Article
Immunology
David Achudhan, Shan-Chi Liu, Yen-You Lin, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, I-Ping Chiang, Yueh-Hsiung Kuo, Chih-Hsin Tang
Summary: The study demonstrates that Antcin K, a compound isolated from Antrodia cinnamomea, shows anti-inflammatory effects by inhibiting proinflammatory cytokine production in human rheumatoid synovial fibroblasts. This indicates the potential of Antcin K in treating rheumatoid arthritis by reducing inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ramkumar Katturajan, S. Vijayalakshmi, Mahabookhan Rasool, Sabina Evan Prince
Summary: Rheumatoid arthritis (RA) is a chronic disorder that severely affects bones and joints, with Methotrexate (MTX) maintaining the standard of care for treating patients. However, the cytotoxicity and side effects of MTX in RA treatment, as well as its mechanism of action, remain not fully understood. This review focuses on exploring the various molecular mechanisms and toxicities of MTX at the molecular level, as well as the importance of combining MTX with targeted therapy in RA treatment.
Article
Nutrition & Dietetics
Remzi Ekici, Abdulsamet Erden, Serdar Can Guven, Berkan Armagan, Bahar Ozdemir, Ozlem Karakass, Kevser Gok, Ahmet Omma, Orhan Kucuksahin, Sukran Erten
Summary: This study aimed to determine the frequency of sarcopenia in patients with newly diagnosed rheumatoid arthritis and assess the effects of treatment on sarcopenia. The results showed that approximately one-third of patients with newly diagnosed RA had sarcopenia, but this rate significantly decreased after 3 months of treatment. Early detection and treatment planning for sarcopenia in RA patients may improve quality of life.
Article
Cell Biology
Durairaj Sekar
Summary: The text discusses arthritis as an autoimmune disease, the role of miR-21 in its pathogenesis and progression, and its potential as a therapeutic target for bone-related disorders. The main aim of the authors is to provide an overview of the current clinical evidence and significance of miR-21 in arthritis and bone-related inflammation disorders.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Immunology
Jianan Zhao, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: Rheumatoid arthritis displays significant clinical heterogeneity and personalized responsiveness to standard treatments, with understanding individual variation in cellular and molecular mechanisms being crucial for improving patient outcomes. Pathological heterogeneity derived from genetic, molecular, and cellular factors influences precision medicine and personalized treatment approaches for rheumatoid arthritis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Liana Barenbrug, Maarten te Groen, Frank Hoentjen, Joris van Drongelen, Juul M. P. A. van den Reek, Irma Joosten, Elke M. G. J. de Jong, Renate G. van der Molen
Summary: The use of anti-TNF alpha agents during pregnancy in women with immune mediated inflammatory diseases, such as IBD, RA, and PS, is associated with an increased risk of preterm birth and infections in newborns, particularly for women with IBD. However, there was no increased risk for adverse pregnancy outcomes in women with RA and PS. Vaccination in children exposed to anti-TNF alpha seems to be safe and important in reducing the risk of infections.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Rheumatology
Gregory C. Mcdermott, Keigo Hayashi, Kazuki Yoshida, Pierre-Antoine Juge, Matthew Moll, Michael H. Cho, Tracy J. Doyle, Gregory L. Kinney, Paul F. Dellaripa, Zachary S. Wallace, Elizabeth A. Regan, Gary M. Hunninghake, Edwin K. Silverman, Samuel Y. Ash, Raul San Jose Estepar, George R. Washko, Jeffrey A. Sparks
Summary: This study aimed to investigate and compare the epidemiological investigation and mortality associations of CT parenchymal lung features between patients with rheumatoid arthritis (RA) and non-RA patients. The results showed that RA patients were associated with a higher percentage of interstitial changes, and the combination of RA and emphysema conferred more than a 5-fold higher mortality.
Article
Pediatrics
Lili Ye, Yingying Jin, Hua Huang, Fei Ding, Xuemei Xu, Chenxi Liu, Shengfang Bao, Jing Wu, Yanliang Jin
Summary: This study explored the role of DKK-1 and SOST in the pathogenesis of JIA. It was found that plasma levels of DKK-1 were significantly higher in JIA patients, especially in those with HLA-B27 positivity. After treatment, DKK-1 levels decreased significantly. However, there was no significant change in SOST levels among different JIA subtypes, before and after treatment, and healthy controls.
PEDIATRIC RESEARCH
(2023)
Article
Environmental Sciences
Jianli Qu, Yun Zhao, Li Zhang, Shilei Hu, Kaizhen Liao, Meirong Zhao, Pengfei Wu, Hangbiao Jin
Summary: This study found that PFAAs are widely present in human blood and have toxic effects on the human body. The study analyzed serum samples from both healthy individuals and rheumatoid arthritis (RA) patients in Hangzhou, China and found a correlation between PFAA exposure and the risk of developing RA. Specifically, higher concentrations of PFOA were associated with an increased risk of RA, as well as elevated levels of rheumatoid factors and anti-cyclic citrullinated peptide antibody.
ENVIRONMENTAL POLLUTION
(2022)
Article
Medicine, General & Internal
Misako Higashida-Konishi, Keisuke Izumi, Satoshi Hama, Hiroshi Takei, Hisaji Oshima, Yutaka Okano
Summary: The study compared the clinical characteristics of RS3PE and SNRA patients with and without malignancies, finding that RS3PE patients had higher inflammation levels and incidence of malignancy. Therefore, older age, male sex, presence of extremity edema, and RS3PE diagnosis should prompt screening for malignancies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Vinit J. Gilvaz, Anthony M. Reginato
Summary: The widespread use of digital health records and advanced diagnostic testing has led to a vast amount of patient data. Artificial intelligence tools like machine learning and deep learning can help extract meaningful insights from these datasets, improving patient management.
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander Akhmedov, Margot Crucet, Branko Simic, Simon Kraler, Nicole R. Bonetti, Caroline Ospelt, Oliver Distler, Adrian Ciurea, Luca Liberale, Matti Jauhiainen, Jari Metso, Melroy Miranda, Rose Cydecian, Lena Schwarz, Vera Fehr, Rita Zilinyi, Mohammad Amrollahi-Sharifabadi, Lydia Ntari, Niki Karagianni, Frank Ruschitzka, Reijo Laaksonen, Paul M. Vanhoutte, George Kollias, Giovanni G. Camici, Thomas F. Luescher
Summary: This study aimed to identify the molecular mechanism of endothelial dysfunction in a mouse model of rheumatoid arthritis (RA) and in patients with RA. The results showed that increased TNF alpha levels contribute to RA and endothelial dysfunction by increasing vascular oxLDL content and activation of the LOX-1/NF kappa B/Arg2 pathway, resulting in reduced NO bioavailability and decreased cGMP levels. Anti-TNF alpha treatment improved both articular symptoms and endothelial function by reducing LOX-1, vascular oxLDL, and Arg2 levels.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Zihan Xu, Wei Shang, Zhiming Zhao, Beibei Zhang, Chunli Liu, Hui Cai
Summary: This study found that curcumin can improve rheumatoid arthritis by inhibiting cell proliferation, migration, invasion, and promoting cell apoptosis. Curcumin also reduces inflammation by decreasing the secretion of inflammatory factors. Therefore, curcumin may be a promising candidate for treating RA.
Article
Medicine, General & Internal
Misako Higashida-Konishi, Keisuke Izumi, Satoshi Hama, Hiroshi Takei, Hisaji Oshima, Yutaka Okano
Summary: The study compared the clinical characteristics and malignancy-related factors between RS3PE and SNRA patients, finding that RS3PE patients had higher levels of inflammation and a higher incidence of malignancy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Mats Geijer, Gerd-Marie Alenius, Lars Andre, Tomas Husmark, Per T. Larsson, Ulla Lindqvist, Ingrid Thyberg, Elke Theander
Summary: This study compared the health-related quality of life (HRQoL) of patients with psoriatic arthritis (PsA) and rheumatoid arthritis (RA) at diagnosis and after five years. The results showed that PsA patients still had impairments in HRQoL after five years, while RA patients had almost normalized HRQoL.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
