Article
Chemistry, Multidisciplinary
Li-jun Du, Yu-xiang Feng, Zhi-xing He, Lin Huang, Qiao Wang, Cheng-ping Wen, Yun Zhang
Summary: Norcantharidin (NCTD) has shown promising therapeutic effects in a mouse model of SLE by decreasing mortality rate, reducing expression of anti-dsDNA IgG antibody, restoring renal structure and function, and inhibiting lymphoproliferation and T cell accumulation in the spleen. Additionally, NCTD specifically targets DN T cell proliferation and Th17 cell differentiation through blocking the STAT3 signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Immunology
Angela Ceribelli, Francesca Motta, Matteo Vecellio, Natasa Isailovic, Francesco Ciccia, Carlo Selmi
Summary: Spondyloarthritis (SpA) is a group of inflammatory musculoskeletal diseases with common genetic backgrounds, and IL-17 and IL-23 have been identified as key cytokines in its pathogenesis. Treatment options for axial SpA differ significantly from peripheral arthritis, with new therapies targeting these cytokines showing promising results for both axial psoriatic arthritis and ankylosing spondylitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Rong Yu, Manoj Kumar Yadav, Minkyung Kang, Yingyos Jittayasothorn, Lijin Dong, Charles E. Egwuagu
Summary: Interleukin-27 (IL-27) and Interleukin-35 (IL-35) have different roles in neuroinflammation and uveitis. IL-27 can suppress encephalomyelitis and autoimmune uveitis, while IL-35 may have a protective role in the retina by constitutive secretion to counteract persistent low-grade inflammation. Decreased expression of IL-35 leads to increased severity of uveitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Nicolas Rosine, Corinne Miceli-Richard
Summary: Spondyloarthritis is a chronic inflammatory rheumatism with various forms, potentially associated with extra-articular manifestations. Studies have shown similarities in the pathophysiology of the disease, particularly in the IL-23/IL-17 pathway, but there are significant differences in the efficacy of IL-23-targeted treatments between different disease types.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Mohamed Mandour, Sijia Chen, Marleen G. H. van de Sande
Summary: Spondyloarthritis (SpA) is a chronic inflammatory joint disease where the IL-23/IL-17 pathway and TNF-α cytokine play important roles in its pathogenesis. Animal models have provided new insights into molecular mechanisms at different stages of SpA, aiding in understanding disease initiation and potential therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Tommy Regen, Sandrine Isaac, Ana Amorim, Nicolas Gonzalo Nunez, Judith Hauptmann, Arthi Shanmugavadivu, Matthias Klein, Roman Sankowski, Ilgiz A. Mufazalov, Nir Yogev, Jula Huppert, Florian Wanke, Michael Witting, Alexandra Grill, Eric J. C. Galvez, Alexei Nikolaev, Michaela Blanfeld, Immo Prinz, Philippe Schmitt-Kopplin, Till Strowig, Christoph Reinhardt, Marco Prinz, Tobias Bopp, Burkhard Becher, Carles Ubeda, Ari Waisman
Summary: Research has shown that IL-17A and IL-17F are not encephalitogenic mediators, but rather modulators of intestinal homeostasis that indirectly alter CNS-directed autoimmunity.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Junichi Ishikawa, Akira Suto, Kazuya Abe, Yuki Hayashi, Kensuke Suga, Shigeru Tanaka, Takahiro Kageyama, Arifumi Iwata, Kazumasa Suzuki, Kotaro Suzuki, Hiroshi Nakajima
Summary: Murine IL-17-producing γδT (γδT17) cells consist of natural γδT17 (nγδT17) cells and inducible γδT17 cells. IL-21 is dispensable for the fetal thymic development of nγδT17 cells, but required for the peripheral maintenance of Vδ4(+)nγδT17 cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Solveig Skovlund Groen, Dovile Sinkeviciute, Anne-Christine Bay-Jensen, Christian S. Thudium, Morten A. Karsdal, Simon Francis Thomsen, Georg Schett, Signe Holm Nielsen
Summary: Spondyloarthritis (SpA) is a group of chronic inflammatory rheumatic diseases characterized by inflammation in the axial skeleton, peripheral joints, and entheseal insertion sites. Genetic evidence and studies point to the significant role of interleukin (IL)-23 and IL-17 in SpA pathogenesis. Targeting the IL-23/17 pathways is seen as a promising strategy for treatment, with ongoing research focusing on serological markers and imaging strategies for early diagnosis and personalized medicine.
AUTOIMMUNITY REVIEWS
(2021)
Article
Immunology
Weiwei Guo, Fengying Xu, Zhuochen Zhuang, Zhe Liu, Jiming Xie, Liping Bai
Summary: The novel exopolysaccharide Ebosin shows promising anti-inflammatory effects in a psoriasis-like model, regulating inflammation through multiple pathways and enhancing the percentage of regulatory T cells, while reducing the number of inflammatory cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Tatsuaki Watanabe, Stephen C. Juvet, Gregory Berra, Jan Havlin, Wenshan Zhong, Kristen Boonstra, Tina Daigneault, Miho Horie, Chihiro Konoeda, Grace Teskey, Zehong Guan, David M. Hwang, Mingyao Liu, Shaf Keshavjee, Tereza Martinu
Summary: Chronic lung allograft dysfunction (CLAD) is a major complication after lung transplantation, resulting from the interaction of innate inflammatory and alloimmune factors and leading to fibrosis of lung parenchyma and/or airway. IL-17A and IL-17RA play important roles in these pathological processes.
Article
Immunology
Song Zhang, Jia Zhang, Juanjuan Yu, Xiaolu Chen, Fangyuan Zhang, Wei Wei, Lingyun Zhang, Wenmao Chen, Nengxing Lin, Yan Wu
Summary: In this study, it was found that hyperforin alleviates inflammation in psoriasis by suppressing IL-17A-producing gamma delta T cells and related cytokines through modulating MAPK/STAT3 pathways. The study also showed that hyperforin reduced epidermal thickness, suppressed infiltration of T cells, and decreased expression of inflammatory cytokines in mice with IMQ-induced psoriasis. Additionally, hyperforin inhibited splenomegaly, reduced TNF-alpha and IL-6 levels, and suppressed the activation of specific pathways in human keratinocytes and gamma delta T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Hu Li, Nan-Nan Liu, Jian-Rui Li, Mei-Xi Wang, Jia-Li Tan, Biao Dong, Pei Lan, Li-Min Zhao, Zong-Gen Peng, Jian-Dong Jiang
Summary: This study revealed the protective effects of Bicyclol in advanced liver diseases such as fibrosis/cirrhosis and hepatocellular carcinoma (HCC). The mechanism of action involves inhibiting the IL-6/STAT3 signaling pathway. This finding offers a promising therapeutic strategy for treating advanced liver diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Emma K. Haley, Mederbek Matmusaev, Imtiyaz N. Hossain, Sean Davin, Tammy M. Martin, Joerg Ermann
Summary: The phenotype of IL-23 induced disease in mice is influenced by genetic background and sex. Different mouse strains show variations in disease development, and gender also plays a role in disease presentation, which may have implications for human spondyloarthritis research.
Article
Chemistry, Medicinal
Dongjin Pan, Bingyao Huang, Yuman Gan, Chenghai Gao, Yonghong Liu, Zhenzhou Tang
Summary: The study found that phycocyanin (PC) can improve inflammation associated with colitis-associated cancer (CAC), reduce tumor number, and inhibit cell proliferation. In addition, PC can alter the expression of genes related to the intestinal barrier and affect the IL-17 signaling pathway.
Article
Microbiology
Nuria Trevijano-Contador, Elena Roselletti, Rocio Garcia-Rodas, Anna Vecchiarelli, Oscar Zaragoza
Summary: The study focused on the role of cytokine IL-17 in the formation of cryptococcal Titan cells, and found that IL-17 deficiency resulted in a lower proportion of Titan cells in infected mice and earlier dissemination to the brain. Additionally, IL-17 deficient mice showed an increased brain size and altered cytokine profile compared to wild-type mice, indicating a compensatory role of cytokines in influencing cryptococcal morphology and dissemination.