Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

In Vivo Drug Interactions of the Teratogen Thalidomide with Midazolam: Heterotropic Cooperativity of Human Cytochrome P450 in Humanized TK-NOG Mice

(2013) Hiroshi Yamazaki et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Can ‘humanized’ mice improve drug development in the 21st century?

(2013) Gary Peltz   TRENDS IN PHARMACOLOGICAL SCIENCES

In Vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites Derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG Mice

(2012) Hiroshi Yamazaki et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Complete Plasmodium falciparum liver-stage development in liver-chimeric mice

(2012) Ashley M. Vaughan et al.   JOURNAL OF CLINICAL INVESTIGATION

Morphological and microarray analyses of human hepatocytes from xenogeneic host livers

(2012) Chise Tateno et al.   LABORATORY INVESTIGATION

Human pharmacogenetic analysis in chimeric mice with ‘humanized livers’

(2012) Yajing Hu et al.   Pharmacogenetics and Genomics

Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

(2012) Masakazu Kakuni et al.   TOXICOLOGY LETTERS

Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

(2012) Kristin Samuelsson et al.   XENOBIOTICA

The reconstituted ‘humanized liver’ in TK-NOG mice is mature and functional

(2011) Masami Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In VivoFormation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG Mice

(2011) Hiroshi Yamazaki et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton's Tyrosine Kinase Inhibitor

(2011) L. Liu et al.   DRUG METABOLISM AND DISPOSITION

Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation

(2011) Marc Lütgehetmann et al.   HEPATOLOGY

Metabolic studies with promagnon, methylclostebol and methasterone in the uPA+/+-SCID chimeric mice

(2011) L. Lootens et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Hepatitis C Virus Infection Suppresses the Interferon Response in the Liver of the Human Hepatocyte Chimeric Mouse

(2011) Masataka Tsuge et al.   PLoS One

Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism

(2011) Mark De Serres et al.   XENOBIOTICA

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers

(2011) Timothy Schulz-Utermoehl et al.   XENOBIOTICA

Hepatic Hyperplasia Associated with Discordant Xenogeneic Parenchymal-Nonparenchymal Interactions in Human Hepatocyte-Repopulated Mice

(2010) Rie Utoh et al.   AMERICAN JOURNAL OF PATHOLOGY

Effect of Hepatitis C Virus Infection on the mRNA Expression of Drug Transporters and Cytochrome P450 Enzymes in Chimeric Mice with Humanized Liver

(2010) R. Kikuchi et al.   DRUG METABOLISM AND DISPOSITION

Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites

(2010) Hidetaka Kamimura et al.   Drug Metabolism and Pharmacokinetics

In Vitro Evaluation of Cytochrome P450 and Glucuronidation Activities in Hepatocytes Isolated from Liver-Humanized Mice

(2010) Chihiro Yamasaki et al.   Drug Metabolism and Pharmacokinetics

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

(2010) Karl-Dimiter Bissig et al.   JOURNAL OF CLINICAL INVESTIGATION

Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice

(2010) Eiji Ohara et al.   JOURNAL OF HEPATOLOGY

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

(2010) David C. Pryde et al.   JOURNAL OF MEDICINAL CHEMISTRY

Approach forin VivoProtein Binding of 5-n-Butyl-pyrazolo[1,5-a]pyrimidine Bioactivated in Chimeric Mice with Humanized Liver by Two-Dimensional Electrophoresis with Accelerator Mass Spectrometry

(2009) Hiroshi Yamazaki et al.   CHEMICAL RESEARCH IN TOXICOLOGY

uPA+/+-SCID Mouse with Humanized Liver as a Model for In Vivo Metabolism of Exogenous Steroids: Methandienone as a Case Study

(2009) L. Lootens et al.   CLINICAL CHEMISTRY

Prediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver

(2009) Tae Inoue et al.   Drug Metabolism and Pharmacokinetics

In vivomodeling of human liver for pharmacological study using humanized mouse

(2009) Katsutoshi Yoshizato et al.   Expert Opinion on Drug Metabolism & Toxicology

Establishment of a humanized model of liver using NOD/Shi- scid IL2Rg null mice

(2008) Hiroshi Suemizu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized Liver

(2008) T. Inoue et al.   DRUG METABOLISM AND DISPOSITION

Aldehyde Oxidase-Catalyzed Metabolism of N1-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver

(2008) S. Kitamura et al.   DRUG METABOLISM AND DISPOSITION

Human Hepatocytes Can Repopulate Mouse Liver: Histopathology of the Liver in Human Hepatocyte-Transplanted Chimeric Mice and Toxicologic Responses to Acetaminophen

(2008) Yasushi Sato et al.   TOXICOLOGIC PATHOLOGY

Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver

(2008) C. Emoto et al.   XENOBIOTICA

Chimeric mice with humanized liver

(2007) Miki Katoh et al.   TOXICOLOGY