Article
Multidisciplinary Sciences
Beibei Qi, Liangbo Li, Rongshao Huang
Summary: The genus Stephania is a rich source of alkaloids and has been traditionally used in China for treating various ailments. However, there is limited understanding of the variation within the genus, which hinders its optimal utilization. This study evaluated the variation in alkaloid content in four commonly cultivated Stephania species in China. The results revealed significant variations in alkaloid abundance among the species, with the genotypes SY-xueteng and SY-hongteng showing relatively high alkaloid abundance. This study provides a foundation for the further utilization of ideal Stephania genotypes by clarifying alkaloid content variations within the genus.
Article
Chemistry, Physical
Pingping Lu, Shuai He, Yue Zhou, Yongmin Zhang
Summary: This study synthesized a series of formyl-containing cationic surfactants with dynamic imine bonds and investigated their adsorption, micellization, and antimicrobial activity. Results showed that inserting specific groups can enhance hydrophobic interaction, making the surfactants more favorable for micelle formation and adsorption film.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Plant Sciences
Aswad Khadilkar, Zoie L. Bunch, Jessica Wagoner, Vandana Ravindran, Jessica M. Oda, Warren S. Vidar, Trevor N. Clark, Preston K. Manwill, Daniel A. Todd, Sarah A. Barr, Lauren K. Olinger, Susan L. Fink, Wendy K. Strangman, Roger G. Linington, John B. MacMillan, Nadja B. Cech, Stephen J. Polyak
Summary: Research finds that botanical natural products show potential usefulness against COVID-19. Six botanical species and 173 isolated natural product compounds were tested for their ability to block wild-type SARS-CoV-2 infection. It was discovered that alkaloid compounds like tetrandrine can inhibit SARS-CoV-2 infection, including the delta variant of concern.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Plant Sciences
Kunlun Li, Xuefei Chen, Jianbo Zhang, Can Wang, Qiwei Xu, Jiangning Hu, Guoyin Kai, Yue Feng
Summary: In this study, candidate genes associated with BIAs biosynthesis in S. tetrandra were identified through metabolite and transcriptomic analyses. A new key gene, St6OMT2, was discovered and is believed to be involved in the methylation reaction of (S)-norcoclaurine. The results of this study are of great significance for a better understanding of the transcriptome information of S. tetrandra and the biosynthesis of BIAs.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Qing-Ru Chu, Ying-Hui He, Chen Tang, Zhi-Jun Zhang, Xiong-Fei Luo, Bao-Qi Zhang, Yong Zhou, Tian-Lin Wu, Sha-Sha Du, Cheng-Jie Yang, Ying-Qian Liu
Summary: Based on the structural characteristics of cryptolepine alkaloid, a series of new quindoline derivatives were synthesized and evaluated for their fungicidal and antibacterial activities. Compound D7 showed superior in vitro fungicidal activities against multiple fungi and apparent antibacterial activities against Xanthomonas oryzae pv. oryzae. In vivo antifungal activity of compound D7 was comparable to the positive control, and preliminary mechanistic studies suggested its potential antifungal mechanism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Applied
Li-Jun Yang, Zhong-Duo Yang, Zhi-Jie Li, Shu-Hong Yang, Zong-Mei Shu
Summary: Four undescribed bisbenzylisoquinoline alkaloids were isolated and identified from the roots of Stephania tetrandra, along with the isolation of N-trans-Feruloyltyramine for the first time from this plant. Stephtetrandrine C exhibited significant inhibitory effect on human hepatoma cell HepG2, while Limacine and 2'-N-chloromethyltetrandrine showed moderate monoamine oxidase inhibitory effects.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Tong Zhang, Wei An, Jiawei Sun, Fei Duan, Zeyu Shao, Fan Zhang, Ting Jiang, Xuliang Deng, Cyrille Boyer, Weiping Gao
Summary: Microbial resistance to antibiotics is a major challenge in global healthcare. A study found that a photoinduced cationic polymer conjugated with lysozyme can effectively overcome bacterial resistance and improve therapeutic efficacy in a rat periodontitis model. This discovery provides an efficient strategy to enhance antimicrobial activities and overcome antimicrobial resistance.
Article
Chemistry, Applied
Yongliang Tu, Peng Shi, Carsten Bolm
Summary: Under mild conditions, an N-phthalimidoyl sulfoximine undergoes aminolysis to provide a wide range of 2-formyl benzamides in good to high yields. An unprecedented variant of McFadyen-Stevens reaction explains the product formation, and the applicability of the products as building blocks for nitriles and alkynes has been demonstrated.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Tan Quang Tu, Phat Tien Do, Doai Van Nguyen, Nhan Thi Thanh Pham, Tam Thi Nguyen, Mau Hoang Chu
Summary: In this study, the CoOMT gene was successfully transformed and expressed in tobacco plants, resulting in an increase in the total alkaloid content.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Chemistry, Organic
Monak Patel, Siddhant Sharma, Hussain Bhukya, Bharatkumar Z. Dholakiya, Togati Naveen
Summary: In this study, a simple, practical, and catalytic methodology for the N-formylation of various amines using iron as a catalyst was developed. This protocol features an inexpensive iron catalyst, short reaction time, mild reaction conditions, good yields, easy workup, and tolerance of a wide variety of functional groups.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Infectious Diseases
Alma Ramic, Mirjana Skocibusic, Renata Odzak, Ana Cipak Gasparovic, Lidija Milkovic, Ana Mikelic, Karlo Sovic, Ines Primozic, Tomica Hrenar
Summary: A series of N-substituted quaternary salts of cinchonidine were prepared and evaluated for their antimicrobial activity, showing good potential against a diverse panel of bacteria. By establishing an activity/potential energy surface model, accurate predictions of activity for new compounds can be made based solely on their potential energy surfaces, facilitating the search for new potential antibiotics.
Article
Immunology
Runa Kuley, Ryan D. Stultz, Bhargavi Duvvuri, Ting Wang, Marvin J. Fritzler, Roger Hesselstrand, J. Lee Nelson, Christian Lood
Summary: This study reveals for the first time the important role of mitochondrial component fMet in neutrophil-mediated inflammation in SSc.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sanhu Gou, Beibei Li, Xu Ouyang, Zufang Ba, Chao Zhong, Jingman Ni
Summary: The research involved modifying anoplin by dendrimerization on the C-terminal and lipidation on the N-terminal to improve antibacterial activity, but with an increase in hemolytic activity. Ultimately, a simple lipopeptide A-C8 with a high therapeutic index was obtained, showing potential as an antibiotic.
Article
Chemistry, Organic
Petr Jansa, Ivan Barvik, Daniela Hulcova, Eliska Matousova
Summary: In this study, polycyclic compounds with N-methyl substitution, structurally related to Amaryllidaceae alkaloids, were synthesised. Two approaches, N-oxidation and Boc protection of the nitrogen, were investigated to avoid interference of the nitrogen lone electron pair with the reaction sequence. The products prepared showed higher activity against BuChE than AChE, indicating a need for larger ligands in future studies.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Plant Sciences
Renzhong Wang, Siyu Wu, Jinye Xu, Fengqing Xu, Deling Wu
Summary: A novel phenanthrene compound diphenanthrin (1) and an undescribed alkaloid compound N-chloromethylstephenanthrine (2), along with two known compounds (3-4), were isolated from the roots of Stephania tetrandra. Their structures were determined using 1D and 2D NMR, mass spectroscopy, and by comparing NMR data with those of known compounds. Compounds 3 and 4 exhibited inhibitory effects on NO production in an anti-inflammatory assay, with IC50 values of 41.51 +/- 0.20 and 23.87 +/- 2.12 μM.
RECORDS OF NATURAL PRODUCTS
(2023)
