Review
Immunology
Sara Assadiasl, Misagh Rajabinejad, Narjes Soleimanifar, Farideh Makiyan, Esfandiar Azizi, Alireza Rezaiemanesh, Mohammad Hossein Nicknam
Summary: Rheumatoid arthritis and ankylosing spondylitis are two common rheumatic disorders characterized by persistent inflammatory joint disease. This review provides an overview of the most important signaling pathways controlled by miRNAs in these diseases.
INFLAMMOPHARMACOLOGY
(2023)
Review
Cell Biology
Ricardo Cardoso Castro, Relber Aguiar Goncales, Fabiana Albani Zambuzi, Fabiani Gai Frantz
Summary: The Notch signaling pathway plays a crucial role in regulating immune responses during infections, influencing cell fate, hematopoiesis, tissue self-renewal, and immune system function. Establishing an approach based on this pathway can help predict the outcomes of infectious diseases.
INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xinglu Chen, Longmei Qiu, Xirui Si, Xiaolin Zhang, Baoying Guo, Zhi Liao, Xiaojun Yan, Pengzhi Qi
Summary: This study investigated the association between Mc-novel_miR_145 and IL-17 homolog (McIL-17-3) and their immunomodulatory effects in Mytilus coruscus. The results showed that McIL-17-3 was highly expressed in immune-associated tissues and responded to bacterial challenges. McIL-17-3 could activate downstream NF-kappa b and was negatively regulated by Mc-novel_miR_145. Moreover, Mc-novel_miR_145 could alleviate LPS-induced apoptosis by negatively regulating McIL-17-3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Zhijie Jian, Rui Ma, Ling Zhu, Huidan Deng, Fengqin Li, Jun Zhao, Lishuang Deng, Siyuan Lai, Xiangang Sun, Huaqiao Tang, Zhiwen Xu
Summary: This article reviews the strategies used by Arteriviruses to antagonize IFN production and thwart IFN-activated antiviral signaling, emphasizing the significance of this research in understanding the pathogenesis of arthritis virus and developing vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Anissa Guillemin, Anuj Kumar, Melanie Wencker, Emiliano P. Ricci
Summary: Innate immunity is the first line of defense against infections and tissue damage, and it relies on a dynamic and coordinated gene expression program. Transcriptional and post-transcriptional regulatory pathways, involving RNA-binding proteins and other effectors, play crucial roles in shaping the innate immune response. Recently, microRNAs and post-transcriptional modification of RNA bases have also emerged as essential players in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guiqin Shi, Junquan Cheng, Yuan Zhou, Fei Ren, Yanxiao Bu
Summary: The Pxt gene plays an important role in the immune response of silkworms. It is induced by Nuclear Polyhedrosis Virus and highly expressed in silkworm hemocytes. Deficiency in the Pxt gene leads to immunosuppression in silkworms.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Immunology
Yuena Sun, Lei Zhang, Ling Hong, Weiwei Zheng, Junxia Cui, Xuezhu Liu, Tianjun Xu
Summary: The study identified miR-181b-2 and miR-21-1 from Miichthys miiuy as negative regulators in host immune response, targeting TRIF to suppress inflammatory cytokines and type I IFN production, thus modulating antiviral and antibacterial immunity. These miRNAs act as negative feedback regulators in host immune response, shedding light on the resistance mechanism of lower vertebrates against pathogen invasion and excessive immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ziwei Li, Peng Tian, Tengbo Huang, Jianzi Huang
Summary: Macronutrient elements play crucial roles in plant growth and development, with deficient or excessive supply triggering various plant responses; noncoding RNAs, including miRNAs and lncRNAs, may serve as key regulators in plant responses to macronutrient stress; high-throughput sequencing has provided valuable data for the identification and characterization of nutrient-responsive ncRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yafeng Dou, Yan Xie, Lingyun Zhang, Sheng Liu, Dandan Xu, Yuying Wei, Yongshuai Li, Xiao-Lian Zhang
Summary: This study explores the role of a protein called PPE68 in the intracellular survival of Mycobacterium tuberculosis (Mtb) in macrophages. The researchers found that PPE68 is essential for efficient Mtb intracellular survival and that a macrophage protein called MKRN1 interacts with PPE68 to facilitate its ubiquitination. This ubiquitination of PPE68 suppresses immune responses and helps Mtb evade the immune system. The findings reveal a previously unrecognized mechanism of Mtb immune escape and suggest that targeting the interaction between MKRN1 and Mtb PPE proteins could be a potential therapeutic strategy for tuberculosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Beatriz Garcillan, Miguel Salavert, Jose R. Regueiro, Sabela Diaz-Castroverde
Summary: Patients with immune-mediated inflammatory diseases (IMIDs) receiving biologic therapies may experience attenuated vaccine responses. Certain therapies impair the immunogenicity and antibody responses to vaccines, while others do not affect immune responses. SARS-CoV-2 vaccination appears to be safe and well tolerated in IMID patients, but the efficacy may be reduced compared to healthy individuals.
Review
Cell Biology
Boyi Cong, Qian Zhang, Xuetao Cao
Summary: TET2, a crucial regulator in hematopoiesis, is involved in the development of hematological malignancies. Recent studies have shown its important role in innate immune homeostasis and inflammation resolution. Understanding the functions and regulation of TET2 can provide insights for intervention in pathological processes caused by TET2 dysregulation.
Review
Geriatrics & Gerontology
Alfonso J. Cruz-Jentoft, Susana Romero-Yuste, Eugenio Chamizo Carmona, Joan M. Nolla
Summary: Sarcopenia, defined by muscle mass and function loss, is associated with mortality, decreased physical performance, falls, and disability. Chronic inflammation and decreased physical activity are risk factors for sarcopenia, making it important to assess its role in immune-mediated rheumatic diseases (IMRDs). Nutritional interventions are key modifiable options to improve physical performance in sarcopenia, with evidence linking nutrition to prevention and treatment of sarcopenia in IMRDs.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Review
Rheumatology
Matteo Vecellio, Haijing Wu, Qianjin Lu, Carlo Selmi
Summary: Epigenetic mechanisms, particularly DNA methylation, are considered to be important in autoimmune and chronic inflammatory diseases, connecting environmental stimuli with genetic susceptibility. The causal relationship between DNA methylation and gene silencing is well established, but there is controversy in comparing DNA methylation results from different studies. Intriguing evidence comes from comparing the epigenome in clinically discordant monozygotic twins.
CLINICAL RHEUMATOLOGY
(2021)
Review
Oncology
Chunyan Zong, Tianyu Zhu, Jie He, Rui Huang, Renbing Jia, Jianfeng Shen
Summary: PARP enzymes, especially PARP1, play important roles in DNA damage response and genome stability maintenance. PARPis can be used as a therapeutic approach for BRCA-deficient tumors, not only through catalytic inhibition and DNA trapping, but also by affecting tumor's immune modulation.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Immunology
Raffaella Parente, Valentina Possetti, Marco Erreni, Francesca D'Autilia, Barbara Bottazzi, Cecilia Garlanda, Alberto Mantovani, Antonio Inforzato, Andrea Doni
Summary: The ubiquitous mold Aspergillus fumigatus is the major cause of invasive aspergillosis, requiring coordinated action of cellular and humoral components of the innate immune system for effective disposal. The complement system and pentraxins form an integrated system with interactions, synergy, and regulation, playing a pivotal role in mounting antifungal immunity. Proteins like PTX3 and SAP target A. fumigatus through complement-dependent pathways, utilising different mechanisms of complement activation and receptor-mediated phagocytosis, adding complexity to the immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Lingling Wu, Yuting Qin, Shiwei Xia, Min Dai, Xiao Han, Yanfang Wu, Xiaoyan Zhang, Jianyang Ma, Yan Wang, Yuanjia Tang, Zheng Liu, Wei Zhu, Bahija Jallal, Yihong Yao, Bo Qu, Nan Shen
ARTHRITIS & RHEUMATOLOGY
(2016)
Article
Rheumatology
Christopher J. Lessard, Satria Sajuthi, Jian Zhao, Kwangwoo Kim, John A. Ice, He Li, Hannah Ainsworth, Astrid Rasmussen, Jennifer A. Kelly, Miranda Marion, So -Young Bang, Young Bin Joo, Jeongim Choi, Hye-Soon Lee, Young Mo Kang, Chang-Hee Suh, Won Tae Chung, Soo-Kon Lcc, Jung-Yoon Choc, Scung Chcol Shim, Ji Hcc Oh, Young Jin Kim, Bok-Ghee Han, Nan Shen, Hwee Siew Howe, Edward K. Wakeland, Quan-Zhen Li, Yeong Wook Song, Patrick M. Gaffney, Marta E. Alarcon-Riquelme, Lindsey A. Criswel, Chaim Jacob, Robert P. Kimberly, Timothy J. Vyse, John B. Harley, Kathy L. Sivils, Sang-Cheol Bae, Carl D. Langefeld, Betty P. Tsao
ARTHRITIS & RHEUMATOLOGY
(2016)
Meeting Abstract
Rheumatology
S. Thornton, T. D. Do, R. Tan, A. Sproles, M. Bennett, M. Medvedovic, M. Delay, N. Shen, A. Grom, G. Schulert
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Article
Rheumatology
Shiyu Zhou, Yan Wang, Yao Meng, Chunyuan Xiao, Zheng Liu, Philip Brohawn, Brandon W. Higgs, Bahija Jallal, Qian Jia, Bo Qu, Xinfang Huang, Yuanjia Tang, Yihong Yao, John B. Harley, Nan Shen
ARTHRITIS & RHEUMATOLOGY
(2016)
Article
Rheumatology
Grant S. Schulert, Ndate Fall, John B. Harley, Nan Shen, Daniel J. Lovell, Sherry Thornton, Alexei A. Grom
ARTHRITIS & RHEUMATOLOGY
(2016)
Article
Rheumatology
Xiao Han, Yan Wang, Xiaoyan Zhang, Yuting Qin, Bo Qu, Lingling Wu, Jianyang Ma, Zhenyuan Zhou, Jie Qian, Min Dai, Yuanjia Tang, Edward K. L. Chan, John B. Harley, Shiyu Zhou, Nan Shen
ARTHRITIS & RHEUMATOLOGY
(2016)
Article
Microbiology
Ye Cui, Huansha Yu, Xin Zheng, Rui Peng, Qiang Wang, Yi Zhou, Rui Wang, Jiehua Wang, Bo Qu, Nan Shen, Qiang Guo, Xing Liu, Chen Wang
Article
Cell Biology
Yonggang Zhou, Binqing Fu, Xiuxiu Xu, Jinghe Zhang, Xianhong Tong, Yanshi Wang, Zhongjun Dong, Xiaoren Zhang, Nan Shen, Yiwen Zhai, Xiangdong Kong, Rui Sun, Zhigang Tian, Haiming Wei
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Rheumatology
Jun Li, Huihua Ding, Yao Meng, Guanhua Li, Qiong Fu, Qiang Guo, Zhihua Yin, Zhizhong Ye, Haibo Zhou, Nan Shen
ARTHRITIS & RHEUMATOLOGY
(2020)
Biographical-Item
Rheumatology
Nan Shen, Peter E. Lipsky
Article
Rheumatology
Yan Ye, Xueliang Zhang, Teng Li, Jiaqiang Ma, Ran Wang, Chunmei Wu, Runci Wang, Chunde Bao, Shuang Ye, Nan Shen, Qiang Guo, Qiong Fu, Xiaoming Zhang
Summary: The aim of this study was to identify immunologic features and biomarkers predicting prognosis in patients with ADM-ILD. The results showed that patients with ADM-ILD can be stratified based on immune cell subsets, which can predict disease activity and clinical outcomes, and immunophenotype is an independent risk factor associated with prognosis.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Engineering, Biomedical
Jiali Zhang, Qianqian Guo, Dai Dai, Jian Yu, Liting Wang, Zhihua Wu, Huihua Ding, Nan Shen, Yourong Duan
Summary: Excessive CD4(+ )T helper (Th)-B-cell interactions and loss of Treg homeostasis are crucial to the pathogenesis of systemic lupus erythematosus (SLE). In this study, RAP-encapsulated ICOS/CD40L bispecific nanoparticles were designed to selectively target SLE Th cells and inhibit Th-B-cell reciprocal activation, with the sustained release of RAP further promoting the expansion of Treg cells and alleviating SLE progression without obvious toxicity.
Article
Immunology
Zhaorui Cheng, Guojun Hou, Nan Shen
Summary: Autoimmune diseases (ADs) are characterized by autoreactive immune cells and inflammation. Non-coding RNAs (ncRNAs) have been found to play a significant role in ADs and immune responses. Dysregulation of ncRNAs in immune cells disrupts immune homeostasis and is implicated in various ADs. ncRNAs could be potential biomarkers for AD diagnosis and therapeutic targets. This review focuses on recent studies on the involvement of ncRNAs in autoimmunity and ADs.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Danting Zhang, Fangfang Sun, Jie Chen, Huihua Ding, Xiaodong Wang, Nan Shen, Ting Li, Shuang Ye
Summary: Four trajectories of 24-hour urine protein in lupus nephritis were identified and user-friendly nomograms were developed to predict treatment response. These findings have important implications for guiding the management of lupus nephritis and designing clinical trials.
Article
Rheumatology
Huihua Ding, Cheng Lin, Jingyi Cai, Qiang Guo, Min Dai, Chandra Mohan, Nan Shen
ARTHRITIS RESEARCH & THERAPY
(2020)