Article
Psychiatry
Joelle LeMoult, Ashley M. Battaglini, Bronwen Grocott, Ellen Jopling, Katerina Rnic, Lisa Yang
Summary: Recent advances in understanding the stress-depression link have focused on examining specific facets of emotion regulation, refined investigations of social support, and the dysregulation of stress-sensitive biological systems. These studies emphasize the importance of adopting a nuanced approach in understanding the mechanisms and moderators of this link, as well as the need for collaborative research that encompasses human diversity.
CURRENT OPINION IN PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Andrew P. Shoubridge, Jocelyn M. Choo, Alyce M. Martin, Damien J. Keating, Ma-Li Wong, Julio Licinio, Geraint B. Rogers
Summary: The gut microbiome has a significant influence on human neurophysiology and mental health, playing a role in the development of psychiatric conditions and the effectiveness of common therapies. With an increasing acceptance of its role, research is now shifting towards using this knowledge to improve clinical outcomes and understanding the mechanisms of gut microbiome-brain interactions.
MOLECULAR PSYCHIATRY
(2022)
Editorial Material
Oncology
Stuart M. Lichtman
Summary: The field of geriatric oncology has made progress, but there are missed opportunities in research due to underrepresentation of older patients in clinical trials, lack of data collection from older patients, and inadequate analysis and reporting of trial data. To advance research, it is necessary to include older patients in trials, gather essential information, and thoroughly analyze and communicate results.
Article
Pharmacology & Pharmacy
Nneka Augustina Akwu, Makhotso Lekhooa, Dou Deqiang, Adeyemi Oladapo Aremu
Summary: This study systematically examines the antidepressant effects of coumarins and their derivatives in relation to time series of research progress in the pharmacological pathways, association with other diseases, toxicity and bibliometric analysis. The findings suggest that coumarins and their derivatives exert antidepressant effects via the inhibition of monoamine oxidase-B (MAO-B) and their effect on neurotransmitter pathways is well-studied. However, there are understudied areas such as epigenetic modification, neuroendocrine, and neurotrophic pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Oncology
Troy A. McEachron, Lee J. Helman
Summary: In recent years, there has been a significant shift in the field of pediatric cancer research, focusing on genetic and epigenetic drivers of disease, cellular origins of different pediatric cancers, disease models, the tumor microenvironment, and cellular immunotherapies.
Review
Pharmacology & Pharmacy
Liming Gong, Heming Zhao, Yanhong Liu, Hao Wu, Chao Liu, Shuangyan Chang, Liqing Chen, Mingji Jin, Qiming Wang, Zhonggao Gao, Wei Huang
Summary: Peptide-drug conjugates (PDCs) are drug delivery systems that combine drugs with peptides using cleavable linkers. They improve drug stability and targeting, while reducing toxic side effects. PDCs have been widely used in drug delivery.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Biotechnology & Applied Microbiology
Liren Wang, Jia Jiang, Hai Lin, Tonghe Zhu, Jiangyu Cai, Wei Su, Jiebo Chen, Junjie Xu, Yamin Li, Jing Wang, Kai Zhang, Jinzhong Zhao
Summary: Regenerative sports medicine aims to treat sports and aging-related conditions using tissue regeneration techniques. This review summarizes the optimal regeneration techniques for each area and assesses the time required for feasible clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alina Finch, Georgios Solomou, Victoria Wykes, Ute Pohl, Chiara Bardella, Colin Watts
Summary: This review discusses recent advances in understanding diffuse glioma development and progression, including the use of various models and techniques, as well as the understanding of glioma heterogeneity, gene expression and DNA methylation changes. It also covers current treatment options and future clinical trials aimed at improving early diagnosis and disease monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Electrical & Electronic
Jing Han, Zixing Zhang, Cecilia Mascolo, Elisabeth Andre, Jianhua Tao, Ziping Zhao, Bjoern W. Schuller
Summary: Mental health is crucial in daily life, and smartphones and wearable devices have played an increasingly important role in mental health research and care. Despite challenges, leveraging innovative signal processing and deep learning techniques can provide key enabling technology for the development of next-generation user-centric mobile mental health applications.
IEEE SIGNAL PROCESSING MAGAZINE
(2021)
Article
Medicine, General & Internal
E. J. Lenze, B. H. Mulsant, S. P. Roose, H. Lavretsky, C. F. Reynolds, D. M. Blumberger, P. J. Brown, P. Cristancho, A. J. Flint, M. A. Gebara, T. R. Gettinger, E. Lenard, J. P. Miller, G. E. Nicol, H. A. Oughli, V. T. Pham, B. L. Rollman, L. Yang, J. F. Karp
Summary: This study investigated the benefits and risks of augmenting or switching antidepressants in older adults with treatment-resistant depression. The study found that augmenting existing antidepressants with aripiprazole significantly improved psychological well-being compared to switching to bupropion. Among patients in whom augmentation or a switch to bupropion failed, the effects on psychological well-being and remission were similar with lithium augmentation or a switch to nortriptyline.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Eric J. Lenze, Benoit H. Mulsant, Steven P. Roose, Helen Lavretsky, Charles F. Reynolds, Daniel M. Blumberger, Patrick J. Brown, Pilar Cristancho, Alastair J. Flint, Marie A. Gebara, Torie R. Gettinger, Emily Lenard, J. Philip Miller, Ginger E. Nicol, Hanadi A. Oughli, Vy T. Pham, Bruce L. Rollman, Lei Yang, Jordan F. Karp
Summary: In this study, a two-step open-label trial was conducted to investigate the effects of augmenting or switching antidepressants in older adults with treatment-resistant depression. The results showed that augmenting existing antidepressants with aripiprazole significantly improved well-being compared to switching to bupropion. Furthermore, augmentation with lithium or a switch to nortriptyline showed similar effects in patients who did not benefit from augmentation or a switch to bupropion. These findings highlight the potential benefits of aripiprazole augmentation in the treatment of treatment-resistant depression in older adults.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Immunology
Mudan Zhang, Ming Fu, Qinxue Hu
Summary: HuNoV is the leading cause of AGE worldwide, but the development of its vaccine faces challenges due to the lack of a robust in vitro cultivation system. Although HuNoV vaccine candidates based on VLPs are being tested in clinical trials, overcoming challenges to achieve broad protection remains unresolved.
Review
Materials Science, Biomaterials
Nian Liu, Xiangyu Xiao, Ziqiang Zhang, Chun Mao, Mimi Wan, Jian Shen
Summary: Cancer vaccines are a promising therapeutic strategy in clinical oncology, stimulating antitumor immunity to fight against cancer. However, there are several challenges that hinder their broad clinical translation.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Nutrition & Dietetics
Jianian Hua, Jieyi Lu, Xiang Tang, Qi Fang
Summary: The study found that a low GNRI was not associated with an increased risk of depression after ischemic stroke. While some patients had malnutrition, the association between nutritional status and PSD remains unclear.
Article
Psychiatry
Brenna N. Renn, Matthew Schurr, Oleg Zaslavsky, Abhishek Pratap
Summary: The application of AI in healthcare has the potential to revolutionize geriatric mental health care and research, but also runs the risk of being disconnected from clinical practice issues. A cross-professional perspective that bridges the experiences of clinical scientists and data scientists can help better apply AI technology to address challenges in geriatric mental health.
FRONTIERS IN PSYCHIATRY
(2021)
