Article
Rheumatology
Giovanni Adami, Ombretta Viapiana, Maurizio Rossini, Giovanni Orsolini, Eugenia Bertoldo, Alessandro Giollo, Davide Gatti, Angelo Fassio
Summary: The study found a significant association between high concentrations of air pollutants and the severity and reactivations of RA. Exposure to higher levels of air pollutants was linked to increased CRP levels and a higher risk of arthritis flare-ups, even at low exposure levels.
Article
Medicine, General & Internal
Codrina Ancuta, Rodica Chirieac, Eugen Ancuta, Oana Tanculescu, Sorina Mihaela Solomon, Ana Maria Fatu, Adrian Doloca, Cristina Iordache
Summary: This study showed that tocilizumab can significantly improve gingival conditions in patients with periodontal disease in the short term, with notable impact on bleeding on probing and probing pocket depth. Additionally, significant correlations were found between periodontal status, disease activity, and serologic biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Rui-Chen Gao, Ni Sang, Cheng-Zhen Jia, Meng-Yao Zhang, Bo-Han Li, Meng Wei, Guo-Cui Wu
Summary: In this study, the causal association between sleep disorders and rheumatoid arthritis (RA) was investigated using Mendelian randomization analysis. The results showed that short sleep duration was causally linked to an increased risk of RA, while other sleep-related traits were not significantly associated with RA.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Jeneen Panezai, Ambereen Ghaffar, Mohammad Altamash, Mikael Aberg, Thomas E. Van Dyke, Anders Larsson, Per-Erik Engstrom
Summary: Periodontal disease enhances the expression of CVD-related biomarkers in RA patients through shared pathological clusters, concurrently enhancing metabolic and skeletal disease protein interactions, independent of autoimmune status.
Article
Immunology
Guangxia Yang, Zeqin Ren, Kai Wang
Summary: This study suggests that HPV infection is positively associated with the prevalence of rheumatoid arthritis (RA) in adults, while HPV immunization can reduce the prevalence of RA in adults. However, more powerful prospective studies are needed to prove these associations.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Angelo Zinellu, Arduino A. Mangoni
Summary: This study investigates the relationship between plasma/serum concentrations of uric acid and allantoin and rheumatoid arthritis (RA). It finds that while there were no significant differences in uric acid concentrations between RA patients and healthy controls, the concentrations of allantoin were significantly higher in RA patients. Further research is needed to explore the connection between uric acid, allantoin, redox balance, and cardiovascular disease in this population.
Article
Immunology
Shengdong Zhong, Liting Lan, Zicheng Zheng, Huaiyuan Zhang, Yuqing Wen
Summary: This study used MR design to examine the potential causal association between RA and AA, and found a significant link between genetically predicted RA and AA. This finding emphasizes the importance for RA diagnosed individuals to be vigilant of the potential development of AA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Lijiangshan Hua, Shate Xiang, Rixiang Xu, Xiao Xu, Ting Liu, Yanan Shi, Lingyun Wu, Rongyun Wang, Qiuhua Sun
Summary: This study reveals a causal relationship between rheumatoid arthritis (RA) and celiac disease (CD), indicating that RA increases the risk of developing CD, but CD does not have a causal effect on RA among individuals of European descent.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Ding-Ping Chen, Ying-Hao Wen, Wei-Tzu Lin, Fang-Ping Hsu, Kuang-Hui Yu
Summary: This study investigated the association between RA and single-nucleotide polymorphisms (SNPs) of co-stimulatory or co-inhibitory molecules. The results showed that there were 13 SNPs associated with RA, which may play an important role in immune regulation and require further research into the pathogenesis of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Mislav Radic, Ivan Vlak, Marijana Vuckovic, Josipa Radic, Erim Besic, Tonko Vlak
Summary: The aim of this study was to evaluate various factors in patients with rheumatoid arthritis (RA) and examine their associations. The results showed that the patients had long disease duration and high disease activity.
Review
Immunology
Xiangsu Liu, Jiaqi Li, Leilei Sun, Tong Wang, Wenxia Liang
Summary: The inflammatory response plays a crucial role in joint injury in rheumatoid arthritis (RA), but it is difficult to assess inflammation levels, making diagnosis challenging. The neutrophil-to-lymphocyte ratio (NLR), a novel non-specific inflammatory indicator, reflects the severity of inflammation. This study aimed to explore the role of NLR in RA progression and evaluate its predictive value for response to disease-modifying antirheumatic drugs (DMARDs) therapy.
INFLAMMOPHARMACOLOGY
(2023)
Review
Clinical Neurology
Chester Yan Hao Ng, Sen Hee Tay, Roger S. McIntyre, Roger Ho, Wilson W. S. Tam, Cyrus S. H. Ho
Summary: There is a bidirectional association between rheumatoid arthritis (RA) and depression, with a higher risk for elderly individuals. RA patients with depression also face an increased risk of all-cause mortality.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, General & Internal
So Young Kim, Dae Myoung Yoo, Ji Hee Kim, Mi Jung Kwon, Joo-Hee Kim, Hyo Geun Choi
Summary: The study found no association between pre-existing rheumatoid arthritis and the occurrence of Meniere's disease, regardless of age subgroup, suggesting that a history of RA is not related to an increased risk of MD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hiroko Hashimoto, Shimpei Hashimoto, Yoshihiro Shimazaki
Summary: The study found that the extent of periodontal inflammation is associated with the severity of rheumatoid arthritis, independent of rheumatoid arthritis medications.
INTERNATIONAL DENTAL JOURNAL
(2021)
Review
Medicine, General & Internal
Julia Guerrero-Girones, Antonio Ros-Valverde, Maria Pilar Pecci-Lloret, Francisco Javier Rodriguez-Lozano, Miguel Ramon Pecci-Lloret
Summary: The review suggests a potential association between apical periodontitis and autoimmune diseases, though most studies did not show statistically significant correlations. Periapical pathologies were found to be linked to diabetes mellitus I, rheumatoid arthritis, and inflammatory bowel disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Maarten Boers, Linda Hartman, Daniela Opris-Belinski, Reinhard Bos, Marc R. Kok, Jose A. P. Da Silva, Eduard N. Griep, Ruth Klaasen, Cornelia F. Allaart, Paul Baudoin, Hennie G. Raterman, Zoltan Szekanecz, Frank Buttgereit, Pavol Masaryk, L. Thomas Klausch, Sabrina Paolino, Annemarie M. Schilder, Willem F. Lems, Maurizio Cutolo
Summary: This study compared the effects and side effects of low-dose prednisolone and placebo treatment in elderly patients with active rheumatoid arthritis. The results showed that low-dose prednisolone can reduce disease activity and joint damage, but the side effects also increased by 24%.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Lotte van Ouwerkerk, Andriko Palmowski, Isabell S. Nevins, Frank Buttgereit, Patrick Verschueren, Josef S. Smolen, Robert B. M. Landewe, Johannes J. W. Bijlsma, Andreas Kerschbaumer, Rene Westhovens, Tom W. J. Huizinga, Cornelia F. Allaart, Sytske Anne Bergstra
Summary: Studies on the success rate of glucocorticoid discontinuation in newly diagnosed rheumatoid arthritis patients using temporary GC as initial therapy are limited. Most clinical trials showed a successful discontinuation rate of 78% at 12 months and 90% at 24 months, despite substantial heterogeneity.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Mariana Luis, Maarten Boers, Ken Saag, Frank Buttgereit, Jose A. P. da Silva
Summary: Glucocorticoids are still considered a cornerstone in the treatment of inflammatory rheumatic diseases, despite the known dose-dependent side effects. However, there is currently limited solid evidence regarding the safety of low-dose glucocorticoids.
CURRENT OPINION IN RHEUMATOLOGY
(2022)
Article
Rheumatology
Linda Hartman, Jose A. P. da Silva, Frank Buttgereit, Maurizio Cutolo, Daniela Opris-Belinski, Zoltan Szekanecz, Pavol Masaryk, Marieke J. H. Voshaar, Martijn W. Heymans, Willem F. Lems, Desiree M. F. M. van der Heijde, Maarten Boers
Summary: This study aims to develop prediction models for individual harm and benefit outcomes in elderly RA patients treated with low-dose glucocorticoid therapy. The results suggest that baseline factors have limited predictive value in determining the chance of benefit or harm.
Article
Rheumatology
Josef S. Smolen, Robert B. M. Landewe, Sytske Anne Bergstra, Andreas Kerschbaumer, Alexandre Sepriano, Daniel Aletaha, Roberto Caporali, Christopher John Edwards, Kimme L. Hyrich, Janet E. Pope, Savia de Souza, Tanja A. Stamm, Tsutomu Takeuchi, Patrick Verschueren, Kevin L. Winthrop, Alejandro Balsa, Joan M. Bathon, Maya H. Buch, Gerd R. Burmester, Frank Buttgereit, Mario Humberto Cardiel, Katerina Chatzidionysiou, Catalin Codreanu, Maurizio Cutolo, Alfons A. den Broeder, Khadija El Aoufy, Axel Finckh, Joao Eurico Fonseca, Jacques-Eric Gottenberg, Espen A. Haavardsholm, Annamaria Iagnocco, Kim Lauper, Zhanguo Li, Iain B. McInnes, Eduardo F. Mysler, Peter Nash, Gyula Poor, Gorica G. Ristic, Felice Rivellese, Andrea Rubbert-Roth, Hendrik Schulze-Koops, Nikolay Stoilov, Anja Strangfeld, Annette van der Helm-van Mil, Elsa van Duuren, Theodora P. M. Vliet Vlieland, Rene Westhovens, Desiree van der Heijde
Summary: This study provides an update on the management recommendations for rheumatoid arthritis (RA) based on the latest developments in the field. The recommendations cover various aspects including medication use, combination therapy, treatment strategies, and dose reduction. The consensus was reached on 5 overarching principles and 11 specific recommendations.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Zhivana Boyadzhieva, Sabrina Mai Nielsen, Frank Buttgereit, Robin Christensen, Andriko Palmowski
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Rheumatology
Frank Buttgereit, Jacob Aelion, Bernadette Rojkovich, Anna Zubrzycka-Sienkiewicz, Su Chen, Yang Yang, Dilek Arikan, Ronilda D'Cunha, Yinuo Pang, Hartmut Kupper, Timothy Radstake, Howard Amital
Summary: This study aimed to assess the efficacy and safety of ABBV-3373, a novel antibody-drug conjugate (ADC), compared to adalimumab in patients with rheumatoid arthritis (RA). The results showed that ABBV-3373 had superior efficacy and safety compared to historical adalimumab, supporting its continued development for RA treatment.
ARTHRITIS & RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Frank Buttgereit, Andriko Palmowski, Idil Esen, Elisabeth Brouwer
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Alessia Alunno, Tadej Avcin, Catherine Haines, Sofia Ramiro, Francisca Sivera, Sara Badreh, Xenofon Baraliakos, Johannes W. J. Bijlsma, Frank Buttgereit, Kaushik Chaudhuri, Jose A. P. Da Silva, Jean Dudler, Ricardo J. O. Ferreira, Tania Gudu, Eric Hachulla, Mette Holland-Fischer, Annamaria Iagnocco, Tue Wenzel Kragstrup, Gyoergy Nagy, Vasco C. Romao, Simon R. Stones, Marloes van Onna, Christopher J. Edwards
Summary: This study aimed to define competences and standards for the training of rheumatologists. Through collaboration and analysis of international training documents, an overall framework, 7 domains, 8 core themes, and 28 competences were established. The results suggest that these standards can contribute to harmonizing rheumatology training across European countries.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Andriko Palmowski, Sabrina M. Nielsen, Zhivana Boyadzhieva, Abelina Schneider, Anne Pankow, Linda Hartman, Jose A. P. Da Silva, John Kirwan, Siegfried Wassenberg, Christian Dejaco, Robin Christensen, Maarten Boers, Frank Buttgereit
Summary: The study aimed to assess the safety and efficacy of long-term low-dose glucocorticoids in Rheumatoid Arthritis (RA). The analysis found that low-dose glucocorticoids did not increase the risk of adverse events, except for a higher risk of infections. It also showed moderate to high evidence of improvement in disease activity and function in RA.
Article
Multidisciplinary Sciences
Angelique Wolter, Christian H. Bucher, Sebastian Kurmies, Viktoria Schreiner, Frank Konietschke, Katharina Hohlbaum, Robert Klopfleisch, Max Loehning, Christa Thoene-Reineke, Frank Buttgereit, Joerg Huwyler, Paulin Jirkof, Anna E. Rapp, Annemarie Lang
Summary: In animal experiments, adequate pain management is necessary and should last for the expected pain period without repeated application. The current depot formulations of Buprenorphine have limited duration of action, but a new sustained-release formulation (BUP-Depot) has been developed as a potential alternative in Europe. It provides effective analgesia for 72 hours, similar to Tramadol in the drinking water.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Lisa Christ, Andrea D. Gloor, Florian Kollert, Timo Gaber, Frank Buttgereit, Stephan Reichenbach, Peter M. Villiger
Summary: This study reported proteome analyses in patients with newly diagnosed, untreated giant cell arteritis (GCA), as well as the changes of protein expression upon treatment with glucocorticoids (GC) and/or tocilizumab (TCZ). The majority of protein changes occurred within 10 days of treatment initiation. GC and TCZ had differential effects on protein regulation. CCL7, CXCL9, and MMP12 are biomarkers reflecting disease activity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Laura Kim, Claudia Kedor, Frank Buttgereit, Harald Heidecke, Desiree Schaumburg, Carmen Scheibenbogen
Summary: Fatigue is a common and debilitating symptom in primary Sjogren's syndrome (pSS) patients. This study aimed to evaluate fatigue and other symptoms in pSS patients and investigate if there is symptom overlap with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The severity of pSS symptoms and disease activity were assessed, and hand grip strength (HGS) and autoantibody levels were measured. Some pSS patients experienced severe fatigue and exhibited higher levels of pain, depression, and sleep disturbances. Four out of eighteen pSS patients met the criteria for ME/CFS. HGS parameters correlated strongly with fatigue severity but fully recovered after exertion, unlike ME/CFS. Elevated levels of certain autoantibodies were associated with disease activity but not fatigue severity. Only a small subgroup of pSS patients fulfilled the criteria for ME/CFS, and post-exertional malaise was primarily triggered by mental/emotional exertion rather than physical exertion. HGS assessment is an objective measure for overall fatigue severity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Andriko Palmowski, Zhivana Boyadzhieva, Sabrina M. Nielsen, Burkhard Muche, Sandra Hermann, Maarten Boers, Henning Bliddal, Robin Christensen, Edgar Wiebe, Frank Buttgereit
Summary: This study investigated whether the association between glucocorticoid (GC) use and reduced bone mineral density (BMD) in rheumatoid arthritis (RA) patients is modified by sex or age. The results showed no significant differences in the association between GC use and BMD reduction, regardless of sex or age.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Rheumatology
Andriko Palmowski, Mitsuteru Akahoshi, Burkhard Muche, Zhivana Boyadzhieva, Sandra Hermann, Chikashi Terao, Edgar Wiebe, Frank Buttgereit
Summary: This study aimed to investigate the association between methotrexate (MTX) use and bone mineral density (BMD) in patients with polymyalgia rheumatica (PMR) and various forms of vasculitis. The results showed that there was no association between MTX use and BMD levels. This study is important for evaluating the use of MTX and its impact on BMD in patients with PMR and vasculitis.
RHEUMATOLOGY INTERNATIONAL
(2023)