Review
Medicine, General & Internal
Marialaura Righetto, Daniele Modonutti, Francesco G. Celso, Vittorio Fulcoli, Mariangela Mancini
Summary: The relationship between metabolic syndrome and bladder cancer is complex and inconsistent, requiring more high-quality research to establish the association and provide tailored strategies for the treatment of bladder cancer.
Article
Oncology
Shuo Fang, Yuchen Liu, Huiru Dai, Tianshun Gao, Leli Zeng, Rui Sun, Zilong Zheng, Jinqiu Yuan, Bin Xia, Yihang Pan
Summary: Metabolic syndrome may be an independent risk factor for bladder cancer, and individualized management of MetS components is important for preventing bladder cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lin-Nei Hsu, Ju-Chuan Hu, Po-Yen Chen, Wei-Chia Lee, Yao-Chi Chuang
Summary: This article discusses the interaction and common pathophysiological mechanisms between metabolic syndrome and overactive bladder. Understanding this association may help identify new diagnostic biomarkers and therapeutic targets.
Review
Endocrinology & Metabolism
Lucas Bandeira Marchesan, Ramon Bossardi Ramos, Poli Mara Spritzer
Summary: The metabolic profiles of women with PCOS in Latin America are worse than those without PCOS in the same region, with higher anthropometric and metabolic parameters. Further studies evaluating metabolic comorbidities and distinct PCOS phenotypes in different Latin American countries are needed for primary and secondary prevention of PCOS in the region.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Wanlapa Nuankaew, Hyo Kyu Lee, Youn Hee Nam, Ji Heon Shim, Na Woo Kim, Sung Woo Shin, Min Cheol Kim, Seung Yeon Shin, Bin Na Hong, Sukanya Dej-adisai, Jong Hwan Kwak, Tong Ho Kang
Summary: Metabolic syndrome is a global health problem, and natural supplements like Diospyros kaki fruit extract and its oligosaccharides show potential benefits for obesity and diabetes patients. The study found that D. kaki oligosaccharides improved insulin resistance and obesity in zebrafish larvae, possibly through affecting gene expression related to inflammation and lipid metabolism. The findings suggest that D. kaki fruit extract and its oligosaccharides have potential for drug development and dietary supplements for metabolic syndrome.
Article
Biochemistry & Molecular Biology
Fayaz Ahmad Mir, Ehsan Ullah, Raghvendra Mall, Ahmad Iskandarani, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study found differential expression of serum metabolites and pathways between Arabic subjects with obesity and metabolic syndrome compared to subjects with obesity only. Lipids, including sphingomyelin, were significantly decreased in the group with metabolic syndrome. Non-lipid metabolites, such as quinolinate, kynurenine, and tryptophan, were also decreased in the group with metabolic syndrome. Metabolites and pathways associated with chronic inflammation were found to be dysregulated in subjects with metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Gang Won Choi, Hyeon-Kyoung Cheong, Soo Young Choi, Young Chan Lee, In-Hwan Oh, Young-Gyu Eun
Summary: This study found a significant association between metabolic syndrome and oral cavity cancer, especially in males and young males under the age of 50. The risk of oral cavity cancer increased with an increasing number of metabolic syndrome factors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Shuwen Dong, Zheng Wang, Kunwei Shen, Xiaosong Chen
Summary: Metabolic syndrome and its related components significantly impact the onset, progression, treatment response, and prognosis of breast cancer. The biochemical reactions caused by metabolic abnormalities affect both the host state and organ-specific tumor microenvironment, leading to increased rates of recurrence and mortality.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Boyoung Park
Summary: This study found an association between obesity, metabolic syndrome, and endometrial cancer in East Asian women, with this association being most significant in obese women.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Gukjin Lee, Kyungdo Han, Seong-Su Lee
Summary: The study found that MetS components are specifically related to the incidence of prostate cancer by age group, and the effects of MetS components on prostate cancer vary among different age groups.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Gukjin Lee, Kyungdo Han, Seong-Su Lee
Summary: This study found that the components of metabolic syndrome have an age-specific effect on the incidence of prostate cancer. The association between metabolic syndrome components and prostate cancer varies among different age groups. In the middle-aged and old age groups, the presence of metabolic syndrome, waist circumference, and blood lipids are significantly associated with an increased incidence of prostate cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Irina Gilyazova, Kadriia Enikeeva, Guzel Rafikova, Evelina Kagirova, Yuliya Sharifyanova, Dilara Asadullina, Valentin Pavlov
Summary: Bladder cancer is a common malignant tumor of the urogenital system, with over 500,000 new cases worldwide annually. Current diagnosis methods include cystoscopy and urine cytology, but they have limitations in sensitivity and invasiveness. There is a need to develop more reliable markers and tests for early detection of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Jeong Wook Kang, Hyeon-Kyoung Cheong, Su Il Kim, Min Kyeong Lee, Young Chan Lee, In-Hwan Oh, Young-Gyu Eun
Summary: The incidence of hypopharyngeal cancer is increasing, but early diagnosis and prevention are important for better management. Metabolic syndrome is inversely associated with the risk of hypopharyngeal cancer, especially in women.
Article
Cardiac & Cardiovascular Systems
Yijun Yang, Justin Kurian, Giana Schena, Jaslyn Johnson, Hajime Kubo, Joshua G. Travers, Chunya Kang, Anna Maria Lucchese, Deborah M. Eaton, Maoting Lv, Na Li, Lorianna G. Leynes, Daohai Yu, Fengzhen Yang, Timothy A. McKinsey, Raj Kishore, Mohsin Khan, Sadia Mohsin, Steven R. Houser
Summary: The study suggests that metabolic syndrome in obese pregnant women may lead to pathological cardiac remodeling, increasing the risk of chronic heart disorders.
Correction
Urology & Nephrology
Luca Boeri, Paolo Capogrosso, Ilaria Ortensi, Carlos Miacola, Tommaso Cai, Paolo Verze, Andrea Salonia, Bruno Giammusso, Alessandro Palmieri
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Review
Andrology
Simone Gianazza, Federico Belladelli, Riccardo Leni, Federica Masci, Piercarlo Rossi, Giuseppe Gianesini, Paolo Maggio, Emanuele Zaffuto, Andrea Salonia, Giulio Carcano, Federico Deho, Paolo Capogrosso
Summary: This narrative review aimed to investigate the role of diabetes in the pathophysiology, diagnosis, and treatment of Peyronie's disease (PD). Diabetes is one of the most common comorbidities in PD patients and is strongly associated with erectile dysfunction. Metabolic alterations typical of diabetes play a pivotal role in the development of PD and resistance to its medical treatment.
Editorial Material
Urology & Nephrology
Zhenjie Wu, Linhui Wang, Savio D. Pandolfo, Riccardo Autorino
Letter
Urology & Nephrology
Enrico Checcucci, Paolo Verri, Daniele Amparore, Giovanni Enrico Cacciamani, Juan Gomez Rivas, Riccardo Autorino, Alex Mottrie, Alberto Breda, Francesco Porpiglia
THERAPEUTIC ADVANCES IN UROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Matteo Ferro, Gennaro Musi, Michele Marchioni, Martina Maggi, Alessandro Veccia, Francesco Del Giudice, Biagio Barone, Felice Crocetto, Francesco Lasorsa, Alessandro Antonelli, Luigi Schips, Riccardo Autorino, Gian Maria Busetto, Daniela Terracciano, Giuseppe Lucarelli, Octavian Sabin Tataru
Summary: Renal cancer management poses challenges throughout the entire process from diagnosis to treatment and follow-up. The differentiation between benign and malignant tissues in cases of small renal masses and cystic lesions can be problematic, even with imaging or renal biopsy. Recent advances in artificial intelligence, imaging techniques, and genomics provide potential for helping clinicians with risk stratification, treatment selection, follow-up strategies, and prognosis. However, further prospective studies with larger patient cohorts are needed to validate previous results and implement these techniques into clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Biagio Barone, Luigi Napolitano, Francesco Paolo Calace, Dario Del Biondo, Giorgio Napodano, Marco Grillo, Pasquale Reccia, Luigi De Luca, Domenico Prezioso, Matteo Muto, Felice Crocetto, Matteo Ferro
Summary: This study evaluates the accuracy and reliability of multiparametric magnetic resonance imaging (mpMRI) in detecting clinically significant prostate cancer. The findings show that mpMRI can serve as a reliable diagnostic tool in patients who have undergone previous negative biopsies, with a comparable detection rate of clinically significant prostate cancer compared to re-biopsy patients.
Article
Health Care Sciences & Services
Biagio Barone, Marco Finati, Francesco Cinelli, Antonio Fanelli, Francesco Del Giudice, Ettore De Berardinis, Alessandro Sciarra, Gianluca Russo, Vito Mancini, Nicola D'Altilia, Matteo Ferro, Angelo Porreca, Benjamin I. Chung, Satvir Basran, Carlo Bettocchi, Luigi Cormio, Ciro Imbimbo, Giuseppe Carrieri, Felice Crocetto, Gian Maria Busetto
Summary: Bladder cancer (BCa) and cardiovascular disease (CVD) have common risk factors and may share a biological pathway. A retrospective study showed a positive association between CVD and BCa incidence, with CVD being an independent protective factor for BCa. However, this effect was not confirmed for high-risk tumors.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Surgery
Hae Sung Kang, Jad Khoraki, Jessie Gie, Dielle Duval, Susan Haynes, Michael Siev, Jay Shah, Fernando Kim, Martin Mangino, Levi Procter, Riccardo Autorino, Samuel Weprin
Summary: This study assesses the feasibility of a novel device (Melzi Sharps Finder (R) or MSF) in effective detection of retained surgical sharps (RSS). The results showed that the MSF group had a higher rate of identification of a needle, decreased time to locate a needle, and increased accuracy in determining the presence of a needle.
PATIENT SAFETY IN SURGERY
(2023)
Letter
Urology & Nephrology
Daniele Cignoli, Andrea Salonia, Roberto Bertini, Francesco Montorsi, Umberto Capitanio, Alessandro Larcher
Review
Biochemistry & Molecular Biology
Francesco Lasorsa, Monica Rutigliano, Martina Milella, Matteo Ferro, Savio Domenico Pandolfo, Felice Crocetto, Riccardo Autorino, Michele Battaglia, Pasquale Ditonno, Giuseppe Lucarelli
Summary: Cancer stem cells (CSCs) possess several characteristics, including clonogenic ability, expression of stem cell markers, differentiation into different cell types, growth in nonadhesive spheroids, and the ability to generate tumors that reflect the heterogeneity of primary cancers. CSCs can arise from normal stem cells, progenitor cells, or differentiated cells due to genetic/epigenetic mutations or fusion with bone marrow stem cells. CSCs utilize signaling pathways similar to those involved in early embryonic development. Targeting these pathways, along with surface proteins, is important for treating RCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Gennaro Musi, Filippo Molinari, Francesco A. Mistretta, Mattia Luca Piccinelli, Sonia Guzzo, Marco Tozzi, Elena Lievore, Oskar Blezien, Matteo Fontana, Antonio Cioffi, Daniela Cullura, Elena Verri, Maria Cossu Rocca, Franco Nole, Matteo Ferro, Ottavio de Cobelli, Stefano Luzzago
Summary: This study examined the feasibility and oncological outcomes of penile-sparing surgery in patients with local recurrent penile cancer after previous glansectomy or partial penectomy. The results showed that penile-sparing surgery is a safe and feasible option for treating local recurrence, but further research is needed to optimize patient selection.
Meeting Abstract
Urology & Nephrology
Carlo Bravi, Paolo Dall'Oglio, Elio Mazzone, Ruben De Groote, Ugo Falagario, Riccardo Schiavina, Pietro Piazza, Marco Borghesi, Simone Scarcella, Marcio Covas Moschovas, Filippo Turri, Iulia Andras, Fabrizio Di Maida, Giuseppe Carrieri, Carlo Terrone, Riccardo Autorino, Vipul Patel, Francesco Porpiglia, Aldo Bocciardi, Andrea Minervini, Francesco Montorsi, Koon Ho Rha, Alexandre Mottrie
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Clara Cerrato, Margaret F. Meagher, Riccardo Autorino, Giuseppe Simone, Bo Yang, Robert Uzzo, Francesco Porpiglia, Umberto Capitanio, James Porter, Alp T. Beksac, Mimi Nguyen, Savio D. Pandolfo, Kevin Hakimi, Luke Wang, Andrea Minervini, Clayton Lau, Monish Aron, Daniel Eun, Alexandre Mottrie, Carmen Mir, Chandru Sundaram, Alessandro Antonelli, Jihad Kaouk, Ithaar H. Derweesh
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Nick Corsi, Chase Morrison, Matthew Davis, Alex Stephens, Devin Rogers, Gabriele Tuderti, Dinno F. Mendiola, Linhui Wang, Enrico Checcucci, Spencer H. Bell, Courtney Yong, Sohail Dhanji, Kevin Hakimi, Jacob Taylor, Erika Wood, Alireza Ghoreifi, Marco Tozzi, Benjamin M. Eilender, Chandru Sundaram, Ithaar H. Derweesh, Vitaly Margulis, Matteo Ferro, Giuseppe Simone, Reza Mehrazin, Mark L. Gonzalgo, Hooman Djaladat, Francesco Porpiglia, Daniel D. Eun, Zhenjie Wu, Riccardo Autorino, Firas Abdollah
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Sohail Dhanji, Franklin Liu, Kevin Hakimi, Hooman Djaladat, Firas Abdollah, Mark L. Gonzalgo, Linhui Wang, Matteo Ferro, Courtney Yong, Jacob Taylor, Savio D. Pandolfo, Francesco Porpiglia, Enrico Checcucci, Benjamin M. Eilender, Daniel D. Eun, Spencer H. Bell, Erika Wood, Alireza Ghoreifi, Matthew Davis, Alex Stephens, Gabriele Tuderti, Dinno F. Mendiola, Marco Tozzi, Riccardo Autorino, Chandru P. Sundaram, Reza Mehrazin, Vitaly Margulis, Giuseppe Simone, Zhenjie Wu, Ithaar Derweesh
JOURNAL OF UROLOGY
(2023)