Article
Cardiac & Cardiovascular Systems
Sneha S. Jain, Kevin J. Clerkin, Edmund Anstey, Qi Liu, Justin A. Fried, Jayant Raikhelkar, Jan M. Griffin, Dylan Marshall, Paolo Colombo, Melana Yuzefpolskaya, Veli Topkara, Yoshifumi Naka, Koji Takeda, Gabriel Sayer, Nir Uriel, Jay Leb
Summary: This study describes the prevalence, imaging findings, and clinical outcomes associated with outflow graft narrowing in patients with the HeartMate 3 left ventricular assist device (LVAD). The results showed that 33% of patients had outflow graft narrowing, which was significantly associated with a longer duration of LVAD support. There was no significant difference in LV unloading between patients with and without narrowing.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Maciej Stapor, Adam Pilat, Andrzej Gackowski, Agnieszka Misiuda, Izabela Gorkiewicz-Kot, Michal Kaleta, Pawel Kleczynski, Krzysztof Zmudka, Jacek Legutko, Boguslaw Kapelak, Karol Wierzbicki
Summary: This study evaluates the feasibility of physiological pump speed optimization based on aortic valve opening (AVO) imaging during a cardiopulmonary exercise test (CPET) in LVAD patients. The results show that dynamic echo-guided pump speed adjustment based on AVO improves exercise tolerance and augments peak oxygen consumption and maximum workload.
Article
Engineering, Biomedical
Gabriel Sayer, Diego Medvedofsky, Teruhiko Imamura, Gene Kim, Francesco Maffessanti, Justin Fried, Eric Kruse, Karima Addetia, Victor Mor-Avi, Valluvan Jeevanandam, Roberto M. Lang, Nir Uriel
Summary: Following LVAD implantation, there is significant decrease in left ventricular volume and improvement in shape, indicating reverse remodeling, but there are no significant changes in right ventricular volume and shape.
Article
Cardiac & Cardiovascular Systems
Anubodh S. Varshney, Ersilia M. DeFilippis, Jennifer A. Cowger, Ivan Netuka, Sean P. Pinney, Michael M. Givertz
Summary: With the increasing prevalence of advanced heart failure, treatment options such as heart transplantation and LVAD support have shown to improve quality of life and extend survival. Recent advancements, including the use of HeartMate 3 in clinical practice and revisions to the organ allocation system, have led to better management of LVAD-related complications. Although contemporary LVAD recipients have higher illness severity preoperatively, they have higher survival rates and lower adverse event rates compared to previous eras. However, challenges such as bleeding, infection, neurologic events, and right ventricular failure still limit the wider implementation of LVAD support. Ongoing efforts to optimize management of current LVAD devices and develop next-generation devices are expected to further enhance outcomes for patients with advanced heart failure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Tanous Aoun, Guillaume Baudry, Gilles Rioufol, Jean Francois Obadia, Matteo Pozzi
Summary: Myocardial recovery in LVAD patients is rare, and surgical explantation is risky. This report highlights the use of a Watchman closure device for deactivation of a HeartMate 3 LVAD.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Annika Ingvarsson, Grunde Gjesdal, Saeideh Borgenvik, Anna Werther Evaldsson, Johan Waktare, Oscar Braun, Gustav J. Smith, Anders Roijer, Goran Radegran, Carl Meurling
Summary: Pre-treatment with LVAD can reduce PVR and improve RV function early following OHT. However, within the first year after transplantation, RV function gradually improves in the non-LVAD group, with no difference compared to the LVAD group.
Article
Cardiac & Cardiovascular Systems
Carlotta Sciaccaluga, Hatem Soliman-Aboumarie, Nicolo Sisti, Giulia Elena Mandoli, Paolo Cameli, Elisa Bigio, Serafina Valente, Sergio Mondillo, Matteo Cameli
Summary: Echocardiography is crucial for evaluating, placing, managing, and following up patients with LVAD. It is important to focus on right ventricular function and aortic regurgitation during pre-operative assessment, use transoesophageal echocardiography for confirming cannula placement and guiding pump speed choice during the procedure, and utilize transthoracic echocardiography for post-operative follow-up to detect complications.
HEART FAILURE REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Maryam Ajmal, Aisha Ajmal, Maryam Rizvi, Umar Salim, Lei Huang
Summary: This study aimed to investigate the changes in myocardial gene expression profile after LVAD implantation and their molecular biological significance. The results showed that inflammatory signaling pathway is crucial for the pathophysiology after LVAD implantation and chemokines mediate cardiac inflammatory response and tissue remodeling through GPCR-ligand binding.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Emergency Medicine
Moira E. Smith, James H. Moak
Summary: LVADs have improved survival for heart failure patients, but the growing population of LVAD patients often experience complications and visits to the Emergency Department. Patients with LVADs may experience dysrhythmias such as ventricular tachycardia and ventricular fibrillation, yet remain asymptomatic in some cases.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Hematology
Kristin Klaeske, Maja-Theresa Dieterlen, Sandra Eifert, Ute Scholz, Jens Garbade, Khalil Jawad, Franz Sieg, Michael A. Borger, Anna L. Meyer
Summary: This study compared platelet receptor expression patterns and oxidative stress levels between LVAD patients with non-surgical bleeding (NSB) and those without coagulation disorders. The findings suggested that changes in three platelet receptors (GPIb alpha, P-selectin, and PECAM-1) and elevated oxidative stress may play a role in bleeding complications following LVAD implantation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Engineering, Biomedical
Paul C. Tang, Neal M. Duggal, Jonathan W. Haft, Matthew A. Romano, Steven F. Bolling, Ashraf Abou El Ela, Xiaoting Wu, Monica M. Colvin, Keith D. Aaronson, Francis D. Pagani
Summary: The study indicates that patients with smaller cardiac dimensions after cfLVAD implantation are more likely to show improvement in severe MR, and have lower rates of late right ventricular failure.
Article
Cardiac & Cardiovascular Systems
Jared P. Beller, J. Hunter Mehaffey, Zachary K. Wegermann, Maria Grau-Sepulveda, Sean M. O'Brien, J. Matthew Brennan, Vinod Thourani, Vinay Badhwar, Francis D. Pagani, Gorav Ailawadi, Leora T. Yarboro, Nicholas R. Teman
Summary: Patients with severe right ventricular failure during durable left ventricular assist device implantation may benefit from the use of RVAD over VA-ECMO. Regardless of the type of support, initiation at the index operation was associated with improved outcomes.
ANNALS OF THORACIC SURGERY
(2022)
Review
Medicine, General & Internal
Alessia Gambaro, Gianmarco Lombardi, Francesco Onorati, Leonardo Gottin, Flavio Luciano Ribichini
Summary: LVAD implantation has complex effects on the kidneys, particularly regarding renal function. Creatinine-based eGFR formulas help in assessing patient prognosis, while deterioration in renal function in LVAD patients negatively impacts outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew N. Rosenbaum, Bradley W. Ternus, Siddharth Pahwa, John M. Stulak, Alfredo L. Clavell, Sarah D. Schettle, Atta Behfar, Jacob C. Jentzer
Summary: In patients undergoing left ventricular assist device implantation, right ventricular stroke work index, right heart catheterization, cardiopulmonary bypass time, and ultrafiltration are strongly associated with incident INT-LD and decreased 1-year survival. Optimization of these factors may reduce the risk of liver dysfunction but further validation is needed.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Koichi Akiyama, Paolo C. Colombo, Eric J. Stoehr, Ruiping Ji, Isaac Y. Wu, Keiichi Itatani, Shohei Miyazaki, Teruyasu Nishino, Naotoshi Nakamura, Yasufumi Nakajima, Barry J. McDonnell, Koji Takeda, Melana Yuzefpolskaya, Hiroo Takayama
Summary: This study aimed to measure the kinetic energy of blood in the right ventricular outflow tract (KE-RVOT) and assess its relationship with other echocardiographic and hemodynamic parameters in heart failure patients undergoing left ventricular assist device (LVAD) implantation. The results showed that KE-RVOT was strongly correlated with echocardiographic parameters but not with hemodynamic parameters. Further research suggested that KE-RVOT may be useful in predicting right ventricular failure post LVAD implantation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Dipesh K. Shah, Salil V. Deo, Andrew D. Althouse, Jeffery J. Teuteberg, Soon J. Park, Robert L. Kormos, Harold M. Burkhart, Victor O. Morell
JOURNAL OF CARDIAC SURGERY
(2016)
Editorial Material
Cardiac & Cardiovascular Systems
Dipesh K. Shah, Lyle D. Joyce, Martha Grogan, Marie Christine Aubry, John A. Miller, Wei Ding, Michael G. Haddock
ANNALS OF THORACIC SURGERY
(2011)
Article
Cardiac & Cardiovascular Systems
Dipesh K. Shah, Zhuo Li, Soon J. Park, Richard C. Daly, Joseph A. Dearani, Hartzell V. Schaff, Thoralf M. Sundt
ANNALS OF THORACIC SURGERY
(2011)
Editorial Material
Cardiac & Cardiovascular Systems
Dipesh K. Shah, Hartzell V. Schaff, Martin D. Abel, Bernard J. Gersh
ANNALS OF THORACIC SURGERY
(2011)
Article
Cardiac & Cardiovascular Systems
Yan Topilsky, Naveen L. Pereira, Dipesh K. Shah, Barry Boilson, John A. Schirger, Sudhir S. Kushwaha, Lyle D. Joyce, Soon J. Park
CIRCULATION-HEART FAILURE
(2011)
Editorial Material
Cardiac & Cardiovascular Systems
Dipesh K. Shah, Matthew J. Ritter, Lawrence J. Sinak, John A. Miller, Thoralf M. Sundt
JOURNAL OF CARDIAC SURGERY
(2011)
Article
Cardiac & Cardiovascular Systems
Yan Topilsky, Jae K. Oh, Fawn W. Atchison, Dipesh K. Shah, Valentina M. Bichara, John A. Schirger, Sudhir S. Kushwaha, Naveen L. Pereira, Soon J. Park
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2011)
Article
Radiology, Nuclear Medicine & Medical Imaging
Patrick Cervini, Soon J. Park, Dipesh K. Shah, Irina E. Penev, Bradley D. Lewis
ULTRASOUND QUARTERLY
(2010)
Article
Cardiac & Cardiovascular Systems
Harry L. Warren III, Neil P. Lewis, Andreas W. Prinz, Jonah M. Pozen, Lisa G. Martin, Bernadette A. Sayegh-Crocco, Dipesh K. Shah