Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Guillermo Sanchez-Rodriguez, Lluis Puig
Summary: The IL-17 family of cytokines, including IL-17A-F, plays important roles in host defence against microbial organisms and the development of inflammatory diseases such as psoriasis, axial spondyloarthritis, and psoriatic arthritis. IL-17A is the most biologically active form and its involvement in these conditions has been confirmed. IL-17F is also overexpressed in patients with these diseases and appears to contribute to inflammation and tissue damage. Dual inhibitors targeting both IL-17A and IL-17F may improve the management of these diseases, as shown in studies of bimekizumab.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Isabelle J. Marie, Lara Brambilla, Doua Azzouz, Ze Chen, Gisele Baracho, Azlann Arnett, Haiyan S. Li, Weiguo Liu, Luisa Cimmino, Pratip Chattopadhyay, Gregg Silverman, Stephanie S. Watowich, Bernard Khor, David E. Levy
Summary: In the absence of tonic interferon (IFN) signaling, mice developed inflammatory diseases spontaneously, including myeloid hyperplasia and inflammatory bowel disease. The dysbiosis in gut bacteria triggered expansion of TH17 cells and loss of splenic Treg cells, which were prevented by reducing bacterial load with antibiotics and blocking IL17 signaling. This study highlights the crucial role of tonic IFNs in regulating gut microbial ecology to maintain immune homeostasis and prevent inflammation.
Review
Biochemistry & Molecular Biology
Longjie Huangfu, Ruiying Li, Yamei Huang, Shan Wang
Summary: This review discusses the recent progress in understanding the IL-17 signaling pathway and its physiological roles, as well as the mechanism underlying IL-17's role in various pathologies. Additionally, promising developments in the diagnosis and treatment of autoimmune diseases and tumors are briefly discussed.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Despoina T. Florou, Athanasios Mavropoulos, Efthymios Dardiotis, Vana Tsimourtou, Vasileios Siokas, Athina-Maria Aloizou, Christos Liaskos, Christina Tsigalou, Christina Katsiari, Lazaros Sakkas, Georgios Hadjigeorgiou, Dimitrios P. Bogdanos
Summary: The study showed that tetracyclines, particularly minocycline, can suppress IFN-gamma and IL-17-producing cells from MS patients in vitro, suggesting a potential therapeutic effect in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Song Zhang, Yanbo Zhou, Pu Yang, Shuo Jia, Cheng Peng, Haiqing Hu, Wei Liu
Summary: Using a murine collagen-induced arthritis model, the heterogeneity of synovial CD8+ T cells was characterized based on various factors. Four subsets were identified, including exhausted CD8+ T cells, Tc17.1 cells, transitional Tc17.1 cells, and Tc17 cells. Transitional Tc17.1 cells can differentiate into Tc17.1 cells under IL-12 stimulation. Tc17.1 cells and transitional Tc17.1 cells strongly induced pro-inflammatory mediators in synovial fibroblasts. IFN-gamma played a role in the higher pathogenicity of Tc17.1 cells and transitional Tc17.1 cells. The study expands understanding of Tc17 biology and suggests potential therapeutic targets for arthritis treatment.
CELLULAR IMMUNOLOGY
(2023)
Article
Cell Biology
A. Helena Jonsson, Fan Zhang, Garrett Dunlap, Emma Gomez-Rivas, Gerald F. M. Watts, Heather J. Faust, Karishma Vijay Rupani, Joseph R. Mears, Nida Meednu, Runci Wang, Gregory Keras, Jonathan S. Coblyn, Elena M. Massarotti, Derrick J. Todd, Jennifer H. Anolik, Andrew McDavid, Kevin Wei, Deepak A. Rao, Soumya Raychaudhuri, Michael B. Brenner
Summary: CD8 T cells play a significant role in the pathogenesis of rheumatoid arthritis by producing pro-inflammatory cytokines. These CD8 T cells are abundant in synovial tissue and belong to an effector population characterized by high expression of granzyme K and low expression of granzyme B and perforin. They are clonally expanded in synovial tissues and maintain their characteristics in blood, suggesting their enrichment in tissues. They also exist in other tissues and diseases, indicating their role as tissue-associated T cells.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sunhee Jang, Eui-Jong Kwon, Jennifer Jooha Lee
Summary: Rheumatoid arthritis is a chronic autoimmune disease with complex pathogenesis, and recent advancements have shed light on the underlying mechanisms, providing new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Zhenpeng Dai, Eddy Hsi Chun Wang, Lynn Petukhova, Yuqian Chang, Eunice Yoojin Lee, Angela M. Christiano
Summary: The IL-7 signaling pathway is crucial in regulating T cell function and survival. Overexpression of IL-7 in AA patients and mice accelerates disease progression, while blocking IL-7 shows potential for enhancing therapeutic effects.
Article
Multidisciplinary Sciences
Stephen W. Tuffs, Mariya Goncheva, Stacey X. Xu, Heather C. Craig, Katherine J. Kasper, Joshua Choi, Ronald S. Flannagan, Steven M. Kerfoot, David E. Heinrichs, John K. McCormick
Summary: This study reveals the pathogenic mechanism of Staphylococcal superantigens (SAgs) in bacterial infections. The findings show that SAgs promote bacterial survival by manipulating the immune response to inhibit effective clearing of the bacteria. This research provides critical therapeutic targets for preventing persistent or severe Staphylococcus aureus diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Medicine, General & Internal
Jia-Lu Shi, Zi-Meng Zheng, Min Chen, Hui-Hui Shen, Ming-Qing Li, Jun Shao
Summary: Interleukin-17 (IL-17) is a proinflammatory cytokine derived from Th17 cells, which plays a pivotal role in inflammatory and autoimmune diseases. It is also linked to endometriosis, where IL-17 expression is up-regulated. IL-17 is involved in the regulation of immune microenvironment and the growth and invasion of ectopic lesions, suggesting its therapeutic value in endometriosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Immunology
Leandro do Nascimento Camargo, Renato Fraga Righetti, Francine Maria de Almeida, Tabata Maruyama dos Santos, Silvia Fukuzaki, Nilo Arthur Bezerra Martins, Miguel Cantadori Barbeiro, Beatriz Mangueira Saraiva-Romanholo, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Edna Aparecida Leick, Carla Maximo Prado, Iolanda de Fatima Lopes Calvo Tiberio
Summary: Inhibiting IL-17 can modulate cell-associated cytokine production, extracellular matrix remodeling, and oxidative stress in ACO.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Matteo Vecellio, Vivien Xanath Hake, Connor Davidson, Maria Cristina Carena, B. Paul Wordsworth, Carlo Selmi
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis, with genetic predisposition playing a key role in its development. The IL-23/IL-17 axis is highlighted as important in the immunopathogenesis of PsA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Forrest C. Walker, Pratyush R. Sridhar, Megan T. Baldridge
Summary: Interferons play specific roles in limiting local and systemic infection, showing synergistic activities and a spectrum of protective and detrimental effects during the infection response.
TRENDS IN IMMUNOLOGY
(2021)