Review
Biochemistry & Molecular Biology
Lluis Rusinol, Luis Puig
Summary: The Jak/STAT pathways play a crucial role in cytokine signaling and have become a focus of research for immune-mediated inflammatory diseases. Dysfunction of Tyk2, a member of the Jak family, has been linked to protection from psoriasis and prevention of IMID without increasing the risk of serious infections. Deucravacitinib, an allosteric inhibitor that binds to the regulatory domain of Tyk2, has shown greater selectivity and a reduced risk of adverse events. In September 2022, deucravacitinib became the first Tyk2 inhibitor approved for the treatment of moderate-to-severe psoriasis. Tyk2 inhibitors hold promise for the future with the development of newer drugs and broader indications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jian Zhao, Baoshan Cai, Zhugui Shao, Lei Zhang, Yi Zheng, Chunhong Ma, Fan Yi, Bingyu Liu, Chengjiang Gao
Summary: The study reveals that TRIM26 positively regulates TAK1 activation by ubiquitinating its binding partner TAB1. Trim26 deficiency reduces the induction of inflammatory cytokines, protecting mice from septic shock and attenuating the severity of colitis.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Medicine, Research & Experimental
Naoual El Menyiy, Aicha El Allam, Sara Aboulaghras, Imane Jaouadi, Saad Bakrim, Nasreddine El Omari, Mohammad Ali Shariati, Alevtin Miftakhutdinov, Polrat Wilairatana, Mohammad S. Mubarak, Abdelhakim Bouyahya
Summary: Autoimmune diseases are caused by the overactivity of the immune system towards self-constituents. Natural compounds derived from medicinal plants have shown potential in modulating the inflammatory responses of these diseases, presenting a promising approach for treatment and prevention.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Anne-Charlotte Heba, Simon Toupance, Djesia Arnone, Laurent Peyrin-Biroulet, Anthanase Benetos, Ndeye Coumba Ndiaye
Summary: Telomeres are repetitive DNA sequences located at the ends of linear chromosomes that play a crucial role in maintaining the integrity and stability of the genome. Research has shown a close connection between telomere length dynamics and immune-mediated inflammatory diseases, although the causality between these diseases and telomere attrition remains controversial.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Dariusz Szukiewicz
Summary: Insulin has comprehensive anabolic effects on the body, including lipid homeostasis and anti-inflammatory modulation, especially in adipose tissue. Obesity, with its accompanying health problems such as glucose intolerance, insulin resistance, and diabetes, has been increasing worldwide. Despite hyperinsulinemia, impaired tissue sensitivity to insulin paradoxically leads to diseases with an inflammatory component. Visceral fat accumulation in obesity disrupts epigenetic regulatory mechanisms in the immune system, resulting in autoimmunity and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Beatriz Garcillan, Miguel Salavert, Jose R. Regueiro, Sabela Diaz-Castroverde
Summary: Patients with immune-mediated inflammatory diseases (IMIDs) receiving biologic therapies may experience attenuated vaccine responses. Certain therapies impair the immunogenicity and antibody responses to vaccines, while others do not affect immune responses. SARS-CoV-2 vaccination appears to be safe and well tolerated in IMID patients, but the efficacy may be reduced compared to healthy individuals.
Review
Pharmacology & Pharmacy
Maria Gonzalez-Rodriguez, Clara Ruiz-Fernandez, Alfonso Cordero-Barreal, Djedjiga Ait Eldjoudi, Jesus Pino, Yousof Farrag, Oreste Gualillo
Summary: Recent research has shown that adipokines play important roles not only in adipose signaling, but also in musculoskeletal diseases, potentially impacting disease progression and treatment response.
DRUG DISCOVERY TODAY
(2022)
Article
Pharmacology & Pharmacy
Yinghong Wang, Xiaojie Hu, Yancai Sun, Yan Huang
Summary: This review focuses on the role of ASIC1a in several inflammatory immune diseases, providing new perspectives for clinical treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Xiaofen Zhang, Li Gao, Haiyang Meng, Ailing Zhang, Yan Liang, Jingli Lu
Summary: Obesity is strongly associated with immunological diseases such as cancer and inflammatory diseases. It worsens immune-driven diseases and causes resistance to immunotherapy. Obesity alters immune cell metabolism, exacerbates tumor and airway inflammation, as well as IL-17-mediated inflammatory diseases.
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Review
Immunology
Feng Zhao, Yang Bai, Xuerong Xiang, Xiaoxiao Pang
Summary: Inflammation is a critical immune response that protects the host organism by eliminating threats. Chronic inflammatory diseases are a leading cause of death worldwide, affecting a large number of individuals and creating economic and social burdens. Small leucine-rich proteoglycans (SLRPs), particularly fibromodulin (FMOD), have been found to play important roles in various inflammatory responses. This review focuses on the role of FMOD in inflammation, including its relationship with the complement system and immune cells, as well as its involvement in diseases associated with inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dandan Xin, Huhu Li, Shiyue Zhou, Hao Zhong, Weiling Pu
Summary: Anthraquinones and their derivatives are widely distributed in nature and have various effects, including anti-inflammatory, antioxidant, antibacterial, and antitumor activities. Inflammation is a comprehensive response to foreign pathogens, and anthraquinones can attenuate symptoms and tissue damages by reducing inflammation. This review provides a scientific summary of the immune responses to anthraquinones under different pathological conditions, as well as their potential for drug development and clinical use.
Review
Rheumatology
Shirish Dubey, Nilay Joshi, Olivia Stevenson, Caroline Gordon, John A. Reynolds
Summary: This review focuses on chilblains secondary to immune-mediated inflammatory disorders, primarily discussing the epidemiology, pathogenesis, and treatment of CHLE.
Review
Immunology
Priyanka Bhoj, Namdev Togre, Vishal Khatri, Kalyan Goswami
Summary: This paper reviews the immune evasion strategies evolved by human lymphatic filariae and discusses their potential application in developing new approaches for the treatment of parasitic and inflammatory diseases.
Article
Immunology
Jie Feng, Yanqing Wu
Summary: The immune response plays a crucial role in the initiation and progression of cardiovascular diseases. IL-35, a novel anti-inflammatory and immunosuppressive cytokine, has been found to have a significant impact on the regulation of inflammation and immune homeostasis. It is closely associated with cardiovascular diseases, particularly in protecting against atherosclerosis and myocarditis. Although the specific molecular mechanisms of IL-35's protective effects are still unclear, targeted therapies with IL-35 have the potential to provide a promising and effective solution for preventing and treating cardiovascular diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Vanessa Lamontain, Tobias Schmid, Dorothea Weber-Steffens, David Zeller, Zsuzsa Jenei-Lanzl, Harald Wajant, Rainer H. Straub, Daniela N. Maennel
CELLULAR & MOLECULAR IMMUNOLOGY
(2019)
Editorial Material
Immunology
Rainer H. Straub
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Orthopedics
Achim Benditz, Svenja Sprenger, Luise Rauch, Markus Weber, Joachim Grifka, Rainer H. Straub
JOURNAL OF ORTHOPAEDIC RESEARCH
(2019)
Article
Rheumatology
Laura Lueckemann, Hubert Stangl, Rainer H. Straub, Manfred Schedlowski, Martin Hadamitzky
ARTHRITIS & RHEUMATOLOGY
(2020)
Review
Rheumatology
S. Mechiel Korte, Rainer H. Straub
Article
Biochemistry & Molecular Biology
Tanja Niedermair, Rainer H. Straub, Christoph Brochhausen, Susanne Graessel
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Tanja Niedermair, Stephan Schirner, Mar Guaza Lasheras, Rainer H. Straub, Susanne Graessel
MECHANISMS OF AGEING AND DEVELOPMENT
(2020)
Article
Biochemistry & Molecular Biology
Jessica Hedderich, Karima El Bagdadi, Peter Angele, Susanne Graessel, Andrea Meurer, Rainer H. Straub, Frank Zaucke, Zsuzsa Jenei-Lanzl
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Rainer H. Straub
PROGRESS IN LIPID RESEARCH
(2020)
Article
Rheumatology
F. Gunther, B. Ehrenstein, W. Hartung, D. Boschiero, M. Fleck, R. H. Straub
Summary: This study found increased extracellular water and elevated serum levels of proANP in patients with PMR, indicating fluid overload. These volume changes are long-lasting mechanisms not affected by short-term anti-inflammatory therapy.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2021)
Review
Rheumatology
Maurizio Cutolo, Rainer H. Straub
NATURE REVIEWS RHEUMATOLOGY
(2020)
Article
Multidisciplinary Sciences
Hubert Stangl, Anita Krammetsvogl, Martin Lesiak, Christine Wolff, Rainer H. Straub
SCIENTIFIC REPORTS
(2020)
Editorial Material
Endocrinology & Metabolism
Rainer H. Straub
NEUROIMMUNOMODULATION
(2022)
Review
Rheumatology
Michael R. Irwin, Rainer H. Straub, Michael T. Smith
Summary: Sleep has a homeostatic role in immune system regulation and can help control inflammation and pain sensitivity. In rheumatoid arthritis (RA) patients, sleep-wake activity dysregulation due to a misaligned inflammatory profile leads to excessive inflammation and increased pain sensitivity. Understanding these risk mechanisms may offer prevention and treatment opportunities for insomnia in RA, potentially improving pain and disease outcomes.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Georg Pongratz, Rainer H. Straub
Summary: The immune system and neuroendocrine system interact in chronic inflammation, with the sympathetic nervous system playing a dual role of promoting inflammation and exerting anti-inflammatory effects. The goal of neuroendocrine immunologic research is to identify new therapeutic targets and translate theoretical knowledge into clinical benefits for patients.
NEUROIMMUNOMODULATION
(2023)