Article
Medicine, General & Internal
Alvaro Gomez, Victor Qiu, Arvid Cederlund, Alexander Borg, Julius Lindblom, Sharzad Emamikia, Yvonne Enman, Jon Lampa, Ioannis Parodis
Summary: The study revealed that despite achieving adequate clinical response with standard therapy plus belimumab or placebo, a substantial proportion of SLE patients still experienced adverse health-related quality of life (HRQoL) outcomes, with factors such as age, ethnicity, and organ damage contributing to these outcomes. Additional belimumab treatment was associated with lower frequencies of adverse physical functioning and fatigue, suggesting a potential protective effect in improving HRQoL in SLE patients.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Lou Kawka, Aurelien Schlencker, Philippe Mertz, Thierry Martin, Laurent Arnaud
Summary: Fatigue is a common symptom in patients with SLE, affecting 67% to 90% of patients. It can impair health-related quality of life and lead to employment disability. Management should include targeted interventions such as pharmacological treatments and non-pharmacological therapies like psychological interventions and lifestyle changes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ning-Sheng Lai, Ming-Chi Lu, Hsiu-Hua Chang, Hui-Chin Lo, Chia-Wen Hsu, Kuang-Yung Huang, Chien-Hsueh Tung, Bao-Bao Hsu, Cheng-Han Wu, Malcolm Koo
Summary: This study compared the correlation of SLE-DAS and SLEDAI-2K with LupusQoL in Taiwanese patients with SLE, showing no clear differences in assessing HRQoL. Both SLEDAI-2K and SLE-DAS were found to be effective tools for measuring disease activity in patients with SLE.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Rheumatology
Sierra Mendelsohn, Lina Khoja, Sofia Alfred, Jennifer He, Melanie Anderson, Denise DuBois, Zahi Touma, Lisa Engel
Summary: This study aimed to synthesize and critically appraise the quantitative literature on the relationship of cognitive impairment (CI) to health-related quality of life (HRQoL) and social role participation in individuals with Systemic Lupus Erythematosus (SLE). The findings suggest a negative relationship between CI and HRQoL as well as social role participation in SLE patients, highlighting the need for further research to clarify this relationship.
Article
Psychology, Multidisciplinary
Sakineh Hashemi, Sahar Farahbakhsh, Zahra Aghakhani, Ali Momayezanmarnani, Nazi Hemati, Somayeh Hashemi
Summary: This study investigated the factors affecting quality of life in SLE patients, including disease duration, physical activity, kidney involvement, and skin involvement. The results showed that Iranian SLE patients had a low quality of life, which was related to age and gender.
Article
Rheumatology
Noortje Groot, Anne Kardolus, Marc Bijl, Radboud J. E. M. Dolhain, Y. K. Onno Teng, Els Zirkzee, Karina de Leeuw, Ruth Fritsch-Stork, Alex Burdorf, Irene E. Bultink, Sylvia Kamphuis
Summary: In adults with childhood-onset systemic lupus erythematosus (cSLE), the disease significantly affects academic achievements and employment, even though patients adjust their educational and vocational choices. Support is necessary to help these patients find suitable education and jobs, and to guide potential adjustments during their careers.
JOURNAL OF RHEUMATOLOGY
(2021)
Review
Medicine, General & Internal
Ioannis Parodis, Paul Studenic
Summary: Systemic lupus erythematosus is a chronic autoimmune disorder with detrimental effects on patient's quality of life. Its management requires interdisciplinary care and emphasis on patient-reported outcome measures to improve patient participation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Manuel Francisco Ugarte-Gil, Rocio Violeta Gamboa-Cardenas, Cristina Reategui-Sokolova, Victor Roman Pimentel-Quiroz, Mariela Medina, Claudia Elera-Fitzcarrald, Zoila Rodriguez-Bellido, Cesar Augusto Pastor-Asurza, Risto Alfredo Perich-Campos, Graciela S. Alarcon
Summary: The objective of this study was to determine the possible predictive value of self-efficacy on health-related quality of life (HRQoL) in patients with SLE. The results showed that better self-efficacy was associated with better HRQoL, even after adjusting for possible confounders. Therefore, clinicians should develop strategies to improve self-efficacy in patients with SLE.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Rheumatology
Alvaro Gomez, Fawz Hani Butrus, Petter Johansson, Emil Akerstrom, Sofia Soukka, Sharzad Emamikia, Yvonne Enman, Susanne Pettersson, Ioannis Parodis
Summary: This study found that overweight and obesity in SLE patients can lead to significant decreases in HRQoL in terms of physical, fatigue, and social functioning. Moreover, these impacts become more pronounced with increasing BMI.
Article
Dentistry, Oral Surgery & Medicine
Brena Rodrigues Manzano, Paulo Sergio da Silva Santos, Matheus Henrique Bariquelo, Nathalia Rodrigues Germano Merlini, Heitor Marques Honorio, Cassia Maria Fischer Rubira
Summary: Individuals with RA have a higher caries index and more frequent periodontal disease, while those with SLE have lower salivary flow and severe xerostomia, impacting their quality of life.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Medicine, General & Internal
Alexander Borg, Julius Lindblom, Alvaro Gomez, Ameneh Soltani, Yvonne Enman, Emelie Heintz, Malin Regardt, David Grannas, Sharzad Emamikia, Ioannis Parodis
Summary: This study found that high BMI (obesity and overweight) is associated with impairments in health-related quality of life (HRQoL) in SLE patients, with obesity being specifically associated with pain and impaired mobility even after treatment.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Alvaro Gomez, Ioannis Parodis
Summary: Despite the development of various biological therapies for SLE, most randomized clinical trials have not achieved their primary efficacy endpoints. This review focuses on the effect of biological therapies on SLE patients' health-related quality of life and fatigue. Patient-reported outcomes are suggested as useful tools for evaluating the impact of interventions on aspects that are important to patients. The differences between generic and disease-specific PRO measures are discussed, and the need for a combination of both is emphasized to comprehensively capture the patient perspective.
AUTOIMMUNITY REVIEWS
(2022)
Article
Rheumatology
Julius Lindblom, Alvaro Gomez, Alexander Borg, Sharzad Emamikia, Dimitris Ladakis, Joaquin Matilla, Martin Pehr, Flordelyn Cobar, Yvonne Enman, Emelie Heintz, Malin Regardt, Ioannis Parodis
Summary: This study shows that EQ-5D-3L full health state (FHS) can differentiate between patients receiving standard therapy (ST) plus belimumab and those only receiving ST, as well as between responders and non-responders. Factors such as SLEDAI-2K and SLICC/ACR Damage Index scores were associated with lower FHS frequencies at week 52, while the addition of belimumab 10 mg/kg to ST was associated with higher FHS frequencies. Additionally, certain patient characteristics, such as antimalarial use and presence of certain antibodies, were also associated with higher FHS frequencies.
Review
Medicine, General & Internal
Dina Zucchi, Chiara Cardelli, Elena Elefante, Chiara Tani, Marta Mosca
Summary: Treat-to-target is a therapeutic approach that aims to achieve well-defined clinical targets by making adjustments to treatment at set intervals. This approach has shown promising results for rheumatoid arthritis, but it has been challenging to determine the most meaningful treatment targets for systemic lupus erythematosus (SLE) due to the complexity and heterogeneity of the disease. This review focuses on describing the treatment targets and methods for achieving them in SLE, and it also discusses the potential of treat-to-target as an approach for this complex disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Elena Grau Garcia, Jorge Juan Fragio Gil, Jose Ivorra Cortes, Francisco Miguel Ortiz Sanjuan, Inmaculada Chalmeta Verdejo, Jose Andres Roman Ivorra
Summary: This study aimed to investigate the relationship between disease activity and health-related quality of life (HRQoL) in patients with systemic lupus erythematosus (SLE). HRQoL was measured using questionnaires on fatigue, quality of life, disability, and a global health status scale. The results showed a statistically significant association between disease activity and HRQoL parameters.
