Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?

JAK/STAT/PKCδ molecular pathways in synovial fluid T lymphocytes reflect the in vivo T helper-17 expansion in psoriatic arthritis

(2014) Ugo Fiocco et al.   IMMUNOLOGIC RESEARCH

Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

(2013) Iain B McInnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Essentials of Th17 cell commitment and plasticity

(2013) P. Muranski et al.   BLOOD

Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial

(2013) Dominique Baeten et al.   LANCET

Th17 and Th22 cells in psoriatic arthritis and psoriasis

(2013) Helen Benham et al.   ARTHRITIS RESEARCH & THERAPY

Targeting interleukin-17 in patients with active rheumatoid arthritis: rationale and clinical potential

(2013) Herbert Kellner   Therapeutic Advances in Musculoskeletal Disease

Effect of IL-17A blockade with secukinumab in autoimmune diseases

(2012) Dhavalkumar D Patel et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

(2012) Kim A. Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Frequency of Th17 CD4+ T Cells in Early Rheumatoid Arthritis: A Marker of Anti-CCP Seropositivity

(2012) Irene Arroyo-Villa et al.   PLoS One

Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis

(2011) Lorenzo Cosmi et al.   ARTHRITIS AND RHEUMATISM

Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis

(2011) Troy Noordenbos et al.   ARTHRITIS AND RHEUMATISM

IL-17 receptor and its functional significance in psoriatic arthritis

(2011) Siba P. Raychaudhuri et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

IL-17A Expression Is Localised to Both Mononuclear and Polymorphonuclear Synovial Cell Infiltrates

(2011) Ellen M. Moran et al.   PLoS One

Analysis of IL-17+ cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response

(2011) Heiner Appel et al.   ARTHRITIS RESEARCH & THERAPY

Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium

(2011) Jolien Suurmond et al.   ARTHRITIS RESEARCH & THERAPY

Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials

(2010) M. G. H. van de Sande et al.   ANNALS OF THE RHEUMATIC DISEASES

LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

(2010) M. C. Genovese et al.   ARTHRITIS AND RHEUMATISM

The transient nature of the Th17 phenotype

(2010) Francesco Annunziato et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cutting Edge: Mast Cells Express IL-17A in Rheumatoid Arthritis Synovium

(2010) A. J. Hueber et al.   JOURNAL OF IMMUNOLOGY

Linking Power Doppler Ultrasound to the Presence of Th17 Cells in the Rheumatoid Arthritis Joint

(2010) Nicola J. Gullick et al.   PLoS One

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

(2010) K. Nistala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

How to perform and analyse synovial biopsies

(2009) Daniëlle M. Gerlag et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Breaking old paradigms: Th17 cells in autoimmune arthritis

(2009) Ariana Peck et al.   CLINICAL IMMUNOLOGY

Genome-Wide Comparison between IL-17A- and IL-17F-Induced Effects in Human Rheumatoid Arthritis Synoviocytes

(2009) S. Zrioual et al.   JOURNAL OF IMMUNOLOGY

Monocyte Derived Interleukin (IL)-23 Is an Important Determinant of Synovial IL-17A Expression in Rheumatoid Arthritis

(2009) L. K. STAMP et al.   JOURNAL OF RHEUMATOLOGY

Interleukin-17 and Type 17 Helper T Cells

(2009) Pierre Miossec et al.   NEW ENGLAND JOURNAL OF MEDICINE

In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses

(2009) H. G. Evans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor  -independent mouse model

(2008) C Plater-Zyberk et al.   ANNALS OF THE RHEUMATIC DISEASES

Structure–function relationships in the IL-17 receptor: Implications for signal transduction and therapy

(2008) Fang Shen et al.   CYTOKINE