Article
Biochemistry & Molecular Biology
Fabiana Baganha, Thijs J. Sluiter, Rob C. M. de Jong, Louise A. van Alst, Hendrika A. B. Peters, J. Wouter Jukema, Mirela Delibegovic, Knut Pettersson, Paul H. A. Quax, Margreet R. de Vries
Summary: Based on the study in mice VG, PC-mAb can effectively inhibit the formation of atherosclerotic lesions by reducing IPA and IPH, decreasing neovessel density and macrophages influx, and increasing neovessel maturation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jeanette Owusu, Eugene Barrett
Summary: Cardio-metabolic disease (CMD) is associated with insulin resistance, which damages microvasculature in various tissues and increases the risk of atherosclerotic vascular disease. However, the impact of CMD on vasa vasorum remains understudied.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Javier Rodriguez-Carrio, Natalia Carrillo-Lopez, Catalina Ulloa, Beatriz Martin-Carro, Carmen Rodriguez-Suarez, Manuel Naves-Diaz, Emilio Sanchez-Alvarez, Minerva Rodriguez-Garcia, Maria Vittoria Arcidiacono, Belinda Fernandez-Marino, Jorge B. Cannata-Andia, Ana Suarez, Adriana S. Dusso
Summary: Novel T cell and monocyte subsets are altered in CKD. Altered T-cell subpopulations, but not monocytes, exhibited distinct associations with different vascular outcomes in CKD. Tang are emerging biomarkers of subclinical vascular deterioration in CKD.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Xi Wu, Gang Ji, Quan Wang, Jing Chen, Xin-Yu Cai, Jing Song, Yan Yan, He Huang
Summary: Studies have shown that vasa vasorum (VV) neovascularization plays a crucial role in the development and vulnerability of coronary atherosclerotic plaques. The relationship between VV, plaque constituents, and the no-reflow phenomenon (NRP) in percutaneous coronary intervention (PCI) is still unclear. This study examined plaque constituents and NRP in VV lesions during PCI. The results demonstrated that VV lesions had higher levels of high-sensitivity C-reactive protein (hs-CRP), increased risk of NRP, and larger plaque size compared to lesions without VV.
Article
Cardiac & Cardiovascular Systems
Kensuke Nishimiya, Akira Suda, Kento Fukui, Kiyotaka Hao, Jun Takahashi, Yasuharu Matsumoto, Kiyoto Mitsuishi, Tasuku Watanabe, Kazuma Ohyama, Jun Sugisawa, Satoshi Tsuchiya, Koichi Satoh, Tomohiko Shindo, Shigeo Godo, Yoku Kikuchi, Takashi Shiroto, Satoshi Yasuda, Hiroaki Shimokawa
Summary: The study found important prognostic links between coronary morphologies and coronary functional abnormalities in patients with INOCA, highlighting the significance of evaluating both aspects in this population.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Xiaoyan Yang, Lei Wang, Zihao Zhang, Jiayi Hu, Xiaoling Liu, Hao Wen, Minghao Liu, Xue Zhang, Hongyan Dai, Mei Ni, Rui Li, Rong Guo, Lei Zhang, Xiaorong Luan, Huili Lin, Mei Dong, Huixia Lu
Summary: The study demonstrated that Ginsenoside Rb-1 can stabilize atherosclerotic plaques by inhibiting adventitial vasa vasorum proliferation and inflammation, reducing plaque burden. These anti-angiogenic and anti-inflammatory effects are exerted through the modulation of miR-33 and its target gene PEDF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Hematology
Dong Chen, Zixi Zhao, Peng Liu, Xinbang Liu, Xin Wang, Qiuyue Ren, Bai Chang
Summary: This study aimed to assess the relationship between adventitial vasa vasorum neovascularization (VVn) and macroangiopathy in type 2 diabetic patients, and its association with the recruitment of macrophages and lymphocytes as well as the occurrence of cardiovascular events. The results indicate that high VVn density is positively correlated with the risk of cardiovascular disease in type 2 diabetic patients, and increased VVn density is associated with adverse cardiovascular events.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Pharmacology & Pharmacy
Meng Li, Zhongwen Qi, Junping Zhang, Ke Zhu, Yueyao Wang
Summary: The study demonstrated that SMYA can effectively reduce the AS plaque area in ApoE(-/-) mice, suppress VV neovascularization, promote VV maturation, and stabilize vulnerable AS plaque. The mechanism may involve regulation of the HIF-1 alpha-Apelin/APJ and Ang-1/Tie signal pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Weiying Zhong, Wenjing Su, Tao Li, Xianjun Tan, Chao Chen, Qian Wang, Donghai Wang, Wandong Su, Yunyan Wang
Summary: This study found that unruptured intracerebral aneurysm wall enhancement is associated with atherosclerosis and inflammatory cell infiltration. Multivariate logistic regression analysis revealed that atherosclerosis is the only factor significantly and independently associated with AWE. Histological assessment showed that inflammatory cell infiltration, intraluminal thrombus, and vasa vasorum are significantly associated with AWE.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shuai Zhang, Lin Gao, Bing Kang, Xinxin Yu, Ran Zhang, Ximing Wang
Summary: A CT-based radiomics nomogram was developed and validated for the detection of intraplaque hemorrhage in carotid arteries. The results showed that the radiomics nomogram had satisfactory performance in distinguishing carotid plaques with and without intraplaque hemorrhage.
INSIGHTS INTO IMAGING
(2022)
Review
Biochemistry & Molecular Biology
Atsushi Sakamoto, Kenichiro Suwa, Rika Kawakami, Alexandra V. Finn, Yuichiro Maekawa, Renu Virmani, Aloke V. Finn
Summary: Acute coronary syndromes due to atherosclerotic coronary artery disease are a leading cause of morbidity and mortality worldwide. Intraplaque hemorrhage (IPH) is a major contributor to plaque progression, causing sudden plaque volume increase and destabilization. Recent studies have revealed the intricate cellular interactions and molecular mechanisms involved in IPH. Advances in diagnostic imaging modalities have allowed for in vivo identification of IPH, which has been shown to be a reliable prognostic indicator of high-risk plaque. This review discusses the significance of IPH on the development of high-risk plaque from both basic and clinical perspectives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Shuai Zhang, Hui Gu, Xinxin Yu, Bing Kang, Xianshun Yuan, Ximing Wang
Summary: The study revealed a strong association between perivascular adipose tissue and intraplaque hemorrhage in the carotid artery. PFD could serve as a novel marker for identifying carotid IPH and risk stratification.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Zhaojun Li, Quan Wang, Hongshu Jing, Xianghong Luo, Lianfang Du, Yourong Duan
Summary: This study developed a targeting nanodelivery system, cRGD peptide-modified RNPs, for delivering the antiangiogenesis drug PEDF to inhibit neovascularization in plaque. In vitro and in vivo experiments demonstrated the effectiveness of PEDF RNPs in reducing plaque area and thickness, suggesting their potential for future clinical applications in atherosclerosis treatment.
ACS APPLIED NANO MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Weiyu Chen, James Nadel, Sergey Tumanov, Roland Stocker
Summary: Near-infrared autofluorescence (NIRAF) is suggested as a new imaging technology for high-risk atherosclerosis. Intraplaque hemorrhage (IPH) and bilirubin have been proposed as the source of NIRAF, but their roles and underlying mechanism are unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Meisam Soleimani, Rohan Deo, Blaz Hudobivnik, Reza Poyanmehr, Axel Haverich, Peter Wriggers
Summary: This paper presents a mathematical model for arterial dissection based on a novel hypothesis proposed by a surgeon, Axel Haverich. The authors aim to extend a previous mathematical framework for modeling atherosclerosis to capture the tearing of the artery wall as a result of micro-injuries in VV. The numerical implementation is carried out using finite element method (FEM).
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Domenico D'Amario, Giuseppe Ciliberti, Attilio Restivo, Renzo Laborante, Stefano Migliaro, Francesco Canonico, Giuseppe Massimo Sangiorgi, Matteo Tebaldi, Italo Porto, Daniele Andreini, Rocco Vergallo, Antonio Maria Leone, Salvatore Gervasi, Michela Cammarano, Vincenzo Palmieri, Francesco Burzotta, Carlo Trani, Paolo Zeppilli, Filippo Crea
Summary: Myocardial bridge may be associated with angina and adverse cardiac events, highlighting the need for long-term prognosis studies. Full-physiology assessment plays a crucial role in improving patients' quality of life and cardiovascular outcomes.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Article
Cardiac & Cardiovascular Systems
Sofia Schino, Andrea Bezzeccheri, Alessandro Russo, Michela Bonanni, Joseph Cosma, Giuseppe Sangiorgi, Gaetano Chiricolo, Eugenio Martuscelli, Francesco Santoro, Enrica Giuliana Mariano
Summary: Takotsubo syndrome is an acute, transient episode of left ventricular dysfunction that occurs predominantly in postmenopausal women following significant physical or emotional stress. It can be diagnosed based on clinical symptoms and the absence of coronary artery disease on angiography. Despite being transient, complications occur in almost half of the patients and the mortality rate is significant. It can also lead to permanent myocardial damage.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
G. Corona, D. Cucinotta, G. Di Lorenzo, A. Ferlin, V. A. Giagulli, L. Gnessi, A. M. Isidori, M. I. Maiorino, P. Miserendino, A. Murrone, R. Pivonello, V. Rochira, G. M. Sangiorgi, G. Stagno, C. Foresta, A. Lenzi, M. Maggi, E. A. Jannini
Summary: Erectile dysfunction (ED) is a common male sexual dysfunction that has been mistakenly considered mainly a psychological symptom. However, growing evidence shows the role of organic factors in the pathophysiology of ED.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Luca Testa, Antonio Rubbio, Mattia Squillace, Flavio Albano, Vincenzo Cesario, Matteo Casenghi, Giuseppe Tarantini, Paolo Pagnotta, Alfonso Ielasi, Grigore Popusoi, Leonardo Paloscia, Alessandro Durante, Diego Maffeo, Francesco Meucci, Giuliano Valentini, Gian Paolo Ussia, Paolo Cioffi, Bernardo Cortese, Giuseppe Sangiorgi, Gaetano Contegiacomo, Francesco Bedogni
Summary: This is an Italian multi-center registry study evaluating the efficacy and safety of PFO closure with the Cocoon PFO Occluder. The results demonstrate successful closure of PFO with minimal complications and satisfactory mid-term clinical outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Oncology
Alberto Cereda, Stefano Lucreziotti, Antonio Gabriele Franchina, Alessandra Laricchia, Valentina De Regibus, Barbara Conconi, Matteo Carla, Andrea Spangaro, Matteo Rocchetti, Luca Ponti, Alessandro Minardi, Elena Sala, Giuseppe Massimo Sangiorgi, Gabriele Tumminello, Lucia Barbieri, Stefano Carugo, Paolo Aseni
Summary: Oral anticoagulant therapy in cancer patients with atrial fibrillation can reduce the risk of ischemic, hemorrhagic, and venous thromboembolic events, but there is a certain bleeding risk, lower than warfarin but higher than non-cancer patients. Further research is needed to determine the optimal anticoagulation strategy in cancer patients with atrial fibrillation.
Article
Health Care Sciences & Services
Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe M. Sangiorgi, Mariangela V. Puci, Allegra R. Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco M. Fiore, Armando Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Piero Modugno, Maurizio Maiorano, Umberto M. Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni M. Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munao, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio S. Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio M. Oddi, Alberto M. Settembrini
Summary: This is a study on the sex-related differences in 30-day/1-year mortality in patients with chronic limb-threatening ischemia (CLTI). The results showed that women had a higher proportion of CLTI cases above the age of 75, while men had a higher proportion of smokers, dialysis patients, and comorbidities such as diabetes. There was no difference in mortality statistics between the sexes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea Matteucci, Daniela Benedetto, Michela Bonanni, Gianluca Massaro, Debora Russo, Giulio Russo, Gaetano Chiricolo, Giuseppe Biondi-Zoccai, Giuseppe Sangiorgi
Summary: This observational study aims to evaluate the feasibility of sirolimus nanocarriers-coated balloon for the treatment of erectile dysfunction (ED). The study plans to recruit 100 ED patients for a two-year follow-up, with the primary endpoints being the IIEF-5 score and dynamic Doppler ultrasound at baseline and 8 months. The results of this study may potentially improve the treatment outcomes for ED patients.
MINERVA CARDIOLOGY AND ANGIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto Cereda, Luca Allievi, Lorenzo Busetti, Rita Koleci, Vincenzo DE Nora, Augustin Vecchia, Marco Toselli, Francesco Giannini, Gabriele Tumminello, Giuseppe Sangiorgi
Summary: This study investigated the use of nurse-led distal radial access in 100 cardiac catheterization patients. The results showed a technical feasibility rate of 89% and a decrease in failure rate with increasing experience. There were no major complications, and the rate of minor complications was consistent with the literature. Therefore, nurse-led distal radial access is feasible and beneficial for improving technical success and reducing complications.
MINERVA CARDIOLOGY AND ANGIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gennaro Sardella, Giulio Stefanini, Pier Pasquale Leone, Giacomo Boccuzzi, Natalia Tovar Fovero, Nicolas Van Mieghem, Giuseppe Giacchi, Javier Escaned, Massimo Fineschi, Luca Testa, Renato Valenti, Carlo Di Mario, Carlo Briguori, Bernardo Cortese, Flavio Ribichini, Jacopo Andrea Oreglia, Antonio Colombo, Giuseppe Sangiorgi, Emanuele Barbato, Jeroen Sonck, Fabrizio Ugo, Carlo Trani, Fausto Castriota, Anita Paggi, Italo Porto, Fabrizio Tomai, Massimo Mancone
Summary: This study evaluated the efficacy and safety of IVL with the Shockwave Coronary Rx Lithotripsy System as an elective or bail-out strategy in lesions with severe CAC after RA. The results showed that IVL was effective and safe in treating severe CAC lesions.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dalgisio Lecis, Gianluca Massaro, Daniela Benedetto, Marco Di Luozzo, Giulio Russo, Alessandro Mauriello, Massimo Federici, Giuseppe Massimo Sangiorgi
Summary: Atherosclerotic cardiovascular disease is a common cause of morbidity and death worldwide. It can be controlled through modulation of immune system activity and finding new treatment strategies is of common interest. This review discusses the experimental and clinical data supporting immune-based therapies, specifically vaccination strategies, for lowering cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Eugenio Martelli, Iolanda Enea, Matilde Zamboni, Massimo Federici, Umberto M. Bracale, Giuseppe Sangiorgi, Allegra R. Martelli, Teresa Messina, Alberto M. Settembrini
Summary: Middle-aged adults may be affected by arterial diseases, which are often asymptomatic or paucisymptomatic before complications occur. Early detection of these diseases is crucial to reduce the risk of major adverse cardiovascular and limb events.
Article
Medicine, General & Internal
Debora Russo, Gianluca Massaro, Giuseppe Massimo Sangiorgi
Summary: We presented a case of high-risk PE treated with a novel percutaneous system for mechanical embolectomy, which successfully removed a 15-centimeter thrombus and achieved fast patient hemodynamic stabilization and symptoms resolution without complications. Further studies are needed to demonstrate the safety and superiority of percutaneous catheter-directed treatments over the currently recommended therapy for PE.
Meeting Abstract
Cardiac & Cardiovascular Systems
Michela Bonanni, Marco Desiati, Giulio Russo, Gianluca Massaro, Daniela Benedetto, Sofia Schino, Marco Di Luozzo, Enrica Mariano, Massimo Marchei, Maurizio Taramasso, Francesco Maisano, Giuseppe Sangiorgi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Vennela Avula, Judit Karacsonyi, Spyridon Kostantinis, Bahadir Simsek, Bavana V. Rangan, Alessandra A. Gutierrez, M. Nicholas Burke, Santiago Garcia, Michael Mooney, Paul Sorajja, Jay H. Traverse, Anil Poulose, Ivan Chavez, Yale Wang, Mario Goessl, Emmanouil S. Brilakis
Summary: This study examined the incidence, treatment, and outcomes of perforation during percutaneous coronary intervention (PCI). The results showed that coronary perforation is a rare complication of PCI, with most perforations being large vessel perforations that often require further intervention. Although there were some complications, the incidence of death or the need for emergent cardiac surgery was low.
JOURNAL OF INVASIVE CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Andrea Matteucci, Michela Bonanni, Francesco Versaci, Giacomo Frati, Mariangela Peruzzi, Giuseppe Sangiorgi, Giuseppe Biondi-Zoccai, Gianluca Massaro
Summary: This article reviews and summarizes the major research and review articles published in 2020 in the field of cardiovascular sciences. It provides a broad overview of the novelties in six major areas of interest, contributing to the improvement of prevention, diagnosis, and treatment of heart and vascular diseases.
MINERVA CARDIOLOGY AND ANGIOLOGY
(2022)