Article
Public, Environmental & Occupational Health
Meng Kang, Bingna Xu, Chunping Chen, Dongfang Wang
Summary: This study found that Internet addiction has both direct and indirect effects on suicidal ideation among college students. The relationship between Internet addiction and suicidal ideation is mediated by psychotic-like experiences. These findings provide valuable information for developing and implementing interventions and strategies to alleviate suicidal ideation among Chinese college students.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Psychiatry
Elizabeth C. Thompson, Samantha Y. Jay, Nicole D. Andorko, Zachary B. Millman, Pamela Rakhshan Rouhakhtar, Kristin Sagun, Susan C. Han, Bruce Herman, Jason Schiffman
Summary: The study found that psychotic-like experiences (PLEs) and sleep difficulties were associated with suicidal ideation (SI) among college students. Sleep quality moderated this relationship, with PLEs being significantly positively associated with SI in individuals with greater sleep difficulties.
PSYCHIATRY RESEARCH
(2021)
Article
Psychology, Clinical
Xi Luo, Taowen Yu, Zilu Yang, Dongfang Wang
Summary: This two-wave longitudinal study aimed to investigate the relationships among PLEs, insomnia symptoms, resilience, and suicidal ideation (SI) among adolescents. The findings revealed a significant positive correlation between PLEs and SI, which was sequentially mediated by insomnia symptoms and resilience. Additionally, insomnia symptoms and resilience played a chain-mediating role between PLEs and adolescent SI. These findings provide important insights into the mechanisms of the PLEs-SI link and contribute to early prevention efforts.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2023)
Article
Psychiatry
Kirstie J. M. O'Hare, Richie Poulton, Richard J. Linscott
Summary: The study found that adolescent schizotypy and psychotic experiences are related to subsequent suicidal ideation and attempts, highlighting the heterogeneous nature of suicidal ideation with schizotypy specifically tied to a persistent passive ideation subgroup.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychiatry
Heather M. Wastler, Daniel Nunez
Summary: This study investigated the relationship between psychotic experiences, emotion regulation, and suicidal ideation among Chilean adolescents. The results showed that paranoid ideation, bizarre experiences, and perceptual abnormalities were moderately associated with suicidal ideation. Greater expressive suppression and cognitive reappraisal were also linked to suicidal ideation, and the relationship between expressive suppression and suicidal ideation was strongest when paranoid ideation was low to moderate.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Developmental
Rui Zhou, Jerome Clifford Foo, Asuka Nishida, Sayoko Ogawa, Fumiharu Togo, Tsukasa Sasaki
Summary: Research suggests a bidirectional longitudinal relationship between psychotic-like experiences (PLEs) and self-injurious thoughts and behaviors (SITBs) in adolescents. Psychological distress (PD) may play a particular role when self-injurious thoughts are followed by PLEs. Understanding the relationship between these factors is important for timely interventions for mental disorders and suicide.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Nicole R. Karcher, Kirstie O'Hare, Samantha Y. Jay, Rebecca Grattan
Summary: This study examines the longitudinal relationship between psychotic-like experiences (PLEs) and suicidal ideation (SI) and suicidal behaviors (SB) in middle childhood and early adolescence. The findings suggest that PLEs are associated with increased risk of SI and SB over time, and baseline PLEs may predict worsening of suicidality. The study highlights the importance of understanding the association between youth-reported PLEs and suicidality over time.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Yue Li, Liang Zhou, Dongfang Wang, Ling Jing, Meng Sun
Summary: In this study, the role of fear response to COVID-19 and depression in the association between psychotic-like experiences and suicidal ideation was explored among technical secondary school and college students. The results showed that there was a direct and indirect relationship between psychotic-like experiences and suicidal ideation, with depression mediating this relationship. Additionally, high levels of fear during the COVID-19 pandemic exacerbated the adverse impact of psychotic-like experiences on mental health problems.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychology, Clinical
Feten Fekih-Romdhane, Diana Malaeb, Alexandre Andrade Loch, Nour Farah, Manel Stambouli, Majda Cheour, Sahar Obeid, Souheil Hallit
Summary: This study examines the mediating role of problematic smartphone use (PSU) in the relationship between suicidal ideation (SI) and positive psychotic experiences (PEs) in young adults. The findings suggest that PSU is significantly associated with both SI and PEs. Therefore, addressing PSU can be an important target for preventing and intervening in psychosis, especially among vulnerable young people with suicidal ideation.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2023)
Article
Psychiatry
Kaori Endo, Syudo Yamasaki, Miharu Nakanishi, Jordan DeVylder, Satoshi Usami, Yuko Morimoto, Daniel Stanyon, Kazuhiro Suzuki, Mitsuhiro Miyashita, Makoto Arai, Shinya Fujikawa, Sho Kanata, Shuntaro Ando, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: This study investigated the longitudinal association between psychotic experiences and loneliness among adolescents. The results showed a significant positive association between psychotic experiences and subsequent loneliness, suggesting that loneliness could be a sign of underlying psychotic experiences in young adolescents. However, the reverse association, between preceding loneliness and later psychotic experiences, was not significant.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Alvaro I. Langer, Klaas Wardenaar, Johanna T. W. Wigman, Jose Luis Ulloa, Daniel Nunez
Summary: Psychotic experiences (PEs) exist in a broader context of other domains of psychopathology and transdiagnostic cognitive and affective processes in adolescents. Through latent profile analysis (LPA), four different patterns of PEs severity levels were identified. The high symptomatology group showed the highest levels of depression, post-traumatic stress symptoms, and defeat/entrapment.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Maja Gregersen, Jens Richardt Mollegaard Jepsen, Julie Marie Brandt, Anne Sondergaard, Sinnika Birkehoj Rohd, Lotte Veddum, Christina Bruun Knudsen, Anna Krogh Andreassen, Birgitte Klee Burton, Carsten Hjorthoj, Mette Falkenberg Krantz, Aja Neergaard Greve, Vibeke Bliksted, Ole Mors, Merete Nordentoft, Anne Amalie Elgaard Thorup, Nicoline Hemager
Summary: Suicide is a leading cause of death in youth and is often preceded by suicidal ideation and non-suicidal self-injury. This study found that children with early childhood psychotic experiences were more likely to have suicidal ideation and self-injury in middle childhood, even after accounting for previous mental disorders. These findings highlight the importance of early detection and intervention for mental health issues in children.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Lisa R. Steenkamp, Nita G. M. de Neve-Enthoven, Amanda Moreira Joao, Diandra C. Bouter, Manon H. J. Hillegers, Witte J. G. Hoogendijk, Laura M. E. Blanken, Steven A. Kushner, Henning Tiemeier, Nina H. Grootendorst-van Mil, Koen Bolhuis
Summary: Previous studies have shown that psychotic experiences are associated with an increased risk of suicidality. However, it is unclear whether this association is causal or arises from shared risk factors. Furthermore, little is known about the association between psychotic experiences and non-suicidal self-injury (NSSI).
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychology, Clinical
Nadia Al-Dajani, Adam G. Horwitz, Ewa K. Czyz
Summary: This study found that seeking professional support and coping strategies perceived as helpful on the previous day were associated with lower subsequent day suicidal urges. Adolescents who reported higher average use of cognitive strategies, personal support seeking, and perceived coping helpfulness had lower daily suicidal urges compared to others. These findings highlight the importance of strengthening personal and professional supportive relationships, assisting youth with developing a broader coping repertoire, and identifying strategies that adolescents perceive as helpful in the prevention of youth suicide.
DEPRESSION AND ANXIETY
(2022)
Article
Psychiatry
Amy Weisman de Mamani, Daisy Lopez
Summary: Higher acculturation and lower enculturation in H/L individuals are associated with increased suicidal ideation. The study suggests that maintaining beliefs and traditions from one's home culture may reduce suicidal ideation in H/L individuals with psychotic spectrum disorders.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Developmental
Lauren M. O'Reilly, Erik Pettersson, Patrick D. Quinn, E. David Klonsky, Jessie R. Baldwin, Sebastian Lundstrom, Henrik Larsson, Paul Lichtenstein, Brian M. D'Onofrio
Summary: The study revealed an independent association between bullying victimization and self-harm/suicide attempt in adolescence, with small effect sizes, indicating the need for additional interventions beyond bullying prevention.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Psychology, Clinical
Amir Sariaslan, Stefan Leucht, Johan Zetterqvist, Paul Lichtenstein, Seena Fazel
Summary: In individuals with psychiatric disorders, the use of specific antipsychotic medications such as clozapine, olanzapine, and risperidone is associated with lower risks of arrests and convictions for drug-related and violent crimes compared to other antipsychotics. Long-acting injectables, particularly risperidone, also show lower risks of these criminal outcomes.
PSYCHOLOGICAL MEDICINE
(2022)
Editorial Material
Multidisciplinary Sciences
Andrea Ganna, Karin J. H. Verweij, Michel G. Nivard, Robert Maier, Robbee Wedow, Alexander S. Busch, Abdel Abdellaoui, Shengru Guo, J. Fah Sathirapongsasuti, Paul Lichtenstein, Sebastian Lundstrom, Niklas Langstrom, Adam Auton, Kathleen Mullan Harris, Gary W. Beecham, Eden R. Martin, Alan R. Sanders, John R. B. Perry, Benjamin M. Neale, Brendan P. Zietsch
Summary: The complexity of human sexuality cannot be fully captured by a single variable, and genetic influences show substantial overlap between the variable and more nuanced measures of sexual behavior, attraction, and identity.
Article
Substance Abuse
Suvi Virtanen, Tyra Lagerberg, Lotfi Khemiri, Jaana Suvisaari, Henrik Larsson, Paul Lichtenstein, Zheng Chang, Antti Latvala
Summary: The cohort study in Sweden found that individuals with anxiety/depression had a higher risk of substance misuse before starting SSRI treatment, but the risk decreased after treatment initiation.
Article
Psychology, Developmental
Paul Lichtenstein, Magnus Tideman, Patrick F. Sullivan, Eva Serlachius, Henrik Larsson, Ralf Kuja-Halkola, Agnieszka Butwicka
Summary: The study found that intellectual disability (ID) aggregates in families, with relatives of ID individuals at increased risk of ID in proportion to their degree of genetic relatedness. Genetic factors play a significant role in the development of ID, while male sex of relatives and maternal line of relationship with proband are associated with higher risk.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Neurosciences
Tyra Lagerberg, Seena Fazel, Arvid Sjoelander, Clara Hellner, Paul Lichtenstein, Zheng Chang
Summary: Using nationwide Swedish registers, researchers found that SSRI treatment did not increase the risk of suicidal behavior, but may actually reduce it. The risk of suicidal behavior decreased over time after SSRI treatment initiation, across different age groups and history of suicide attempts. Further research with different study designs and populations is warranted to confirm these findings.
NEUROPSYCHOPHARMACOLOGY
(2022)
Letter
Neurosciences
Tyra Lagerberg, Seena Fazel, Paul Lichtenstein, Zheng Chang
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ashley E. Tate, Hanna Sahlin, Shengxin Liu, Yi Lu, Sebastian Lundstrom, Henrik Larsson, Paul Lichtenstein, Ralf Kuja-Halkola
Summary: This article presents one of the largest and most comprehensive studies on borderline personality disorder (BPD) to date. The study reveals that individuals diagnosed with BPD have higher risks of various psychiatric disorders, violent crime victimization, and self-harm. The study also finds that the risks are similar for both males and females with BPD. Additionally, having a sibling with BPD increases the risk for psychiatric disorders, trauma, and adverse behaviors.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Jie Song, Shuyang Yao, Kaarina Kowalec, Yi Lu, Amir Sariaslan, Jin P. Szatkiewicz, Henrik Larsson, Paul Lichtenstein, Christina M. Hultman, Patrick F. Sullivan
Summary: Schizophrenia is a highly heterogeneous disorder with no well-characterized subtypes for treatment response or longitudinal course. Cognitive impairment, a core clinical feature of schizophrenia, is strongly associated with poorer outcomes. This study investigates the complex genetic overlap between schizophrenia and cognitive traits using comprehensive epidemiological and genomic evidence. The findings highlight the robust relationship between cognitive traits and schizophrenia, emphasizing the importance of cognition in understanding the heterogeneity of the disorder.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychiatry
Miguel Garcia-Argibay, Ebba du Rietz, Yi Lu, Joanna Martin, Elis Haan, Kelli Letho, Sarah E. Bergen, Paul Lichtenstein, Henrik Larsson, Isabell Brikell
Summary: Growing evidence suggests that ADHD is associated with poor somatic health in adulthood, but the mechanisms underlying these associations are poorly understood. This study found that ADHD polygenic risk scores (PRS) are associated with multiple somatic health problems in mid-to-late life, particularly in the cardiometabolic domain. These associations were observed in the general population and appear to be partially mediated by life-course risk factors.
TRANSLATIONAL PSYCHIATRY
(2022)
Correction
Psychiatry
Miguel Garcia-Argibay, Ebba du Rietz, Yi Lu, Joanna Martin, Elis Haan, Kelli Lehto, Sarah E. Bergen, Paul Lichtenstein, Henrik Larsson, Isabell Brikell
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Miguel Garcia-Argibay, Ebba Du Rietz, Catharina A. Hartman, Paul Lichtenstein, Zheng Chang, Cristiano Fava, Samuele Cortese, Henrik Larsson
Summary: This study found that there is an association between cardiovascular risk factors and ADHD, and this association is not influenced by medication treatment for ADHD, but is partly due to shared familial risk factors.
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Miguel Garcia-Argibay, Yanli Zhang-James, Samuele Cortese, Paul Lichtenstein, Henrik Larsson, Stephen V. V. Faraone
Summary: This study examined the use of different machine learning techniques to assess the feasibility of using registry data for diagnosing ADHD in children and adolescents in Sweden. The findings showed that a DNN model achieved good predictive ability for ADHD and identified several important features for classification. If validated and proven to be cost-effective in external samples, this model could potentially serve as a useful tool in clinical practice to aid in ADHD screening and decision-making.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Ashley E. Tate, Wonuola A. Akingbuwa, Robert Karlsson, Jouke-Jan Hottenga, Rene Pool, Magnus Boman, Henrik Larsson, Sebastian Lundstrom, Paul Lichtenstein, Christel M. Middeldorp, Meike Bartels, Ralf Kuja-Halkola
Summary: This study aimed to create a model that predicted if individuals will exhibit suicidal behaviour, aggressive behaviour, both, or neither in late adolescence. The model was validated using twin samples from Sweden and the Netherlands, and showed generalizability across Northern Europe. However, the model's prediction performance for suicidal behavior in the Netherlands sample was not better than chance.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Aleksandra Kanina, Henrik Larsson, Arvid Sjolander, Agnieszka Butwicka, Mark J. J. Taylor, Miriam I. I. Martini, Paul Lichtenstein, Frida E. E. Lundberg, Brian M. D. Onofrio, Mina A. A. Rosenqvist
Summary: Cumulative exposure to psychosocial adversity at an early age has been found to increase the risk of ADHD and autism, but it is unclear if this association is causal or due to familial confounding. This study used a population-based cohort in Sweden to examine the relationship between cumulative psychosocial adversity and neurodevelopmental conditions. The results showed a dose-response relationship between psychosocial adversity and ADHD, but no clear dose-response relationship for autism. The findings also highlighted the importance of accounting for familial confounding in studies of psychosocial adversity and neurodevelopmental conditions.
TRANSLATIONAL PSYCHIATRY
(2023)