Article
Clinical Neurology
Francini Franscescon, Thiele P. Souza, Talise E. Muller, Paula Michelotti, Julia Canzian, Flavia Stefanello, Denis B. Rosemberg
Summary: Schizophrenia is a chronic neuropsychiatric disorder characterized by a shortened lifespan and impaired social and vocational functioning, often involving dysfunctions in the hypothalamic-pituitary-adrenal axis and cortisol regulation. Taurine, with its neuroprotective properties, shows promise in targeting various brain disorders, including schizophrenia, by modulating behaviors and neuroendocrine responses. The study on zebrafish models suggests that taurine can have a protective effect on behaviors and neuroendocrine responses associated with MK-801-induced schizophrenia-like phenotypes.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Neurosciences
Carly L. Clayman, Victoria P. Connaughton
Summary: This study examines the neuropharmacological and behavioral consequences of caffeine and alcohol exposure in zebrafish model, highlighting the potential of alcohol as an anxiolytic substance that could offset the anxiogenic effects of caffeine and affect neural circuit development.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hideyuki Maeda, Noritoshi Fukushima, Akihiro Hasumi
Summary: Zebrafish are popular for research due to easy breeding and transparency, different intervals of light-dark stimuli affect larvae travel distance, acclimating for 1 hour and collecting data every 5 minutes provide stable results for studying unknown lethal concentrations.
Article
Environmental Sciences
Luciana Joner Guerra, Aline Monique Blank do Amaral, Vanessa Andreatta de Quadros, Tiago da Luz Fiuza, Denis Broock Rosemberg, Osmar Damian Prestes, Renato Zanella, Barbara Clasen, Vania Lucia Loro
Summary: Exposure of zebrafish to imidacloprid resulted in decreased locomotion and exploratory behavior, as well as alterations in some biochemical parameters.
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2021)
Article
Environmental Sciences
Huiting Yang, Xuefang Liang, Yanyan Zhao, Xiaohong Gu, Zhigang Mao, Qingfei Zeng, Huihui Chen, Christopher J. Martyniuk
Summary: The study investigated the behavioral and molecular responses in larval fish following exposure to different concentrations of SER. It was found that exposure to SER altered the behavior of early-stage zebrafish, with changes in locomotor activity and dark-avoidance. Additionally, an increase in mRNA levels of serotonin transporter and serotonin receptor 2c was observed in fish exposed to 10 μg/L SER.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Engineering, Environmental
Francisco Carlos da Silva Junior, Thais Agues-Barbosa, Ana Carolina Luchiari, Silvia Regina Batistuzzo de Medeiros
Summary: The study demonstrates the genotoxic and neurotoxic effects of Retene on zebrafish, indicating the potential to induce DNA micronuclei formation and behavioral changes. The results suggest that alterations in oxidative stress and mRNA expression of neurotransmitter systems may contribute to these effects.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Endocrinology & Metabolism
Ulrich Herget, Soojin Ryu, Rodrigo J. De Marco
Summary: The transcription factor rx3 is crucial for the formation of the pituitary and parts of the hypothalamus. This study investigated the behavioral phenotypes of rx3 mutant animals and found deficits in stress regulation and cortisol release, but nominal behavioral responses to both stressful and non-stressful stimuli were still observed in larval zebrafish lacking rx3 function, suggesting that corticotroph cells do not play a major role in these behavioral responses.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Yuanzhao Wu, Anli Wang, Lixiang Fu, Meng Liu, Kang Li, Song Chian, Weixuan Yao, Binjie Wang, Jiye Wang
Summary: This study investigated the behavioral changes and neurotoxicity induced by fentanyl addiction using zebrafish models. The results showed that high doses of fentanyl significantly affected the behavior and neurotransmitters in zebrafish. Multiple neurobehavioral assessments were used to evaluate the addiction risk of new psychoactive substances.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Vanessa A. Quadros, Luiz Rosa, Fabiano Costa, Gessi Koakoski, Leonardo J. G. Barcellos, Denis B. Rosemberg
Summary: The study investigates how predictable chronic stress affects the behavioral and physiological responses in zebrafish, demonstrating that different stressors induce distinct changes in the fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi Zhang, Chen Chen, Kun Chen
Summary: Many studies have shown that the combination of microplastics (MPs) and chemical pollutants can increase their toxicity to organisms. However, little is known about the combined effects of MPs and amitriptyline on aquatic species. This study found that exposure to MPs and amitriptyline can alter the behavior and ocular oxidative stress of zebrafish, with a stronger additive effect on behavioral toxicity. In addition, their combined exposure also led to decreased levels of antioxidant enzymes in the eyes of the fish.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Psychiatry
Aleksandra M. Mech, Munise Merteroglu, Ian M. Sealy, Muy-Teck Teh, Richard J. White, William Havelange, Caroline H. Brennan, Elisabeth M. Busch-Nentwich
Summary: Developmental consequences of prenatal drug exposure, including motor and cognitive impairments, cranial and cardiac anomalies, and increased prevalence of ADHD, place a socioeconomic burden worldwide. This study using zebrafish as a model identifies behavioral and cellular changes in response to developmental exposure to amphetamine, nicotine, and oxycodone, and reveals differential expression of genes and alterations in pathways related to cell death, immunity, and circadian rhythm regulation. Downregulation of immediate-early genes associated with synaptic plasticity and reduced expression in neuroanatomical regions implicated in reward processing and addiction are observed. These early changes in gene expression may contribute to the long-lasting deficits caused by prenatal exposure and have the potential to guide therapeutic intervention.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Yun-Mi Jeong, Tae-Ik Choi, Kyu-Seok Hwang, Jeong-Soo Lee, Robert Gerlai, Cheol-Hee Kim
Summary: Recent advancements in optogenetics have allowed researchers to manipulate the olfactory system in zebrafish, revealing that light stimulation can activate olfactory neurons. Zebrafish larvae exhibit a preference for light over aversive odors when presented with conflicting sensory cues, showcasing the importance of olfaction in decision-making processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Becca Franks, Leigh P. P. Gaffney, Courtney Graham, Daniel M. M. Weary
Summary: This study investigates curiosity in zebrafish and finds that they show novelty-seeking behavior and sustained interest in some objects, but habituation occurs over time. Additionally, specific objects also affect the social behavior of fish.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Juliet E. Kitson, James Ord, Penelope J. Watt
Summary: Prenatal alcohol exposure can cause serious health issues known as Foetal Alcohol Spectrum Disorders (FASD). The underlying mechanisms are still unclear, and animal models are used to overcome the limitations of human studies. This study used zebrafish to investigate the effects of chronic alcohol exposure in females and found that the offspring had reduced stress responses.
Review
Chemistry, Multidisciplinary
Peilong Liao, Jianbin Huang, Yun Yan, Ben Zhong Tang
Summary: Clusterization-triggered emission (CTE) is a photophysical phenomenon that allows for highly efficient light emission from non-conjugated molecules. Applications of CTE include optical anti-counterfeiting, white LED materials, bioimaging, and molecular sensing. In the future, CTE may revolutionize the design of advanced functional luminescent materials.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Review
Neurosciences
Radharani Benvenutti, Matheus Gallas-Lopes, Matheus Marcon, Cristina R. Reschke, Ana Paula Herrmann, Angelo Piato
Summary: This review integrates the major findings from zebrafish literature regarding the behavioral effects of NMDAR antagonists relevant to schizophrenia, suggesting that zebrafish is a suitable model organism for studying drug-induced behavioral phenotypes. However, more studies are needed to further understand the behavioral differences compared to mammals.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Agricultural Engineering
Adrieli Sachett, Matheus Gallas-Lopes, Radharani Benvenutti, Matheus Marcon, Gean Pablo S. Aguiar, Ana Paula Herrmann, J. Vladimir Oliveira, Anna M. Siebel, Angelo Piato
Summary: Curcumin has been shown to have various beneficial properties, but its low bioavailability limits its therapeutic potential. Micronization can enhance the bioavailability by reducing particle size. In this study, micronized curcumin exhibited superior antioxidant effects both in vitro and in vivo compared to regular curcumin. However, it was unable to fully block the behavioral effects induced by chronic stress.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Adrieli Sachett, Radharani Benvenutti, Carlos G. Reis, Matheus Gallas-Lopes, Leonardo M. Bastos, Gean Pablo S. Aguiar, Ana P. Herrmann, J. Vladimir Oliveira, Anna M. Siebel, Angelo Piato
Summary: Zebrafish larvae are widely used in neuroscience and drug research. This study found that micronized curcumin has a stimulant effect on the behavior of zebrafish larvae.
NEUROCHEMICAL RESEARCH
(2022)
Article
Behavioral Sciences
Kanandra Taisa Bertoncello, Rodrigo Zanandrea, Carla Denise Bonan
Summary: Epilepsy affects patients' quality of life, and our study on zebrafish shows that PTZ exposure can lead to cognitive deficits.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Matheus Marcon, Radharani Benvenutti, Matheus Gallas-Lopes, Ana Paula Herrmann, Angelo Piato
Summary: Studies on animals' innate preferences can improve and develop behavioral tasks by avoiding bias. This study investigated the directional and color preferences of male and female zebrafish in plus-maze and T-maze tasks. The results showed no difference in directional preference between male and female zebrafish, but revealed color preference differences, with males showing no color preference and females preferring red. In the T-maze task, both male and female zebrafish displayed a strong preference for black over white. These findings contribute to the standardization of future protocols by identifying possible biases.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jefferson Pedroso, Sabrina Ester Schneider, Cassia Alves Lima-Rezende, Gean Pablo S. Aguiar, Liz Girardi Muller, J. Vladimir Oliveira, Angelo Piato, Anna Maria Siebel
Summary: This study investigated the effects of resveratrol and piceatannol in controlling seizures in adult zebrafish. The results showed that neither resveratrol nor piceatannol had any anticonvulsant or neuroprotective potential in adult zebrafish.
NEUROCHEMICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Adrieli Sachett, Matheus Gallas-Lopes, Radharani Benvenutti, Matheus Marcon, Amanda M. Linazzi, Gean P. S. Aguiar, Ana P. Herrmann, J. Vladimir Oliveira, Anna M. Siebel, Angelo Piato
Summary: The study compared the effects of non-micronized curcumin and micronized curcumin on the behavior and neurochemical effects of adult zebrafish under acute restraint stress conditions, showing that curcumin did not prevent stress-induced behavioral and biochemical effects.
PHARMACOLOGICAL REPORTS
(2022)
Editorial Material
Pharmacology & Pharmacy
Carla Denise Bonan, Anna Maria Siebel
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Jessica Valadas, Adrieli Sachett, Matheus Marcon, Leonardo M. Bastos, Angelo Piato
Summary: This study investigated the effects of exposure to different doses of OTA on behavior and neurochemical parameters in adult zebrafish. The results showed that OTA altered the behavior of zebrafish in the open tank test and affected neurochemical levels in the brain.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Behavioral Sciences
Gabriela Madalena de Melo Martins, Barbara Dutra Petersen, Gabriel Ruebensam, Julia Maria Kuhl da Silva, Karina Vidarte Gaspary, Melissa Talita Wiprich, Stefani Altenhofen, Carla Denise Bonan
Summary: This study used zebrafish as a model to investigate the effects of reserpine on behavior and neurotransmitter levels. The results showed that reserpine exposure induced behavioral changes and alterations in neurotransmitter levels. Additionally, the study found that exposure to fluoxetine and physical exercise could reverse the negative effects caused by reserpine.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Biochemistry & Molecular Biology
Kanandra Taisa Bertoncello, Carla Denise Bonan
Summary: Epilepsy is a condition characterized by spontaneous and recurring seizures. This study investigated the role of adenosine modulation in controlling seizures and cognitive impairment in zebrafish. The results showed that certain drugs like valproate, CPA, and EHNA had anti-seizure effects and prevented memory impairments induced by PTZ exposure. Other drugs like DPCPX, ZM 241385, and dipyridamole prevented memory impairments without affecting seizure development. These findings highlight the potential of adenosine signaling as a target for preventing cognitive impairments associated with epilepsy.
NEUROCHEMICAL RESEARCH
(2023)
Article
Clinical Neurology
Melissa Talita Wiprich, Stefani Altenhofen, Darlan Gusso, Rafaela da Rosa Vasques, Rodrigo Zanandrea, Luiza Wilges Kist, Mauricio Reis Bogo, Carla Denise Bonan
Summary: This study investigated the effects of acute exposure to different substances in an HD pharmacological model induced by 3-NPA in adult zebrafish. The results showed that some substances could reverse or exacerbate the bradykinesia symptoms of HD, and also reverse memory impairment. The study suggests that these substances play an important role in modulating locomotor function and memory, and may be a potential pharmacological strategy against late-stage symptoms of HD.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Clinical Neurology
Rafael Chitolina, Matheus Gallas-Lopes, Carlos G. Reis, Radharani Benvenutti, Thailana Stahlhofer-Buss, Maria Elisa Calcagnotto, Ana P. Herrmann, Angelo Piato
Summary: The use of zebrafish as a model organism in epilepsy research is increasing. However, there is a lack of standardized protocols, making it difficult to compare results between studies. This systematic review provides a comprehensive overview of chemically-induced seizure models in zebrafish. The most common chemoconvulsants used were pentylenetetrazole, kainic acid, and pilocarpine, with significant variability in administration route, exposure duration, and dose/concentration. Improved methodological and reporting practices are needed to enhance the reproducibility and reliability of zebrafish models for studying epilepsy.
Article
Pharmacology & Pharmacy
Rafael Chitolina, Carlos G. Reis, Thailana Stahlhofer-Buss, Amanda Linazzi, Radharani Benvenutti, Matheus Marcon, Ana P. Herrmann, Angelo Piato
Summary: In this study, the effects of N-acetylcysteine (NAC) and Acetyl-l-carnitine (ALC) on acute PTZ-induced seizures in adult and larval zebrafish were evaluated. The results showed that neither NAC nor ALC at any tested concentration were able to reduce PTZ-induced epileptic seizures. In contrast, administration of diazepam showed a significant reduction in seizure intensity and increased latencies to higher scores of epileptic seizures.
PHARMACOLOGICAL REPORTS
(2023)
Article
Developmental Biology
Giovanna Trevisan Couto, Higor Arruda Caetano, Guilherme Pietro da Silva, Liliana Rockenbach, Jessica Scheid da Silva, Monica Ryff Vianna, Rosane Souza Da Silva
Summary: In this study, the functionality of the A(1) adenosine receptor in zebrafish was evaluated, and it was found that zebrafish showed similar responses to CPA as mammals. To avoid confounding factors, it is ideal to use a concentration below 75 μM or a dose below 20 mg/kg of CPA in zebrafish at larval and adult stages, respectively.