期刊
VIRUSES-BASEL
卷 2, 期 11, 页码 2436-2442出版社
MDPI
DOI: 10.3390/v2112436
关键词
virus replication; membrane remodeling; host factor; poliovirus; Arf1
类别
资金
- NIH-NIAID
Positive-stranded RNA (+RNA) viruses exploit host cell machinery by subverting host proteins and membranes and altering cellular pathways during infection. To achieve robust replication, some +RNA viruses, such as poliovirus (PV), build special intracellular compartments, called viral replication organelles. A recent work from the Altan-Bonnett laboratory [1] gave new insights into the formation of poliovirus replication organelles, which are unique subcellular structures containing many individual replication complexes as a result of dynamic cellular membrane remodeling.
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