECV) and global longitudinal strain (GLS) by cardiac magnetic resonance can provide valuable prognostic information for predicting all-cause death or heart failure hospitalizations in patients suspected of heart failure. This incremental prognostic value of ECV and GLS goes beyond traditional markers such as left ventricular ejection fraction (LVEF) and late gadolinium enhancement (LGE). Additionally, the joint assessment of GLS and ECV has been shown to significantly improve model discrimination and risk reclassification for adverse outcomes in this patient population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Letter
Endocrinology & Metabolism
Ikaro Breder, Vaneza Lira W. Wolf, Alexandre A. S. Soares, Luiz Sergio F. de Carvalho, Sheila T. Kimura-Medorima, Riobaldo M. Cintra, Joaquim Barreto, Daniel B. Munhoz, Jessica S. Cunha, Isabella Bonilha, Otavio R. Coelho-Filho, Thiago Quinaglia, Wilson Nadruz, Gil Guerra-Junior, Elza Muscelli, Andrei C. Sposito
DIABETES & METABOLISM
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Raymond Y. Kwong, Rhanderson Cardoso, Michael Jerosch-Herold
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Andrei C. Sposito, Ikaro Breder, Joaquim Barreto, Jessica Breder, Isabella Bonilha, Marcus Lima, Alessandra Oliveira, Vaneza Wolf, Beatriz Luchiari, Helison R. do Carmo, Daniel Munhoz, Daniela Oliveira, Otavio R. Coelho-Filho, Otavio R. Coelho, Jose Roberto Matos-Souza, Filipe A. Moura, Luiz Sergio F. de Carvalho, Wilson Nadruz, Thiago Quinaglia, Sheila T. Kimura-Medorima
Summary: The addition of evolocumab to empagliflozin in individuals with T2D improves endothelial function, leading to better vascular function.
CARDIOVASCULAR DIABETOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Michael Jerosch-Herold, Otavio Coelho-Filho
Editorial Material
Cardiac & Cardiovascular Systems
Raymond Y. Kwong, Michael Jerosch-Herold
Editorial Material
Cardiac & Cardiovascular Systems
Toral R. Y. Patel, Todd Villines, Christopher M. Kramer
EUROPEAN HEART JOURNAL
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Thiago Quinaglia A. C. Silva, Theo Pezel, Michael Jerosch-Herold, Otavio R. Coelho-Filho
Summary: Despite advances in noninvasive detection techniques, cardiac magnetic resonance (CMR) remains a valuable tool for the diagnosis of ischemic heart disease. CMR combines multiple capabilities including assessment of wall motion abnormalities, myocardial perfusion imaging, and detection of fibrosis markers. It is well tolerated, safe, and can provide prognosis for cardiovascular events. According to the 2019 ESC guidelines, stress CMR is recommended for the diagnosis of symptomatic coronary artery disease.
JOURNAL OF THORACIC IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Jerosch-Herold, Carsten Rickers, Steffen E. E. Petersen, Otavio R. Coelho-Filho
Summary: This study found that biological factors can moderate cardiac magnetic resonance myocardial tissue markers in cohorts recovering from COVID-19 infection. The %Delta of native T-1 and T-2 between COVID-19 and control groups showed lower interstudy heterogeneity compared to native T-1 and T-2. Factors such as recovery duration, cardiac troponins, C-reactive protein, and age can moderate the %Delta of T-1 and/or T-2.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Dominik C. Benz, Christoph Grani, Panagiotis Antiochos, Bobak Heydari, Mark Colin Gissler, Yin Ge, Sarah A. M. Cuddy, Sharmila Dorbala, Raymond Y. Kwong
Summary: Cardiac magnetic resonance offers multiple facets in the diagnosis, risk stratification, and management of patients with myocardial diseases. Particularly, its feature to precisely monitor disease activity lends itself to quantify response to novel therapeutics.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Christoph Grani, Marius R. Bigler, Raymond Y. Kwong
Summary: The purpose of this review is to evaluate how noninvasive comprehensive anatomic- and physiologic evaluation can guide patient management for anomalous aortic origin of a coronary artery (AAOCA). The review explores the role of noninvasive multimodality imaging in characterizing AAOCA, with a focus on the pathophysiology of myocardial ischemia and stress testing protocols.
CURRENT CARDIOLOGY REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Andrew E. Arai, Raymond Y. Kwong, Michael Salerno, John P. Greenwood, Chiara Bucciarelli-Ducci
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)
Article
Cardiac & Cardiovascular Systems
Ankur Pandya, Yuan-Jui Yu, Yin Ge, Eike Nagel, Raymond Y. Kwong, Rafidah Abu Bakar, John D. Grizzard, Alexander E. Merkler, Ntobeko Ntusi, Steffen E. Petersen, Nina Rashedi, Juerg Schwitter, Joseph B. Selvanayagam, James A. White, James Carr, Subha V. Raman, Orlando P. Simonetti, Chiara Bucciarelli-Ducci, Lilia M. Sierra-Galan, Victor A. Ferrari, Mona Bhatia, Sebastian Kelle
Summary: Based on the research, cardiovascular magnetic resonance (CMR) is usually a cost-effective option compared to relevant comparators for assessing significant coronary artery disease. The findings suggest that CMR can provide both health benefits and cost savings, making it a favorable choice for evaluating CAD.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)