期刊
VIRUSES-BASEL
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/v10080407
关键词
influenza; mutation; epistasis; evolution; reassortment
类别
资金
- NIH [R01 AI118886, F31 AI140618]
- Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases Award
- University of Michigan Medical Scientist Training Program [NIH T32GM007863]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [F31AI140618, R01AI118886] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007863] Funding Source: NIH RePORTER
Influenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains. This evolvability is driven, in part, by the virus's capacity to generate diversity through mutation and reassortment. Because many new traits require multiple mutations and mutations are frequently combined by reassortment, epistatic interactions between mutations play an important role in influenza virus evolution. While mutation and epistasis are fundamental to the adaptability of influenza viruses, they also constrain the evolutionary process in important ways. Here, we review recent work on mutational effects and epistasis in influenza viruses.
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