Article
Urology & Nephrology
Seth Winfree, Courtney Weiler, Sharon B. Bledsoe, Tony Gardner, Andre J. Sommer, Andrew P. Evan, James E. Lingeman, Amy E. Krambeck, Elaine M. Worcester, Tarek M. El-Achkar, James C. Williams
Summary: This study utilized multimodal microscopy to detect a unique blue autofluorescence signature specific to RP in kidney stones. Additionally, high-resolution mineral mapping revealed a transition in mineral composition from apatite within RP to calcium oxalate in the stone overgrowth. These findings suggest a novel autofluorescence signature of RP and provide insights into the molecular and spatial transitions associated with kidney stone formation.
Article
Biochemistry & Molecular Biology
Chiharuko Ushimoto, Shigeru Sugiki, Kenshirou Kunii, Shinya Inoue, Eriko Kuroda, Ryoko Akai, Takao Iwawaki, Katsuhito Miyazawa
Summary: Oxidative stress is a significant risk factor for calcium oxalate nephrolithiasis. This study investigates the association between oxidative stress response and stone formation through analyzing the response during different phases and observing the effect on crystal formation in mouse models. The findings suggest that the oxidative stress response via Keap1-Nrf2 pathway may contribute to crystal formation and could be a potential target for preventing and treating nephrolithiasis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Daniel Turudic, Anja Tea Golubic, Mila Lovric, Marko Bilic, Danko Milosevic
Summary: The research found different risks and important variables in urinary stone development between prepubertal and pubertal/postpubertal children, with citrate and glycosaminoglycans increasingly important in children. J48 classifier confirmed the importance of certain variables for distinguishing between children with urolithiasis and healthy children of the same age and gender.
Review
Nutrition & Dietetics
Joseph J. Crivelli, Tanecia Mitchell, John Knight, Kyle D. Wood, Dean G. Assimos, Ross P. Holmes, Sonia Fargue
Summary: The prevalence of kidney stone disease is on the rise, with calcium oxalate being the most common stone composition. Dietary oxalate intake and endogenous production of oxalate play important roles in the pathophysiology of calcium oxalate stone disease, while oxalate-degrading bacteria in the gut microbiome may mitigate stone risk.
Article
Biotechnology & Applied Microbiology
Zhu Wang, Qiong Deng, Yanli Gu, Min Li, Ying Zhang, Qiyi Hu, Shenping Zhang, Xisheng Wang, Hui Liang
Summary: This study investigated the gene expression changes in the kidney of a rat model with kidney stones. The results showed dysregulated genes related to injury, apoptosis, immune response, solute carriers, transporters, and metabolic factors. These findings contribute to a better understanding of the pathogenesis of nephrolithiasis and could potentially lead to the development of new strategies for prevention and treatment.
Article
Biochemistry & Molecular Biology
Chan Jung Liu, Yau Sheng Tsai, Ho Shiang Huang
Summary: This study demonstrates that statins can suppress hyperlipidemia-induced CaOx nephrolithiasis by restoring the expression of anti-lithic protein, leading to a decrease in renal CaOx stone deposits and a change in the dominant calcium crystal composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Crystallography
Ana Petrovic, Tomislav Kizivat, Ines Bilic Curcic, Robert Smolic, Martina Smolic
Summary: Urolithiasis is a multifactorial disease with a high recurrence rate, characterized by solid deposits forming in the urinary tract. The most common type is calcium oxalate stones. In vitro models offer insight into molecular processes leading to renal stone formation and are significant for patient management.
Article
Veterinary Sciences
Osamu Ichii, Kazuhisa Oyamada, Hazuki Mizukawa, Nozomu Yokoyama, Takashi Namba, Yuki Otani, Yaser Hosny Ali Elewa, Noboru Sasaki, Teppei Nakamura, Yasuhiro Kon
Summary: Cats are highly susceptible to urinary organ-related diseases. This study investigated the morphologies of healthy ureters and compared them with surgically resected ureters affected by urolithiasis obstruction. The findings revealed that healthy ureters exhibited a decrease in size, lumen area, and submucosa area from the proximal to middle segment. Diseased ureters showed increased connective tissue, inflammation, and decreased nerves. These findings provide important insights into the pathogenesis of feline ureteral obstruction.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Applied
Peng Sun, Shang-Gao Liao, Rao-Qiong Yang, Chuan-Li Lu, Kai -Long Ji, Dong-Hua Cao, Hua-Bin Hu, Jian-Mei Lu, Xing-Zhen Song, Min Wu, Hui-Zhen Jia, Chun -Fen Xiao, Zhi-Wei Ma, You -Kai Xu
Summary: This study identified a 2.3 kD fructan from Aspidopterys obcordata vine with unique anti-urolithiasis activity, reducing the size of calcium oxalate crystals through multiple mechanisms.
CARBOHYDRATE POLYMERS
(2022)
Review
Multidisciplinary Sciences
Widi Atmoko, Putu Angga Risky Raharja, Ponco Birowo, Agus Rizal Ardy Hariandy Hamid, Akmal Taher, Nur Rasyid
Summary: Genetic polymorphisms have complex associations with recurrent kidney stones, with different genetic variants having varying effects on risk in different populations. Certain polymorphisms may increase the likelihood of recurrent kidney stones, while others have a protective effect.
Review
Health Care Sciences & Services
Kyriaki Stamatelou, David S. Goldfarb
Summary: In the past two decades, there have been no major breakthroughs in the understanding and therapy of kidney stones, which remains a challenging disease for patients, physicians, and healthcare systems. Epidemiological studies play a crucial role in identifying global changes in the prevalence and burden of kidney stones and modifiable risk factors. The expanding knowledge of kidney stone epidemiology significantly enhances the modern management of the disease.
Article
Biology
Muhammad Afzal, Imran Kazmi, Anwarulabedin Mohsin Quazi, Aftab Ahmad, Fahad A. Al-Abaasi, Faisal Imam, Khalid Saad Alharbi, Sami I. Alzarea, Ameeduzzafar Zafar
Summary: The study demonstrated the significant antiurolithic effect of 6-shogaol in rats with experimental urolithiasis, reducing serum levels of BUN, creatinine, and uric acid, and restoring oxidative stress parameters.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Els van de Perre, Dominique Bazin, Vincent Estrade, Elise Bouderlique, Karl Martin Wissing, Michel Daudon, Emmanuel Letavernier
Summary: This article provides an overview of the formation mechanisms of Randall's plaque and associated calcium oxalate stones, along with a historical and epidemiological perspective. It also highlights recent advances, including the development of an animal model.
COMPTES RENDUS CHIMIE
(2022)
Article
Veterinary Sciences
Lucy Kopecny, Carrie A. Palm, Gilad Segev, Jennifer A. Larsen, Jodi L. Westropp
Summary: The proportion of calcium oxalate-containing uroliths in cats has decreased over the years, while the proportion of struvite-containing uroliths has increased. Different types of uroliths have significantly different proportions in the upper urinary tract, and the predispositions based on sex and age are similar to previous reports.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Review
Urology & Nephrology
Saeed R. Khan, Benjamin K. Canales, Paul R. Dominguez-Gutierrez
Summary: Calcium oxalate kidney stones are often found attached to Randall's plaques in the kidney papilla. The formation of Randall's plaques involves mineralization modulators, inflammation, and immune cells.
NATURE REVIEWS NEPHROLOGY
(2021)
Review
Urology & Nephrology
Aslam Khan, Samra Bashir, Saeed R. Khan
Summary: Urolithiasis, an ancient disease, has sparked interest in herbal remedies for treatment. Current research focuses on in vivo studies, primarily examining the impact of plant extracts on stone formation.
Review
Chemistry, Medicinal
Rizwan Ahmad, Muhammad Riaz, Aslam Khan, Ahmed Aljamea, Mohammad Algheryafi, Deya Sewaket, Aljawharah Alqathama
Summary: Reishi mushroom has exceptional value in nutrition, cosmeceuticals, and medical treatments, but there is a lack of quality clinical data to support its pharmacological activities for human use. While Reishi shows promising pharmacological potential, further clinical studies are needed to validate its safety and efficacy.
PHYTOTHERAPY RESEARCH
(2021)
Article
Environmental Sciences
Faisal F. Alamri, Aslam Khan, Abdulaziz O. Alshehri, Ahmed Assiri, Shahd Khan, Leen A. Aldwihi, Munirah A. Alkathiri, Omar A. Almohammed, Ahmad M. Salamatullah, Amer S. Alali, Waleed Badoghaish, Abdulmajeed A. Alshamrani, Yazed AlRuthia, Faleh Alqahtani
Summary: This study conducted in Saudi Arabia on COVID-19 survivors found that a healthier diet was associated with a shorter recovery time from COVID-19, but further research is needed to thoroughly investigate the relationship between the two.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Chemistry, Applied
Naveed Muhammad, Shafiq Ur Rahman, Hilal Uddin, Omer Shehzad, Muhammad Ismail, Niaz Ali, Aslam Khan, Muhammad Shahid, Abid Ullah, Shujaat Ahmad, Haya Hussain, Ikram ul Haq, Sara Vitalini, Marcello Iriti
Summary: Trillium govanianum has a significant antidiarrheal effect, reducing stool number and weight while increasing stool latency time. It also inhibits contractions in the intestine and acts as a calcium channel blocker, showing promise for medicinal use in treating diarrhea and gut spasms.
NATURAL PRODUCT RESEARCH
(2022)
Article
Environmental Sciences
Zackary Alghamdy, Ashwaq Alshahrani, Ismail Memon, Aslam Khan, Muhammad Anwar Khan, Yazeed Alrayan, Fulwah Alfawzan, Syed Faisal Zaidi
Summary: In light of the COVID-19 outbreak, this study explores the impact of the pandemic on the mental health of pre-professional health sciences students. Findings reveal that a majority of students are experiencing depression and anxiety, with females and those with separated parents being more susceptible to severe symptoms. Proper action should be taken to address this issue.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Nutrition & Dietetics
Nisar Fatima, Fareeha Anwar, Uzma Saleem, Aslam Khan, Bashir Ahmad, Irum Shahzadi, Hammad Ahmad, Tariq Ismail
Summary: The methanolic extract of Brugmansia aurea has potential antidiabetic activity, increasing insulin sensitivity and reducing insulin resistance in diabetic rats. It also lowers blood glucose levels and improves glucose tolerance.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Razia Hanif, Muhammad Imran Khan, Asadullah Madni, Muhammad Furqan Akhtar, Muhammad Farhan Sohail, Ammara Saleem, Mubashar Rehman, Sufyan Junaid Usmani, Aslam Khan, Athar Masood
Summary: The study aimed to enhance the oral bioavailability of the poorly water-soluble drug tacrolimus by developing niosomes using polyoxyethylene lauryl ether (Brij-35) and poloxamer 407 surfactants. The niosomes were prepared using a thin film hydration technique and evaluated using various techniques including FTIR, ultra-centrifugation, DLS experiments, SEM microscopy, and DSC technique. The results showed that the newly developed niosomes can improve the dissolution profile of tacrolimus and can be considered as potential oral carriers.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2023)
Article
Immunology
Yasmin Bangash, Ammara Saleem, Muhammad Furqan Akhtar, Fareeha Anwar, Bushra Akhtar, Ali Sharif, Muhammad Imran Khan, Aslam Khan
Summary: This study found that PTN can alleviate the symptoms of atopic dermatitis by reducing inflammation, oxidative damage, and inflammatory cytokine expression in the skin of diseased animals. Therefore, PTN may be an effective drug for treating atopic dermatitis and other inflammatory skin disorders.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Amna Tahir, Muhammad Furqan Akhtar, Ammara Saleem, Muhammad Naveed, Basiru Olaitan Ajiboye, Fareeha Anwar, Aslam Khan
Summary: PCCR is a traditional herbal medicine used for treating muscular swelling, inflammation, pain, and fever. This study confirmed the anti-inflammatory, analgesic, and neuroprotective effects of PCCR in arthritic rats. PCCR exhibited antioxidant and anti-inflammatory activities, improved oxidative stress, and reduced inflammatory markers in rats with arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Plant Sciences
Sana Saleem, Fareeha Anwar, Aslam Khan, Uzma Saleem, Muhammad Furqan Akhtar, Irum Shahzadi, Tariq Ismail
Summary: This study aimed to detect any hazardous effects of B. aurea on animals and find out its LD50. The results revealed no mortality and morbidity in both acute oral and sub-acute toxicity studies. However, oxidative stress markers were significantly increased in the treatment groups, and animals showed decreased food and water intake in the acute oral toxicity study. A slight difference in renal function tests was observed, but no significant change in histopathology was found in selected organs. This study concluded that B. aurea can be safely used for pharmacological purposes.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Oncology
Amna Roheel, Aslam Khan, Fareeha Anwar, Zunaira Akbar, Muhammad Furqan Akhtar, Mohammad Imran Khan, Mohammad Farhan Sohail, Rizwan Ahmad
Summary: This review examines the likelihood of variation in incidence, prevalence, and risk factors for breast cancer by geographic region, food, and cultural practices. The systematic review analyzes epidemiological and risk factor reports from different world regions, finding that demographic, genetic, and lifestyle risk factors vary among countries.
FRONTIERS IN ONCOLOGY
(2023)
Article
Environmental Sciences
Sadaf Yasmeen, Aslam Khan, Fareeha Anwar, Muhammad Furqan Akhtar, Sidra Yasmeen, Shafeeq Ali Shah
Summary: This study aimed to examine the antifibrotic effect of direct-acting antiviral drugs Sofosbuvir and Velpatasvir in a rat model of carbon tetrachloride-induced fibrosis. The results showed that Sofosbuvir and Velpatasvir, alone or in combination, significantly inhibited fibrosis and mediated this effect by reducing the levels of TNF-a/NF-& kappa;B and the IL-6 signaling pathway. Therefore, Sofosbuvir and Velpatasvir may have antifibrotic effects independent of their antiviral activity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Urology & Nephrology
Aslam Khan, Anwar H. Gilani
Summary: The crude extract of Trachyspermum ammi seeds (Ta.Cr) has shown antiurolithic activity through diuretic effects, inhibition of calcium oxalate crystal aggregation, antioxidant effects, renal epithelial cell protection, and antispasmodic effects. This suggests that Ta.Cr has therapeutic potential in urolithiasis.
Article
Medicine, General & Internal
Syed Faisal Zaidi, Abdullah Alzahrani, Zackary Alghamdy, Dheyya Alnajar, Nawaf Alsubhi, Aslam Khan, Mohamed E. Ahmed
Summary: This study investigated the awareness, self-use, perceptions, beliefs, and attitudes towards complementary and alternative medicine (CAM) in the general public of Jeddah, Saudi Arabia. The majority of the population was aware of various CAM modalities and considered prayers and spirituality to be the most effective. Information about CAM was mainly obtained from friends and relatives, while lack of knowledge and lack of trained professionals were perceived as barriers to CAM implementation. Gender, educational level, and relationship to the medical field were found to be associated with awareness and self-use of CAM modalities.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Integrative & Complementary Medicine
Syed Faisal Zaidi, Sheikh Abdul Saeed, Muhammad Anwar Khan, Aslam Khan, Yaqoub Hazazi, Mohammed Otayn, Mohammed Rabah, Muhammad Daniyal
Summary: This study evaluated the knowledge, attitudes, and practices regarding herbal medicines among the general population in Saudi Arabia. The results showed that the use of herbal medicines is common in Jeddah, with a significant association between female gender and usage. Despite the belief that herbal medicines are safe and do not require consultation, there is a need to increase awareness and establish strategies to evaluate their safety and efficacy.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)