Copper-catalyzed Synthesis and Antimicrobial Activity of Disubstituted 1,2,3-Triazoles Starting from 1-Propargyluracils and Ethyl (4-Azido-1,2,3-trihydroxybutyl)furan-3-carboxylate

1,3-Dipolar cycloaddition reactions of 1-propargyluracils 2a-h with the azido derivative 3 afforded the corresponding 1,2,3-triazoles 4a-h. Hydrazinolysis of the esters 4a-h gave the corresponding acid hydrazides 5a-h. Reaction of 5a-h with carbon disulfide in ethanol afforded 6a-h. The antimicrobial activity of compounds 4-6 was determined.