期刊
ZOONOSES AND PUBLIC HEALTH
卷 57, 期 6, 页码 423-428出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1863-2378.2009.01242.x
关键词
Salmonella Typhimurium; in vivo trial; pig; tannins
资金
- Institute for the Promotion of Innovation by Science and Technology in Flanders (IWT Vlaanderen), Brussels, Belgium [040791]
- Sanluc International nv/Global Nutrition sa, Oosterzele, Belgium
- Research Foundation-Flanders (FWO)
- University of Ghent, Belgium
P>The aim of this study was to determine whether a hydrolysable tannin extract of sweet chestnut wood (Globatan (R)) has an inhibitory effect on Salmonella Typhimurium survival both in vitro and in vivo in pigs. In a first experiment, the minimal inhibitory concentration of Globatan (R) on 57 Salmonella Typhimurium isolates was determined. For all isolates, an MIC of 160-320 mu g/ml was found. The second in vitro study revealed that Salmonella growth was strongly reduced using Globatan (R) concentrations of 25-50 mu g/ml and nearly completely inhibited at a concentration of 100 mu g/ml Globatan (R). In an in vivo trial, two groups of six piglets, each group receiving feed with or without the addition of Globatan (R) (3 g/kg), were orally inoculated with 107 colony forming units of a Salmonella Typhimurium strain. Globatan (R) had no effect on faecal excretion of Salmonella, and no differences in colonization of the intestines and internal organs were demonstrated in pigs euthanized at 4 days post-inoculation. In conclusion, the hydrolysable tannin extract used in this study showed strong action against Salmonella Typhimurium in vitro but not in vivo.
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