Article
Microbiology
Katherine I. Young, Federico Valdez, Christina Vaquera, Carlos Campos, Lawrence Zhou, Helen K. Vessels, J. Kevin Moulton, Barbara S. Drolet, Paula Rozo-Lopez, Angela M. Pelzel-McCluskey, Debra C. Peters, Luis L. Rodriguez, Kathryn A. Hanley
Summary: VSV periodically crosses the border from southern Mexico to cause outbreaks in the US, with black flies along the Rio Grande in New Mexico being identified as vectors carrying the virus. The study found a correlation between precipitation, temperature, vegetation, and black fly abundance, contributing to a better understanding of VSV transmission.
Article
Multidisciplinary Sciences
Jingyuan Cong, Xiaoying Feng, Huiling Kang, Wangjun Fu, Lei Wang, Chenlong Wang, Xuemei Li, Yutao Chen, Zihe Rao
Summary: This study investigates the structure-function relationship of the L-P complex of Newcastle disease virus (NDV) using cryo-EM and enzymatic assays. The research reveals distinct conformations and interactions between L and P proteins, advancing our understanding of Paramyxoviridae RNA synthesis and providing potential therapeutic targets.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Delphine C. Malherbe, Drishya Kurup, Christoph Wirblich, Adam J. Ronk, Chad Mire, Natalia Kuzmina, Noor Shaik, Sivakumar Periasamy, Matthew A. Hyde, Julie M. Williams, Pei-Yong Shi, Matthias J. Schnell, Alexander Bukreyev
Summary: The study developed a SARS-CoV-2 ConVac vaccine which, through animal experiments, showed that a single dose of the vaccine could rapidly control viral replication after disease challenge, protecting animals from weight loss and lung virus replication, with some inflammation still detected.
Article
Multidisciplinary Sciences
Stefania Dispinseri, Massimiliano Secchi, Maria Franca Pirillo, Monica Tolazzi, Martina Borghi, Cristina Brigatti, Maria Laura De Angelis, Marco Baratella, Elena Bazzigaluppi, Giulietta Venturi, Francesca Sironi, Andrea Canitano, Ilaria Marzinotto, Cristina Tresoldi, Fabio Ciceri, Lorenzo Piemonti, Donatella Negri, Andrea Cara, Vito Lampasona, Gabriella Scarlatti
Summary: The study reveals that antibody responses to SARS-CoV-2 spike protein play a significant role in neutralization and protection against severe COVID-19, unaffected by heterologous boosting or common cold immunity, and can last for up to 8 months.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Daisy A. Hoagland, Rasmus Moller, Skyler A. Uhl, Kohei Oishi, Justin Frere, Ilona Golynker, Shu Horiuchi, Maryline Panis, Daniel Blanco-Melo, David Sachs, Knarik Arkun, Jean K. Lim, Benjamin R. tenOever
Summary: This study investigated the systemic response to SARS-CoV-2 infection in hamsters and found that inflammation was present in all tissues but not enough to prevent disease progression. Bolstering the antiviral response with intranasal administration of recombinant IFN-I reduced viral disease, prevented transmission, and lowered inflammation in vivo. This suggests that intranasal IFN-I could be an effective early treatment for SARS-CoV-2 infection.
Article
Veterinary Sciences
Jung-Eun Park, Hyun-Jin Shin
Summary: Rabies is a viral disease with severe neurological manifestations, and the new VSV/RABV-GP vaccine could be a promising platform for vaccination. Studies show that it induces immune responses and produces high titers of antibodies.
VETERINARY QUARTERLY
(2021)
Article
Multidisciplinary Sciences
Annette Runge, Melissa Mayr, Theresa Schwaiger, Susanne Sprung, Paolo Chetta, Timo Gottfried, Jozsef Dudas, Maria C. Greier, Marlies C. Glatz, Johannes Haybaeck, Knut Elbers, Herbert Riechelmann, Patrik Erlmann, Monika Petersson
Summary: The etiology and architecture of head and neck cancer are diverse and complex, making it difficult to predict patient responses to specific cancer immunotherapy or combination treatment. To bridge this gap, researchers have developed a patient-derived HNSCC (head and neck squamous cell carcinoma) slice culturing system. This system preserves the heterogeneous contexture of the human tumor ecosystem and functional immune cell compartment, allowing for assessment of immunomodulatory effects and oncolytic virus action.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Wenzheng Han, Qing Chen, Jun Cui, Yinxia Zhao, Min Li, Xiaoning Li
Summary: The study found that human RNF114 promotes VSV replication by inhibiting the type I interferon signaling pathway and demonstrated its negative regulatory role in vivo.
MICROBIAL PATHOGENESIS
(2022)
Article
Virology
Katherine E. Havranek, Judith Mary Reyes Ballista, Kelly Marie Hines, Melinda Ann Brindley
Summary: The viral lifecycle is highly dependent on host lipids, which are important for viral entry, replication, and egress. This study used an untargeted lipidomics approach to analyze changes in host lipid species during vesicular stomatitis virus (VSV) infection. The results revealed significant alterations in glycerophospholipids and sphingolipids, suggesting that these changes impact the properties of host membranes and are hijacked by the virus for replication.
Article
Multidisciplinary Sciences
Stephanie L. Foster, Courtney Woolsey, Viktoriya Borisevich, Krystle N. Agans, Abhishek N. Prasad, Daniel J. Deer, Joan B. Geisbert, Natalie S. Dobias, Karla A. Fenton, Robert W. Cross, Thomas W. Geisbert
Summary: Nipah virus is an emerging highly lethal zoonotic disease that can be transmitted via respiratory droplets. A study has shown that a recombinant vesicular stomatitis virus-based vaccine can rapidly protect monkeys from lethal Nipah virus infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Wenjun Zhu, Guodong Liu, Wenguang Cao, Shihua He, Anders Leung, Ute Stroher, Michael J. Fairchild, Rick Nichols, Joseph Crowell, Joan Fusco, Logan Banadyga
Summary: This study confirms the protective efficacy of a cloned rVSV candidate vaccine against MARV and highlights the potential predictive value of the guinea pig model in evaluating MARV countermeasures.
Article
Oncology
Jingshu Xiao, Jiaming Liang, Junjie Fan, Panpan Hou, Xiaodong Li, Haipeng Zhang, Kai Li, Lang Bu, Ping Li, Miao He, Yongheng Zhong, Liping Guo, Penghui Jia, Qiaoqiao Xiao, Junyu Wu, Hong Peng, Chunmei Li, Fan Xing, Deyin Guo
Summary: This study presents a promising strategy for the treatment of aggressive glioblastoma (GBM) by combining CDK4/6 inhibitors with oncolytic viruses (OV). CDK4/6 inhibition enhances the efficacy of OV by promoting autophagic degradation of MAVS, impairing antiviral responses, and amplifying oncolysis. Furthermore, CDK4/6 inhibitors and OV synergistically induce immuno-genic cell death and boost antitumor immunity, inhibiting tumor growth and prolonging survival in GBM models.
Review
Immunology
Yuguo Zhang, Bolni Marius Nagalo
Summary: This article explores the use of vesicular stomatitis virus (VSV) as an immunovirotherapy in human cancers and discusses future perspectives and research areas to improve VSV-based oncotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Yukari Itakura, Koshiro Tabata, Takeshi Saito, Kittiya Intaruck, Nijiho Kawaguchi, Mai Kishimoto, Shiho Torii, Shintaro Kobayashi, Naoto Ito, Michiko Harada, Satoshi Inoue, Ken Maeda, Ayato Takada, William W. Hall, Yasuko Orba, Hirofumi Sawa, Michihito Sasaki
Summary: The interaction between the structural protein of the Ebola virus and the host TSG101 protein plays a significant role in the replication and spread of the virus.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xing Liu, Fang Li, Jiwen Zhang, Lulu Wang, Jinliang Wang, Zhiyuan Wen, Zilong Wang, Lei Shuai, Xijun Wang, Jinying Ge, Dongming Zhao, Zhigao Bu
Summary: The study demonstrates that ATP6V1A interacts with RABV M protein to promote virus replication and is involved in viral uncoating process through specific residue interactions. Upregulation of ATP6V1A enhances RABV growth in cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Shuyun Qin, Dmitriy Volokhov, Elvira Rodionova, Christoph Wirblich, Matthias J. Schnell, Vladimir Chizhikov, Alena Dabrazhynetskaya
Editorial Material
Immunology
Emma Taylor, Ashley C. Banyard, Herve Bourhy, Florence Cliquet, Hildegund Ertl, Christine Fehlner-Gardiner, Daniel L. Horton, Reeta S. Mani, Thomas Mueller, Charles E. Rupprecht, Matthias J. Schnell, Victor Del Rio Vilas, Anthony R. Fooks
Article
Immunology
Rohan Keshwara, Thomas Shiels, Elena Postnikova, Drishya Kurup, Christoph Wirblich, Reed F. Johnson, Matthias J. Schnell
Correction
Immunology
Rohan Keshwara, Thomas Shiels, Elena Postnikova, Drishya Kurup, Christoph Wirblich, Reed F. Johnson, Matthias J. Schnell
Article
Surgery
Gwenyth L. Day, Michelle L. Bryan, Scott A. Northrup, Douglas S. Lyles, Marlena M. Westcott, John H. Stewart
JOURNAL OF SURGICAL RESEARCH
(2020)
Article
Virology
Venice Du Pont, Christoph Wirblich, Jeong-Joong Yoon, Robert M. Cox, Matthias J. Schnell, Richard K. Plemper
JOURNAL OF VIROLOGY
(2020)
Article
Oncology
Robert S. Bayne, Shelby Puckett, Lindsey Ulkus Rodrigues, Scott D. Cramer, Jingyun Lee, Cristina M. Furdui, Jeff W. Chou, Lance D. Miller, David A. Ornelles, Douglas S. Lyles
MOLECULAR THERAPY-ONCOLYTICS
(2020)
Article
Immunology
Drishya Kurup, Christoph Wirblich, Holly Ramage, Matthias J. Schnell
Article
Virology
Nisha Asok Kumar, Sreenath Muraleedharan Suma, Umerali Kunnakkadan, Joydeep Nag, Reshma Koolaparambil Mukesh, Douglas S. Lyles, John Bernet Johnson
Summary: This study found that VSV infection resulted in down-regulation of CD46 protein, but not CD55, and the mRNA of RCAs was significantly down-regulated by VSV, but with a delay in the case of CD55. Immunoblot analysis showed an equal distribution ratio of CD55 and CD46 relative to viral proteins in the progeny virion harvested at specific time intervals.
Article
Microbiology
Drishya Kurup, Delphine C. Malherbe, Christoph Wirblich, Rachael Lambert, Adam J. Ronk, Leila Zabihi Diba, Alexander Bukreyev, Matthias J. Schnell
Summary: The study developed an inactivated rabies virus vectored vaccine platform, resulting in a vaccine against SARS-CoV-2 named CORAVAX. CORAVAX demonstrated effectiveness in preventing viral replication and lung disease in hamster models, showing potential for robust immune responses in humans.
Article
Immunology
Drishya Kurup, Christoph Wirblich, Rachael Lambert, Leila Zabihi Diba, Benjamin E. Leiby, Matthias J. Schnell
Summary: The study showed that a measles vaccine expressing both ZIKV-E and -NS1 provided complete clearance of the virus and full protection for fetuses in a lethal Zika challenge model. NS1 antibodies were found to enhance the protective effects of ZIKV-E antibodies in the female reproductive tract.
Article
Virology
Steven J. Moran, Shelby Puckett, David A. Ornelles, Jed C. Macosko, George Holzwarth, Douglas S. Lyles
Summary: A recent study using pattern recognition and machine learning analyzed the movement of single viral ribonucleoprotein particles in living cells and provided a quantitative molecular explanation for active diffusion. The study found that these particles are temporarily confined to traps or pores formed by cytoskeletal elements, and active diffusion occurs when they escape from one trap to another. This research has important implications for understanding the motion of other viral and cellular elements.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Catherine Yankowski, Christoph Wirblich, Drishya Kurup, Matthias J. Schnell
Summary: The objective of this study is to analyze the effectiveness of the recombinant rabies virus-vectored SARS-CoV-2 vaccine, CORAVAX, as a COVID-19 vaccine strategy. The study found that CORAVAX is immunogenic and protective against SARS-CoV-2, and it addresses the issue of waning immunity seen in other COVID-19 vaccines. By selecting the right adjuvants and tackling pre-existing rabies-vector immunity, CORAVAX has shown long-term potential as a COVID-19 vaccine.
Article
Immunology
Catherine Yankowski, Drishya Kurup, Christoph Wirblich, Matthias J. Schnell
Summary: Ebola virus is a major cause of severe hemorrhagic fever with a high mortality rate. An Ebola virus glycoprotein expressing inactivated bivalent filovirus/rabies virus vaccine called FILORAB1 has shown immunogenicity and protection against Ebola virus in mice and non-human primates, especially when formulated with toll-like receptor 4 agonist GLA and squalene oil-in-water emulsion. The immune response to FILORAB1 is long-lasting and characterized by maintained serum antibody titers and long-lived cells in the spleen and bone marrow.
Article
Immunology
Gabrielle Scher, Dennis A. Bente, Megan C. Mears, Maria N. B. Cajimat, Matthias J. Schnell
Summary: Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic disease in humans. Recent research has shown that a monoclonal antibody against the GP38 glycoprotein can protect mice from lethal CCHFV infection. In this study, three inactivated rhabdoviral-based CCHFV-M vaccines were tested, and only the vaccines containing GP38 provided protection against CCHFV challenge in mice.