Article
Radiology, Nuclear Medicine & Medical Imaging
Shiqin Yu, Xiuyu Chen, Kai Yang, Jiaxin Wang, Kankan Zhao, Wenhao Dong, Weipeng Yan, Guohai Su, Shihua Zhao
Summary: This study revealed that LV systolic dysfunction could be early detected in LVNC patients with normal LVEF using cardiac MRI feature tracking, and it was associated with the complexity of excessive trabeculation assessed by FD.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Giovanni Donato Aquaro, Elisabetta Corsi, Giancarlo Todiere, Crysanthos Grigoratos, Andrea Barison, Valerio Barra, Gianluca Di Bella, Michele Emdin, Fabrizio Ricci, Alessandro Pingitore
Summary: This study evaluates the diagnostic and prognostic role of cardiac magnetic resonance (CMR) in patients with evidence of left ventricular hypertrophy (LVH) on transthoracic echocardiography (TTE) and/or electrocardiography (ECG). Results showed that CMR can change the initial echocardiographic diagnosis in almost half of LVH patients and can identify LVH in a majority of patients with abnormal ECG. CMR is valuable in characterizing the type, extent, and severity of LVH detected on echocardiography and suspected with ECG.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Marie F. Borresen, Elisabeth Blixenkrone-Moller, Thilde O. Kock, Anne-Sophie Sillesen, R. Ottilia B. Vogg, Christian A. Pihl, Jakob B. Norsk, Niels G. Vejlstrup, Alex H. Christensen, Kasper K. Iversen, Henning Bundgaard, Anna Axelsson Raja
Summary: Left ventricular noncompaction (LVNC) is characterized by excessive trabeculations of the LV and may be associated with reduced systolic function or severe adverse outcomes. This study found a prevalence of 0.076% for LVNC in neonates and significant association with lower LV systolic function.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Wei Bai, Rong Xu, Xiao Li, Huayan Xu, Hang Fu, Ruilai Hou, Ziqi Zhou, Wei Huang, Yining Wang, Yingkun Guo
Summary: The combination of CMR-FT with traditional CMR parameters may not increase the prognostic value of CMR in LVNC patients with reduced LVEF, while the presence of LGE was a strong independent predictor of MACEs and significantly improved the predictive value.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pei-Lun Han, Meng-Ting Shen, Yu Jiang, Ze-Kun Jiang, Kang Li, Zhi-Gang Yang
Summary: Patients with LVNC have impaired left atrial function, and left atrial longitudinal strain plays a predictive role in high-risk HF events. Left ventricular global longitudinal strain is associated with left atrial reservoir strain.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pei-Lun Han, Ze-Kun Jiang, Ran Gu, Shan Huang, Yu Jiang, Zhi-Gang Yang, Kang Li
Summary: This study used machine learning and radiomics features to build predictive models for predicting major adverse cardiovascular events in patients with left ventricular myocardial noncompaction (LVNC). The results showed that the machine learning models performed well and adding radiomics features offered incremental prognostic value over clinical factors alone.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea Szucs, Anna Reka Kiss, Zsofia Gregor, Marton Horvath, Attila Toth, Zsofia Dohy, Liliana Erzsebet Szabo, Ferenc Imre Suhai, Bela Merkely, Hajnalka Vago
Summary: For patients with left ventricular noncompaction (LVNC), as the ejection fraction (EF) decreases, both strain values and rotational parameters change, affecting global LV function. LV mechanical dispersion increases significantly in LVNC patients, and there are variations in rotational patterns and degrees.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lina Zhu, Jiang Wu, Xiaoyong Hao, Xuan Li
Summary: This study explored the value of myocardial strain in the differential diagnosis of ILVNC and DCM using CMR feature tracking technology. The results showed that myocardial strain parameters have considerable value in the differential diagnosis of ILVNC and DCM.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Agata Paszkowska, Jedrzej Sarnecki, Alicja Mirecka-Rola, Monika Kowalczyk-Domagala, Lukasz Mazurkiewicz, Lidia Ziolkowska
Summary: Left ventricular noncompaction (LVNC) is a distinct cardiomyopathy with heterogeneous diagnostic criteria. This study evaluated the echocardiographic and CMR findings in a group of children with isolated LVNC and found that echocardiography can accurately identify LVNC patients, while CMR provides more precise assessment of LV remodeling, ventricular size and function.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Review
Cardiac & Cardiovascular Systems
Javier Cuevas, Helena Cigarran, Juan Calvo, Maria Martin
Summary: Left ventricular noncompaction cardiomyopathy is a complex disease associated with other cardiac malformations, genetic syndromes, and neuromuscular disorders. Diagnostic and differential diagnosis are crucial, requiring the use of echocardiogram and cardiac magnetic resonance. Left ventricular dilatation, dysfunction, and fibrosis are prognosis factors.
KARDIOLOGIA POLSKA
(2022)
Article
Cardiac & Cardiovascular Systems
Marie Cambon-Viala, Hilla Gerard, Karine Nguyen, Pascale Richard, Flavie Ader, Jean-Francois Pruny, Erwan Donal, Jean-Christophe Eicher, Olivier Huttin, Christine Selton-Suty, Pascale Raud-Raynier, Guillaume Jondeau, Nicolas Mansencal, Caroline Sawka, Anne-Claire Casalta, Nicolas Michel, Valeria Donghi, Helene Martel, Laurence Faivre, Philippe Charron, Gilbert Habib
Summary: The study revealed the importance of genotype-phenotype relationship in patients with LVNC, particularly in those with ion channel gene mutations. Patients with ion channel gene mutations presented higher LV ejection fraction and more frequent biventricular noncompaction compared to those without mutations, highlighting the significance of identifying causative mutations for genetic counseling and management of the disease.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Jay Ramchand, Pooja Podugu, Nancy Obuchowski, Serge C. Harb, Michael Chetrit, Alex Milinovich, Brian Griffin, Louise M. Burrell, W. H. Wilson Tang, Deborah H. Kwon, Scott D. Flamm
Summary: This study aimed to evaluate whether the presence of a thin compacted myocardial layer leads to poorer outcomes in patients with left ventricular non-compaction. The results showed that the risk of adverse clinical events is increased in the presence of significant compacted myocardial thinning, an elevated B-type natriuretic peptide, or increased left ventricular dimensions. These markers could enhance risk assessment and help reduce overdiagnosis of left ventricular non-compaction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Medicine, General & Internal
Emanuele Monda, Marta Rubino, Giuseppe Palmiero, Federica Verrillo, Michele Lioncino, Gaetano Diana, Annapaola Cirillo, Adelaide Fusco, Francesca Dongiglio, Martina Caiazza, Ippolita Altobelli, Alfredo Mauriello, Natale Guarnaccia, Alessandra Scatteia, Arturo Cesaro, Giuseppe Pacileo, Berardo Sarubbi, Giulia Frisso, Barbara Bauce, Antonello D'Andrea, Santo Dellegrottaglie, Maria Giovanna Russo, Paolo Calabro, Giuseppe Limongelli
Summary: Arrhythmogenic cardiomyopathy (ACM) is a broad term for myocardial diseases characterized by progressive fibrotic or fibrofatty replacement, which leads to ventricular tachyarrhythmias and ventricular dysfunction. Arrhythmogenic left ventricular cardiomyopathy (ALVC) is a specific subtype that exclusively affects the left ventricle. Diagnosis of ALVC requires a combination of family history, clinical, electrocardiographic, and imaging features, with genetic testing for confirmation. Multimodality imaging techniques, such as echocardiography, cardiac magnetic resonance, and cardiac nuclear imaging, are essential for diagnosis, differential diagnosis, risk stratification, and management of ALVC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Wei Huang, Ran Sun, Wenbin Liu, Rong Xu, Ziqi Zhou, Wei Bai, Ruilai Hou, Huayan Xu, Yingkun Guo, Li Yu, Lu Ye
Summary: In this study, the clinical and cardiovascular magnetic resonance data of 75 patients with left ventricular noncompaction were retrospectively analyzed. The results showed a correlation between late gadolinium enhancement types and major adverse cardiovascular events. A specific ring-like pattern and involvement of the free wall or mid-wall were associated with an increased risk of adverse cardiovascular events. The extent of late gadolinium enhancement greater than 7.5% and the presence of ring-like, multiple segments, and free-wall enhancement were significantly associated with major adverse cardiovascular events.
Article
Cardiac & Cardiovascular Systems
David Lewandowski, Eric Y. Yang, Duc T. Nguyen, Mohammad A. Khan, Maan Malahfji, Carlos El Tallawi, Mohammed A. Chamsi Pasha, Edward A. Graviss, Dipan J. Shah, Sherif F. Nagueh
Summary: This study aimed to determine the association between left ventricular diastolic function assessed by echocardiography and cardiac magnetic resonance-determined global fibrosis burden, as well as the incremental value of fibrosis with diastolic function grade in predicting total mortality and heart failure hospitalizations.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Antonio Pelliccia, Stefano Caselli, Sanjay Sharma, Cristina Basso, Jeroen J. Bax, Domenico Corrado, Antonello D'Andrea, Flavio D'Ascenzi, Fernando M. Di Paolo, Thor Edvardsen, Sabiha Gati, Maurizio Galderisi, Hein Heidbuchel, Alain Nchimi, Koen Nieman, Michael Papadakis, Cataldo Pisicchio, Christian Schmied, Bogdan A. Popescu, Gilbert Habib, Diederick Grobbee, Patrizio Lancellotti
EUROPEAN HEART JOURNAL
(2018)
Article
Cardiac & Cardiovascular Systems
Sabiha Gati, Sanjay Sharma, Dudley Pennell
JACC-CARDIOVASCULAR IMAGING
(2018)
Review
Cardiac & Cardiovascular Systems
Sabiha Gati, Aneil Malhotra, Sanjay Sharma
Article
Medicine, General & Internal
Aneil Malhotra, Harshil Dhutia, Gherardo Finocchiaro, Sabiha Gati, Ian Beasley, Paul Clift, Charlotte Cowie, Antoinette Kenny, Jamil Mayet, David Oxborough, Kiran Patel, Guido Pieles, Dhrubo Rakhit, David Ramsdale, Leonard Shapiro, John Somauroo, Graham Stuart, Amanda Varnava, John Walsh, Zaheer Yousef, Maite Tome, Michael Papadakis, Sanjay Sharma
NEW ENGLAND JOURNAL OF MEDICINE
(2018)
Article
Cardiac & Cardiovascular Systems
Sabiha Gati, Aneil Malhotra, Catherine Sedgwick, Nikolaos Papamichael, Harshil Dhutia, Rajan Sharma, Anne H. Child, Michael Papadakis, Sanjay Sharma
Editorial Material
Cardiac & Cardiovascular Systems
Sanjay Sharma, Gemma Parry-Williams, Sabiha Gati
EUROPEAN HEART JOURNAL
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Raghav T. Bhatia, Sabiha Gati, Michael Papadakis, Sanjay Sharma
EUROPEAN HEART JOURNAL
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Sabiha Gati, Jonathan Drezner, Sanjay Sharma
Article
Cardiac & Cardiovascular Systems
Harshil Dhutia, Aneil Malhotra, Gherardo Finocchiaro, Sameer Parpia, Raghav Bhatia, Andrew D'Silva, Sabiha Gati, Greg Mellor, Rajay Narain, Navin Chandra, Elijah Behr, Maite Tome, Michael Papadakis, Sanjay Sharma
Summary: Screening with electrocardiography (ECG) in combination with a health questionnaire can significantly increase the ability to detect cardiovascular diseases associated with sudden cardiac death (SCD) in young individuals, and is more cost effective compared to screening with a health questionnaire alone.
Review
Cardiac & Cardiovascular Systems
Gemma Parry-Williams, Sabiha Gati, Sanjay Sharma
Summary: Moderate physical exercise is linked to reduced cardiac morbidity and mortality; However, the long-term effects of endurance exercise on the heart remain unclear; Some studies suggest a diminishing mortality benefit for individuals performing the highest volume of exercise.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Sabiha Gati, Sanjay Sharma
Summary: Hypertrophic cardiomyopathy (HCM) is a common cause of sudden cardiac death (SCD) during exercise in young individuals. Previous exercise recommendations for HCM patients were conservative, but recent research suggests that mild to moderate exercise is safe and beneficial for both asymptomatic and symptomatic HCM patients.
Article
Cardiac & Cardiovascular Systems
Silvia Castelletti, Sabiha Gati
Summary: The number of female athletes participating in sports is increasing, but there is less research on cardiovascular adaptations in women compared to men. Despite some differences in cardiovascular health between genders, such as risk of sudden cardiac death, cardiac dimensions, and ECG changes, women who engage in lifelong exercise do not have a higher prevalence of cardiovascular diseases compared to sedentary counterparts.
EUROPEAN CARDIOLOGY REVIEW
(2021)
Article
Cardiac & Cardiovascular Systems
Raghav T. Bhatia, Aneil Malhotra, Hamish MacLachlan, Sabiha Gati, Sarandeep Marwaha, Nikhil Chatrath, Saad Fyyaz, Haroldo Aleixo, Samar Al-Turaihi, Aswin Babu, Joyee Basu, Paul Catterson, Robert Cooper, Joelle J. N. Daems, Harshil Dhutia, Filipe Ferrari, Juliette C. van Hattum, Zafar Iqbal, Alexandros Kasiakogias, Antoinette Kenny, Tamim Khanbhai, Shafik Khoury, Chris Miles, David Oxborough, Kashif Quazi, Dhrubo Rakhit, Anushka Sharma, Amanda Varnava, Maria Teresa Tome Esteban, Gherardo Finocchiaro, Ricardo Stein, Harald T. Jorstad, Michael Papadakis, Sanjay Sharma
Summary: In this study, 3% of athletes showed de-novo ECG changes after COVID-19 infection, and 88% of them were diagnosed with cardiac inflammation. The presence of these ECG changes contributed to a diagnosis of cardiac inflammation in 20% of athletes without cardiac symptoms.
Article
Sport Sciences
Aneil Malhotra, Harshil Dhutia, Sabiha Gati, Tee-Joo Yeo, Gherardo Finnochiaro, Tracey Keteepe-Arachi, Thomas Richards, Mike Walker, Robin Birt, David Stuckey, Laurence Robinson, Maite Tome, Ian Beasley, Michael Papadakis, Sanjay Sharma
BRITISH JOURNAL OF SPORTS MEDICINE
(2019)
Article
Cardiac & Cardiovascular Systems
David Oxborough, Daniel Augustine, Sabiha Gati, Keith George, Allan Harkness, Thomas Mathew, Michael Papadakis, Liam Ring, Shaun Robinson, Julie Sandoval, Rizwan Sarwar, Sanjay Sharma, Vishal Sharma, Nabeel Sheikh, John Somauroo, Martin Stout, James Willis, Abbas Zaidi
ECHO RESEARCH AND PRACTICE
(2018)
