Article
Multidisciplinary Sciences
Liuyang Tian, Zhilong Jia, Zhenguo Xu, Jinlong Shi, XiaoJing Zhao, Kunlun He
Summary: Oxygen metabolism is closely related to intestinal homeostasis. The hypobaric hypoxic environment of the plateau can cause intestinal diseases. Small intestine cells show changes in gene expression under hypobaric hypoxic conditions, with upregulation of metabolic and digestive pathways starting from the second week.
Review
Gastroenterology & Hepatology
Yu-De Chu, Chun-Wei Chen, Ming-Wei Lai, Siew-Na Lim, Wey-Ran Lin
Summary: This review summarizes the metabolic reprogramming and bioenergetic alterations in gastrointestinal (GI) cancers, highlighting the interplay between different metabolic pathways and their oncogenetic links. It emphasizes the potential of targeting bioenergetic regulators for anti-cancer therapy, provides details on various anti-cancer drugs and strategies, and discusses the challenges faced by targeted therapies due to the diverse metabolic patterns. Further research is needed to understand specific mechanisms of inhibiting bioenergetic enzymes and address side effects, as well as leverage omics technologies for targeted bioenergetic therapies.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Neurosciences
Linlin Jing, Yanru Huang, Huiping Ma, Haibo Wang
Summary: The study found that a synthesized compound called HPN-C-6, which is a nitronyl nitroxide radical, can protect against brain damage caused by hypobaric hypoxia. HPN-C-6 reduces oxidative stress, decreases inflammation, and inhibits cell apoptosis by preventing the release of mitochondrial cytochrome C.
NEUROSCIENCE LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Jan Schmitz, Lydia J. Kolaparambil Varghese, Felix Liebold, Moritz Meyer, Lukas Nerlich, Clement Starck, Seamus Thierry, Stefanie Jansen, Jochen Hinkelbein
Summary: The present study aims to investigate the time-dependent changes in protein expression due to hypobaric hypoxia. The results show that protein expression differs based on the duration of exposure, with significant differences in proteins associated with hemostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Rahul Ranjan, Amitabh, Dipti N. Prasad, Ekta Kohli
Summary: The study showed that hypothermic preconditioning can prevent spatial memory deficit and neurodegeneration induced by HH, reduce oxidative stress, and restore hippocampal neuronal structure and spatial memory in rats.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Shuhui Dai, Yuan Feng, Chuanhao Lu, Hongchen Zhang, Wenke Ma, Wenyu Xie, Xiuquan Wu, Peng Luo, Lei Zhang, Fei Fei, Zhou Fei, Xia Li
Summary: Acute hypobaric hypoxic brain damage is a potentially fatal high-altitude sickness. Autophagy plays a critical role in ischemic brain injury, but its role in hypobaric hypoxia remains unknown. This study demonstrates that acute exposure to hypobaric hypoxia impairs autophagic activity in the mouse brain, leading to oxidative stress, neuronal loss, and brain damage. This research also suggests that the protein dynamin2 potentially regulates autophagic flux, and enhancing autophagic activity can attenuate the negative effects of hypobaric hypoxia.
NEUROSCIENCE BULLETIN
(2023)
Review
Pharmacology & Pharmacy
Yue Wu, Yang Wu, Hongwei Wu, Changxun Wu, Enhui Ji, Jing Xu, Yi Zhang, Junying Wei, Yi Zhao, Hongjun Yang
Summary: The study demonstrated that in rats with GID, there was an increase in the relative abundances of Erysipelotrichaceae, Lachnospiraceae, Streptococcaceae and a decrease in Ruminococcaceae. XEFP restored the imbalances in metabolites through the ether lipid metabolism pathway and improved the Firmicutes/Bacteroidetes (F/B) ratio. Additionally, XEFP alleviated the symptoms of GID rats by modulating the levels of specific bacteria in faecal microbiota.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Karem Arriaza, Constanza Cuevas, Eduardo Pena, Patricia Siques, Julio Brito
Summary: This review investigates the relationship between altered zinc (Zn2+) levels and oxidative stress in hypoxic pulmonary vasoconstriction (HPV) under hypobaric hypoxic conditions. The results suggest that elevated Zn2+ levels are associated with increased mitochondrial ROS, nitric oxide, metallothionein, zinc-regulated iron-regulated transporter-like protein, and NADPH oxidase-induced PKC ε activation in the development of HPV.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Nazim Husain, Samra Hasan, Aijaz Ahmed Khan, Riaz Mahmood
Summary: Oral administration of copper chloride in rats led to significant oxidative damage in the intestine, affecting cellular metabolism, cell membrane, and DNA damage, which in turn can impair digestive and absorptive functions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Jipeng Shi, Zhao Liu, Maoxing Li, Jie Guo, Lele Chen, Ling Ding, Xu Ding, Tao Zhou, Ji Zhang
Summary: This study demonstrated the therapeutic potential of Potentilla anserina L polysaccharide (PAP) for high-altitude pulmonary edema (HAPE), mainly by reducing lung edema and protecting lung tissue through suppression of oxidative stress and inflammatory reactions.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Swati Sharma, Yamini Singh, Rajat Sandhir, Sayar Singh, Lilly Ganju, Bhuvnesh Kumar, Rajeev Varshney
Summary: High altitude pulmonary edema (HAPE) may be related to genetic factors and abnormal mitochondrial redox status, with mutations in Complex I genes and mtDNA haplogroup H2a2a1 potentially affecting the pathogenesis of HAPE. Increased oxidative stress, reduced mitochondrial biogenesis, and metabolic reprogramming induced by hypobaric hypoxia may contribute to mitochondrial dysfunction in HAPE individuals.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2021)
Article
Biochemistry & Molecular Biology
Guohua Zhang, Xianghui Yan, Jiaheng Xia, Junxin Zhao, Maomao Ma, Ping Yu, Deming Gong, Zheling Zeng
Summary: The ethanol extracts from Cinnamomum camphora seed kernel have shown strong anti-inflammatory activities by inhibiting inflammatory markers, regulating NF-kappa B/MAPK pathway, and enhancing intestinal barrier function, suggesting its potential application in the prevention or treatment of intestinal inflammation.
Article
Pharmacology & Pharmacy
Yan Tang, Ya Hou, Yong Zeng, Yao Hu, Yi Zhang, Xiaobo Wang, Xianli Meng
Summary: Salidroside alleviates hypoxic injury in PC12 cells by inhibiting oxidative stress, anti-apoptosis, and enhancing mitochondrial energy synthesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Environmental Sciences
Muhammad Awais Piracha, Muhammad Ashraf, Sher Muhammad Shahzad, Muhammad Imtiaz, Muhammad Saleem Arif, Muhammad Shahid Rizwan, Ahsan Aziz, Shuxin Tu, Gadah Albasher, Saad Alkahtani, Awais Shakoor
Summary: Phosphorus can affect the dynamics of arsenic in soil and its toxicity to plants. The addition of P increased labile, calcium-bound, organic matter-bound, and residual As fractions, while decreased iron-bound and aluminum-bound As fractions. P reduced arsenic accumulation in plant tissues and mitigated oxidative stress, resulting in improved growth and yield of sunflower.
Article
Agriculture, Multidisciplinary
Fuhao Tang, Qiqi Cao, Baoyao Wei, Jianwen Teng, Li Huang, Ning Xia
Summary: This study identified multiple phenolic compounds in passion fruit peel using liquid chromatography-tandem mass spectrometry and multivariate analysis. The relative activity of these compounds in inhibiting alpha-glucosidase and alpha-amylase was evaluated using the active contribution rate (ACR). The results showed that the inhibitory capacity of the compounds changed after simulated digestion.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)