Article
Immunology
Sang-Uk Seo, Jae-Hyeon Jeong, Bum-Seo Baek, Je-Min Choi, Youn Soo Choi, Hyun-Jeong Ko, Mi-Na Kweon
Summary: The study demonstrated that BLM-mediated ALI in mice induced the release of double-stranded DNA, which potentiated IFN-I-dependent pulmonary viral resistance by activating the STING/TBK1/IRF3 pathway in association with pDCs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Nadine Szumilas, Odilia B. J. Corneth, Christian H. K. Lehmann, Heike Schmitt, Svenia Cunz, Jolie G. Cullen, Talyn Chu, Anita Marosan, Attila Mocsai, Vladimir Benes, Dietmar Zehn, Diana Dudziak, Rudi W. Hendriks, Lars Nitschke
Summary: Siglec-H regulates TLR-9-dependent inflammatory responses after virus infections, but not TLR-7 dependent responses. Lack of Siglec-H in pDCs leads to impaired Hck expression and downregulation of chemokine receptor CCR9, affecting pDC function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kerstin H. Mair, Maria Stadler, Mahsa Adib Razavi, Armin Saalmuller, Wilhelm Gerner
Summary: This study demonstrates the expression and function of NKp46 on porcine plasmacytoid dendritic cells (pDCs). It was found that the majority of porcine pDCs express NKp46 and have an active signaling pathway upon NKp46 triggering, leading to cytokine production. However, unlike NK cells, NKp46 on porcine pDCs does not seem to be involved in cytotoxicity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Tae Jin Yun, Suzu Igarashi, Haoquan Zhao, Oriana A. Perez, Marcus R. Pereira, Emmanuel Zorn, Yufeng Shen, Felicia Goodrum, Adeeb Rahman, Peter A. Sims, Donna L. Farber, Boris Reizis
Summary: Plasmacytoid dendritic cells (pDCs) can recognize live infected cells and produce a unique antiviral immune response, including high amounts of interferons, prolonged and efficient responses to CMV-infected cells, and activation of natural killer cells. Patients with CMV viremia show activated pDCs and increased circulating IFN-I and IFN-III.
SCIENCE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Juliette Leon, Daniel A. Michelson, Judith Olejnik, Kaitavjeet Chowdhary, Hyung Suk Oh, Adam J. Hume, Silvia Galvan-Pena, Yangyang Zhu, Felicia Chen, Brinda Vijaykumar, Liang Yang, Elena Crestani, Lael M. Yonker, David M. Knipe, Elke Muhlberger, Christophe Benoist
Summary: Through in vitro co-culture modeling, the study found that the interaction between infected epithelial cells and immunocytes in SARS-CoV-2 infection leads to immune dysregulation, which may be the root cause of the inflammatory malfunction in COVID-19.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Virology
Yinuo Gu, Xu Zuo, Siyu Zhang, Zhuoer Ouyang, Shengyu Jiang, Fang Wang, Guoqiang Wang
Summary: Influenza viruses pose a serious threat to human health, and severe cases can lead to cytokine storms which exacerbate immune pathology. Factors such as sex, age, and obesity can contribute to differences in cytokine storms induced by the influenza virus.
Article
Immunology
Seung-Ji Kang, Ki-Jeong Park, Hye-Mi Jin, Young-Nan Cho, Tae Hoon Oh, Seong Eun Kim, Uh Jin Kim, Kyung-Hwa Park, Sook-In Jung, Tae-Ok Kim, Hyo Shin Kim, Young-Goun Jo, Jae Kyun Ju, Seung-Jung Kee, Yong-Wook Park
Summary: This study reveals that circulating pDCs and cDCs are numerically deficient and functionally impaired in scrub typhus patients. Changes in the expression levels of surface phenotypes of pDCs and cDCs may be influenced by pro-inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yingxue Wang, Parul Sharma, Matthew Jefferson, Weijiao Zhang, Ben Bone, Anja Kipar, David Bitto, Janine L. Coombes, Timothy Pearson, Angela Man, Alex Zhekova, Yongping Bao, Ralph A. Tripp, Simon R. Carding, Yohei Yamauchi, Ulrike Mayer, Penny P. Powell, James P. Stewart, Thomas Wileman
Summary: The study demonstrates that non-canonical autophagy in airway epithelial cells is a novel innate defense mechanism that restricts influenza virus infection and reduces lethal inflammation.
Article
Multidisciplinary Sciences
Meiling Zheng, Zhi Hu, Xiaole Mei, Lianlian Ouyang, Yang Song, Wenhui Zhou, Yi Kong, Ruifang Wu, Shijia Rao, Hai Long, Wei Shi, Hui Jing, Shuang Lu, Haijing Wu, Sujie Jia, Qianjin Lu, Ming Zhao
Summary: This study compares the differences between cutaneous lesions from DLE and SLE patients and healthy controls using single-cell RNA sequencing data. The findings reveal differential immune cell recruitment, cell type, and gene expression, highlighting potential therapeutic targets for lupus erythematosus.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yeong-Bin Baek, Hyung-Jun Kwon, Muhammad Sharif, Jeongah Lim, In-Chul Lee, Young Bae Ryu, Jae-In Lee, Ji-Sun Kim, Young-Seung Lee, Dong-Hoon Kim, Sang-Ik Park, Don-Kyu Kim, Jeong-Sun Kim, Hyon E. Choy, Sunwoo Lee, Hueng-Sik Choi, Timothy F. Osborne, Tae-Il Jeon, Kyoung-Oh Cho
Summary: The activation of LD-associated lipase is linked to the breakdown of LDs during the late stage of RNA viral infections, providing a potential anti-viral target. Inhibiting LD-associated lipases can suppress viral replication and mitigate lung lesions caused by SARS-CoV-2 and IAV infections. Furthermore, lipase inhibitors can reduce proinflammatory cytokine levels, which are important for the severe infection or mortality in COVID-19 and IAV patients.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Immunology
Matthew J. Wiest, Laurie Baert, Chao Gu, Kevin M. Gayler, Hyoungjun Ham, Laurent Gorvel, Mira T. Keddis, Leroy W. Griffing, Hyemee Joo, Jean-Pierre Gorvel, Daniel D. Billadeau, Robert R. Kane, Sangkon Oh
Summary: This study investigated the mechanisms of cytokine expression mediated by TLR7 in pDCs and found that specific intracellular trafficking pathways can regulate the production of IFN alpha and TNF alpha by pDCs. This has important implications for understanding the pathogenesis of autoimmune diseases and developing potential therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Binhui Zhou, Toby Lawrence, Yinming Liang
Summary: Plasmacytoid dendritic cells (pDCs) are a special subtype of dendritic cells that produce massive amounts of type I interferon (IFN-I) and play a pivotal role in antiviral immunity. However, in many types of cancer, tumor-infiltrating pDCs do not respond to Toll-like receptor (TLR) stimulation, leading to reduced IFN-alpha production and promoting tumor growth.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rebeca Arroyo Hornero, Juliana Idoyaga
Summary: Since their discovery, the identity and classification of plasmacytoid dendritic cells (pDCs) have been a subject of debate in the field. pDCs are distinct from other dendritic cell family members and may have dual origin from myeloid and lymphoid progenitors. They have the unique ability to quickly secrete abundant levels of type I interferon in response to viral infections and can activate T cells independently. This article provides an overview of the historic and current understanding of pDCs and argues for their inclusion within the dendritic cell network due to their role in linking innate and adaptive immune responses.
MOLECULAR IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaopeng Wan, Jiqing Li, Yupeng Wang, Xiaofei Yu, Xijun He, Jianzhong Shi, Guohua Deng, Xianying Zeng, Guobin Tian, Yanbing Li, Yongping Jiang, Yuntao Guan, Chengjun Li, Feng Shao, Hualan Chen
Summary: This study found that the H7N9 virus can replicate efficiently in mouse lungs and activate gasdermin E (GSDME)-mediated pyroptosis, leading to a cytokine storm. Knockout of the Gsdme gene changed the death pathway of alveolar epithelial cells from pyroptosis to apoptosis, and Gsdme knockout mice survived lethal H7N9 virus infection. These findings reveal the key and unique mechanism of GSDME activation in the pulmonary cytokine storm and lethal outcome of H7N9 virus infection, providing a new avenue for the development of antivirals.
NATIONAL SCIENCE REVIEW
(2022)
Review
Oncology
Xavier Roussel, Francine Garnache Ottou, Florian Renosi
Summary: Plasmacytoid dendritic cells (pDC) are the main type I interferon-producing cells in humans and are capable of regulating innate and adaptive immune responses. Tumor infiltration by pDC is well-documented in various cancers and is associated with unfavorable clinical outcomes. While Blastic Plasmacytoid Dendritic Cells Neoplasm (BPDCN) is a well-described aggressive leukemia derived from pDCs, the understanding of tumor infiltration by mature pDCs in Myeloid Neoplasms (MN) is limited. This review aims to provide a comprehensive overview of pDC biology in MN, emphasizing the need for further research into pDC oncogenesis and immune responses for better therapeutic strategies.
Review
Pharmacology & Pharmacy
Virgil Schijns, Dragomira Majhen, Peter van der Ley, Aneesh Thakur, Artur Summerfield, Rita Berisio, Cristina Nativi, Alberto Fernandez-Tejada, Carmen Alvarez-Dominguez, Sveinbjorn Gizurarson, Alla Zamyatina, Antonio Molinaro, Camillo Rosano, Ziga Jakopin, Ihsan Gursel, Siobhan McClean
Summary: Vaccines are crucial in preventing infections and improving mortality rates worldwide, and rational design of vaccines can enhance their efficacy. Understanding immune correlates of protection is key in selecting the best vaccine antigens and adjuvants for optimal immune responses. Harnessing this knowledge is imperative in preventing future life-threatening diseases.
Review
Agriculture, Dairy & Animal Science
Francois Meurens, Charlotte Dunoyer, Christine Fourichon, Volker Gerdts, Nadia Haddad, Jeroen Kortekaas, Marta Lewandowska, Elodie Monchatre-Leroy, Artur Summerfield, Paul J. Wichgers Schreur, Wim H. M. van der Poel, Jianzhong Zhu
Summary: The human-animal interface plays a crucial role in the emergence of zoonotic diseases, especially in the context of globalization, habitat destruction, and climate change. Understanding the specific drivers and mechanisms is essential for preparedness against future disease outbreaks.
Article
Microbiology
Melanie Brugger, Thomas Demoulins, G. Tuba Barut, Beatrice Zumkehr, Blandina I. Oliveira Esteves, Kemal Mehinagic, Quentin Haas, Aline Schogler, Marie-Anne Rameix-Welti, Jean-Francois Eleouet, Ueli Moehrlen, Thomas M. Marti, Ralph A. Schmid, Artur Summerfield, Horst Posthaus, Nicolas Ruggli, Sean R. R. Hall, Marco P. Alves
Summary: The research highlights the critical role of lung-resident MSCs in virus-induced acute lung injury, showing their involvement in immune response, repair mechanisms, and expansion of the pulmonary MSC pool following infection. These findings contribute to a better understanding of host response and lung repair mechanisms, with potential therapeutic implications.
Article
Multidisciplinary Sciences
Lorenz Ulrich, Nico Joel Halwe, Adriano Taddeo, Nadine Ebert, Jacob Schoen, Christelle Devisme, Bettina Salome Trueb, Bernd Hoffmann, Manon Wider, Xiaoyu Fan, Meriem Bekliz, Manel Essaidi-Laziosi, Marie Luisa Schmidt, Daniela Niemeyer, Victor Max Corman, Anna Kraft, Aurelie Godel, Laura Laloli, Jenna N. Kelly, Brenda M. Calderon, Angele Breithaupt, Claudia Wylezich, Ines Berenguer Veiga, Mitra Gultom, Sarah Osman, Bin Zhou, Kenneth Adea, Benjamin Meyer, Christiane S. Eberhardt, Lisa Thomann, Monika Gsell, Fabien Labroussaa, Joerg Jores, Artur Summerfield, Christian Drosten, Isabella Anne Eckerle, David E. Wentworth, Ronald Dijkman, Donata Hoffmann, Volker Thiel, Martin Beer, Charaf Benarafa
Summary: Experimental assessments of major VOCs show that Alpha and Beta variants have a higher affinity for the human ACE2 receptor compared to the progenitor variant. Competition experiments demonstrate that Alpha has a clear fitness advantage over wt-S-614G in ferrets and mouse models.
Article
Immunology
Roger-Junior Eloiflin, Gael Auray, Sylvie Python, Valerie Rodrigues, Martial Seveno, Serge Urbach, Khadija El Koulali, Philippe Holzmuller, Philippe Totte, Genevieve Libeau, Arnaud Bataille, Artur Summerfield
Summary: Small ruminants' disease Peste des petits ruminants (PPR) is caused by PPR virus (PPRV) and can affect sheep and goats differently based on the strain's virulence. Regardless of the strain's virulence, all PPRV strains trigger a classical antiviral response in the host. High virulence strains induce stronger inflammatory responses and activate more genes related to lymphocyte migration and recruitment, and inflammatory processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Loic Vivien Bocard, Andrew Robert Kick, Corinne Hug, Heidi Erika Lisa Lischer, Tobias Kaser, Artur Summerfield
Summary: This study aimed to understand the nature of innate and adaptive immune responses to PRRSV, revealing differences in regulation by PRRSV-2 strains and MLV. Different PRRSV strains induced varied immune responses, impacting platelet activation, dendritic cell activity, interferon type I, and plasma cell responses. Correlations of BTMs with T-cell responses showed both positive and negative associations post-infection, indicating complexities in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
S. Ruefenacht, S. Schellenberg, S. Borio, A. Summerfield, M. E. Ricklin
Summary: This study found that using oral prednisolone as a monotherapy for four weeks can effectively treat aural hematoma in dogs. The treatment led to at least 80% clinical improvement in most dogs and reduced the ear thickness by at least 50%.
SCHWEIZER ARCHIV FUR TIERHEILKUNDE
(2022)
Article
Immunology
Stephanie C. Talker, G. Tuba Barut, Heidi E. L. Lischer, Reto Rufener, Lilly von Munchow, Remy Bruggmann, Artur Summerfield
Summary: This study investigates the transcriptome profiles and functions of bovine monocytes. The findings reveal three subtypes of monocytes in bovine, each with distinct functional roles. Classical monocytes are involved in pro-inflammatory and antibacterial responses, while nonclassical and intermediate monocytes are specialized in regulatory/anti-inflammatory functions, tissue repair, antiviral responses, and T-cell immunomodulation. Furthermore, heterogeneity within classical monocytes is discovered, and intermediate monocytes are proposed as a transient differentiation stage between classical and nonclassical monocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Emilia Radulovic, Kemal Mehinagic, Tsering Wuethrich, Markus Hilty, Horst Posthaus, Artur Summerfield, Nicolas Ruggli, Charaf Benarafa
Summary: In this study, the immunological profile of specific pathogen-free (SPF) and farm-raised Large White domestic pigs before and after African Swine Fever virus (ASFV) infection was compared. The results showed that SPF pigs had lower immune cell counts and basal inflammatory responses at steady state. When infected with a highly virulent virus strain, SPF pigs showed earlier and more severe clinical signs and pro-inflammatory cytokines, indicating a reduced ability to control early virus replication. In contrast, SPF pigs presented a milder and shorter disease course with full recovery when infected with an attenuated virus strain.
Article
Veterinary Sciences
Artur Summerfield, Heidi Gerber, Rebeka Schmitt, Matthias Liniger, Santina Grazioli, Emiliana Brocchi
Summary: This study demonstrates that monoclonal antibodies targeting FMDV O and A serotypes are able to opsonize the virus and induce cell death. Opsonization shows broader reactivity within the serotype and correlates better with vaccine dose compared to neutralization. Neutralization and opsonization titers are similarly predictive of protection.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Gueliz Tuba Barut, Marco Kreuzer, Remy Bruggmann, Artur Summerfield, Stephanie C. Talker
Summary: Dendritic and monocytic cells work together to initiate and shape adaptive immune responses in secondary lymphoid tissue. By sequencing mononuclear phagocytes at the single-cell level in mesenteric lymph nodes of cows, researchers identified distinct clusters of dendritic cells and monocytes/macrophages with different transcriptomic profiles. They also discovered subsets of highly activated migratory dendritic cells and potential differentiation paths for certain cell types. Additionally, they found sub-clusters of monocytes and macrophages driven by pro- or anti-inflammatory gene expression signatures. This study provides valuable insight into the functional properties and differentiation trajectories of mononuclear phagocytes in the immune system.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yulia Postnikova, Anastasia Treshchalina, Alexandra Gambaryan, Alla Belyakova, Aydar Ishmukhametov, Mikhail Matrosovich, Galina Sadykova, Alexey Prilipov, Natalia Lomakina, Elizaveta Boravleva
Summary: This study isolated 45 strains of AIVs from wild aquatic birds in Moscow, Russia, and examined their genetic dynamics in their natural habitat. The genes of the same lineage persisted over the years, but were often associated with novel HA and NA subtypes. Reassortment events were frequent among internal genes, but not between HA and NA segments. The study discusses the differences in persistence and evolutionary strategy between surface and internal proteins of AIVs in their primary hosts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Patrick Thalmann, Simone Ehrhard, Artur Summerfield, Meret Elisabeth Ricklin
Summary: This retrospective study described patients presenting to the emergency department of a large university hospital in Switzerland with complaints of tick bite. The study found that although tick bites were not frequently seen in the emergency department, there were many patients with neurological symptoms following tick bites, indicating the need for a systematic assessment of vaccination status, virus serology, and further diagnostic evaluations.
INFECTIOUS DISEASE REPORTS
(2023)
Article
Veterinary Sciences
Roger-Junior Eloiflin, Llorenc Grau-Roma, Sylvie Python, Kemal Mehinagic, Aurelie Godel, Genevieve Libeau, Artur Summerfield, Arnaud Bataille, Obdulio Garcia-Nicolas
Summary: This study confirmed the difference in virulence between Peste des petits ruminants (PPR) virus strains and found that viral RNA can be detected in the tissues and serum samples of vaccinated animals.
VETERINARY RESEARCH
(2022)
Review
Veterinary Sciences
Dominiek Maes, Filip Boyen, Bert Devriendt, Peter Kuhnert, Artur Summerfield, Freddy Haesebrouck
Summary: Mycoplasma hyopneumoniae is a major pathogen involved in the porcine respiratory disease complex, causing one of the most important diseases in pigs worldwide. Current commercial vaccines provide only partial protection, do not prevent infection, and have limited effect on transmission. There is a need for the development of more effective vaccines to control M. hyopneumoniae infections in the future.
VETERINARY RESEARCH
(2021)