期刊
JOURNAL OF TOXICOLOGIC PATHOLOGY
卷 23, 期 2, 页码 67-74出版社
JAPANESE SOC TOXICOLOGIC PATHOLOGY
DOI: 10.1293/tox.23.67
关键词
metabolomics; metabolic fingerprinting; toxicological assessment; FT-ICR MS; NMR; MS
Detection of the toxicity of a candidate compound at an early stage of drug development is an emerging area of interest. It is difficult to determine all of the effects of metabolism of a compound using traditional approaches such as histopathology and serum biochemistry. The goal of a metabolomics approach is to determine all metabolites in a living system, with the potential to detect and identify biomarkers involved in toxicity onset. Here, we summarize the metabolic fingerprints for detection and identification of metabolic changes and biomarkers related to drug-induced toxicity using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). (J Toxicol Pathol 2010; 23: 67-74)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据