Article
Medicine, General & Internal
Koji Akeda, Kohshi Ohishi, Norihiko Takegami, Takao Sudo, Junichi Yamada, Tatsuhiko Fujiwara, Rui Niimi, Takeshi Matsumoto, Yuki Nishimura, Toru Ogura, Satoshi Tamaru, Akihiro Sudo
Summary: This study investigated the efficacy and safety of platelet-rich plasma releasate (PRPr) injection in patients with discogenic low back pain. The results showed that PRPr injection can relieve pain, improve disability, and enhance quality of life without significant adverse events during 60 weeks of observation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Takahiro Hasegawa, Koji Akeda, Junichi Yamada, Koki Kawaguchi, Norihiko Takegami, Tatsuhiko Fujiwara, Takahiro Natsume, Koichiro Ide, Yukihiro Matsuyama, Akihiro Sudo
Summary: Intradiscal injection of PRPr has the potential to enhance the regeneration of degenerated rabbit IVDs induced by condoliase, indicating its potential use as a treatment option for patients with lumbar disc herniation who have poor recovery from disc degeneration after chemonucleolysis treatment with condoliase.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Hiroki Ohnishi, Zhongying Zhang, Takashi Yurube, Yoshiki Takeoka, Yutaro Kanda, Ryu Tsujimoto, Kunihiko Miyazaki, Tomoya Matsuo, Masao Ryu, Naotoshi Kumagai, Kohei Kuroshima, Yoshiaki Hiranaka, Ryosuke Kuroda, Kenichiro Kakutani
Summary: This study investigated the effects of AdipoRon on human intervertebral disc (IVD) nucleus pulposus (NP) cells using a three-dimensional in vitro culturing system, and also examined the effects of AdipoRon on rat tail IVD tissues using an in vivo puncture-induced IVD degeneration model. The results demonstrated that AdipoRon suppressed the gene expression of proinflammatory factors and phosphorylation of p65 via the AMPK pathway, thereby alleviating IVD degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
J-Y Wang, J. C. Mansfield, S. Brasselet, C. Vergari, J. R. Meakin, C. P. Winlove
Summary: Needle injection is widely used in spinal therapeutic or diagnostic processes, but it has been suspected to cause mild disc degeneration leading to long-term back pain. This study found that needle punctures cause local microscopic damage to collagen and cell nuclei, resulting in progressive damage. The size of the needle used did not significantly affect the damage, with more damage observed using larger needles.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcus Raudner, Markus M. Schreiner, Tom Hilbert, Tobias Kober, Michael Weber, Anna Szelenyi, Reinhard Windhager, Vladimir Juras, Siegfried Trattnig
Summary: The study evaluated GRAPPATINI, an accelerated T-2 mapping sequence that combines undersampling and model-based reconstruction to facilitate clinical implementation of T-2 mapping of the lumbar intervertebral disc. Results showed that T2 values obtained using GRAPPATINI were significantly different for normal discs compared to bulging or herniated discs, as well as discs with and without annular tears. The study concluded that GRAPPATINI can be used as a quantitative imaging biomarker to detect disc pathologies while significantly reducing acquisition time.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Lizhen Wang, Kaixiang Jin, Nan Li, Peng Xu, Hao Yuan, Harsha Ramaraju, Scott J. Hollister, Yubo Fan
Summary: This study developed a new minimally invasive biodegradable nucleus pulposus scaffold inspired by cucumber tendril, using a shape memory polymer called poly(glycerol-dodecanoate) (PGD) with mechanical properties similar to human nucleus pulposus. The scaffold immobilized the chemokine stromal cell-derived factor-1α (SDF-1α) to recruit autologous stem cells from peripheral tissue, resulting in better disc height maintenance, autologous stem cell recruitment, and induction of nucleus pulposus regeneration compared to scaffolds without the chemokine and hydrogel groups. This provides an innovative approach to design biodegradable and functionally recoverable minimally invasive implants for irreversible tissue injuries such as nucleus pulposus and cartilage.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Weikang Zhang, Yuhang Gong, Xiaohang Zheng, Jianxin Qiu, Ting Jiang, Lihua Chen, Fangying Lu, Xinhui Wu, Fengmin Cheng, Zhenghua Hong
Summary: PDGF-BB promotes extracellular matrix synthesis of NPCs and inhibits pyroptosis, participating in the inhibition of IDD through regulating the MAPK signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Orthopedics
G. Chao-yang, C. Peng, Z. Hai-hong
Summary: This article summarizes the role of the NLRP3 inflammasome in the pathogenesis of IVDD and its application in treatment.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Medicine, Research & Experimental
Chao-yang Gong, Hai-hong Zhang
Summary: Autophagy plays a dual role in intervertebral disc degeneration, as inducing autophagy can slow down the process while excessive autophagy activation-mediated apoptosis may accelerate degeneration.
Review
Cell & Tissue Engineering
Wentao Zhang, Tianze Sun, Ying Li, Ming Yang, Yantao Zhao, Jing Liu, Zhonghai Li
Summary: Stem cell therapy for intervertebral disc degeneration is emerging as a potential treatment option, with evidence from in vitro, in vivo, and clinical trials showing its effectiveness in relieving pain and symptoms, reversing the degenerative cascade, delaying the aging process, and maintaining spinal function. Further research is needed to understand the mechanisms and effects of stem cells in IDD treatment.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biotechnology & Applied Microbiology
Yijian Ying, Kaiwen Cai, Xiongxiong Cai, Kai Zhang, Rongzhang Qiu, Guoqiang Jiang, Kefeng Luo
Summary: This article systematically reviews recent advances in repairing intervertebral discs, describes their advantages and shortcomings, and explores future directions in repair technology.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dihua Meng, Weiyou Chen, Cheng Pan, Kunxue Yang, Yewen Guan, Jiaqi Wang, Abu Moro, Qingjun Wei, Hua Jiang
Summary: This study aimed to verify the potential therapeutic mechanisms of miR-106b-5p for intervertebral disc degeneration (IDD). The results showed that overexpression of miR-106b-5p inhibited cell growth, induced apoptosis, hindered extracellular matrix formation, and increased the expression of matrix-degrading enzymes through the SIRT2/MAPK/ERK signaling pathway. Additionally, inhibition of miR-106b-5p significantly attenuated IDD development.
Article
Biochemistry & Molecular Biology
Long Zhang, Guicheng Du, Bogang Teng, Xueqing Shi, Xuemei He, Na Li, Yu Chen, Ren Xu
Summary: This study established a mouse model of intervertebral disc degeneration by needle puncture, and evaluated the morphological and molecular changes. Accurate localization of puncture positions was achieved by injecting colored perfusates, improving the accuracy and safety of the surgery.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Clinical Neurology
Ke Yang, Zhanfeng Song, Dingding Jia, Jianqing Ma, Yachong Huo, Yachao Zhao, Wei Zhang, Wenyuan Ding, Zhanyong Wu, Sidong Yang
Summary: This study compared the effects of needle puncture and ChABC injection on inducing IVDD in rabbits, and found that both methods were successful in inducing IVDD, but needle puncture caused more severe IVDD.
EUROPEAN SPINE JOURNAL
(2022)
Article
Immunology
Jun Qian, Xiangdong Wang, Guanghui Su, Xiaolin Shu, Zucheng Huang, Huaji Jiang, Qingan Zhu
Summary: PRP-derived exosomes can alleviate IDD-associated inflammation by regulating macrophage polarization, NLRP3 inflammasome degradation, and reducing nucleus pulposus cell apoptosis, providing new insights into the treatment of IDD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tim Finkenstaedt, Palanan Siriwanarangsun, Suraj Achar, Michael Carl, Sina Finkenstaedt, Nirusha Abeydeera, Christine B. Chung, Won C. Bae
INVESTIGATIVE RADIOLOGY
(2019)
Article
Orthopedics
Aticha Ariyachaipanich, Emel Kaya, Sheronda Statum, Reni Biswas, Betty Tran, Won C. Bae, Christine B. Chung
SKELETAL RADIOLOGY
(2020)
Article
Orthopedics
Won C. Bae, Anthony S. Tadros, Tim Finkenstaedt, Jiang Du, Sheronda Statum, Christine B. Chung
Summary: The study found that UTE T2* values can effectively differentiate normal, degenerated, and torn menisci, and are significantly correlated with histopathology.
SKELETAL RADIOLOGY
(2021)
Article
Orthopedics
Brian Forsythe, Jorge Chahla, Avinaash Korrapati, Ophelie Lavoie-Gagne, Enrico Forlenza, Connor C. Diaz, Christine B. Chung, Won C. Bae, Bernard R. Bach, Brian Cole, Adam B. Yanke, Nikhil N. Verma
Summary: The use of bone marrow aspiration concentrate (BMAC) augmentation in ACL reconstruction with BTB allografts can improve clinical outcomes and MRI findings, with increased signal intensity scores on MRI at 3 months and better patient-reported outcomes at 9 months postoperatively.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mitsue Miyazaki, Asako Yamamoto, Vadim Malis, Sheronda Statum, Christine B. Chung, Jesse Sozanski, Won C. Bae
Summary: This study introduced a novel application of noncontrast magnetic resonance (MR) technique for evaluating blood perfusion in lumbar paraspinal muscles and demonstrated the effect of exercise on perfusion parameters. The results showed significantly increased perfusion after exercise in healthy subjects.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Computer Science, Artificial Intelligence
Sewon Kim, Hanbyol Jang, Seokjun Hong, Yeong Sang Hong, Won C. Bae, Sungjun Kim, Dosik Hwang
Summary: The study introduces a method for generating spine T2 FS images using Bloch equation-based autoencoder regularization generative adversarial network, achieving accurate diagnosis of various contrast MR images.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Respiratory System
Won Bae, Chang-Hoon Lee, Jinwoo Lee, Young Whan Kim, Kyungdo Han, Sun Mi Choi
Summary: A total of 25,113 individuals with incident IPF were identified, out of 23,242,836 participants registered in the database. The risk of IPF was significantly higher in current and former smokers compared to never smokers, with a higher risk for current smokers. Smoking intensity and duration showed a dose-response relationship with the development of IPF.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Won C. Bae
Article
Clinical Neurology
Tim Finkenstaedt, Palanan Siriwananrangsun, Koichi Masuda, Graeme M. M. Bydder, Karen C. C. Chen, Won C. C. Bae
Summary: Using UTE MRI, the study determined the prevalence of abnormal CEP and its association with disc degeneration in human lumbar spines. The results showed a 33% prevalence of CEP abnormality, which tended to increase with older age and lower spinal levels of L5. There was a significant association between abnormal CEPs and disc degeneration.
EUROPEAN SPINE JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Won C. Bae, Vadim Malis, Yoshimori Kassai, Mitsue Miyazaki
Summary: The purpose of this study was to compare three T1rho sequences based on FASE, UTE, and MAPSS acquisitions for the evaluation of knee tissues. The T1rho values of cartilage and meniscus varied with the pulse sequence, with the lowest values found in the 3D UTE T1rho sequence.
JAPANESE JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vadim Malis, Yoshimori Kassai, Diana Vucevic, Won C. Bae, Yoshiharu Ohno, Andrew Yen, Mitsue Miyazaki
Summary: The purpose of this study was to develop 3D ultrashort-TE (UTE) sequences with tight TE intervals to accurately map T2* values of lungs during free breathing. A Monte-Carlo simulation was used to optimize the number of echoes and a validation study was conducted on a known T2* phantom. The sequence was successfully applied to human lung imaging and provided valuable insights into diseased lungs.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ken Mautner, Michael Gottschalk, Scott D. Boden, Alison Akard, Won C. Bae, Lora Black, Blake Boggess, Paramita Chatterjee, Christine B. Chung, Kirk A. Easley, Greg Gibson, Josh Hackel, Katie Jensen, Linda Kippner, Chad Kurtenbach, Joanne Kurtzberg, R. Amadeus Mason, Benjamin Noonan, Krishnendu Roy, Verle Valentine, Carolyn Yeago, Hicham Drissi
Summary: This study compared the safety and efficacy of various cellular injections to corticosteroid injections for knee osteoarthritis. The results showed that none of the orthobiologic injections were superior to corticosteroid injection in terms of pain outcomes at 1 year post treatment.
Article
Chemistry, Analytical
Suraj Achar, Dosik Hwang, Tim Finkenstaedt, Vadim Malis, Won C. Bae
Summary: Isthmic spondylolysis can cause fracture in the lumbar spine, particularly in adolescent athletes with persistent low back pain. The use of ultrashort echo time (UTE) MRI and deep learning tools can generate CT-like images and saliency maps, providing improved image contrast and easier identification of bone fractures. It has shown potential in the evaluation of isthmic spondylolysis.
Article
Orthopedics
Won C. Bae, Sheronda Statum, Koichi Masuda, Christine B. Chung
Summary: This study demonstrates the sensitivity of T1rho values to spatially varying function and composition of cartilage, and that the strength of correlation depends on the method of data analysis and consideration of multiple variables.
SKELETAL RADIOLOGY
(2023)
Meeting Abstract
Critical Care Medicine
W. Bae, J. Cho, J. Lee, Y. Park, C. Lee, S. Lee, J. Yim, C. Yoo, Y. Kim, S. Han, S. Choi
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
