Investigation of the prerequisites for the optimization of specific plasma protein binding as a strategy for the reduction of first-pass hepatic metabolism

Implications of Plasma  9-Tetrahydrocannabinol, 11-Hydroxy-THC, and 11-nor-9-Carboxy-THC Concentrations in Chronic Cannabis Smokers

(2013) E. L. Karschner et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

The Clinical Relevance of Plasma Protein Binding Changes

(2012) Jason A. Roberts et al.   CLINICAL PHARMACOKINETICS

Quantitative structure—plasma protein binding relationships of acidic drugs

(2012) Zvetanka Zhivkova et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacokinetics of ropivacaine in patients with chronic renal failure

(2011) P.J. Pere et al.   BRITISH JOURNAL OF ANAESTHESIA

Use of the Oie-Tozer Model in Understanding Mechanisms and Determinants of Drug Distribution

(2010) N. J. Waters et al.   DRUG METABOLISM AND DISPOSITION

Use of intrinsic clearance for prediction of human hepatic clearance

(2010) Piyun Chao et al.   Expert Opinion on Drug Metabolism & Toxicology

The Corrected Traditional Equations for Calculation of Hepatic Clearance that Account for the Difference in Drug Ionization in Extracellular and Intracellular Tissue Water and the Corresponding Corrected PBPK Equation

(2010) Leonid M. Berezhkovskiy   JOURNAL OF PHARMACEUTICAL SCIENCES

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

(2010) Dennis A. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Physicochemical Determinants of Human Renal Clearance

(2009) Manthena V. S. Varma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Do the kidneys contribute to propofol elimination?

(2008) K. Takata et al.   BRITISH JOURNAL OF ANAESTHESIA

Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds

(2008) R. S. Obach et al.   DRUG METABOLISM AND DISPOSITION

A Mini Review of Mammalian Toxicity (Q)SAR Models

(2007) Ivanka Tsakovska et al.   Quantitative structure-activity relationships & combinatorial science