Article
Chemistry, Multidisciplinary
Zhaoming Chen, Yang Tian, Jieyu Yang, Fapu Wu, Senyao Liu, Wenwen Cao, Weijia Xu, Tao Hu, Daniel J. Siegwart, Hu Xiong
Summary: A library of linker-degradable ionizable lipids (LDILs) was synthesized by introducing a disulfide bond-bridged ester linker, aiming to improve mRNA delivery in vivo. The optimized LDILs demonstrated superior endosomal escape and rapid mRNA release abilities, significantly enhancing mRNA delivery in the liver and enabling efficient gene editing and cancer metastasis delineation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Yan Zong, Yi Lin, Tuo Wei, Qiang Cheng
Summary: This review summarizes the development of lipid nanoparticle (LNP) for mRNA delivery in anticancer therapy, including strategies, therapeutic approaches, and future directions.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Yecheng Feng, Wenjing Yang, Xiaojing Shi, Xubo Zhao
Summary: This study developed a pH-responsive alginate-based assembly for selective drug delivery in cancer treatment. The assembly disassembles under acidic conditions to release the drug and inhibit tumor growth. These findings inspire the development of drug delivery systems for cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Chemistry, Multidisciplinary
Xiaoli Wang, Yufei Ye, Zhaohui Huang, Peter H. Seeberger, Jing Hu, Jian Yin
Summary: This study introduces a near-infrared light activated fluorescence resonance energy transfer strategy for efficient and reliable simultaneous dual imaging of MUC1 protein backbone and MUC1-specific sialic acid. The platform allows for dual imaging and relative quantification of MUC1 and its sialylation in vitro, in vivo, and in clinical tissue samples, showing significant potential for clinical cancer diagnostics.
Article
Oncology
Sibi Raj, Sartaj Khurana, Ramesh Choudhari, Kavindra Kumar Kesari, Mohammad Amjad Kamal, Neha Garg, Janne Ruokolainen, Bhudev C. Das, Dhruv Kumar
Summary: Nanotechnology offers a promising approach for cancer diagnosis and treatment, providing specific and efficient drug delivery to target tissues while minimizing side effects. Various types of nanocarriers are being studied for potential use in cancer therapy.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xiaowei Xie, Tianxiang Yue, Wenting Gu, Weiyi Cheng, Li He, Weiye Ren, Fanzhu Li, Ji-Gang Piao
Summary: This paper discusses the use of surface-functionalized mesoporous silica nanoparticles (MSN) as delivery vehicles for siRNA in cancer therapy. The advantages of using MSNs for siRNA loading and strategies to improve cellular uptake and endosomal escape are highlighted. Attention is also paid to the exciting progress made by combining RNAi with other therapies to improve cancer therapeutic outcomes.
Article
Chemistry, Multidisciplinary
Chao Hu, Tengyu Guo, Huizhou Li, Pengfei Xu, Yudong Xiao
Summary: In this study, a novel probe IR-RGD with bright emission in the NIR-II region and high quantum yield was reported. Moreover, IR-RGD was successfully utilized for tumor-targeting NIR-II fluorescence imaging, showing great potential for clinical translation.
Review
Chemistry, Physical
Cristiana Maria Grapa, Lucian Mocan, Dana Crisan, Mira Florea, Teodora Mocan
Summary: Pancreatic cancer poses great challenges in treatment, but nanotechnology may offer hope for improving survival rates. Targeted delivery with biomarkers can reduce drug toxicity and enhance efficacy.
Article
Chemistry, Multidisciplinary
Mubin Tarannum, Katherine Holtzman, Didier Dreau, Pinku Mukherjee, Juan L. Vivero-Escoto
Summary: Mesoporous silica nanoparticles (MSNs) can be used as drug carriers to reduce the stroma in pancreatic cancer by inhibiting the sonic hedgehog (SHh) pathway, leading to improved therapeutic outcomes.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biophysics
Haolan Li, Liangliang Yue, Li Li, Genyan Liu, Jie Zhang, Xiaogang Luo, Fengshou Wu
Summary: A new organic compound PIT with a typical D-A-D structure was designed and synthesized, and its NPs exhibited good water dispersibility, high photothermal conversion efficiency, and strong photoacoustic signal, inducing significant reactive oxygen species. These PIT NPs showed good biocompatibility and outstanding photocytotoxicity, making them excellent candidates for photoacoustic imaging and photodynamic/photothermal therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Pharmacology & Pharmacy
Mkhuseli Zenze, Aliscia Daniels, Moganavelli Singh
Summary: The formulation of nanoscale systems with well-defined sizes and shapes is important for various applications, including drug and gene delivery. Dendrimers have unique characteristics that make them suitable for modifying nanoparticles for biomedical purposes. They can incorporate multiple drugs or genes and can be easily modified for targeted delivery. In this review, the properties of dendrimers and their use as modifiers of inorganic nanoparticles for enhanced therapeutic delivery are discussed.
Review
Pharmacology & Pharmacy
Xiaoran Yin, Yifan Cheng, Yan Feng, Wesley R. Stiles, Seung Hun Park, Homan Kang, Hak Soo Choi
Summary: Phototheranostics combine light-induced therapeutic and diagnostic modalities to diagnose and treat human diseases. The development of nanomedicines and bioimaging has led to the advancement of phototheranostics, which show potential in improving treatment efficacy and minimizing side effects.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Monu Kumar Shukla, Arpana Parihar, Chandrabose Karthikeyan, Deepak Kumar, Raju Khan
Summary: This review discusses the potential of multifunctional graphene quantum dots (GQDs) as a platform for receptor targeting, drug delivery, and bioimaging in pancreatic cancer. GQDs have the ability to selectively target pancreatic cancer cells and serve as drug delivery vehicles for controlled and targeted release of therapeutics. Additionally, GQDs show promise as imaging agents for pancreatic cancer detection and monitoring.
Review
Chemistry, Multidisciplinary
Monu Kumar Shukla, Arpana Parihar, Chandrabose Karthikeyan, Deepak Kumar, Raju Khan
Summary: This review discusses the potential of multifunctional graphene quantum dots as a platform for receptor targeting, drug delivery, and bioimaging in pancreatic cancer. Multifunctional graphene quantum dots showed great promise as a versatile platform for the diagnosis and treatment of pancreatic cancer.
Review
Chemistry, Multidisciplinary
Pavan Kumar Chintamaneni, Dasari Nagasen, Katta Chanti Babu, Atul Mourya, Jitender Madan, Dadi A. Srinivasarao, R. K. Ramachandra, P. Madhuri Santhoshi, Sai Kiran S. S. Pindiprolu
Summary: Breast cancer is the most common type of cancer in women, and early diagnosis and effective therapeutic interventions are crucial for improving survival and quality of life. Nanotheranostics, specifically rare earth metal-doped upconversion nanoparticles (UCNPs), show promise in providing both in vivo diagnosis and therapeutics in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)