Article
Pharmacology & Pharmacy
Qing-Yun Xie, Lu-Ping Huang, Feng-Wei Gao, Da-Qing Liu, Xia Wang, Kang-Yi Jiang, Jie Gong, Xin Zhao, Ben-Jian Gao, Ze-Hua Lei
Summary: This study investigated the therapeutic efficacy of lenvatinib combined with sequential TACE on primary HCC and its effects on serum bFGF and VEGF. The results showed that the combination treatment group had a higher objective response rate, lower serum bFGF and VEGF levels, and better survival rates.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Leah R. Benington, Gunesh Rajan, Cornelia Locher, Lee Yong Lim
Summary: This study aimed to develop stable formulations of FGF-2 using pharmaceutical excipients to withstand physical stressors encountered in processing and storage. Formulations containing MC and alanine (F5) or MC and HSA (F6) were the most effective in stabilizing FGF-2 against thermal and processing stressors. These stabilized solutions have potential applications in medicinal products or in more advanced forms for wound healing and tissue regeneration.
Review
Cell Biology
Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alberto Repici, Marika Lanza, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
Summary: Cancer, the leading cause of death worldwide, requires successful strategies for treatment. Growth factors like VEGF, bFGF, and TGF-beta play significant roles in tumor growth, activating essential signaling pathways and promoting cell proliferation, angiogenesis, and metastasis. Specifically, bFGF is secreted by tumor cells and interacts with its receptors (FGFRs), leading to tumor cell proliferation, invasion, and upregulation of pro-inflammatory and anti-apoptotic proteins. Studies have focused on developing therapeutic strategies targeting the bFGF/FGFR axis, considering its involvement in oncogenesis. This review comprehensively examines the biological mechanisms of bFGF in the tumor microenvironment, available anticancer therapies targeting FGFRs, and the prognostic value of bFGF.
Article
Reproductive Biology
Corrine F. Monaco, Michele R. Plewes, Emilia Przygrodzka, Jitu W. George, Fang Qiu, Peng Xiao, Jennifer R. Wood, Andrea S. Cupp, John S. Davis
Summary: During the regression of the ovarian corpus luteum, fibroblasts are responsible for rapid matrix remodeling. However, little is known about the role of fibroblasts in the functional or regressing corpus luteum. In this study, it was found that FGF2 activates luteal fibroblasts, leading to collagen production and cell proliferation.
BIOLOGY OF REPRODUCTION
(2023)
Article
Cardiac & Cardiovascular Systems
Fumi Yokote, Yoshikane Yamauchi, Hiroko Komura, Tadashi Tanuma, Yukinori Sakao, Masafumi Kawamura, Makoto Komura
Summary: The study found that a single injection of basic fibroblast growth factor promoted tracheal cartilage regeneration and reinforced the anastomosis in a rabbit model, suggesting potential clinical applications for strengthening tracheal anastomoses.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Engineering, Biomedical
Fenzan Wu, Penghui Wang, Xiaojie Wei, Yanhong Yang, Abdullah Al Mamun, Xie Zhang, Yunsen Zhu, Tingting Mo, Hongyu Zhang, Chang Jiang, Jie Hu, Jian Xiao
Summary: This study developed a dual-targeting liposome for delivering bFGF to treat spinal cord injury (SCI), with the ability to target the injury lesion and penetrate the blood-spinal cord barrier (BSCB). The results showed that the dual-targeted liposomes could effectively cross the BSCB and accumulate at the injury site. Continuous treatment with the liposomes promoted BSCB repair, facilitated M2 polarization of macrophages, enhanced angiogenesis, and improved motor function in SCI rats.
MATERIALS TODAY BIO
(2023)
Article
Multidisciplinary Sciences
Xu Zhou, Ruth A. Franklin, Miri Adler, Trevor S. Carter, Emily Condiff, Taylor S. Adams, Scott D. Pope, Naomi H. Philip, Matthew L. Meizlish, Naftali Kaminski, Ruslan Medzhitov
Summary: This article reports on the mechanisms controlling the population numbers of different cell types in animal tissues. The study shows that fibroblasts are limited in proliferation due to space availability, while macrophages are constrained by growth factor availability. The transcriptional coactivator YAP1 in fibroblasts directly regulates the expression of the macrophage-specific growth factor Csf1. The findings suggest that tissue environment sensing is a general strategy for controlling tissue composition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Gensuke Okamura, Kosuke Ebina, Makoto Hirao, Ryota Chijimatsu, Yasukazu Yonetani, Yuki Etani, Akira Miyama, Kenji Takami, Atsushi Goshima, Hideki Yoshikawa, Takuya Ishimoto, Takayoshi Nakano, Masayuki Hamada, Takashi Kanamoto, Ken Nakata
Summary: Adding basic fibroblast growth factor (bFGF) to the culture of synovial mesenchymal stem cells (SMSC) can significantly promote cartilage regeneration in vivo, leading to better cartilage repair outcomes and more obvious cartilage matrix formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Leidan Huang, Carole Quesada, Mitra Aliabouzar, J. Brian Fowlkes, Renny T. Franceschi, Zheng Liu, Andrew J. Putnam, Mario L. Fabiilli
Summary: Vascularization following tissue implantation is crucial for viability, and the ability to spatially control this process using acoustically responsive scaffolds has been demonstrated in this study. The study found that spatially-defined patterns of acoustic droplet vaporization can elicit spatially-defined patterns of angiogenesis.
ACTA BIOMATERIALIA
(2021)
Article
Biotechnology & Applied Microbiology
Qiao Pan, Ruyi Fan, Rui Chen, Jiayi Yuan, Shixuan Chen, Biao Cheng
Summary: The pH value of the wound microenvironment is important for skin wound healing. Low pH is generally favorable for wound regeneration, but alkaline microenvironments may be required for certain healing processes. Growth factors with different isoelectric points can have different effects in different pH wound microenvironments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Danielle Dixon, Michael Edmonds
Summary: Recent evidence-based treatments for diabetic foot ulcers have emerged from multicentre, randomised, controlled trials, highlighting new advances in wound therapy. The overview of current and future pharmacotherapies includes proposed mechanisms of action and supporting evidence for various treatments. Looking forward, novel therapies utilizing nanotechnology and bioactive agents may provide possibilities for pharmacotherapy in the future.
Article
Pharmacology & Pharmacy
Xinze Li, Guangliang Hong, Guangju Zhao, Hui Pei, Jie Qu, Changju Chun, Zhiwei Huang, Zhongqiu Lu
Summary: This study demonstrates the therapeutic potential of bFGF in sepsis-induced cardiac injury, using red blood cell membrane-camouflaged nanoparticles for targeted delivery. The results show the protective effects of bFGF against oxidative and inflammatory damage in cardiomyocytes, and its therapeutic benefits in treating myocardial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Hongqi Zhang, Gang Xiang, Jiong Li, Sihan He, Yunjia Wang, Ang Deng, Yuxiang Wang, Chaofeng Guo, Xiuyuan Hao
Summary: This study investigated the relationship between congenital scoliosis (CS) and fibroblast growth factor 23 (FGF23). The results showed that CS patients had increased FGF23 mRNA levels in the peripheral blood and decreased bone mineral density. Additionally, FGF23 may contribute to osteopenia in CS patients through the FGFr3/TNAP/OPN pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Hongqi Zhang, Gang Xiang, Jiong Li, Sihan He, Yunjia Wang, Ang Deng, Yuxiang Wang, Chaofeng Guo
Summary: The study investigates the relationship between congenital scoliosis (CS) and fibroblast growth factor 23 (FGF23). The results show that CS patients have increased peripheral blood FGF23 mRNA levels and decreased bone mineral density, suggesting that FGF23 may contribute to osteopenia in CS patients through the FGFr3/TNAP/OPN pathway.
CHINESE MEDICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Kosuke Sako, Daisuke Sakai, Yoshihiko Nakamura, Jordy Schol, Erika Matsushita, Takayuki Warita, Natsumi Horikita, Masato Sato, Masahiko Watanabe
Summary: FGF2 and cFGF supplementation in whole tissue culture can support and enhance NPPC and Tie2 expression, promoting Tie2 maintenance of human NPPC. FGF2 supports Tie2 expression via MEK/ERK and PI3K/Akt signals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)