Article
Immunology
Charlotte Chene, Dominique Rongvaux-Gaida, Marine Thomas, Francois Rieger, Carole Nicco, Frederic Batteux
Summary: In this study, the combination of arsenic trioxide (ATO) and copper chloride (CuCl2) was used to treat a mouse model of systemic sclerosis (SSc). The results showed that the combination treatment could achieve the same therapeutic effect as a high dose of ATO alone, while reducing the dosage of ATO and improving the health status of the mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jingjing Huang, Hydia Puente, Nancy E. E. Warening, Minghua Wu, Maureen D. D. Mayes, Harry Karmouty-Quintana, Shervin Assassi, Tingting W. W. Mills
Summary: This study found that phosphorylation of STAT6 increased in fibrotic skin samples from SSc patients and bleomycin-injected mice. Knockout of Stat6 in mice suppressed fibrotic cytokines expression and reduced collagen and fibronectin production. STAT6 inhibition also attenuated skin fibrosis in mice. Co-culture experiments further demonstrated the role of STAT6 in cytokine and fibrotic marker expression in skin epithelial cells and fibroblasts.
Article
Multidisciplinary Sciences
Xianguo Lang, Zhouqiao Zhao, Haoran Ma, Kangjun Huang, Songzhuo Li, Chuanming Zhou, Shuhai Xiao, Yongbo Peng, Yonggang Liu, Wenbo Tang, Bing Shen
Summary: The study reveals the mechanism of superheavy pyrite deposition globally during the Neoproterozoic Cryogenian Period, suggesting a potential mechanism for the formation of sulfur-34 enriched seawater and superheavy pyrite, highlighting the importance of VOSC cycling in the sulfur cycle of Proterozoic oceans.
NATIONAL SCIENCE REVIEW
(2021)
Article
Immunology
Fatemeh Vafashoar, Kazem Mousavizadeh, Hadi Poormoghim, Amir Haghighi, Salar Pashangzadeh, Nazanin Mojtabavi
Summary: The study found that progesterone treatment increased collagen content in fibrotic and normal lung tissues, as well as increased alpha-SMA and TGF-beta in fibrotic lung tissues while decreasing MMP9. Furthermore, progesterone treatment also decreased the gene expression of Col1a2, Ctgf, and End1 in bleomycin-injured lung tissues.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Anderson Rodrigues de Almeida, Andrea Tavares Dantas, Maria Eduarda de Oliveira Goncalves, Charlotte Chene, Mohamed Jeljeli, Sandrine Chouzenoux, Marine Thomas, Eudes Gustavo Constantino Cunha, Lilian David de Azevedo Valadares, Joao Victor de Melo Gomes, Simao Kalebe Silva de Paula, Marina Galdino da Rocha Pitta, Ivan da Rocha Pitta, Moacyr Jesus Barreto de Melo Rego, Michelly Cristiny Pereira, Angela Luzia Branco Pinto Duarte, Dulcineia Saes Parra Abdalla, Carole Nicco, Frederic Batteux, Maira Galdino da Rocha Pitta
Summary: This study aimed to investigate the immunomodulatory and antifibrotic properties of a TZD derivative called LPSF/GQ-16 in peripheral blood mononuclear cells (PBMC) from SSc patients and in a murine model of SSc. The results showed that LPSF/GQ-16 modulated the secretion of cytokines and significantly reduced dermal fibrosis in the mouse model. This study suggests the therapeutic potential of LPSF/GQ-16 for SSc.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei Yang, Ziyuan Wang, Qing Li, Yating Jia, Shuimiao Song, Zichu Ma, Jie Liu, Jing Wang
Summary: The study found that PDI using curcumin associated with LED can effectively prevent and disrupt the formation of Staphylococcus saprophyticus biofilms, including inducing biofilm prevention and removal, metabolic inactivation, intracellular membrane damage, and cell death.
Article
Cell Biology
Jong Seong Roh, Hoim Jeong, Beomgu Lee, Byung Wook Song, Seung Jin Han, Dong Hyun Sohn, Seung-Geun Lee
Summary: The study revealed that mirodenafil has the potential to alleviate skin fibrosis caused by SSc by downregulating the TGF-β/Smad signaling pathway.
ANIMAL CELLS AND SYSTEMS
(2021)
Article
Rheumatology
Dianyu Cao, Jina Zheng, Zheng Li, Yong Yu, Zengrui Chen, Qiang Wang
Summary: The study demonstrates that ACSL4 induces inflammatory macrophage ferroptosis, exacerbating fibrosis progression in SSc. ACSL4 and its regulators calpains may serve as potential therapeutic targets for SSc.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Medicine, Research & Experimental
Stella Baliou, Michael Sofopoulos, Maria Goulielmaki, Demetrios A. Spandidos, Petros Ioannou, Anthony M. Kyriakopoulos, Vassilios Zoumpourlis
Summary: The study demonstrated that both BAT and taurine were effective in suppressing inflammation, reducing cell infiltration, and decreasing thickness.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Md Abdullah Shamim, Steven Yeung, Ayaz Shahid, Mengbing Chen, Jeffrey Wang, Preshita Desai, Cyrus Parsa, Robert Orlando, Frank L. Meyskens, Kristen M. Kelly, Bradley T. Andresen, Ying Huang
Summary: This study characterized a topical delivery system based on transfersome (T-CAR) for preventing UV-induced skin cancer. The T-CAR gel showed promising results in reducing skin edema, tumor incidence, and expression of cancer-related markers without significant systemic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Immunology
Mahmoud Mohammadi, Leila Kohan, Mohsen Saeedi, Marie Saghaeian Jazi, Saeed Mohammadi
Summary: Naringin has been shown to have protective effects against fibrotic complications induced by HOCl in skin tissue, reducing collagenesis and decreasing the levels of fibrosis-associated genes.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Environmental Sciences
Antonio Cascajosa-Lira, Remedios Guzman-Guillen, Alberto Banos Arjona, Maria Arantzazu Aguinaga-Casanas, Nahum Ayala-Soldado, M. Rosario Moyano-Salvago, Ana Molina, Angeles Jos, Ana M. Camean, Silvia Pichardo
Summary: The organosulfur compound PTSO from Allium cepa has potential applications in the agrifood industry. In vivo study on mice showed that exposure to PTSO did not cause significant reproductive toxicity, confirming its safety for agrifood applications.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Takahiro Yamazaki, Sayuri Yamada, Konomi Ohshio, Miho Sugamata, Yuji Morita
Summary: Lactobacillus paracasei KW3110 has anti-inflammatory effects and prevents inflammatory stress-induced mitochondrial damage by promoting IL-10 production in mouse macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Daphne N. Dorst, Arjan P. M. van Caam, Elly L. Vitters, Birgitte Walgreen, Monique M. A. Helsen, Christian Klein, Shreya Gudi, Tirza Wubs, Jyoti Kumari, Madelon C. Vonk, Peter M. van der Kraan, Marije I. Koenders
Summary: The study investigated the potential of using FAP-tPDT in treating fibrosis in SSc skin. The results demonstrated dose-dependent cytotoxicity of FAP-tPDT in primary skin fibroblasts, and complete prevention of collagen plug contraction when seeded with primary SSc fibroblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Michael M. Schuendeln, Jakob Hoeppner, Felix L. Meyer, Wiebke Schmuck, Max D. Kauther, Gero Hilken, Bodo Levkau, Martina Rauner, Corinna Grasemann
Summary: This study investigated the effects of prednisone on osteoclast functioning in vivo in a mouse model of particle-induced bone loss. Prednisone was found to significantly inhibit particle-induced osteolysis in the skull without affecting osteoclast numbers. Short-term low-dose prednisone had osteoprotective effects in this preventive experimental design.
Article
Oncology
Trefa M. Abdullah, Jacqueline Whatmore, Edwin Bremer, Rimantas Slibinskas, Marek Michalak, Paul Eggleton
Summary: The study found that ER stress partially regulates the distribution of CRT in human ovarian cancer cells, which may play a role in immunogenic cell death (ICD).
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Food Science & Technology
Andrea M. McGrattan, Blossom C. M. Stephan, Oliver M. Shannon, Mohsen Mazidi, Mark Gilchrist, Miranda Smallwood, Paul Winyard, Nicholas McMahon, Lauren C. Blekkenhorst, Devi Mohan, Stefania Bandinelli, Louise Robinson, Luigi Ferrucci, Mario Siervo
Summary: This study investigated the associations between dietary sodium and nitrate intakes with cognitive function and blood pressure. The results showed that urinary nitrate excretion was associated with lower blood pressure, while sodium intake did not significantly correlate with cognitive performance. Further longitudinal studies are needed to confirm these findings.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Chemistry, Medicinal
Sotiris Kyriakou, Venetia Tragkola, Heba Alghol, Ioannis Anestopoulos, Tom Amery, Kyle Stewart, Paul G. Winyard, Dimitrios T. Trafalis, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis
Summary: This study chemically characterized and biologically evaluated watercress, finding that the edible part contained higher amounts of nutrients and phytochemicals compared to the non-edible part. The edible watercress showed higher cytotoxic potential against malignant melanoma cells, indicating its potential as an anti-cancer agent.
Article
Cell Biology
Carole Nicco, Marine Thomas, Julie Guillermet, Maryline Havard, Fanny Laurent-Tchenio, Ludivine Doridot, Francois Dautry, Frederic Batteux, Thierry Tchenio
Summary: Self-sustained quiescence (SSQ) is a stable but reversible non-proliferative cellular state that limits the cloning of cultured cancer cells. It has been found that low cell density and the use of drugs can induce cells into SSQ state. In SSQ state, the tumor growth rate of pancreatic adenocarcinoma cells slows down, but eventually transitions to a rapid growth phase. Identifying new agents targeting cancer cells in SSQ may improve patient survival.
Article
Endocrinology & Metabolism
Rocky Strollo, Chiara Vinci, Y. K. Stella Man, Sara Bruzzaniti, Erica Piemonte, Ghadeer Alhamar, Silvia Irina Briganti, Ilaria Malandrucco, Flavia Tramontana, Chiara Fanali, James Garnett, Roberto Buccafusca, Perrin Guyer, Mark Mamula, Eddie A. James, Paolo Pozzilli, Johnny Ludvigsson, Paul G. Winyard, Mario Galgani, Ahuva Nissim
Summary: The study found that patients with type 1 diabetes had stronger antibody and T cell responses to insulin with oxidative post-translational modifications. Specific peptide segments induced stronger stimulation of CD4(+) and CD8(+) T cells in type 1 diabetes patients, leading to more antibody responses.
Review
Cell Biology
Paul Eggleton, Jorge De Alba, Michael Weinreich, Perry Calias, Roly Foulkes, Valerie M. M. Corrigall
Summary: Two major chaperones, calreticulin (CRT) and binding immunoglobulin protein (GRP78/BiP), have immunoregulatory or anti-inflammatory functions depending on their location. CRT induces pro-inflammatory responses, while GRP78/BiP induces anti-inflammatory responses. Therapies targeting these chaperones have the potential to rebalance immune homeostasis and improve clinical outcomes. Ongoing clinical trials are exploring interventions to enhance endogenous cell surface CRT or introduce an analogue of GRP78/BiP (IRL201805).
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Stuart P. P. Cocksedge, Adam J. J. Causer, Paul G. G. Winyard, Andrew M. M. Jones, Stephen J. J. Bailey
Summary: This study investigated the effects of oral temperature and pH on the increases in salivary and plasma [NO2-] after dietary NO3- supplementation. The results showed that salivary [NO2-] increased when oral pH was elevated, regardless of oral temperature, while plasma [NO2-] increased to a greater extent at a higher oral pH.
Article
Gastroenterology & Hepatology
Maximilien Barret, Ludivine Doridot, Morgane Le Gall, Frederic Beuvon, Sebastien Jacques, Anna Pellat, Arthur Belle, Einas Abou Ali, Marion Dhooge, Sarah Leblanc, Marine Camus, Carole Nicco, Romain Coriat, Stanislas Chaussade, Frederic Batteux, Frederic Prat
Summary: Our study aimed to identify transcripts specifically overexpressed or repressed in patients who developed post-endoscopic esophageal stricture, as potential targets for stricture prevention. Transcriptomic analysis revealed activation of the interleukin (IL)-1 group and inhibition of interferon-gamma (INF gamma) and NUPR1 in the stricture group on Day 14, but these differences were no longer significant on Day 90.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Engineering, Biomedical
Emily J. Owen, Rachel A. Heylen, Kyle Stewart, Paul G. Winyard, A. Toby A. Jenkins
Summary: This review discusses the current understanding of the prevention and treatment of Incontinence Associated Dermatitis (IAD). It emphasizes the need for specific preventative measures targeting faecal/urinary irritants, including the use of urease inhibitors. The lack of internationally accepted diagnostic methods for IAD severity is identified, with current diagnosis relying on visual inspection. Non-invasive techniques, such as impedance spectroscopy, could potentially provide objective assessments of skin barrier function and aid in early detection and intervention.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2023)
Article
Immunology
Charlotte Chene, Dominique Rongvaux-Gaida, Marine Thomas, Francois Rieger, Carole Nicco, Frederic Batteux
Summary: In this study, the combination of arsenic trioxide (ATO) and copper chloride (CuCl2) was used to treat a mouse model of systemic sclerosis (SSc). The results showed that the combination treatment could achieve the same therapeutic effect as a high dose of ATO alone, while reducing the dosage of ATO and improving the health status of the mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alex S. Ferecsko, Miranda J. Smallwood, Adrian Moore, Corin Liddle, Jia Newcombe, Janet Holley, Jacqueline Whatmore, Nicholas J. Gutowski, Paul Eggleton
Summary: The cGAS-STING pathway is activated in neurodegenerative diseases through mitochondrial stress and DNA leakage, leading to neuroinflammation. This pathway could be a potential target for future therapeutics.
Article
Biology
Deepika Raman, Charlotte Chene, Carole Nicco, Mohamed Jeljeli, Jie Qing Eu, Marie-Veronique Clement, Frederic Batteux, Shazib Pervaiz
Summary: Graft-versus-host disease (GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). A pilot study on a murine model of sclerodermatous cGVHD showed that treatment with the senolytic combination of dasatinib and quercetin (DQ) significantly improved physical and tissue-specific features associated with cGVHD pathogenesis. The study suggests the involvement of senescent cells in cGVHD and highlights the potential therapeutic strategy of using DQ.
Article
Biochemistry & Molecular Biology
Chenguang Wei, Anni Vanhatalo, Stefan Kadach, Zdravko Stoyanov, Mohammed Abu-Alghayth, Matthew I. Black, Miranda J. Smallwood, Raghini Rajaram, Paul G. Winyard, Andrew M. Jones
Summary: Dietary nitrate supplementation can increase nitric oxide bioavailability and lower blood pressure in humans. This study investigated the correlations between changes in NO biomarkers in different blood compartments and changes in blood pressure following acute nitrate ingestion.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2023)
Article
Immunology
Anderson Rodrigues de Almeida, Andrea Tavares Dantas, Maria Eduarda de Oliveira Goncalves, Charlotte Chene, Mohamed Jeljeli, Sandrine Chouzenoux, Marine Thomas, Eudes Gustavo Constantino Cunha, Lilian David de Azevedo Valadares, Joao Victor de Melo Gomes, Simao Kalebe Silva de Paula, Marina Galdino da Rocha Pitta, Ivan da Rocha Pitta, Moacyr Jesus Barreto de Melo Rego, Michelly Cristiny Pereira, Angela Luzia Branco Pinto Duarte, Dulcineia Saes Parra Abdalla, Carole Nicco, Frederic Batteux, Maira Galdino da Rocha Pitta
Summary: This study aimed to investigate the immunomodulatory and antifibrotic properties of a TZD derivative called LPSF/GQ-16 in peripheral blood mononuclear cells (PBMC) from SSc patients and in a murine model of SSc. The results showed that LPSF/GQ-16 modulated the secretion of cytokines and significantly reduced dermal fibrosis in the mouse model. This study suggests the therapeutic potential of LPSF/GQ-16 for SSc.
INFLAMMOPHARMACOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
R. Nice, J. R. Goodhand, N. Kennedy, T. Ahmad, P. Winyard, T. J. McDonald
JOURNAL OF CROHNS & COLITIS
(2022)