Article
Obstetrics & Gynecology
Nicola Vousden, Marian Knight
Summary: Influenza during pregnancy is associated with an increased risk of hospital admission, and there is variability in policies and uptake of immunization globally. Immunization is cost-effective and safe in preventing influenza in pregnant women and their infants.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyesun Jang, Ted M. Ross
Summary: The study found that the humoral response to trivalent seasonal influenza virus vaccines was influenced by rapid antigenic switching of H1 HA. While successful induction of antibodies against H1N1 and H3N2 vaccine components was observed, a strong immune response against CA/09 H1N1 influenza virus negatively influenced the induction of novel humoral responses to other vaccine strains.
Article
Biotechnology & Applied Microbiology
Gabriel Figueroa-Parra, Jorge Antonio Esquivel-Valerio, Leticia Santoyo-Fexas, Andrea Moreno-Salinas, Carmen Magdalena Gamboa-Alonso, Ana Laura De Leon-Ibarra, Dionicio Angel Galarza-Delgado
Summary: This study investigated the knowledge and attitudes about influenza vaccination among patients with rheumatic diseases and found that concerns about safety, efficacy, side effects, fear of the vaccine, and knowledge of cost can diminish vaccine uptake. These factors are related to confidence, complacency, and convenience as components of vaccine hesitancy in this population.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Review
Rheumatology
Rebecca Grainger, Alfred H. J. Kim, Richard Conway, Jinoos Yazdany, Philip C. Robinson
Summary: This review summarizes the current knowledge on SARS-CoV-2 infection, COVID-19 prevention and treatment in people with rheumatic disease. It suggests that rheumatic disease is associated with a slightly higher risk of SARS-CoV-2 infection, but outcomes of COVID-19 are influenced by comorbidities and specific disease states or treatments. Further research is needed to address the specific considerations for people with rheumatic disease.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Article
Oncology
Kjersti Flatmark, Annette Torgunrud, Karianne G. Fleten, Ben Davidson, Hedvig Juul, Nadia Mensali, Christin Lund-Andersen, Else Marit Inderberg
Summary: Pseudomyxoma peritonei (PMP) is a rare abdominal cancer without effective treatments in non-resectable cases, but GNAS mutations are common, providing a target for therapeutic cancer vaccines. Tumor samples from PMP patients showed a pre-existing immunity towards mutated Gs alpha, but immune checkpoint molecules may inhibit antitumor T cells. This suggests that peptide vaccination with Gs alpha peptides in combination with immune checkpoint inhibition could be a potential treatment for PMP and other GNAS mutated cancers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Public, Environmental & Occupational Health
Alex Asamoah Ankomah, Aye Moa, Abrar Ahmad Chughtai
Summary: This study examines the development and rollout of the 2009 influenza A(H1N1) pandemic vaccine and identifies knowledge challenges for COVID-19 vaccination programs and future influenza pandemics. The findings reveal initial high demand, vaccine shortages, skewed distribution towards high-income countries, and low vaccination rates due to low-risk perception, safety concerns, and fear of adverse effects.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Immunology
Tor Kristian Andersen, Johanna Bodin, Fredrik Oftung, Bjarne Bogen, Siri Mjaaland, Gunnveig Grodeland
Summary: The 2009 swine flu pandemic exposed the limitations of egg-based vaccines in terms of global supply, prompting the urgent need for efficient new vaccine platforms; DNA vaccines have since been developed as a temperature stable, cost-effective option for pandemic responses, capable of inducing rapid protective immune responses without the need for adjuvants.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanne Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy
Summary: Research demonstrates that utilizing combinations of conserved antigens of influenza A virus, such as NP and various forms of M2e, can generate broad immune protection in mice, reducing lung viral burden and weight loss.
Article
Immunology
Celeste J. Romano, Clinton Hall, Zeina G. Khodr, Anna T. Bukowinski, Gia R. Gumbs, Ava Marie S. Conlin
Summary: This study examined the association between receiving pandemic H1N1 (pH1N1) vaccines in consecutive influenza seasons and adverse pregnancy outcomes among vaccine-compliant pregnant military women. The results showed no significant association between receiving pH1N1-containing vaccine during pregnancy and spontaneous abortion or birth defects. Therefore, vaccination against pH1N1 in pregnancy is supported regardless of prior influenza season vaccination history.
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Sergi Lopez-Serrano, Lorena Cordoba, Monica Perez-Maillo, Patricia Pleguezuelos, Edmond J. Remarque, Thomas Ebensen, Carlos A. Guzman, Dennis Christensen, Joaquim Segales, Ayub Darji
Summary: This study found that pigs vaccinated with NG34 vaccine in combination with CAF(R)01 or CDA/alpha GCM exhibited different immune responses, with animals in the NG34 + CAF(R)01 group showing lower lung lesions and viral shedding post-infection, while pigs in the NG34 + CDA/alpha GCM group showing more severe pathology and viral shedding.
Review
Biotechnology & Applied Microbiology
Simin Wen, Zhengyu Wu, Shuyi Zhong, Mao Li, Yuelong Shu
Summary: This paper reviews the factors that may influence the immunogenicity of influenza vaccines, including vaccine factors, adjuvants, individual factors, repeated vaccination, and genetic factors, and emphasizes the importance of fully identifying these factors.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Oncology
Shu Yazaki, Tatsuya Yoshida, Yuki Kojima, Shigehiro Yagishita, Hiroko Nakahama, Keiji Okinaka, Hiromichi Matsushita, Mika Shiotsuka, Osamu Kobayashi, Satoshi Iwata, Yoshitaka Narita, Akihiro Ohba, Masamichi Takahashi, Satoru Iwasa, Kenya Kobayashi, Yuichiro Ohe, Tomokazu Yoshida, Akinobu Hamada, Toshihiko Doi, Noboru Yamamoto
Summary: This study evaluated the serum SARS-CoV-2 antibody status in cancer patients and healthcare workers in Japan during the COVID-19 pandemic. The seroprevalence did not differ significantly between the two groups, but it was found that cancer comorbidity and treatment with chemotherapy and immune checkpoint inhibitors may impact the immune response to SARS-CoV-2.
Review
Immunology
Sofia M. Buonocore, Robbert G. van der Most
Summary: This article reviews the association between the 2009-2010 H1N1 influenza pandemic and the increased risk of narcolepsy in children and adolescents after vaccination. Studies have suggested that immune responses and molecular mimicry may play a role in this association.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Hanna Kallmark, Jon T. Einarsson, Jan-Ake Nilsson, Tor Olofsson, Tore Saxne, Pierre Geborek, Meliha C. Kapetanovic
Summary: The study compared the real-life effectiveness of biologic therapy and triple therapy for sustained remission of rheumatoid arthritis. Results showed that biologic therapy was more effective in achieving sustained remission and remaining on therapy, but similar probabilities were found for sustained remission among patients remaining on therapy and at any time during follow-up regardless of therapy retention.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Per Nived, Asa Pettersson, Goran Jonsson, Anders A. Bengtsson, Bo Settergren, Lillemor Skattum, Asa Johansson, Meliha C. Kapetanovic
Summary: Methotrexate affects antibody response after pneumococcal vaccination in RA patients, influencing phenotypes of B and T cell subsets. MTX group showed lower postimmunization plasmablast concentrations and reduced Th17 cells, while 0DMARD and HC groups displayed opposite changes post-PCV.
SCIENTIFIC REPORTS
(2021)
Meeting Abstract
Rheumatology
T. Fatima, Y. Borne, M. Dehlin, S. Burgess, A. Mason, L. T. H. Jacobsson, M. C. Kapetanovic
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Meeting Abstract
Rheumatology
M. Frodlund, K. Chatzidionysiou, A. Sodergren, E. Klingberg, M. Hansson, E. Pin, S. Olsson, A. Bengtsson, L. Klareskog, M. C. Kapetanovic
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
M. Frodlund, K. Chatzidionysiou, A. Sodergren, E. Klingberg, A. Bengtsson, L. Klareskog, M. C. Kapetanovic
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
O. Palsson, J. T. Einarsson, J. K. Wallman, T. Love, B. Gudbjornsson, M. C. Kapetanovic
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Evelina Elmer, Per Nived, Asa Pettersson, Lillemor Skattum, Thomas Hellmark, Meliha C. Kapetanovic, Asa C. M. Johansson
Summary: This study investigates the role of the innate immune system in the impaired antibody response to PCV vaccination in RA patients treated with MTX. The study found that MTX suppresses monocyte concentration and frequency, which could serve as a biomarker to identify nonresponders to PCV vaccination.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Rheumatology
George E. Fragoulis, Elena Nikiphorou, Mrinalini Dey, Sizheng Steven Zhao, Delphine Sophie Courvoisier, Laurent Arnaud, Fabiola Atzeni, Georg M. N. Behrens, Johannes W. J. Bijlsma, Peter Boehm, Costas A. Constantinou, Silvia Garcia-Diaz, Meliha Crnkic Kapetanovic, Kim Lauper, Mariana Luis, Jacques Morel, Gyoergy Nagy, Eva Poleverino, Jef van Rompay, Marco Sebastiani, Anja Strangfeld, Annette de Thurah, James Galloway, Kimme L. Hyrich
Summary: This study aims to develop recommendations for screening and prevention of chronic and opportunistic infections in patients with autoimmune inflammatory rheumatic diseases (AIIRD). Four overarching principles and eight specific recommendations were formulated through international collaboration. These recommendations provide guidance for clinical practice to reduce the burden of opportunistic infections in AIIRD patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
J. Nagel, G. Jonsson, J-A. Nilsson, C. Manuswin, M. Englund, T. Saxne, M. C. Kapetanovic
Summary: A study found that within 10 years after receiving the 7-valent conjugated pneumococcal vaccine (PCV7), arthritis patients who were vaccinated had a lower risk of serious pneumococcal infections compared to non-vaccinated arthritis patients.
Article
Rheumatology
C. Roseman, J. k Wallman, A. Joud, M. E. C. Schelin, J. T. Einarsson, E. Lindqvist, J. Lampa, M. C. Kapetanovic, T. Olofsson
Summary: This study aimed to investigate the occurrence/predictors of persistent pain after starting anti-TNF therapy in psoriatic arthritis patients. The results showed that a substantial proportion of patients still reported unacceptable pain throughout the first year of treatment. Refractory pain constituted a significant portion of this remaining pain load.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
Martina Frodlund, Katerina Chatzidionysiou, Anna Soedergren, Eva Klingberg, Anders A. Bengtsson, Monika Hansson, Sophie Ohlsson, Elisa Pin, Lars Klareskog, Meliha Kapetanovic
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Tony Merriman, Hirotaka Matsuo, Riku Takei, Megan Leask, Ruth Topless, Yuya Shirai, Zhiqiang Li, Murray Cadzow, Richard Reynolds, Kenneth Saag, Tayaza Fadason, Justin O'Sullivan, Nicola Dalbeth, Lisa Stamp, Abhishek Abhishek, Michael Doherty, Edward Roddy, Lennart Jacobsson, Meliha Kapetanovic, Mariano Andres, Fernando Perez-Ruiz, Rosa Torres Jimenez, Timothy Radstake, Timothy Jansen, Matthijs Janssen, Leo Joosten, Tania Octavia Crisan, Tom Huizinga, Frederic Liote, Pascal Richette, Thomas Bardin, Tristan Pascart, Geraldine McCarthy, Blanka Stiburkova, Anne Tausche, Till Uhlig, Veronique Vitart, Philip Riches, Stuart Ralston, Thomas MacDonald, Akiyoshi Nakayama, Masahiro Nakatochi, Kimiyoshi Ichida, Tappei Takada, Chaeyoung Lee, Matthew Brown, Philip Robinson, Catherine Hill, Hyon Choi, Nicholas Sumpter, Marilyn Merriman, Amanda Phipps-Green, Wenhua Wei, Sally McCormick, Olle Melander, Rene Toes, Hang-Korng Ea, Fina Kurreeman, Laura Helbert, Thibaud Boutin, Nariyoshi Shinomiya, Linda Bradbury, Russell Buchanan, Susan Lester, Malcolm Smith, Maureen Rischmueller, Eli Stahl, Jeff Miner, Daniel Solomon, Jing Cui, Kathleen Giacomini, Deanna Brackman, Eric Jorgenson, Suyash Shringapure, Alexander So, Yukinori Okada, Changgui Li, Yongyong Shi, Tanya Major
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
M. Ostergaard, R. Van Vollenhoven, A. Rudin, M. L. Hetland, M. Heiberg, D. Nordstrom, M. Nurmohamed, B. Gudbjornsson, L. Midtboll Ornbjerg, P. Boyesen, I. Olsen, K. Lend, K. Horslev-Petersen, T. Uhlig, T. Sokka-Isler, G. Grondal, S. Krabbe, J. Lindqvist, I. Gjertsson, D. Glinatsi, M. C. Kapetanovic, A. B. Aga, F. Faustini, P. Parmanne, T. Lorenzen, G. Cagnotto, J. Back, O. Hendricks, D. Vedder, T. Rannio, E. Grenholm, H. M. Lindegaard, M. K. A. Ljosa, E. Brodin, A. Soderbergh, M. Rizk, E. Hermansson, L. Uhrenholt, P. Larsson, S. A. Just, G. Bakland, D. Stevens, T. B. Laurberg, E. A. Haavardsholm, J. Lampa
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
Mikkel Ostergaard, Ronald van Vollenhoven, Anna Rudin, Merete Hetland, Marte S. Heiberg, Dan Nordstrom, Michael Nurmohamed, Bjorn Gudbjornsson, Lykke Ornbjerg, Pernille Boyesen, Inge Olsen, Kristina Lend, Kim Horslev-Petersen, Till Uhlig, Tuulikki Sokka-Isler, Gerdur Grondal, Simon Krabbe, Joakim Lindqvist, Inger Gjertsson, Daniel Glinatsi, Meliha Kapetanovic, Anna-Birgitte Aga, Francesca Faustini, Pinja Parmanne, Tove Lorenzen, Cagnotto Giovanni, Johan Back, Oliver Hendricks, Daisy Vedder, Tuomas Rannio, Emma Grenholm, Maud Kristine Ljosa, Eli Brodin, Hanne Merete Lindegaard, Annika Soderbergh, Milad Rizk, Elsa Hermansson, Per Larsson, Line Uhrenholt, Soren Andreas Just, David John Stevens, Trine Bay Laurberg, Gunnstein Bakland, Espen Haavardsholm, Jon Lampa
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Victoria Furer, Christien Rondaan, Nancy Agmon-Levin, Sander van Assen, Marc Bijl, Meliha Crnkic Kapetanovic, Annette de Thurah, Ulf Mueller-Ladner, Daphna Paran, Karen Schreiber, Klaus Warnatz, Nico M. Wulffraat, Ori Elkayam
Summary: This paper reviews the current data on COVID-19 infection in patients with autoimmune inflammatory rheumatic diseases (AIIRD) and discusses the efficacy and safety of vaccination against COVID-19 in this population. It proposes preliminary considerations for vaccination based on expert opinion and knowledge of vaccination in AIIRD patients.