期刊
VIRUSES-BASEL
卷 2, 期 4, 页码 972-986出版社
MDPI
DOI: 10.3390/v2040972
关键词
phospholipids; transmembrane proteins; virus entry; endocytosis; virus assembly; exocytosis
类别
资金
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Poxviruses replicate in the cytoplasm, where they acquire multiple lipoprotein membranes. Although a proposal that the initial membrane arises de novo has not been substantiated, there is no accepted explanation for its formation from cellular membranes. A subsequent membrane-wrapping step involving modified trans-Golgi or endosomal cisternae results in a particle with three membranes. These wrapped virions traverse the cytoplasm on microtubules; the outermost membrane is lost during exocytosis, the middle one is lost just prior to cell entry, and the remaining membrane fuses with the cell to allow the virus core to enter the cytoplasm and initiate a new infection.
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