Review
Cell Biology
Weixiong Zheng, Lingxiang Yang, Shiming Jiang, Mingxiang Chen, Jinzheng Li, Zuojing Liu, Zhongjun Wu, Jianping Gong, Yong Chen
Summary: Liver transplantation is a effective treatment for end-stage liver disease and significantly prolongs the survival time of patients, but acute and chronic rejection still remain major obstacles. Investigating induced immune tolerance is of crucial theoretical significance and socio-economic value. This paper comprehensively summarizes the important roles of Kupffer cells in establishing immune tolerance after transplantation, including phagocytosis, cell polarization, antigen presentation, and cell membrane proteins, providing a theoretical basis for further study and clinical application of Kupffer cells in liver transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Oncology
Wenhui Zhang, Zhikun Liu, Xiao Xu
Summary: Liver transplantation is the most effective treatment for end-stage liver diseases, with significant changes in the immunometabolism microenvironment after transplantation. Immune cells play a crucial role in this environment and studying their complex pathobiology is critical to prevent post-transplant complications. The interplay between cellular metabolism and immune function is evident, with potential for shaping immune responses through targeting different metabolic pathways.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Immunology
Weikang Zhang, Ding Cao, Menghao Wang, Yakun Wu, Jianping Gong, Jingzheng Li, Yiming Liu
Summary: The study reveals the regulatory role of XBP1 in kupffer cells, affecting the immune response after liver transplantation through different signaling pathways that modulate KC polarization, showing either immunosuppressive or pro-inflammatory effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Liam M. Casey, Kevin R. Hughes, Michael N. Saunders, Stephen D. Miller, Ryan M. Pearson, Lonnie D. Shea
Summary: The delivery of disease-relevant antigens by polymeric nanoparticles has shown to induce immune tolerance in various disorders. This study investigated the contribution of liver sinusoidal endothelial cells and Kupffer cells in nanoparticle-induced tolerance in a mouse model of multiple sclerosis. The results suggest that both cell types play important roles in the induction of tolerance through the secretion of specific factors and interaction with CD4 T cells. This mechanistic support provides insights for the development of biomaterial platforms in clinical trials.
Review
Cell Biology
Xiaodong Du, Mingqian Li, Chen Huan, Guoyue Lv
Summary: This review discusses the origin, maturation, migration, and pathological effects of dendritic cell subsets in liver transplantation, as well as their roles in transplant rejection and tolerance. The latest progress in dendritic cell-based treatment regimens is also outlined.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Mingjie Ding, Yuting He, Shuijun Zhang, Wenzhi Guo
Summary: Liver transplantation is an effective therapy for end-stage liver disease, but most postoperative patients require immunosuppressive drugs. Some transplant recipients achieve immune tolerance with normal liver function and no organ rejection after immunosuppressive drug withdrawal. Costimulatory molecules are crucial in T cell-mediated immune responses and tolerance maintenance, with potential for inducing immune tolerance in transplantation through costimulatory blockade.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ryosuke Nakano, Lillian M. Tran, David A. Geller, Camila Macedo, Diana M. Metes, Angus W. Thomson
Summary: Liver allograft recipients are more likely to develop transplantation tolerance, with liver interstitial dendritic cells playing pivotal roles. Interstitial liver DCs, recruited in situ or derived from circulating precursors, are involved in regulating ischemia/reperfusion injury and anti-donor immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xuhao Ni, Qi Wang, Jian Gu, Ling Lu
Summary: Rejection after organ transplantation is a challenge in the field of transplantation immunology, and inducing tolerance is crucial. The liver, being immunologically privileged, has high rates of tolerance after transplantation. Tregs play a pivotal role in regulating immune balance and can effectively prevent rejection without significant side effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Jun Pan, Fang Ye, Hui Li, Chengxuan Yu, Jiajia Mao, Yanyu Xiao, Haide Chen, Junqing Wu, Jiaqi Li, Lijiang Fei, Yijun Wu, Xiaoming Meng, Guoji Guo, Yingying Wang
Summary: By analyzing single-cell transcriptome, we described the immune microenvironment of mouse solid organ allografts. We compared the immune response in heart/kidney transplantation rejection and liver transplantation tolerance. Our findings revealed the coordinated function of Kupffer cells, macrophages, and associated metabolic processes in liver transplantation tolerance induction.
CELL PROLIFERATION
(2023)
Article
Multidisciplinary Sciences
T. Hautz, S. Salcher, M. Fodor, G. Sturm, S. Ebner, A. Mair, M. Trebo, G. Untergasser, S. Sopper, B. Cardini, A. Martowicz, J. Hofmann, S. Daum, M. Kalb, T. Resch, F. Krendl, A. Weissenbacher, G. Otarashvili, P. Obrist, B. Zelger, D. Oefner, Z. Trajanoski, J. Troppmair, R. Oberhuber, A. Pircher, D. Wolf, S. Schneeberger
Summary: This study comprehensively characterized the immune cell population and their dynamic changes during liver NMP. It was found that neutrophils decreased significantly during NMP, while anti-inflammatory/tolerogenic monocytes/macrophages increased. The findings may contribute to future immune-interventional studies.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Taojian Tu, Mario M. Alba, Aditi A. Datta, Handan Hong, Brittney Hua, Yunyi Jia, Jared Khan, Phillip Nguyen, Xiatoeng Niu, Pranav Pammidimukkala, Ielyzaveta Slarve, Qi Tang, Chenxi Xu, Yiren Zhou, Bangyan L. Stiles
Summary: Obesity is independently associated with an increased risk of carcinogenesis, particularly liver cancer. Liver lipid dysfunction and inflammation, as well as the involvement of liver macrophages, play crucial roles in driving the progression of liver cancer. Specific inflammatory mediators and molecular signals related to lipid metabolism are also involved in the activation and reprogramming of liver macrophages, contributing to the development of liver cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Yi Shan, Debin Qi, Lei Zhang, Lixue Wu, Wenfang Li, Hao Liu, Tao Li, Zhiren Fu, Haili Bao, Shaohua Song
Summary: In this study, the expression and distribution of immune cells in donor organs before and after liver transplantation were explored using single-cell RNA sequencing and T cell receptor (TCR) / B cell receptor (BCR) repertoire sequencing. Functional properties of monocytes/Kupffer cells, T cells, and B cells in grafts were investigated, and shifts in TCR/BCR repertoire after transplantation were observed. This study provides novel strategies for monitoring recipient immune function and treating rejection after liver transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Guojiao Lin, Jialiang Wang, Yong-Guang Yang, Yuning Zhang, Tianmeng Sun
Summary: This paper reviews the research progress on how nano-delivery systems can be modulated for targeted delivery to dendritic cells and induce immune tolerance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Immunology
Jingyu Jiang, Haitao Huang, Ruihan Chen, Yimou Lin, Qi Ling
Summary: Hepatocellular carcinoma is a major cause of cancer-related death globally, and liver transplantation is the best treatment option. However, HCC recurrence after transplantation remains a challenge. Immune checkpoint inhibitors have revolutionized cancer treatment and offer a new strategy for HCC recurrence after transplantation. This review summarizes the use of immunotherapy for post-transplant HCC recurrence and evaluates its efficacy and safety.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Filip Cvetkovski, J. Mark Hexham, Erik Berglund
Summary: Liver transplant recipients require lifelong immunosuppression therapy to preserve allograft function, which may lead to increased risks of malignancy, infection, renal impairment, and other toxicities. Although rare cases may achieve operational tolerance, predicting successful withdrawal of immunosuppression is difficult and requires long-term study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
