Article
Biochemistry & Molecular Biology
Edwin R. Sukandar, Sutin Kaennakam, Pia Raab, Xuehong Noest, Kitiya Rassamee, Rudolf Bauer, Pongpun Siripong, Taslim Ersam, Santi Tip-pyang, Warinthorn Chavasiri
Summary: Garcinia picrorhiza, a woody plant native to Indonesia, was found to contain 15 phenolic compounds in its stem bark, including newly discovered bioactive molecules with cytotoxic and anti-inflammatory properties. These findings suggest the potential for furanxanthone derivatives as cytotoxic and anti-inflammatory agents for further pharmacological studies.
Article
Chemistry, Medicinal
Lucas da Silva Santos, Matheus Fillipe Langanke de Carvalho, Ana Claudia de Souza Pinto, Amanda Luisa da Fonseca, Julio Cesar Dias Lopes, Fernando de Pilla Varotti, Rossimiriam Pereira de Freitas, Rosemeire Brondi Alves
Summary: Malaria has a significant impact on global health, and drug resistance is a major challenge in its treatment, highlighting the need for new antimalarial drugs. Through a key reaction catalyzed by Copper(I), 31 triazole compounds were successfully synthesized, with active substances showing promising antiplasmodial activity in the malaria test.
MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Bandari Manga, Banoth Venkateswara Rao, Kopparapu Sudeshna, Sai Balaji Andugulapati, Surender Singh Jadav, Vaikundamoorthy Ramalingam, K. Suresh Babu
Summary: A series of novel nimbolide derivatives were synthesized and evaluated for their anticancer activity. Compound 3a showed potent activity against lung cancer cells and induced apoptosis by downregulating BcL2 expression and upregulating Bax gene expression.
Article
Chemistry, Multidisciplinary
Gang Wang, Pengcheng Hao, Yajuan Chang, Qiuping Zhang, Wanyi Liu, Bin Duan, Haijuan Zhan, Shuxian Bi
Summary: Modified polyaniline self-stabilizing Cu/Pd bimetallic sub-nanocluster composite materials obtained through oxidative polymerization, structural modification, and metal self-trapping show excellent catalytic performance.
Article
Nanoscience & Nanotechnology
Amir Khojastehnezhad, Hichem Gamraoui, Maziar Jafari, Zhiyuan Peng, Farid Moeinpour, Mohamed Siaj
Summary: To reduce environmental impact and cut costs, the development of recyclable and green heterogeneous catalysts is extremely important. In this research, a core-shell magnetic structure consisting of Fe3O4 and a microporous organic network (MON) was successfully developed, and palladium nanoparticles (NPs) were physically absorbed onto the outer surface of the shell substance. Various analyses confirmed the effective bonding between Pd NPs and the MON materials, and the immobilization of the palladium NPs. The prepared nanoheterogeneous catalysts exhibited excellent catalytic performance in mild conditions for C-C formation.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Feng Lu
Summary: The ligand-free, copper-free Sonogashira coupling reaction and styrene hydrogenation catalysis by linear organic dodecanethiol stabilized palladium nanoparticles (PdTNPs) were studied. PdTNPs catalysts showed high catalytic activity for the Sonogashira reaction of iodobenzene with phenyl acetylene and the hydrogenation of styrene at room temperature, with excellent yield and recyclability.
JOURNAL OF COORDINATION CHEMISTRY
(2021)
Article
Chemistry, Physical
Daiene de P. Lapa, Luana G. de Souza, Edgar Schaeffer, Eunice C. de Jesus, Andre A. Vieira, Alcides J. M. da Silva
Summary: A fast tandem reaction was used to synthesize a series of novel 1,4-naphthoquinones fused with specific N -O isoxazole, with moderate yield (up to 62%). The compounds were characterized by NMR, GC-MS, and ESI-HRMS. Computational analyses revealed the superior stability and polarizability of the N-O isomers, supporting the importance of this study and their potential biological activity.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Organic
Qiang Zhang, Xuecong Huang, Yuting Gui, Youyuan He, Siyang Liao, Guan Huang, Taoyuan Liang, Zhuan Zhang
Summary: An efficient Pd-II- and Rh-III-controlled site-selective C-H bond alkynylation of imidazopyridines using (bromoethynyl)triisopropylsilane is described, providing access to a wide range of products alkynylated at the C3 and ortho positions. This methodology shows potential as a practical platform for late stage diversification and could aid in the development of more selective and complementary catalytic systems.
Article
Chemistry, Organic
Qiang Zhang, Xuecong Huang, Yuting Gui, Youyuan He, Siyang Liao, Guan Huang, Taoyuan Liang, Zhuan Zhang
Summary: An efficient method for site-selective C-H bond alkynylation of imidazopyridines using (bromoethynyl)triisopropylsilane controlled by PdII and RhIII is disclosed. The divergent approach allows easy access to a range of alkynylated products at the C3 and ortho positions. This strategy may have practical implications for late-stage diversification and the development of more selective and complementary catalytic systems.
Article
Chemistry, Multidisciplinary
Lucas Bacheley, Quentin Llopis, Anne Westermeyer, Gerard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana-Vidal
Summary: Functionalized 1,3-enynes bearing an acetal moiety at the 2-position were prepared through Sonogashira reaction. The reaction showed excellent substrate tolerance and could be easily scaled up. This method has important application in the synthesis of a key intermediate for glucagon antagonist.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Fusheng Bie, Chengwei Liu, Michal Szostak, Xuejing Liu
Summary: A robust palladium-catalyzed decarbonylative alkynylation of aryl anhydrides is reported. The catalytic system of Pd(OAc)(2)/XantPhos and DMAP as a nucleophilic additive has been identified as effective promoters for decarbonylative Sonogashira alkynylation. The present process expands this reactivity to readily available aryl anhydrides as electrophilic reagents for decarbonylative alkynylation.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Raha Orfali, Shagufta Perveen, Mohamed Fahad AlAjmI, Safina Ghaffar, Md Tabish Rehman, Abdullah R. AlanzI, Saja Bane Gamea, Mona Essa Khwayri
Summary: Antibiotic resistance is a major global health concern, and finding new antibiotics or antibiotic adjuvants to inhibit bacterial growth and overcome resistance is crucial. In this study, five potentially antibacterial compounds were discovered from sediment-derived fungus and showed good affinity with bacterial beta-Lactamase enzymes according to molecular docking data.
Article
Chemistry, Multidisciplinary
Mikus Purins, Lucas Eichenberger, Jerome Waser
Summary: We present a mild approach for the synthesis of propargyl silanes from terminal alkynes. A bromonaphthyl-substituted silane was used as a silylmethyl electrophile surrogate, which underwent an aryl-to-alkyl Pd-migration followed by a Sonogashira reaction. A total of 27 propargyl silanes were obtained with yields up to 88%. The resulting products serve as versatile building blocks for addition reactions with electrophiles, triple bond hydrogenation, or silyl group cleavage with acid or fluoride sources.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Mohammad Gholinejad, Zhwan Naghshbandi, Jose M. Sansano
Summary: A bimetallic PdCu catalyst supported on amine functionalized ZIF-67 has been found to exhibit high activity and stability in Sonogashira-Hagihara coupling reaction and 4-nitrophenol reduction reaction. It shows superior efficiency compared to other reported catalysts in the same transformations.
MOLECULAR CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Lingling Xu, Nanhui Liu, Wenjun Zhan, Yu Deng, Zhaoxia Chen, Xiaoyang Liu, Ge Gao, Qian Chen, Zhuang Liu, Gaolin Liang
Summary: The study developed a near-infrared fluorescence probe Cy5.5-CBT-NPs for noninvasive and sensitive evaluation of cancer immunotherapy efficacy. The probe enabled real-time monitoring and enhancement of cytotoxic T lymphocytes (CTLs) responses against tumor cells.
