Phytochemical Constituents and Biological Activities of Origanum syriacum

The cytotoxicity of the methanol extract of Origanum syriacum against human cerivical adenocarcinoma, Hela cells, was evaluated by the MTT assay. From the crude extract, a new flavone glycoside, acacetin-7-O-[2 ''-O-alpha-L-rhamnopyranosy]-6 ''-O-beta-D-glucopyranosyl-beta-D-glucopyranoside (1) together with the ten known flavonoids luteolin (2), apigenin (3), luteolin-6-C-glucoside (4), luteolin-3'-methylether-6-C-glucoside (5), luteolin-7,4'-dimethyether-6-C-glucoside, (6), apigenin-7-methylether-6-C-glucoside (7), apigenin-7-O-glucoside (8), diosmetin-7-O-glucoside (9), acacetin-7-O-glucoside (10) and acacetin-7-O-rutinoside (11), was isolated from the methanol extract of the aerial parts of Origanum syriacum. The structure elucidation of the isolated compounds was performed by spectroscopic and chromatographic methods.