Review
Biochemistry & Molecular Biology
Sunao Sugita, Hiroshi Takase, Satoko Nakano
Summary: Infectious uveitis is a serious eye condition that requires urgent diagnosis and appropriate treatment. However, diagnosing infectious uveitis accurately and quickly is still challenging. PCR tests and other examination techniques are being developed to be performed at the bedside, allowing for faster diagnosis and treatment. This review provides an updated overview of recent studies on clinical microbiological techniques, particularly PCR tests, for infectious uveitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Civil
Eduardo Fortunato, Andre Paixao, Paulo Morais, Carlos Santos, Joao Morais, Jorge Cruz, Nuno Cruz
Summary: The research focuses on reinforcing the subgrade of old railway tracks by injecting grouts into short soil-binder columns formed by drilling through the ballast layer. The study shows a reduction of about 60-80% in settlement amplitudes of the reinforced physical models under cyclic loading, and a general reduction of about 15-20% in peak vertical accelerations measured on the sleepers after treatment, suggesting the proposed reinforcement method is a valid alternative for rehabilitating railway platforms, notably in old single-track lines.
TRANSPORTATION GEOTECHNICS
(2021)
Article
Environmental Sciences
Jenny Rydh Stenstrom, Jenny Kreuger, Willem Goedkoop
Summary: Long-term monitoring in agricultural streams revealed the presence of multiple pesticides, with some dominating pesticides contributing significantly to the mixture's toxicity towards algae. Inhibition tests with in situ stream water showed frequent inhibitory effects despite low ETU levels, with confounding factors affecting results. Spiked reconstituted water tests demonstrated significant inhibitory effects, surpassing levels observed in field samples, suggesting that pesticide contamination in agricultural streams may impact algae populations.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medical Laboratory Technology
Ji Yeon Sung, Jong Do Seo, Dae-Hyun Ko, Min-Jeong Park, Sang Mee Hwang, Sohee Oh, Sail Chun, Moon-Woo Seong, Junghan Song, Sang Hoon Song, Sung Sup Park
Summary: This study aimed to establish reference intervals for routine laboratory tests for Korean pediatric patients through retrospective multicenter data analysis. The pediatric reference intervals determined in this study were different from existing adult reference intervals and pediatric reference intervals for other ethnicities, with most tests requiring age- and sex-specific partitioning.
ANNALS OF LABORATORY MEDICINE
(2021)
Article
Critical Care Medicine
Shyam J. Deshpande, Sally Vitali, Ravi Thiagarajan, Steven Brediger, Michael McManus, Alon Geva
Summary: In children supported with extracorporeal membrane oxygenation, there is poor correlation between heparin dose and common laboratory measures of anticoagulation, and laboratory measures also correlate poorly with each other. Neither heparin dose nor laboratory measures are significantly associated with hemorrhage or thrombosis. Further research is needed to identify more effective measures of anticoagulation to reduce morbidity and mortality in patients on extracorporeal membrane oxygenation.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Manish Mair, Hitesh Singhavi, Ameya Pai, Jinesh Singhavi, Prachi Gandhi, Peter Conboy, Andrew Baker, Sudip Das
Summary: This meta-analysis aimed to investigate the prevalence of symptoms, laboratory tests, and imaging in COVID-19 infected patients, revealing fever and cough as the most common symptoms, while anosmia and dysguesia are also relatively common. Common abnormalities in laboratory tests include elevated CRP and ESR, as well as decreased white blood cells and lymphocytes.
Article
Obstetrics & Gynecology
Clare E. Counsilman, Lisanne E. Heeger, Ratna Tan, Vincent Bekker, Jaap Jan Zwaginga, Arjan B. te Pas, Enrico Lopriore
Summary: Extreme preterm infants lose almost one-third of their total blood volume in the first month of life as a result of iatrogenic blood loss from multiple blood draws and procedures.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Yiting Wang, Dandan Gao, Xuewen Li, Panyang Xu, Qi Zhou, Junguo Yin, Jiancheng Xu
Summary: This study established an early prediction model using laboratory test data of patients with moderate COVID-19 to assess the risk of liver function damage. The model showed high discrimination and clinical usefulness in predicting and evaluating liver function damage in patients with moderate COVID-19.
BMC GASTROENTEROLOGY
(2022)
Article
Surgery
Mounir J. Haurani, Daisy Chou, Patrick S. Vaccaro, Bhagwan Satiani
Summary: This study aimed to investigate the impact of the Patient Protection and Affordable Care Act (ACA) on physician reimbursement for vascular surgery procedures and vascular laboratory studies. The results showed that post-ACA reimbursement for most Medicare and Medicaid procedures was significantly lower than the inflation-adjusted reimbursement. However, for most vascular laboratory studies, reimbursement exceeded inflation.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Medicine, Research & Experimental
Luis Garcia de Guadiana-Romualdo, Daniel Morell-Garcia, Cristian Morales-Indiano, Josep Miquel Bauca, Maria Jose Alcaide Martin, Clara Esparza del Valle, Jose Gutierrez Revilla, Eloisa Urrechaga, Jose M. Alamo, Ana M. Hernando Holgado, Maria-Carmen Lorenzo-Lozano, Silvia Sanchez Fdez-Pacheco, Patricia de la Hera Cagigal, Maria A. Juncos Tobarra, Juan A. Vilchez, Isabel Virseda Chamorro, Irene Gutierrez Garcia, Yolanda Pastor Murcia, Laura Sahuquillo Frias, Laura Altimira Queral, Elisa Nuez-Zaragoza, Juan Adell Ruiz de Leon, Alicia Ruiz Ripa, Paloma Salas Gomez-Pablos, Iria Cebreiros Lopez, Amaia Fernandez Uriarte, Alex Larruzeaz, Maria L. Lopez Yepes, Patricia Esteban Torrella, Maria C. Zamorano Andres, Jose Pedregosa Diaz, Cristina Acevedo Alcaraz, Alfonso-L Blazquez-Manzanera, Ana M. L. Padilla Jimenez, Maria C. Baamonde Calzada, Marina Vera, Matilde Chafer Rudilla, Magdalena Canalda Campas, Sara Garcia Munoz, Luis Vicente Gutierrez, Laura Jimenez Anon, Alfonso Perez Martinez, Aurelio Pons Castillo, Ruth Gonzalez Tamayo, Jorge Ferriz Vivancos, Olaia Rodriguez-Fraga, Vicente Ferrer Diaz de Brito Fernandez, Vicente Aguadero, Maria G. Garcia Arevalo, Maria Arnaldos Carrillo, Mercedes Gonzalez Morales, Maria Nunez Garate, Cristina Ruiz Iruela, Natalia Sancho-Rodriguez, Marti Vila Perez, Jose M. Egea-Caparros, Luis Saenz, Alvaro Blasco Barbero, Amparo Galan Ortega
Summary: This observational, retrospective cohort study involving 2873 hospitalized COVID-19 patients in Spain identified nine independent predictors for in-hospital mortality, including creatinine, troponin, platelet count, and C-reactive protein. Adjustments were made to ensure comparability of laboratory test results, providing comprehensive information for early identification of higher risk patients.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Eleonora Balkanska, Stoyan Georgiev, Alexandre Kounov, Takahiro Tagami, Shigeru Sueoka
Summary: This contribution presents fission-track analysis performed at the first Low-Temperature Thermochronology Laboratory in Bulgaria, using the LA-ICP-MS technique. The experiments included laboratory procedures for sample preparation, etching, observations, measurements, uranium content analyses, and age calculations. The study was conducted on samples from Upper Cretaceous and Carboniferous igneous rocks in Central Sredna Gora Zone, Central Bulgaria.
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES
(2021)
Article
Peripheral Vascular Disease
Lingli Wang, Xiaomei Zhang, Yi Qin, Feng Wang, Ming Cui, Yingjuan Shi, Yu Chen
Summary: The study aimed to demonstrate the equivalence and substitutability of the push-pull method from a CVC and direct venous puncture in blood collection. Comparative analysis showed similar variability and reliability in laboratory results between the two methods, and the blood samples obtained by the push-pull method were clinically acceptable.
JOURNAL OF VASCULAR ACCESS
(2022)
Article
Geosciences, Multidisciplinary
Azadeh Hojat, Maddalena Ferrario, Diego Arosio, Marco Brunero, Vladislav Ivov Ivanov, Laura Longoni, Andrea Madaschi, Monica Papini, Greta Tresoldi, Luigi Zanzi
Summary: The study utilized ERT and FBG technologies to investigate time-lapse variations caused by seepage in a river levee constructed with clayey material. Results showed ERT images could detect seepages early on, while fiber optic sensors demonstrated their ability to detect water infiltrations by measuring temperature changes.
Article
Anesthesiology
Navid Wani, Tina Pasha
Summary: The kidneys play a crucial role in regulating fluid balance, waste product removal, electrolyte homeostasis, acid-base balance, and endocrine functions in the body. They receive a significant amount of blood supply and produce urine through selective reabsorption to maintain overall bodily functions.
ANAESTHESIA AND INTENSIVE CARE MEDICINE
(2021)
Article
Nutrition & Dietetics
Mariane de Almeida Alves, Maria Del Carmen Bisi Molina, Maria de Jesus Mendes da Fonseca, Paulo Andrade Lotufo, Isabela Martins Bensenor, Dirce Maria Lobo Marchioni
Summary: This study applied three statistical methods to identify dietary patterns in the ELSA-Brasil population and compared their similarities and differences. The results showed that these methods were able to capture the dietary patterns in a similar way while highlighting the particularities of each method.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Vanderlei Carneiro Silva, Bartira Gorgulho, Dirce Maria Marchioni, Tania Aparecida de Araujo, Itamar de Souza Santos, Paulo Andrade Lotufo, Isabela Martins Bensenor
Summary: This study used machine learning algorithms to predict dietary patterns in Brazilian public employees and identified two main patterns. The models developed in this study may provide support in analyzing dietary data and screening tasks for health professionals.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Nutrition & Dietetics
Patricia de Oliveira da Silva Scaranni, Leticia de Oliveira Cardoso, Rosane Harter Griep, Paulo Andrade Lotufo, Sandhi Maria Barreto, Maria de Jesus Mendes da Fonseca
Summary: This study aimed to examine the association between consumption of ultra-processed foods (UPF) and the incidence of dyslipidaemia in Brazilian civil servants. The results showed that individuals with higher consumption of UPF had an increased risk of developing hypercholesterolemia, hypertriglyceridemia, mixed hyperlipidemia, and low HDL.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Peripheral Vascular Disease
Deborah de Farias Lelis, Roberto S. Cunha, Raul D. Santos, Andrei C. Sposito, Rosane Harter Griep, Sandhi Maria Barreto, Maria del Carmen B. Molina, Maria Ines Schmidt, Bruce B. Duncan, Isabela Bensenor, Paulo Andrade Lotufo, Jose Geraldo Mill, Marcelo Perim Baldo
Summary: Atherogenic dyslipidemia is associated with carotid-femoral pulse wave velocity (cf-PWV), and there is a linear association between triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and the triglycerides to high-density lipoprotein (TG/HDL-C) ratio with arterial stiffness. HDL-C has a stronger association with arterial stiffness, while the association of TG/HDL-C with arterial stiffness is dependent on HDL-C levels.
Article
Peripheral Vascular Disease
Suellen Ferreira Chagas, Divanei Zaniqueli, Marcelo Perim Baldo, Paulo Andrade Lotufo, Bruce B. Duncan, Rosane Harter Griep, Isabela Martins Bensenor, Rafael de Oliveira Alvim, Jose Geraldo Mill
Summary: Salt intake has direct and body mass index (BMI)-mediated effects on blood pressure (BP) in normotensive individuals, but not in hypertensive individuals.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Biology
C. Szlejf, A. F. M. Batista, L. Bertola, P. A. Lotufo, I. M. Bensenor, A. D. P. Chiavegatto Filho, C. K. Suemoto
Summary: Machine learning models were developed and tested to predict cognitive impairment based on primary care data, showing good discrimination and high specificity. This can optimize resource allocation and support the detection of patients who would not benefit from cognitive assessment.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Aida de Melo Spilack, Alessandra C. Goulart, Bianca de Almeida-Pititto, Carolina Castro Porto Silva Janovsky, Paulo A. Lotufo, Itamar de Souza Santos, Isabela M. Bensenor
Summary: The association of subclinical hypothyroidism and diabetes with carotid Intima-Media Thickness (cIMT) as a surrogate marker for early cardiovascular disease was analyzed. Diabetes was found to be associated with higher cIMT values. However, no additive effect of subclinical hypothyroidism associated with diabetes over cIMT was detected.
Article
Pharmacology & Pharmacy
Adriana Nancy Medeiros dos Santos, Daniela Souza Farias-Iao, Isabela M. Bensenor, Alessandra C. Goulart, Andre R. Brunoni, Maria Carmen Viana, Paulo A. Lotufo, Claudia Kimie Suemoto
Summary: This study investigated the association between the use of potentially inappropriate medications (PIM) and medications that may impair cognition (PIM-Cog) with cognitive performance among older adults. The study found that the use of PIM and PIM-Cog was associated with poor cognitive function. Therefore, reviewing the use of PIM and deprescribing these drugs may be an effective way to improve cognitive function.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Correction
Pharmacology & Pharmacy
Adriana Nancy Medeiros dos Santos, Daniela Souza Farias-Itao, Isabela M. Bensenor, Alessandra C. Goulart, Andre R. Brunoni, Maria Carmen Viana, Paulo A. Lotufo, Claudia Kimie Suemoto
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Vandrize Meneghini, William R. Tebar, Itamar Souza Santos, Carolina Castro Porto Silva Janovsky, Bianca de Almeida-Pititto, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor
Summary: This study investigated the relationship between psoriasis, thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triodothyronine (FT3), thyroid peroxidase antibodies (TPOAb), and subclinical thyroid dysfunctions. The results showed a positive association between FT4 levels and psoriasis in women, and a significant association between FT3 levels and psoriasis in the overall sample and men. However, further prospective data are needed to clarify the association between thyroid function and psoriasis.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
William R. Tebar, Itamar de S. Santos, Vandrize Meneghini, Marcio Sommer Bittencourt, Paulo A. Lotufo, Isabela M. Bensenor
Summary: This study aimed to analyze the association between psoriasis (PSO) and carotid intima-media thickness (cIMT) in a cohort of 10,530 civil servants from the ELSA-Brasil study. The results showed no significant association between PSO and cIMT, suggesting the need for further investigation.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Biology
R. A. Hoshi, I. S. Santos, M. S. Bittencourt, E. M. Dantas, R. V. Andreao, J. G. Mill, P. A. Lotufo, I. M. Bensenor
Summary: Current data suggests that there is a relationship between heart rate variability (HRV) and coronary artery calcium (CAC) in the general population. This study aimed to further investigate this association using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The results showed that participants aged 35 to 74 years with lower HRV values were more likely to have prevalent CAC, and this relationship may be influenced by sex and age factors.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Biology
W. R. Tebar, I. S. Santos, V. Meneghini, M. S. Bittencourt, P. A. Lotufo, I. M. Bensenor
Summary: This study aimed to compare carotid intima-media thickness (CIMT) and its change (ACIMT) after an 8-year follow-up according to psoriasis diagnosis and the association with risk factors in the ELSA-Brasil study. The results showed that there was no association between psoriasis and CIMT, but CIMT in psoriasis participants was associated with age and hypertension.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Primary Health Care
Cassia S. S. Silva, Isabela M. Bensenor, Alessandra C. Goulart, Paulo A. Lotufo, Itamar S. Santos
Summary: This study evaluated the frequency and main causes of anaemia in middle-aged adults in Brazil. The results showed that anaemia was more common in women than men, and the frequency was particularly high in the Black population. The main causes of anaemia included iron deficiency in women and chronic kidney disease and chronic inflammation in men. Unexplained anaemia was more common among individuals of Black or Mixed races.
Article
Public, Environmental & Occupational Health
Priscila Santana Oliveira, Jessica Levy, Eduardo De Carli, Isabela Judith Martins Bensenor, Paulo Andrade Lotufo, Rosangela Alves Pereira, Edna Massae Yokoo, Rosely Sichieri, Sandra Patricia Crispim, Dirce Maria Lobo Marchioni
Summary: This study aimed to compare the identification of energy intake underreporters using different predictive equations and instruments to collect dietary data. The results showed a low prevalence of underreported energy intake among the self-report-based dietary data collection methods, with a high agreement of energy intake between GloboDiet and Brasil-Nutri.
CADERNOS DE SAUDE PUBLICA
(2022)
