期刊
WOUND REPAIR AND REGENERATION
卷 17, 期 3, 页码 447-455出版社
WILEY
DOI: 10.1111/j.1524-475X.2009.00492.x
关键词
-
资金
- G. Harold and Leila Y. Mathers Charitable Foundation
- W. W. Smith Foundation
- F. M. Kirby Foundation
- NCI Cancer Center [P30 CA10815]
- DOD/DARPA
Digit regrowth following amputation injury proximal to the first phalangeal joint is not a property of mammalian wound healing. However, the regenerative potential observed in the MRL mouse invites a reexamination of this rule. In this study, healing was assessed in three mouse strains after amputation midway through the second phalangeal bone. Three distinct outcomes were observed though evidence for regrowth was observed only in the MRL mouse. Here, a blastema-like structure was seen along with apparent chondrogenesis, consistent with a histological profile of a regenerative response to injury. Analysis of trichrome staining and basement membrane changes, proliferation and apoptosis indicated that these processes contributed to the formation of new digit tissue. On the other hand, SW and B6 digits did not show evidence of growth with little mesenchymal BrdU incorporation or phosphorylation of H3.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据