期刊
VIRUSES-BASEL
卷 3, 期 9, 页码 1610-1623出版社
MDPI AG
DOI: 10.3390/v3091610
关键词
coronaviruses; nidoviruses; double-membrane vesicles; MHV; SARS-coronavirus; autophagy; EDEMosomes; EDEM1; OS-9; ERAD; ER quality control
类别
资金
- Netherlands Organization for Health Research and Development [ZonMW-VIDI-917.76.329]
- Utrecht University
- Netherlands Organization for Scientific Research [700.59.003]
- Netherlands Organization for Scientific Research (NWO-ALW)
- Foundation for Research on Neurodegenerative Diseases
- Fondazione San Salvatore
- Swiss National Science Foundation
- Association Francaise contre les Myopathies
- Novartis Stiftung fur Medizinisch Biologische Forschung
- ONELIFE Advisors SA
Pathogens of bacterial and viral origin hijack pathways operating in eukaryotic cells in many ways in order to gain access into the host, to establish themselves and to eventually produce their progeny. The detailed molecular characterization of the subversion mechanisms devised by pathogens to infect host cells is crucial to generate targets for therapeutic intervention. Here we review recent data indicating that coronaviruses probably co-opt membranous carriers derived from the endoplasmic reticulum, which contain proteins that regulate disposal of misfolded polypeptides, for their replication. In addition, we also present models describing potential mechanisms that coronaviruses could employ for this hijacking.
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