Article
Immunology
Chiharu Hidekawa, Ryusuke Yoshimi, Yusuke Saigusa, Jun Tamura, Noriko Kojitani, Naoki Suzuki, Natsuki Sakurai, Yuji Yoshioka, Yumiko Sugiyama-Kawahara, Yosuke Kunishita, Daiga Kishimoto, Kana Higashitani, Yuichiro Sato, Takaaki Komiya, Hideto Nagai, Naoki Hamada, Ayaka Maeda, Naomi Tsuchida, Lisa Hirahara, Yutaro Soejima, Kaoru Takase-Minegishi, Yohei Kirino, Nobuyuki Yajima, Ken-ei Sada, Yoshia Miyawaki, Kunihiro Ichinose, Shigeru Ohno, Hiroshi Kajiyama, Shuzo Sato, Yasuhiro Shimojima, Michio Fujiwara, Hideaki Nakajima
Summary: Hydroxychloroquine may help extend the time until the occurrence of infection complications in patients with systemic lupus erythematosus and tends to decrease infection rates.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Ji-Hyoun Kang, Sung-Eun Choi, Dong-Jin Park, Shin-Seok Lee
Summary: This study investigated the effects of serum HCQ concentration on clinical manifestations, disease activity, and organ damage in SLE patients. The results showed that patients with subtherapeutic HCQ concentration had a higher incidence of newly developed LN and higher disease activity and organ damage scores over 5 years. Therefore, maintaining an appropriate HCQ concentration can improve the clinical outcomes of SLE patients.
Article
Rheumatology
Amaia Ugarte, Alazne Garcia de Bustos, Ioana Ruiz-Arruza, Adriana Soto-Peleteiro, Daniel Martin-Iglesias, Cristina Gonzalez-Echavarri, Guillermo Ruiz-Irastorza
Summary: This study compared the influence of aPLs on global and cardiovascular damage in patients with SLE diagnosed before and after the year 2000. The results showed that the effects of aPL on damage accrual in SLE patients have been reduced over recent years, possibly due to the widespread use of HCQ and improved thromboprophylaxis.
Article
Rheumatology
Meenakshi Jolly, Vinay Sehgal, Shilpa Arora, Desiree Azizoddin, Benzeeta Pinto, Aman Sharma, Herve Devilliers, Mitsuyo Inoue, Sergio Toloza, Ana Bertoli, Ivana Blazevic, Luis M. Vila, Ioana Moldovan, Karina D. Torralba, Davide Mazzoni, Elvira Cicognani, Sarfaraz Hasni, Berna Goker, Seminur Haznedaroglu, Josiane Bourre-Tessier, Sandra Navarra, Ann Clarke, Michael Weisman, Daniel Wallace, Chi Chiu Mok
Summary: The use of hydroxychloroquine (HCQ) in SLE is associated with better patient reported health outcomes, such as quality of life (QOL), and this effect is mainly mediated through disease activity.
Article
Rheumatology
Celline C. Almeida-Brasil, John G. Hanly, Murray Urowitz, Ann Elaine Clarke, Guillermo Ruiz-Irastorza, Caroline Gordon, Rosalind Ramsey-Goldman, Michelle Petri, Ellen M. Ginzler, D. J. Wallace, Sang-Cheol Bae, Juanita Romero-Diaz, Mary Anne Dooley, Christine Peschken, David Isenberg, Anisur Rahman, Susan Manzi, Soren Jacobsen, Sam Lim, Ronald F. van Vollenhoven, Ola Nived, Andreas Jonsen, Diane L. Kamen, Cynthia Aranow, Jorge Sanchez-Guerrero, Dafna D. Gladman, Paul R. Fortin, Graciela S. Alarcon, Joan T. Merrill, Kenneth Kalunian, Manuel Ramos-Casals, Kristjan Steinsson, Asad Zoma, Anca Askanase, Munther A. Khamashta, Ian N. Bruce, Murat Inanc, Michal Abrahamowicz, Sasha Bernatsky
Summary: The risk of SLE flare was higher after HCQ tapering or discontinuation compared to HCQ maintenance, especially for patients with low educational level and prednisone use. Special attention should be paid to specific subgroups when making decisions on HCQ maintenance.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Sarah L. Patterson, Laura Trupin, Jinoos Yazdany, Maria Dall'Era, Cristina Lanata, Kimberly Dequattro, Wendy Hartogensis, Patricia Katz
Summary: Physical inactivity is a significant predictor of incident depression in systemic lupus erythematosus (SLE) patients, emphasizing the need to reduce sedentary behavior.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Alfredo Aguirre, Zara Izadi, Laura Trupin, Kamil E. Barbour, Kurt J. Greenlund, Patti Katz, Cristina Lanata, Lindsey Criswell, Maria Dall'Era, Jinoos Yazdany
Summary: This study analyzed racial and ethnic differences in the risk of end-organ lupus manifestations following SLE diagnosis. The results showed that Hispanic and Asian patients with SLE had heightened risks of developing renal, hematologic, and multiorgan disease.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Sarah Patterson, Laura Trupin, Wendy Hartogensis, Kimberly DeQuattro, Cristina Lanata, Caroline Gordon, Kamil E. E. Barbour, Kurt J. J. Greenlund, Maria Dall'Era, Jinoos Yazdany, Patricia Katz
Summary: Several studies have shown a potential link between traumatic experiences, psychological stress, and autoimmunity. However, the impact of stress on disease activity and symptom severity in systemic lupus erythematosus (SLE) has not been fully understood. This study aimed to examine whether increases in perceived stress independently associate with worse SLE disease outcomes over a 3-year follow-up period. The results suggest that an increase in stress is associated with greater disease activity and symptom burden in individuals with SLE.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Maria G. Lang, Carmen G. C. Vinagre, Eloisa Bonfa, Fatima R. Freitas, Sandra G. Pasoto, Tatiane S. Brito, Luciana P. C. Seguro, Raul C. Maranhao, Eduardo F. Borba
Summary: This study demonstrates for the first time that hydroxychloroquine (HCQ) promotes the transfer of unesterified cholesterol, leading to increased levels of high-density lipoprotein (HDL) in systemic lupus erythematosus (SLE) patients. This beneficial effect may contribute to the reduced atherosclerosis reported in SLE.
Review
Rheumatology
Christie M. Bartels, April Jorge, Candace H. Feldman, JoAnn Zell, Bonnie Bermas, Claire E. H. Barber, Ali Duarte-Garcia, Shivani Garg, Leah Haseley, Shraddha Jatwani, Tracy Johansson, Alex Limanni, Wendy Rodgers, Brad H. Rovin, Yesenia Santiago-Casas, Lisa G. Suter, April Barnado, Jennifer Ude, Alfredo Aguirre, Jing Li, Gabriela Schmajuk, Jinoos Yazdany
Summary: This study aimed to develop measurable digital quality measure statements for clinical care in systemic lupus erythematosus (SLE) using a consensus method. A panel of SLE experts reviewed guidelines and extracted quality constructs to generate evidence-based quality measure statements. Through a Delphi process, three top-ranked statements on hydroxychloroquine use, glucocorticoid reduction, and kidney monitoring were selected for further specification and testing.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
R. Ezequiel Borgia, Manuel F. Ugarte-Gil, Luis M. Vila, John D. Reveille, Gerald McGwin Jr, Graciela S. Alarcon
Summary: This study aimed to compare the long-term impact of childhood-onset SLE and adult-onset SLE on health-related quality of life (HRQoL), and found that adults with childhood-onset SLE had better physical functioning but lower HRQoL than the general US population.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Toxicology
Aylin Balci-Ozyurt, Anil Yirun, Deniz Arca Cakir, N. Dilara Zeybek, Didem Oral, Suna Sabuncuoglu, Pinar Erkekoglu
Summary: Nanoparticles (NPs) between 1 to 100 nm in diameter have toxic effects on both humans and the environment. In this study, the effects of normal-sized and nano-sized titanium dioxide (TiO2) NPs on cells were compared. It was found that normal-sized TiO2 resulted in lower H3 acetylation and nano-sized TiO2 caused higher DNA damage and global DNA methylation. Melatonin showed partial protection against the toxicity of TiO2 NPs.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Rheumatology
John G. Hanly, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Ann E. Clarke, Daniel J. Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Murray B. Urowitz, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, M. A. Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, S. Sam Lim, Murat Inanc, Kenneth C. Kalunian, Soren Jacobsen, Christine A. Peschken, Diane L. Kamen, Anca Askanase, Vernon Farewell
Summary: This large and long-term study on neuropsychiatric events in systemic lupus erythematosus (SLE) identified predictors of occurrence and resolution, showing that the nature and attribution of the events greatly impact their course. Factors such as disease activity, medications, and ethnicity were found to influence the prognosis and resolution of these events in SLE patients.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Yanjie Hao, Shereen Oon, Lanlan Ji, Dai Gao, Yong Fan, Yan Geng, Xiaohui Zhang, Guangtao Li, Eric F. Morand, Mandana Nikpour, ZhuoLi Zhang
Summary: In a prospective cohort of Chinese lupus patients, achieving the lupus low disease activity state (LLDAS) was a feasible goal in clinical practice. Nephritis-related markers and C3 level negatively influenced LLDAS attainment, while achieving LLDAS was significantly protective against disease flare and damage accrual.
CLINICAL RHEUMATOLOGY
(2022)
Article
Toxicology
Muhammad Umar Ijaz, Faryal Jabeen, Asma Ashraf, Muhammad Imran, Nazia Ehsan, Abdul Samad, Muhammad Kashif Saleemi, Javed Iqbal
Summary: In summary, the study revealed that chrysin has significant therapeutic effects against arsenic-induced nephrotoxicity in rats, by alleviating oxidative stress, inflammatory response, DNA and histopathological damages.
Article
Rheumatology
G. S. Alarcon, M. F. Ugarte-Gil, G. Pons-Estel, L. M. Vila, J. D. Reveille, G. McGwin
Editorial Material
Rheumatology
Bridget Hodkinson, Prasun Singh, Ayanda Gcelu, Wilson Bautista Molano, Guillermo Pons-Estel, Deshire Alpizar-Rodriguez
CLINICAL RHEUMATOLOGY
(2020)
Article
Rheumatology
Rosa Serrano, Guillermo J. Pons-Estel, Gerard Espinosa, Rosana M. Quintana, Joan C. Reverter, Dolors Tassies, Joan Monteagudo, Ricard Cervera
Article
Rheumatology
Rosana Quintana, Guillermo J. Pons-Estel, Karen Roberts, Monica Sacnun, Rosa Serrano, Romina Nieto, Silvana Conti, Viviana Gervasoni, Luis J. Catoggio, Enrique R. Soriano, Marina Scolnik, Mercedes A. Garcia, Alejandro Alvarellos, Veronica Saurit, Guillermo A. Berbotto, Emilia Sato, Lilian T. Lavras Costallat, Eduardo Ferreira Borba Neto, Eloisa Bonfa, Ricardo M. Xavier, Ana Carolina de Oliveira e Silva Montandon, Jose Fernando Molina-Restrepo, Antonio Iglesias-Gamarra, Marlene Guibert-Toledano, Gil Alberto Reyes-Llerena, Loreto Massardo, Oscar J. Neira, Mario H. Cardiel, Leonor A. Barile-Fabris, Mary-Carmen Amigo, Luis H. Silveira, Ignacio Garcia De La Torre, Eduardo M. Acevedo-Vasquez, Manuel F. Ugarte-Gil, Jose Luis Alfaro-Lozano, Maria Ines Segami, Rosa Chacon-Diaz, Maria H. Esteva-Spinetti, Jose A. Gomez-Puerta, Graciela S. Alarcon, Bernardo A. Pons-Estel
Letter
Rheumatology
Ariel Izcovich, Graciela S. Alarcon, Jose A. Gomez-Puerta, Guillermo J. Pons-Estel, Manuel F. Ugarte-Gil, Mario H. Cardiel, Bernardo A. Pons-Estel
Editorial Material
Rheumatology
Guillermo J. Pons-Estel, Graciela S. Alarcon
Summary: The new 2019 EULAR-ACR classification criteria for SLE showed promising results in initial derivative and validation cohorts, but further research is needed to determine if these criteria outperform previous classification criteria across genders, disease durations, and ethnicities.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Letter
Rheumatology
Guillermo J. Pons-Estel, Manuel F. Ugarte-Gil, Guillermina B. Harvey, Bernardo A. Pons-Estel, Graciela S. Alarcon
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Leonor A. Barile-Fabris, Hilda Fragoso-Loyo, Daniel Wojdyla, Rosana Quintana, Guillermo J. Pons-Estel, Luis J. Catoggio, Mercedes A. Garcia, Veronica Saurit, Cristina Drenkard, Eloisa Bonfa, Eduardo F. Borba, Emilia Sato, Joao C. Tavares Brenol, Fernando Cavalcanti, Nilzio A. Da Silva, Lilian T. Lavras Costallat, Marlene Guibert Toledano, Loreto Massardo, Oscar Neira, Mario H. Cardiel, Mary Carmen Amigo, Ignacio Garcia De La Torre, Luis H. Silveira, Eduardo M. Acevedo Vasquez, Rosa Chacon-Diaz, Maria H. Esteva-Spinetti, Graciela S. Alarcon, Bernardo A. Pons-Estel
Summary: In early SLE, factors such as myalgias/myositis, pneumonitis, shrinking lung, and hemolytic anemia are associated with a higher risk of NP involvement. On the other hand, longer disease duration at cohort entry is linked to a lower risk of developing NP manifestations.
Article
Rheumatology
Manuel Francisco Ugarte-Gil, Graciela S. Alarcon, Zara Izadi, Ali Duarte-Garcia, Cristina Reategui-Sokolova, Ann Elaine Clarke, Leanna Wise, Guillermo J. Pons-Estel, Maria Jose Santos, Sasha Bernatsky, Sandra Lucia Euzebio Ribeiro, Samar Al Emadi, Jeffrey A. Sparks, Tiffany Y-T Hsu, Naomi J. Patel, Emily L. Gilbert, Maria O. Valenzuela-Almada, Andreas Jonsen, Gianpiero Landolfi, Micaela Fredi, Tiphaine Goulenok, Mathilde Devaux, Xavier Mariette, Viviane Queyrel, Vasco C. Romao, Graca Sequeira, Rebecca Hasseli, Bimba Hoyer, Reinhard E. Voll, Christof Specker, Roberto Baez, Vanessa Castro-Coello, Hernan Maldonado Ficco, Edgard Torres Reis Neto, Gilda Aparecida Aparecida Ferreira, Odirlei Andre Andre Monticielo, Emily Sirotich, Jean Liew, Jonathan Hausmann, Paul Sufka, Rebecca Grainger, Suleman Bhana, Wendy Costello, Zachary S. Wallace, Lindsay Jacobsohn, Tiffany Taylor, Clairissa Ja, Anja Strangfeld, Elsa F. Mateus, Kimme L. Hyrich, Loreto Carmona, Saskia Lawson-Tovey, Lianne Kearsley-Fleet, Martin Schaefer, Pedro M. Machado, Philip C. Robinson, Milena Gianfrancesco, Jinoos Yazdany
Summary: The severity of COVID-19 outcomes in individuals with SLE is associated with factors such as gender, age, steroid dosage, comorbidities, and the activity of SLE.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Savino Sciascia, Dario Roccatello, Massimo Radin, Ioannis Parodis, Jinoos Yazdany, Guillermo Pons-Estel, Marta Mosca
Summary: This review summarizes the differentiation between early systemic lupus erythematosus (SLE) and undifferentiated connective tissue disease (UCTD), as well as clinical approaches to diagnosing these conditions. It emphasizes the importance of accurately distinguishing between stable UCTD and early-stage SLE to prevent irreversible organ damage.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Review
Rheumatology
Luis A. Gonzalez, Manuel F. Ugarte-Gil, Guillermo J. Pons-Estel, Sergio Duran-Barragan, Sergio Toloza, Paula Burgos, Ana Bertoli, R. Ezequiel Borgia, Graciela S. Alarcon
Summary: Systemic lupus erythematosus disproportionately affects vulnerable populations, such as women, ethnic minorities, individuals living in poverty, less educated, and lacking medical insurance. Both genetic and non-genetic factors contribute to these disparities. Interventions targeting non-genetic amendable factors, particularly social health determinants, are necessary to overcome health disparities among disadvantaged SLE populations.
Article
Rheumatology
Luis Alonso Gonzalez, Graciela S. Alarcon, Guillermina B. Harvey, Rosana Quintana, Guillermo J. Pons-Estel, Manuel F. Ugarte-Gil, Gloria Vasquez, Luis J. Catoggio, Mercedes A. Garcia, Eduardo F. Borba, Nilzio A. Da Silva, Joao C. Tavares Brenol, Marlene Guibert Toledano, Loreto Massardo, Oscar Neira, Virginia Pascual-Ramos, Mary-Carmen Amigo, Leonor A. Barile-Fabris, Ignacio Garcia De La Torre, Jose Alfaro-Lozano, Maria Segami, Rosa Chacon-Diaz, Maria H. Esteva-Spinetti, Antonio Iglesias-Gamarra, Bernardo A. Pons-Estel
Summary: This study aimed to determine the predictors of severe autoimmune hemolytic anemia (AIHA) occurrence and its impact on damage accrual and mortality in patients with systemic lupus erythematosus (SLE). The study found that male sex and higher disease activity at diagnosis were associated with a shorter time to severe AIHA occurrence. Although not statistically significant, hematological abnormalities at SLE diagnosis showed a certain trend toward predicting the occurrence of severe AIHA in a shorter time. Severe AIHA did not seem to impact damage and mortality.
Article
Rheumatology
Luis A. Gonzalez, Manuel F. Ugarte-Gil, Guillermo J. Pons-Estel, Graciela S. Alarcon
Summary: Despite the challenges in early diagnosis, the incidence and prevalence of SLE has increased over the last four decades, attributed to various factors including better understanding of the disease, diverse population, improved diagnostic criteria, and enhanced survival. This article also discusses the genetic, environmental, and lifestyle factors associated with SLE risk and the potential of preventive strategies in improving outcomes.
Article
Rheumatology
Cristina Reategui-Sokolova, Manuel F. Ugarte-Gil, Guillermina B. Harvey, Daniel Wojdyla, Guillermo J. Pons-Estel, Rosana Quintana, Rosa M. Serrano-Morales, Monica P. Sacnun, Luis J. Catoggio, Enrique R. Soriano, Mercedes A. Garcia, Veronica Saurit, Alejandro Alvarellos, Francisco Caeiro, Guillermo A. Berbotto, Emilia Sato, Eduardo Ferreira Borba Neto, Eloisa Bonfa, Ana Carolina de Oliveira e Silva Montandon, Nilzio A. Da Silva, Fernando Cavalcanti, Gloria Vasquez, Marlene Guibert-Toledano, Gil A. Reyes-Llerena, Loreto Massardo, Oscar J. Neira, Mario H. Cardiel, Leonor A. Barile-Fabris, Mary-Carmen Amigo, Luis H. Silveira, Margarita Portela-Hernandez, Ignacio Garcia de la Torre, Maria Ines Segami, Rosa Chacon-Diaz, Maria H. Esteva-Spinetti, Graciela S. Alarcon, Bernardo A. Pons-Estel
Article
Rheumatology
Guillermo J. Pons-Estel, Manuel Francisco Ugarte-Gil, Guillermina B. Harvey, Daniel Wojdyla, Rosana Quintana, Veronica Saurit, Enrique R. Soriano, Eloisa Bonfa, Loreto Massardo, Mario Cardiel, Luis M. Vila, Russell Griffin, Bernardo A. Pons-Estel, Graciela S. Alarcon