Arenaviruses and Lethal Mutagenesis. Prospects for New Ribavirin-based Interventions

Safety, Tolerability, and Efficacy of KP-1461 as Monotherapy for 124 Days in Antiretroviral-Experienced, HIV Type 1-Infected Subjects

(2012) Charles Hicks et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Recent advances in novel targeted therapies for HER2-positive breast cancer

(2012) Conleth G. Murphy et al.   ANTI-CANCER DRUGS

Anti-Tumor Monoclonal Antibodies in Conjunction with β-Glucans: A Novel Anti- Cancer Immunotherapy

(2012) D. Xiang et al.   CURRENT MEDICINAL CHEMISTRY

Concomitant Lethal Mutagenesis of Human Immunodeficiency Virus Type 1

(2012) Michael J. Dapp et al.   JOURNAL OF MOLECULAR BIOLOGY

Viral Quasispecies Evolution

(2012) E. Domingo et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mutagenesis-Mediated Virus Extinction: Virus-Dependent Effect of Viral Load on Sensitivity to Lethal Defection

(2012) Héctor Moreno et al.   PLoS One

The impact of quasispecies dynamics on the use of therapeutics

(2012) Celia Perales et al.   TRENDS IN MICROBIOLOGY

Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model

(2012) Marco A. Goicochea et al.   VACCINE

Development of Peptide-Conjugated Morpholino Oligomers as Pan-Arenavirus Inhibitors

(2011) Benjamin W. Neuman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Junin virus RNA synthesis by an antiviral acridone derivative

(2011) Claudia S. Sepúlveda et al.   ANTIVIRAL RESEARCH

Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin

(2011) Andrey A. Kolokoltsov et al.   ARCHIVES OF VIROLOGY

Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses

(2011) Aarthi Narayanan et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Argentine hemorrhagic fever vaccines

(2011) Ana Ambrosio et al.   Human vaccines & immunotherapeutics

Ribavirin Can Be Mutagenic for Arenaviruses

(2011) H. Moreno et al.   JOURNAL OF VIROLOGY

Mutation of HIV-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside KP1461

(2011) James I. Mullins et al.   PLoS One

Accurate sampling and deep sequencing of the HIV-1 protease gene using a Primer ID

(2011) C. B. Jabara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tempo and mode of inhibitor-mutagen antiviral therapies: A multidisciplinary approach

(2011) J. Iranzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arbovirus high fidelity variant loses fitness in mosquitoes and mice

(2011) L. L. Coffey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242

(2011) Antonella Pasquato et al.   VIROLOGY

Selection of hepatitis C virus resistant to ribavirin

(2011) Dino A Feigelstock et al.   Virology Journal

Quasispecies as a matter of fact: Viruses and beyond

(2011) Samuel Ojosnegros et al.   VIRUS RESEARCH

Effective Oral Favipiravir (T-705) Therapy Initiated after the Onset of Clinical Disease in a Model of Arenavirus Hemorrhagic Fever

(2011) Michelle Mendenhall et al.   PLoS Neglected Tropical Diseases

Mutant spectra in virus behavior

(2010) Celia Perales et al.   Future Virology

Antiviral Activity of a Small-Molecule Inhibitor of Arenavirus Glycoprotein Processing by the Cellular Site 1 Protease

(2010) S. Urata et al.   JOURNAL OF VIROLOGY

Structure of Foot-and-Mouth Disease Virus Mutant Polymerases with Reduced Sensitivity to Ribavirin

(2010) C. Ferrer-Orta et al.   JOURNAL OF VIROLOGY

Novel approaches in anti-arenaviral drug development

(2010) Andrew M. Lee et al.   VIROLOGY

Optimal Drug Synergy in Antimicrobial Treatments

(2010) Joseph Peter Torella et al.   PLoS Computational Biology

A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

(2010) Rubén Agudo et al.   PLoS Pathogens

Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

(2010) Laura I. Levi et al.   PLoS Pathogens

An interfering activity against lymphocytic choriomeningitis virus replication associated with enhanced mutagenesis

(2009) V. Martin et al.   JOURNAL OF GENERAL VIROLOGY

5-Azacytidine Can Induce Lethal Mutagenesis in Human Immunodeficiency Virus Type 1

(2009) M. J. Dapp et al.   JOURNAL OF VIROLOGY

Counteracting Quasispecies Adaptability: Extinction of a Ribavirin-Resistant Virus Mutant by an Alternative Mutagenic Treatment

(2009) Celia Perales et al.   PLoS One

Potential Benefits of Sequential Inhibitor-Mutagen Treatments of RNA Virus Infections

(2009) Celia Perales et al.   PLoS Pathogens

Genetic Detection and Characterization of Lujo Virus, a New Hemorrhagic Fever–Associated Arenavirus from Southern Africa

(2009) Thomas Briese et al.   PLoS Pathogens

Stochastic extinction of viral infectivity through the action of defectors

(2008) J. Iranzo et al.   EPL

Therapeutically targeting RNA viruses via lethal mutagenesis

(2008) Jason D Graci et al.   Future Virology

Molecular Characterization of a Dual Inhibitory and Mutagenic Activity of 5-Fluorouridine Triphosphate on Viral RNA Synthesis. Implications for Lethal Mutagenesis

(2008) Rubén Agudo et al.   JOURNAL OF MOLECULAR BIOLOGY

Determinants of RNA-Dependent RNA Polymerase (In)fidelity Revealed by Kinetic Analysis of the Polymerase Encoded by a Foot-and-Mouth Disease Virus Mutant with Reduced Sensitivity to Ribavirin

(2008) A. Arias et al.   JOURNAL OF VIROLOGY

A New Arenavirus in a Cluster of Fatal Transplant-Associated Diseases

(2008) Gustavo Palacios et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of Late Stage Disease in a Model of Arenaviral Hemorrhagic Fever: T-705 Efficacy and Reduced Toxicity Suggests an Alternative to Ribavirin

(2008) Brian B. Gowen et al.   PLoS One