期刊
YEAST
卷 25, 期 5, 页码 349-357出版社
WILEY
DOI: 10.1002/yea.1592
关键词
yeast apoptosis; L-amino acid oxidase; hydrogen peroxide; glycan moiety; amino acid depriviation; synthetic lethality
Here we report for the first time that L-amino acid oxidase (LAAO), a major component of snake venom, induces apoptosis in yeast. The causative agent for induction of apoptosis has been shown to be hydrogen peroxide, produced by the enzymatic activity of LAAO. However, the addition of catalase, a specific hydrogen peroxide scavenger, does not prevent cell demise completely. Intriguingly, depletion of leucine from the medium by LAAO and the interaction of LAAO with yeast cells are shown to be the major factors responsible for cell demise in the presence of catalase. Copyright (c) 2008 John Wiley & Sons, Ltd.
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