Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: This study aimed to externally validate a revised Boolean remission criteria using a higher patient global assessment (PtGA) threshold and validate the provisionally endorsed index-based criteria. The results showed that using the higher PtGA threshold increased the proportion of patients classified as achieving remission under the "Boolean2.0" criteria, improved agreement with index-based criteria, and did not compromise predictive value for radiographic or functional outcomes. The study findings were endorsed by ACR and EULAR.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Nina Paulshus Sundlisaeter, Ulf Sundin, Anna-Birgitte Aga, Joseph Sexton, Hilde Berner Hammer, Till Uhlig, Tore K. Kvien, Espen A. Haavardsholm, Siri Lillegraven
Summary: This study investigated the limiting factors of achieving ACR/EULAR Boolean remission in rheumatoid arthritis (RA) patients. Patient global assessment and tender joints were found to be the most common factors limiting remission. Although imaging inflammation levels were not elevated in patients failing to meet the criteria, the odds of using biologic disease modifying anti-rheumatic drugs (DMARDs) were higher.
Article
Rheumatology
Julio Ramirez, Jose Inciarte-Mundo, Andrea Cuervo, Raquel Celis, Virginia Ruiz-Esquide, Raul Castellanos-Moreira, Andres Ponce, Jose A. Gomez-Puerta, Raimon Sanmarti, Juan D. Canete
Summary: This study compared the long-term clinical, immunological, and radiographic outcomes of rheumatoid arthritis patients under five different remission criteria. The results showed that patients in remission based on different criteria had comparable clinical and radiographic outcomes, with ultrasound remission being the closest to structural damage abrogation.
CLINICAL RHEUMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shipeng Zhang, Yimeng Lei, Tao Sun, Ziyu Gao, Zhuoqi Li, Hui Shen
Summary: This study found that Metrnl is involved in the pathogenesis of rheumatoid arthritis and the increase in serum Metrnl levels is closely related to disease activity.
Review
Rheumatology
Kulveer Mankia, Heidi J. Siddle, Andreas Kerschbaumer, Deshire Alpizar Rodriguez, Anca Irinel Catrina, Juan D. Canete, Andrew P. Cope, Claire Immediato Daien, Kevin D. Deane, Hani El Gabalawy, Axel Finckh, V. Michael Holers, Marios Koloumas, Francesca Ometto, Karim Raza, Condruta Zabalan, Annette Van der Helm-van Mil, Dirkjan van Schaardenburg, Daniel Aletaha, Paul Emery
Summary: This study investigated methods for conducting clinical trials and observational studies in populations at risk of rheumatoid arthritis (RA) and formulated consensus statements, including measuring epidemiological and demographic characteristics, defining different at-risk populations, and determining study end-points. The study also emphasized the importance of risk factor assessment, trial interventions, and communication of risk knowledge to individuals at risk.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medical Laboratory Technology
Yunus H. Polat, Sukran Erten, Ahmet Kor, Ismail Dogan, Yuksel Maras, Orhan Kucuksahin, Guniz Y. Ustuner, Ozcan Erel
Summary: This study aimed to evaluate the thiol/disulfide balance in patients with rheumatoid arthritis (RA) compared to healthy controls, and to examine its relationship with Disease Activity Score-28 (DAS28). The results showed that RA patients had lower thiol levels and higher disulfide levels compared to controls. Additionally, the group in remission had higher thiol levels and lower disulfide levels compared to other DAS28 groups. These findings suggest that the antioxidant defense system is impaired in RA patients, leading to oxidative stress and imbalance.
CLINICAL BIOCHEMISTRY
(2023)
Article
Rheumatology
Gyorgy Nagy, Nadia M. T. Roodenrijs, Paco M. J. Welsing, Melinda Kedves, Attila Hamar, Marlies C. van der Goes, Alison Kent, Margot Bakkers, Polina Pchelnikova, Etienne Blaas, Ladislav Senolt, Zoltan Szekanecz, Ernest H. Choy, Maxime Dougados, Johannes W. G. Jacobs, Rinie Geenen, Johannes W. J. Bijlsma, Angela Zink, Daniel Aletaha, Leonard Schoneveld, Piet van Riel, Sophie Dumas, Yeliz Prior, Elena Nikiphorou, Gianfranco Ferraccioli, Georg Schett, Kimme L. Hyrich, Ulf Mueller-Ladner, Maya H. Buch, Iain B. McInnes, Desiree van der Heijde, Jacob M. van Laar
Summary: The EULAR Task Force developed evidence-based points to consider for the management of difficult-to-treat rheumatoid arthritis, covering diagnostic confirmation, evaluation of inflammatory disease activity, pharmacological and non-pharmacological interventions, treatment adherence, functional disability, pain, fatigue, goal setting, self-efficacy, and impact of comorbidities. The strength of recommendations varied from level C to D, with a generally high level of agreement.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Abhishek Abhishek, Sara K. K. Tedeschi, Tristan Pascart, Augustin Latourte, Nicola Dalbeth, Tuhina Neogi, Amy Fuller, Ann Rosenthal, Fabio Becce, Thomas Bardin, Hang Korng Ea, Georgios Filippou, John FitzGerald, AnnaMaria Iagnocco, Frederic Liote, Geraldine M. M. McCarthy, Roberta Ramonda, Pascal Richette, Francisca Sivera, Mariano Andres, Edoardo Cipolletta, Michael Doherty, Eliseo Pascual, Fernando Perez-Ruiz, Alexander So, Tim L. L. Jansen, Minna J. J. Kohler, Lisa K. K. Stamp, Janeth Yinh, Antonella Adinolfi, Uri Arad, Thanda Aung, Eva Benillouche, Alessandra Bortoluzzi, Jonathan Dau, Ernest Maningding, Meika A. A. Fang, Fabiana A. A. Figus, Emilio Filippucci, Janine Haslett, Matthijs Janssen, Marian Kaldas, Maryann Kimoto, Kelly Leamy, Geraldine M. Navarro, Piercarlo Sarzi-Puttini, Carlo Scire, Ettore Silvagni, Silvia Sirotti, John R. R. Stack, Linh Truong, Chen Xie, Chio Yokose, Alison M. M. Hendry, Robert Terkeltaub, William J. J. Taylor, Hyon K. K. Choi
Summary: The 2023 ACR/EULAR CPPD disease classification criteria have been developed to facilitate research in the field of symptomatic CPPD disease, providing excellent performance characteristics with high sensitivity and specificity.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Hong Ki Min, Hae-Rim Kim, Sang-Heon Lee, Kwi Young Kang, Sung-Hwan Park, Seung-Ki Kwok
Summary: The study evaluated the predictive role of time-averaged DAS28 and HAQ on CVD events in patients with RA. The results showed that high time-averaged DAS28 was significantly associated with CVD incidence and had a higher cumulative risk of CVD.
Review
Rheumatology
Jennie H. Best, Yuting Kuang, Yilin Jiang, Rajpal Singh, Andreas Karabis, Jennifer Uyei, Joseph Dang, William G. Reiss
Summary: This study utilized a Bayesian network meta-analysis to evaluate the efficacy of targeted immune modulators (TIMs) in treating rheumatoid arthritis. The results showed that tocilizumab had a greater likelihood of achieving remission compared to other TIMs, especially when used in combination with traditional disease-modifying antirheumatic drugs (cDMARDs).
RHEUMATOLOGY AND THERAPY
(2021)
Review
Rheumatology
Jacqueline Uson, Sebastian Cruz Rodriguez-Garcia, Raul Castellanos-Moreira, Terence W. O'Neill, Michael Doherty, Mikael Boesen, Hemant Pandit, Ingrid Moller Parera, Valentina Vardanyan, Lene Terslev, Willm Uwe Kampen, Maria-Antonietta D'agostino, Francis Berenbaum, Elena Nikiphorou, Irene A. Pitsillidou, Jenny de la Torre-Aboki, Loreto Carmona, Esperanza Naredo
Summary: The study established evidence and expert opinion-based recommendations to guide health professionals using intra-articular therapies in adult patients with peripheral arthropathies. The recommendations focus on practical aspects to guide health professionals before, during, and after IAT in adult patients, covering a wide range of considerations that should be taken into account in practice.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Nathalie Luurssen-Masurel, Elise van Mulligen, Angelique Elisabeth Adriana Maria Weel-Koenders, Johanna Maria Wilhelmina Hazes, Pascal Hendrik Pieter de Jong
Summary: This study compared the long-term clinical outcomes of three clinical arthritis phenotypes: undifferentiated arthritis (UA), autoantibody-negative (RA-) and autoantibody-positive RA (RA+). The results showed that there were differences in remission rates and sustained remission rates between these phenotypes. The data confirm that rheumatoid arthritis can be subdivided based on clinical phenotypes and that treatment should be stratified accordingly.
Article
Rheumatology
Christian Dejaco, Pedro M. Machado, Francesco Carubbi, Philipp Bosch, Lene Terslev, Giorgio Tamborrini, Luca Maria Sconfienza, Carlo Alberto Scire, Sebastian Ruetten, Jef van Rompay, Fabian Proft, Costantino Pitzalis, Marina Obradov, Rikke Helene Moe, Vasco V. Mascarenhas, Clara Malattia, Andrea Sabine Klauser, Alison Kent, Lennart Jans, Wolfgang Hartung, Hilde Berner Hammer, Christina Duftner, Peter Balint, Alessia Alunno, Xenofon Baraliakos
Summary: This study developed evidence-based Points to Consider (PtC) for the use of imaging modalities to guide interventional procedures in patients with rheumatologic and musculoskeletal diseases. Recommendations included preference for imaging over palpation to guide targeted interventions at peripheral joints, periarticular musculoskeletal structures, nerves and the spine, with ultrasound as the favored imaging technique for peripheral joints and nerves.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
J. Wiegel, B. F. Seppen, M. M. ter Wee, M. T. Nurmohamed, M. Boers, W. H. Bos
Summary: RAPID3 is a reliable tool for detecting patients with rheumatoid arthritis in a stable low disease activity state, with an accuracy of 92% when classifying patients into this state. 28% of patients may potentially postpone their consultations following screening with RAPID3.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Yeon-Kyung Lee, Ga Young Ahn, Jiyoung Lee, Jung-Min Shin, Tae-Han Lee, Dae Jin Park, Yeo-Jin Song, Mi Kyung Kim, Sang-Cheol Bae
Summary: The study revealed that the mortality rate of Korean patients with rheumatoid arthritis is higher than the general population, with malignancy, respiratory disease, and cardiovascular disease being the most common causes of death. Mortality rate and causes of death vary according to the age of onset and year of diagnosis. Deceased patients are more likely to have specific characteristics such as being male, smokers, diagnosed with RA at an older age, and having longer disease duration and more comorbidities.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Immunology
Zeynab Alshelh, Daniel S. Albrecht, Courtney Bergan, Oluwaseun Akeju, Daniel J. Clauw, Lisa Conboy, Robert R. Edwards, Minhae Kim, Yvonne C. Lee, Ekaterina Protsenko, Vitaly Napadow, Kimberly Sullivan, Marco L. Loggia
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Rheumatology
Yvonne C. Lee, Patricia Katz, Amanda Quebe, Luna Sun, Himanshu Patel, Carol L. Gaich, Kaleb Michaud
Summary: The study found that pain interference was most common in daily activities among RA patients, while least common in ability to concentrate. The average pain level at which activities were no longer interfered with was 2.8, while the average pain level at which everything could be done without interference was 2.3. More severe pain intensity was associated with higher levels of noninterfering pain reported by the patients.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Rheumatology
Josh Colls, Yvonne C. Lee, Chang Xu, Cassandra Corrigan, Fengxin Lu, Georgia Marquez-Grap, Meredith Murray, Dong H. Suh, Daniel H. Solomon
Summary: The study developed and tested an ePRO app for RA over a 6-month period, with strong adherence observed among patients. Older age and lower disease activity were found to be significant predictors of increased adherence to the app.
Article
Rheumatology
Andrew C. Heisler, Jing Song, Lutfiyya N. Muhammad, Alyssa C. Wohlfahrt, Wendy Marder, Marcy B. Bolster, Clifton O. Bingham, Daniel J. Clauw, Dorothy D. Dunlop, Tuhina Neogi, Yvonne C. Lee
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Sameer Prasada, Adovich Rivera, Arvind Nishtala, Anna E. Pawlowski, Arjun Sinha, Joshua D. Bundy, Simran A. Chadha, Faraz S. Ahmad, Sadiya S. Khan, Chad Achenbach, Frank J. Palella, Rosalind Ramsey-Goldman, Yvonne C. Lee, Jonathan Silverberg, Babafemi O. Taiwo, Sanjiv J. Shah, Donald M. Lloyd-Jones, Matthew J. Feinstein
JACC-HEART FAILURE
(2020)
Article
Rheumatology
Chandrasekar Gopalakrishnan, Rishi J. Desai, Jessica M. Franklin, Yinzhu Jin, Joyce Lii, Daniel H. Solomon, Jeffrey N. Katz, Yvonne C. Lee, Patricia D. Franklin, Seoyoung C. Kim
Summary: This study aimed to develop a claims-based model for predicting persistent high-dose opioid use among patients who underwent total knee replacement (TKR). The study utilized Medicare claims data and employed group-based trajectory modeling to identify different patterns of opioid use. The findings revealed that approximately 10.6% of older patients became persistent high-dose opioid users after TKR.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Yvonne C. Lee, Fengxin Lu, Joshua Colls, Dee Luo, Penny Wang, Dorothy D. Dunlop, Lutfiyya N. Muhammad, Jing Song, Kaleb Michaud, Daniel H. Solomon
Summary: A smartphone application designed to monitor electronic patient-reported outcomes in RA patients did not significantly impact patient satisfaction or disease activity compared to care coordination alone. However, both patients and physicians reported positive experiences with the app.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Jing Song, Lutfiyya N. Muhammad, Tuhina Neogi, Dorothy D. Dunlop, Alyssa Wohlfahrt, Marcy B. Bolster, Clifton O. Bingham, Daniel J. Clauw, Wendy Marder, Yvonne C. Lee
Summary: This study examined the relationship between pain sensitization and sleep disturbances in patients with rheumatoid arthritis (RA) using quantitative sensory testing (QST). The results showed a correlation between sleep disturbances and pain sensitization, suggesting that pain sensitization may be one mechanism through which sleep disturbances contribute to pain.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Alyssa Wohlfahrt, Lutfiyya N. Muhammad, Jing Song, Dorothy D. Dunlop, Tuhina Neogi, Clifton O. Bingham III, Marcy B. Bolster, Wendy Marder, Daniel J. Clauw, Yvonne C. Lee
Summary: This study used regression tree methodology to determine the mechanisms most predictive of disease activity after DMARD treatment. The results showed that lower knee pressure pain thresholds were the strongest predictor of higher posttreatment disease activity in patients with low/moderate disease activity. In patients with high baseline disease activity, less efficient descending pain modulation was the strongest predictor of higher posttreatment disease activity.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Rheumatology
Anne E. Murphy, Deeba Minhas, Daniel J. Clauw, Yvonne C. C. Lee
Summary: This article discusses the burdensome and prevalent problem of chronic pain in individuals with rheumatic disease. It introduces the three types of pain and their treatment options. The focus is on nociplastic pain, which can occur independently as in fibromyalgia or as a comorbidity in individuals with primary autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematosus. Practical advice on how rheumatology health care providers can approach and manage chronic pain is also provided.
ARTHRITIS CARE & RESEARCH
(2023)
Letter
Rheumatology
Yoon Y. Qiu, Tuhina Neogi, Lutfiyya N. Muhammad, Jing Song, Marcy B. Bolster, Wendy Marder, Andrew C. Heisler, Alyssa Wohlfahrt, Dorothy Dunlop, Yvonne C. Lee
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Janet E. Pope, Yvonne C. Lee, Jeffrey R. Curtis, Daojun Mo, Li Xie, Christina L. Dickson, Douglas E. Schlichting, Anabela Cardoso, Lee S. Simon, Peter C. Taylor
Summary: Pain reduction with baricitinib was found to be effective in both opioid users and nonusers, while adalimumab did not show significant pain reduction in nonusers in this analysis of three randomized, double-blind phase 3 trials.
ACR OPEN RHEUMATOLOGY
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Chandrasekar Gopalakrishnan, Jessica M. Franklin, Yinzhu Jin, Daniel H. Solomon, Jeffrey N. Katz, Yvonne C. Lee, Patricia D. Franklin, Joyce Lii, Rishi J. Desai, Seoyoung C. Kim
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2020)
Meeting Abstract
Rheumatology
Janet Pope, Yvonne Lee, Jeffrey Curtis, Daojun Mo, Terence Rooney, Li Xie, Christina Dickson, Douglas Schlichting, Amanda Quebe, Anabela Cardoso, Lee Simon, Peter Taylor
JOURNAL OF RHEUMATOLOGY
(2020)
Review
Medicine, Research & Experimental
Jeffrey A. Haspel, Ron Anafi, Marishka K. Brown, Nicolas Cermakian, Christopher Depner, Paula Desplats, Andrew E. Gelman, Monika Haack, Sanja Jelic, Brian S. Kim, Aaron D. Laposky, Yvonne C. Lee, Emmanuel Mongodin, Aric A. Prather, Brian Prendergast, Colin Reardon, Albert C. Shaw, Shaon Sengupta, Eva Szentirmai, Mahesh Thakkar, Wendy E. Walker, Laura A. Solt