期刊
ZEBRAFISH
卷 6, 期 2, 页码 201-213出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/zeb.2008.0572
关键词
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资金
- NIDCD NIH HHS [R01 DC004184-05, R01 DC004184-03, R01 DC004184-06, R01 DC004184-08S1, T32 DC000011, R01 DC004184-01A1S1, R01 DC004184-02, R01 DC004184, R01 DC004184-03S1, R01 DC004184-08, R01 DC004184-04A1, R01 DC004184-01A1, R01 DC004184-07] Funding Source: Medline
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC004184] Funding Source: NIH RePORTER
The zebrafish is a valuable model for teaching developmental, molecular, and cell biology; aquatic sciences; comparative anatomy; physiology; and genetics. Here we demonstrate that zebrafish provide an excellent model system to teach engineering principles. A seven-member undergraduate team in a biomedical engineering class designed, built, and tested a zebrafish microfluidic bioreactor applying microfluidics, an emerging engineering technology, to study zebrafish development. During the semester, students learned engineering and biology experimental design, chip microfabrication, mathematical modeling, zebrafish husbandry, principles of developmental biology, fluid dynamics, microscopy, and basic molecular biology theory and techniques. The team worked to maximize each person's contribution and presented weekly written and oral reports. Two postdoctoral fellows, a graduate student, and three faculty instructors coordinated and directed the team in an optimal blending of engineering, molecular, and developmental biology skill sets. The students presented two posters, including one at the Zebrafish meetings in Madison, Wisconsin ( June 2008).
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