Article
Rheumatology
Diane L. Kamen, Julie A. Birt, Monica A. Hadi, Elizabeth Gibbons, Donald M. Bushnell, Ren Yu, Laure A. Delbecque, Kirstin Griffing, Anca Askanase
Summary: Many people with SLE experience joint symptoms such as pain, swelling, and stiffness, which can impact physical functioning and work disability. A survey was conducted on adults with SLE to examine the burden and impact of joint symptoms.
Article
Rheumatology
Patricia Katz, Maria Dall'Era, Laura Trupin, Stephanie Rush, Louise B. Murphy, Cristina Lanata, Lindsey A. Criswell, Jinoos Yazdany
Summary: Health disparities in patient-reported outcomes by income and education levels are well-documented, but the impact of health literacy has received less attention. This study found that individuals with limited health literacy had significantly worse patient-reported outcomes scores, even after controlling for disease activity and damage. Further research is needed to determine whether these disparities stem from actual health differences or measurement issues.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Medicine, General & Internal
Oliver Skoglund, Tomas Walhelm, Ingrid Thyberg, Per Eriksson, Christopher Sjowall
Summary: Manifestations related to ongoing inflammation in SLE can be managed, but fatigue and low quality of life remain burdens for patients. DHEA has shown potential for managing fatigue in mild SLE. Retrospective evaluation of data on DHEA usage in SLE patients showed no significant changes in disease activity or damage accrual. Numerical improvements in PROMs were observed in the DHEA-treated group, but they did not reach statistical significance. DHEA-exposed patients initially reported worse fatigue, pain, and well-being compared to controls, but these differences diminished over time. DHEA supplementation appears to benefit individuals with mild SLE in terms of improved fatigue and quality of life.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Alexandra Legge, Alicia Malone, John G. Hanly
Summary: The SLICC frailty index (SLICC-FI) has been validated in a prevalent cohort of individuals with longstanding SLE, showing that higher baseline SLICC-FI values are associated with increased mortality risk and damage accrual.
Article
Rheumatology
Sarah B. Lieber, Musarrat Nahid, Stephen Paget, Jessica R. Berman, Medha Barbhaiya, Lisa R. Sammaritano, Kyriakos Kirou, John A. Carrino, Mangala Rajan, Dina Sheira, Lisa A. Mandl
Summary: This study compared two frailty assessment measures in patients with systemic lupus erythematosus (SLE), and found that frailty was associated with self-reported disability. The use of self-report measures may more accurately identify frail women with SLE.
JOURNAL OF RHEUMATOLOGY
(2022)
Review
Medicine, General & Internal
Ioannis Parodis, Paul Studenic
Summary: Systemic lupus erythematosus is a chronic autoimmune disorder with detrimental effects on patient's quality of life. Its management requires interdisciplinary care and emphasis on patient-reported outcome measures to improve patient participation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Gabriel Figueroa-Parra, Jose A. Meade-Aguilar, Cassondra A. Hulshizer, Tina M. Gunderson, Alanna M. Chamberlain, Uma Thanarajasingam, Kurt J. Greenlund, Kamil E. Barbour, Cynthia S. Crowson, Ali Duarte-Garcia
Summary: The study aimed to assess the prevalence and incidence of multimorbidity and its association with the SLICC/ACR damage index (SDI) among patients with SLE. The results showed that patients with SLE were more likely to have multimorbidity, both before and after the onset of the disease. Multimorbidity was driven by both SDI-related and unrelated conditions.
Article
Pediatrics
Ana Luisa Rodriguez-Lozano, Francisco Eduardo Rivas-Larrauri, Silvestre de la Puente, Daniel Alfredo Alcivar-Arteaga, Alejandro Gabriel Gonzalez-Garay
Summary: This study found that neurologic disease, vasculitis, and hemolytic anemia present at diagnosis in childhood-onset systemic lupus erythematosus patients are prognostic factors associated with the development of damage. Therefore, closer follow-up is recommended for patients with these factors to reduce the likelihood of damage development.
FRONTIERS IN PEDIATRICS
(2022)
Article
Rheumatology
Meenakshi Jolly, Vinay Sehgal, Shilpa Arora, Desiree Azizoddin, Benzeeta Pinto, Aman Sharma, Herve Devilliers, Mitsuyo Inoue, Sergio Toloza, Ana Bertoli, Ivana Blazevic, Luis M. Vila, Ioana Moldovan, Karina D. Torralba, Davide Mazzoni, Elvira Cicognani, Sarfaraz Hasni, Berna Goker, Seminur Haznedaroglu, Josiane Bourre-Tessier, Sandra Navarra, Ann Clarke, Michael Weisman, Daniel Wallace, Chi Chiu Mok
Summary: The use of hydroxychloroquine (HCQ) in SLE is associated with better patient reported health outcomes, such as quality of life (QOL), and this effect is mainly mediated through disease activity.
Article
Biochemistry & Molecular Biology
Julia Mercader-Salvans, Maria Garcia-Gonzalez, Juan C. Quevedo-Abeledo, Adrian Quevedo-Rodriguez, Alejandro Romo-Cordero, Soledad Ojeda-Bruno, Fuensanta Gomez-Bernal, Raquel Lopez-Mejias, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: Ratios derived from complete blood count can be used as inflammatory biomarkers in systemic lupus erythematosus (SLE) patients. Despite lower cell counts, NLR, MLR, and PLR are higher in SLE patients. However, the relationship between these scores and disease characteristics is limited, with the complement system being the most consistent.
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to investigate the relationship between serum levels of transforming growth factor beta 1 (TGF-β1) and disease characteristics, activity, damage, or severity in patients with systemic lupus erythematosus (SLE). The results showed that TGF-β1 serum levels were associated with disease severity and activity, with ocular and cardiovascular manifestations positively correlated, while gastrointestinal and musculoskeletal involvements negatively correlated with circulating TGF-β1 levels.
Review
Medicine, General & Internal
Matteo Piga, Laurent Arnaud
Summary: Systemic lupus erythematosus is an immune-mediated multi-systemic disease with unpredictable clinical course. Despite advances in pathophysiology understanding, challenges remain in early diagnosis, biomarker identification, and development of new drugs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Fulvia Ceccarelli, Carlo Perricone, Francesco Natalucci, Licia Picciariello, Giulio Olivieri, Giacomo Cafaro, Elena Bartoloni, Gerli Roberto, Fabrizio Conti
Summary: The prevention of chronic damage, especially in early disease phases, remains an unmet need in the management of Systemic Lupus Erythematous (SLE) patients. Multiple factors, including disease activity, antiphospholipid antibodies, drugs used for treatment, genetic background, and demographic factors, contribute to the development of SLE-related damage. New outcomes are needed to assess comprehensive disease control.
AUTOIMMUNITY REVIEWS
(2023)
Article
Rheumatology
Maddalena Larosa, Veronique Le Guern, Gaelle Guettrot-Imbert, Nathalie Morel, Noemie Abisror, Chafika Morati-Hafsaoui, Pauline Orquevaux, Elisabeth Diot, Andrea Doria, Francoise Sarrot Reynauld, Nicolas Limal, Viviane Queyrel, Odile Souchaud-Debouverie, Laurent Sailler, Maelle Le Besnerais, Tiphaine Goulenok, Anna Molto, Emmanuelle Pannier-Metzger, Loic Sentilhes, Luc Mouthon, Estibaliz Lazaro, Nathalie Costedoat-Chalumeau
Summary: The specific roles of remission status, lupus low disease activity state (LLDAS), and damage accrual on the prognosis of pregnancies in women with SLE are unknown. This study found that damage at conception and lupus anticoagulant were significantly associated with adverse pregnancy outcomes, while hypocomplementemia in the first trimester was associated with maternal flares later in pregnancy.
Article
Dentistry, Oral Surgery & Medicine
Eduardo Bernabe, Wael Sabbah, Elsa K. Delgado-Angulo, Jason E. Murasko, Stuart A. Gansky
EUROPEAN JOURNAL OF ORAL SCIENCES
(2015)
Article
Dentistry, Oral Surgery & Medicine
Benjamin W. Chaffee, Elizabeth T. Couch, Stuart A. Gansky
JOURNAL OF PUBLIC HEALTH DENTISTRY
(2018)
Article
Health Care Sciences & Services
Jing Cheng, Nancy F. Cheng, Zijian Guo, Steven Gregorich, Amid I. Ismail, Stuart A. Gansky
STATISTICAL METHODS IN MEDICAL RESEARCH
(2018)
Article
Dentistry, Oral Surgery & Medicine
Francisco J. Ramos-Gomez, Stuart A. Gansky, John D. B. Featherstone, Bonnie Jue, Rocio Gonzalez-Beristain, William Santo, Ed Martinez, Jane A. Weintraub
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2012)
Article
Dentistry, Oral Surgery & Medicine
J. A. Weintraub, P. Prakash, S. G. Shain, M. Laccabue, S. A. Gansky
JOURNAL OF DENTAL RESEARCH
(2010)
Article
Dentistry, Oral Surgery & Medicine
Tracy L. Finlayson, Stuart A. Gansky, Sara G. Shain, Jane A. Weintraub
JOURNAL OF PUBLIC HEALTH DENTISTRY
(2010)
Article
Substance Abuse
Benjamin W. Chaffee, Elizabeth T. Couch, Janelle Urata, Stuart A. Gansky, Gwen Essex, Jing Cheng
SUBSTANCE USE & MISUSE
(2019)
Article
Dentistry, Oral Surgery & Medicine
Stuart A. Gansky, Sarah Shafik
JOURNAL OF PUBLIC HEALTH DENTISTRY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Joel M. White, Elizabeth A. Mertz, Joanna M. Mullins, Joshua B. Even, Trey Guy, Elena Blaga, Aubri M. Kottek, Shwetha V. Kumar, Suhasini Bangar, Ram Vaderhobli, Ryan Brandon, William Santo, Larry Jenson, Stuart A. Gansky
Article
Dentistry, Oral Surgery & Medicine
Tracy L. Finlayson, MarkJason Cabudol, Jenny X. Liu, Jeremiah R. Garza, Stuart A. Gansky, Francisco Ramos-Gomez
Article
Medicine, Research & Experimental
Molly A. Martin, Lacey J. Zimmerman, Genesis F. Rosales, Helen H. Lee, Nattanit Songthangtham, Oksana Pugach, Anna S. Sandoval, David Avenetti, Gizelle Alvarez, Stuart A. Gansky
CONTEMPORARY CLINICAL TRIALS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Francisco J. Ramos-Gomez, Molly A. Martin, Suchitra S. Nelson, Belinda Borrelli, Michelle M. Henshaw, Shelley Curtan, Helen E. Lindau, Nicolle Rueras, Anna S. Sandoval, Stuart A. Gansky
Summary: The COVID-19 pandemic has posed significant challenges to the dental field, affecting providers, healthcare workers, patients, and researchers alike. By examining the impact on community-based clinical trials, researchers can better prepare for future disruptions and challenges.
FRONTIERS IN DENTAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
T. Tiwari, N. K. Rai, A. R. Wilson, S. A. Gansky, J. Albino
Summary: The study evaluated strength-based motivators within Hispanic families supporting health creation in children. Parents of caries-free children showed higher oral hygiene behavior scores, perceived fewer barriers, and considered their children more susceptible to cavities compared to caries-active group. Parental behaviors and health beliefs were significant determinants of caries status in Hispanic children, indicating the importance of tailoring oral health promotional messaging to improve oral health in this population.
JDR CLINICAL & TRANSLATIONAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
J. Cheng, S. E. Gregorich, S. A. Gansky, S. A. Fisher-Owens, A. M. Kottek, J. M. White, E. A. Mertz
JDR CLINICAL & TRANSLATIONAL RESEARCH
(2020)