Article
Medicine, Research & Experimental
Liwen Li, Fan Sun, Lei Han, Xujie Liu, Yadong Xiao, Alyssa D. Gregory, Steven D. Shapiro, Gutian Xiao, Zhaoxia Qu
Summary: The tumor suppressor gene PDLIM2 plays a crucial role in lung tumor suppression, regulated by the ROS/BACH1 pathway, affecting the polarization and differentiation of AMs to promote lung cancer.
Article
Virology
Hengbo Li, Feng Zou, Jie Zhang, Shengyu Zhu, Kaifei Chu, Xu Zhang, Tiejun Zhao
Summary: This study reveals the negative regulatory role of Yes-associated protein (YAP) in Tax activation of HTLV-1 transcription. YAP interacts with Tax and prevents the association between Tax and p300, resulting in the inhibition of HTLV-1 transcription. This finding is important for understanding the mechanisms underlying the persistent infection and latency of HTLV-1 in host cells.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Tiejun Zhao, Zhilong Wang, Jinyong Fang, Wenzhao Cheng, Yiling Zhang, Jinhua Huang, Lingling Xu, Hongwei Gou, Linghui Zeng, Zhigang Jin, Masao Matsuoka
Summary: In this study, it was found that YAP activation is associated with HTLV-1 infection in adult T-cell leukemia/lymphoma (ATL), and this activation is mediated by the NF-kappa B/p65 pathway. YAP activation plays a critical role in the pathogenesis of ATL, suggesting YAP as a potential therapeutic target for ATL treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Greta Forlani, Mariam Shallak, Roberto Sergio Accolla, Maria Grazia Romanelli
Summary: Cellular and animal models play important roles in studying HTLV-1-associated diseases; cell models can be used to study the mechanisms of HTLV proteins, while animal models can be used to recapitulate pathological processes and validate the effectiveness of treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Michi Miura, Tadasuke Naito, Mineki Saito
Summary: Human T-cell leukemia virus type 1 (HTLV-1) is a replication-competent human retrovirus that is associated with two types of diseases, adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although most infected individuals remain asymptomatic, a subpopulation develops these diseases. The complex virus-host interactions and the host immune response may regulate the development of HTLV-1-associated diseases.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Shinsuke Nakajima, Kazu Okuma
Summary: This article summarizes the characteristics and applications of animal models of adult T cell leukemia (ATL) caused by human T cell leukemia virus type 1 (HTLV-1) infection, including transgenic and immunodeficient mice. Mouse models play an important role in ATL research, helping to understand the pathogenesis of ATL and develop related treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Roberto S. Accolla
Summary: This review discusses the expression of HTLV-1 basic leucine-zipper factor HBZ during HTLV-1 infection, providing a deeper understanding of HTLV-1 infection and oncogenesis mechanisms, and suggesting new directions for further research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Asami Yamada, Jun-ichirou Yasunaga, Lihan Liang, Wenyi Zhang, Junya Sunagawa, Shinji Nakaoka, Shingo Iwami, Yasunori Kogure, Yuta Ito, Keisuke Kataoka, Masanori Nakagawa, Masako Iwanaga, Atae Utsunomiya, Ki-Ryang Koh, Toshiki Watanabe, Kisato Nosaka, Masao Matsuoka
Summary: This study demonstrates that profiling the humoral immunity to HTLV-1 antigens and measuring proviral load can be used to classify disease status and predict the development of HTLV-1-associated diseases. The study also highlights the importance of anti-Gag proteins in disease prognosis.
Article
Oncology
Miku Ishizawa, Undrakh Ganbaatar, Atsuhiko Hasegawa, Natsuko Takatsuka, Nobuyo Kondo, Takeru Yoneda, Kuniko Katagiri, Takao Masuda, Atae Utsunomiya, Mari Kannagi
Summary: Activation of Tax-specific CD8(+) CTL is a new therapeutic strategy for ATL caused by HTLV-1. Using HTLV-1-infected cells as a vaccine can activate Tax-specific CTL without HLA restriction. The study demonstrates that HTLV-1-infected T-cells can induce cross-presentation of Tax antigen in antigen presenting cells, leading to activation of Tax-specific CTL with potential therapeutic implications for ATL patients.
Article
Chemistry, Multidisciplinary
Zhu-Qi Huang, Wu Luo, Wei-Xin Li, Pan Chen, Zhe Wang, Rui-Jie Chen, Yi Wang, Wei-Jian Huang, Guang Liang
Summary: Costunolide (CTD) has anti-atherosclerotic effects by reducing inflammatory responses and oxLDL uptake, and its mechanism involves the inhibition of NF-kappa B signaling pathway through covalent binding to IKKβ.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Immunology
Kazumi Nakano, Toshiki Watanabe
Summary: HTLV-1 is an oncovirus that causes ATL and other inflammatory diseases. Most infected individuals maintain a latent state, which may be an intrinsic characteristic acquired during HTLV-1's evolution. We compared the pathological aspects of HTLV-1 and HIV-1 and investigated the importance of viral replication regulators in infected T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Kisato Nosaka, Masao Matsuoka
Summary: ATL is a lymphomatous neoplasm caused by HTLV-1 infection, with viral genes and alterations of the host genome playing important roles in leukemogenesis. Expression patterns of HBZ and Tax vary among ATL cases, leading to proposed subtypes. Host immune responses to Tax also contribute to the disease's heterogeneity.
Article
Biotechnology & Applied Microbiology
Xiaoming Jiang, Zhe Chu, Yang Cao, Ying Tang, Ying Shi, Xu Shi
Summary: Hepatocellular carcinoma (HCC) is a common and deadly malignancy worldwide. This study found that the downregulation of PDLIM2 in HCC is associated with poor prognosis, and overexpressed PDLIM2 can inhibit HCC cell proliferation, migration, invasion, and EMT by regulating beta-catenin, suggesting PDLIM2 as a promising therapeutic target for HCC.
CANCER GENE THERAPY
(2021)
Letter
Biochemistry & Molecular Biology
Adnan Erol
Summary: Oxidative stress plays a significant role in the development of obesity-related nephropathy (ORN). A causal relationship between IKK and ORN via CYLD-mediated inhibition of NRF2 has been identified. However, contradictory explanations regarding the mechanisms involved need clarification.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Eileen Dahlke, Toni Engmann, Yaman Anan, Robert Haesler, Giovanni Solinas, Franziska Theilig
Summary: Acute kidney injury (AKI) is a common renal injury with significant morbidity and mortality worldwide. This study investigated the role of NF-kappa B in AKI and found that its deletion improved renal function, reduced tissue damage and fibrosis, and enhanced vascularization, metabolism, reactive species disposal, and fine-tuned cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)