期刊
VIRUSES-BASEL
卷 5, 期 7, 页码 1607-1632出版社
MDPI
DOI: 10.3390/v5071607
关键词
herpesvirus; HDAC; IFI16; acetylation; NF-kappa B; p53; proteomics; metabolomics; chemoproteomics
类别
资金
- NIH/NIDA [DP1DA026192]
- NIH [R21AI102187]
- HFSPO [RGY0079/2009-C]
- NSF
Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based omic technologies to infectious disease research, offering a systems biology view of infection.
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