期刊
VIRUSES-BASEL
卷 5, 期 5, 页码 1346-1373出版社
MDPI
DOI: 10.3390/v5051346
关键词
Kaposi's sarcoma-associated herpesvirus; KSHV; KS; viral chromatin; polycomb; EZH2; minichromosome; histone modifications; MLL/Set1; JMJD2A
类别
资金
- Fletcher Jones Foundation
- Hastings Foundation
- [CA082057]
- [CA31363]
- [CA115284]
- [DE019085]
- [AI073099]
Kaposi's sarcoma-associated herpesvirus is an oncogenic gamma-herpesvirus that causes latent infection in humans. In cells, the viral genome adopts a highly organized chromatin structure, which is controlled by a wide variety of cellular and viral chromatin regulatory factors. In the past few years, interrogation of the chromatinized KSHV genome by whole genome-analyzing tools revealed that the complex chromatin landscape spanning the viral genome in infected cells has important regulatory roles during the viral life cycle. This review summarizes the most recent findings regarding the role of histone modifications, histone modifying enzymes, DNA methylation, microRNAs, non-coding RNAs and the nuclear organization of the KSHV epigenome in the regulation of latent and lytic viral gene expression programs as well as their connection to KSHV-associated pathogenesis.
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