期刊
VIRUSES-BASEL
卷 4, 期 12, 页码 3494-3510出版社
MDPI AG
DOI: 10.3390/v4123494
关键词
PVM; inflammation; leukocytes; eosinophils; respiratory syncytial virus; RSV; TLR; IFN; heterologous immunity; MIP-1 alpha
类别
资金
- NIAID Division of Intramural Research [AI000943]
- Children's Miracle Network of NY
Pneumonia Virus of Mice (PVM) is related to the human and bovine respiratory syncytial virus (RSV) pathogens, and has been used to study respiratory virus replication and the ensuing inflammatory response as a component of a natural host-pathogen relationship. As such, PVM infection in mice reproduces many of the clinical and pathologic features of the more severe forms of RSV infection in human infants. Here we review some of the most recent findings on the basic biology of PVM infection and its use as a model of disease, most notably for explorations of virus infection and allergic airways disease, for vaccine evaluation, and for the development of immunomodulatory strategies for acute respiratory virus infection.
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